Phenotype: decreased circulating total protein level

Definition total serum protein level below the normal range

Synonyms
  • hypoproteinemia
  • hypoproteinemia
  • decreased plasma total protein level
  • decreased plasma total protein level
  • decreased total protein level
  • reduced circulating total protein level
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Phenotype associations stats

1.70% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased circulating total protein level (55/3229)

1.24% females (40/3214) 1.68% males (54/3205)

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Gene variants with decreased circulating total protein level

Total number of significant genotype-phenotype associations: 103

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Cenpj
Cenpjtm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein WTSI | EuroPhenome 1.56E-12
Cyb561
Cyb561tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein MRC Harwell | EuroPhenome 1.0E-8
Slc38a10
Slc38a10tm2a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein ICS | EuroPhenome 1.13E-8
Chd7
Chd7Whi
HET Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein WTSI | EuroPhenome 2.07E-8
Dbn1
Dbn1tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein WTSI | EuroPhenome 2.4E-8
Aak1
Aak1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein ICS | IMPC 4.32E-8
Akap9
Akap9tm1a(KOMP)Wtsi
HET Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein WTSI | EuroPhenome 4.96E-8
Akap9
Akap9tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein WTSI | EuroPhenome 4.96E-8
Tmem189
Tmem189tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein WTSI | IMPC 5.32E-8
Gatm
Gatmtm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein HMGU | IMPC 2.19E-7
Pex3
Pex3tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein WTSI | EuroPhenome 3.16E-7
Usmg5
Usmg5tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein MRC Harwell | IMPC 5.58E-7
Pgam5
Pgam5tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein ICS | IMPC 9.94E-7
Gse1
Gse1tm1a(EUCOMM)Wtsi
HET Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein MRC Harwell | MGP 1.29E-6
Myl12b
Myl12btm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein WTSI | EuroPhenome 1.68E-6
Col4a5
Col4a5tm1b(EUCOMM)Wtsi
HOM Female postnatal decreased circulating total protein level Clinical Chemistry | Total protein MRC Harwell | IMPC 1.89E-6
Cyb561
Cyb561tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein MRC Harwell | IMPC 2.1E-6
Rspo1
Rspo1tm1.1(KOMP)Vlcg
HOM Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein UC Davis | IMPC 2.25E-6
Rnf10
Rnf10tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein ICS | IMPC 2.27E-6
Fzd2
Fzd2tm1.1(KOMP)Vlcg
HET Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein UC Davis | IMPC 2.4E-6
Fkbp9
Fkbp9tm1a(EUCOMM)Hmgu
HOM Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein ICS | EuroPhenome 2.45E-6
Psmc2
Psmc2tm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein HMGU | IMPC 4.17E-6
Boc
Boctm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein MRC Harwell | IMPC 4.29E-6
Sptbn1
Sptbn1tm1a(EUCOMM)Wtsi
HET Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein WTSI | EuroPhenome 4.45E-6
Esco1
Esco1tm1(KOMP)Wtsi
HOM Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein WTSI | EuroPhenome 4.59E-6
Sema3f
Sema3ftm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein MRC Harwell | IMPC 4.73E-6
Abca6
Abca6tm2b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein TCP | IMPC 4.87E-6
Amfr
Amfrtm1a(KOMP)Wtsi
HET Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein WTSI | EuroPhenome 4.91E-6
Amfr
Amfrtm1a(KOMP)Wtsi
HOM Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein WTSI | EuroPhenome 4.91E-6
Mir28a
Mir28atm1(mirKO)Wtsi
HOM Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein MARC | IMPC 5.64E-6
Aldh2
Aldh2tm1a(EUCOMM)Wtsi
HOM Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein WTSI | EuroPhenome 6.27E-6
Fbxl19
Fbxl19tm1b(EUCOMM)Wtsi
HET Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein MARC | IMPC 6.47E-6
Miga2
Miga2tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein WTSI | EuroPhenome 6.53E-6
Arpc4
Arpc4tm1a(EUCOMM)Wtsi
HET Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein WTSI | EuroPhenome 7.21E-6
Acsl5
Acsl5tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein UC Davis | IMPC 7.52E-6
Ltbp1
Ltbp1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein WTSI | EuroPhenome 9.25E-6
Col4a5
Col4a5tm1b(EUCOMM)Wtsi
HEM Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein MRC Harwell | IMPC 1.07E-5
Adnp2
Adnp2em1Tcp
HOM Female postnatal decreased circulating total protein level Clinical Chemistry | Total protein TCP | IMPC 1.14E-5
Parvb
Parvbtm1a(EUCOMM)Wtsi
HOM Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein MRC Harwell | MGP 1.26E-5
Mysm1
Mysm1tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein WTSI | EuroPhenome 1.32E-5
Fam20c
Fam20ctm1b(KOMP)Wtsi
HET Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein UC Davis | IMPC 1.46E-5
Ggnbp2
Ggnbp2tm1b(KOMP)Wtsi
HET Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein TCP | IMPC 1.47E-5
Ggnbp2
Ggnbp2tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein TCP | IMPC 1.47E-5
Cacybp
Cacybptm1b(EUCOMM)Wtsi
HET Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein UC Davis | IMPC 1.78E-5
Tmem116
Tmem116tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein HMGU | IMPC 1.81E-5
Gna11
Gna11tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein MRC Harwell | MGP 2.42E-5
Pear1
Pear1tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein WTSI | IMPC 2.8E-5
Dusp26
Dusp26tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein WTSI | EuroPhenome 2.9E-5
Usp54
Usp54tm1b(KOMP)Wtsi
HOM Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein MRC Harwell | IMPC 2.9E-5
Emx1
Emx1tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein UC Davis | IMPC 2.96E-5
Kdm4b
Kdm4btm1a(EUCOMM)Wtsi
HET Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein WTSI | EuroPhenome 3.54E-5
Tbc1d2b
Tbc1d2btm1a(EUCOMM)Hmgu
HOM Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein MRC Harwell | EuroPhenome 3.81E-5
Padi2
Padi2tm1b(KOMP)Wtsi
HET Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein UC Davis | IMPC 5.58E-5
Kif21b
Kif21btm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein WTSI | EuroPhenome 5.89E-5
Nfya
NfyaGt(EUCJ0004f10)Hmgu
HET Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein WTSI | EuroPhenome 6.04E-5
Hprt
Hprttm1a(EUCOMM)Hmgu
HEM Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein HMGU | EuroPhenome 6.53E-5
Arl5c
Arl5ctm1.1(KOMP)Vlcg
HOM Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein UC Davis | IMPC 7.52E-5
Slc38a10
Slc38a10tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein WTSI | EuroPhenome 8.03E-5
Tmem167
Tmem167tm1a(EUCOMM)Hmgu
HET Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein MRC Harwell | MGP 8.07E-5
Pkd1
Pkd1tm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein MRC Harwell | IMPC 8.29E-5
Fbxo11
Fbxo11tm2b(EUCOMM)Wtsi
HET Female Male postnatal decreased circulating total protein level Clinical Chemistry | Total protein MRC Harwell | IMPC 9.09E-5

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