Phenotype: decreased mean corpuscular hemoglobin

Definition less than the average levels of hemoglobin contained in an erythrocyte

Synonyms
  • decreased mean corpuscular haemoglobin
  • decreased mean corpuscular haemoglobin
  • low MCH
  • low MCH
  • hypochromasia
  • hypochrosis
  • reduced mean corpuscular hemoglobin
  • decreased MCH
  • hypochromic red cell
  • reduced mean corpuscular haemoglobin
  • hypochromatism
  • hypochromic erythrocyte
  • low mean corpuscular haemoglobin
  • low mean corpuscular hemoglobin
  • hypochromia
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MP browserMP:0005562

Phenotype associations stats

1.58% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased mean corpuscular hemoglobin (60/3804)

1.40% females (53/3773) 1.38% males (52/3775)

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Gene variants with decreased mean corpuscular hemoglobin

Total number of significant genotype-phenotype associations: 107

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Cp
Cptm1b(KOMP)Wtsi
HOM Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 0.0
Prkab1
Prkab1tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 1.6E-40
Gimap6
Gimap6tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 2.6E-31
Adgrf5
Adgrf5tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin TCP | IMPC 1.1E-20
Mul1
Mul1em1(IMPC)H
HOM Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin MRC Harwell | IMPC 4.38E-17
Unk
Unktm1a(KOMP)Wtsi
HOM Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 1.24E-15
Pacsin2
Pacsin2tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 2.43E-15
Atp6v1b2
Atp6v1b2tm1b(KOMP)Wtsi
HET Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin TCP | IMPC 1.24E-14
Ap4e1
Ap4e1tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | EuroPhenome 5.94E-12
Hbb-bh2
Hbb-bh2tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin RBRC | IMPC 1.65E-11
Hemgn
Hemgntm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 7.3E-11
Epb41
Epb41tm1b(KOMP)Mbp
HET Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 6.66E-10
Kat2b
Kat2bem1(IMPC)Wtsi
HOM Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 1.39E-9
Ppp2r2b
Ppp2r2btm1a(KOMP)Wtsi
HOM Female Male postnatal decreased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | EuroPhenome 1.03E-8
Il22ra1
Il22ra1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | EuroPhenome 2.92E-8
Fcho2
Fcho2tm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 6.61E-8
Exd1
Exd1tm1b(EUCOMM)Hmgu
HOM Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin ICS | IMPC 1.37E-7
AW112010
AW112010em1(IMPC)Marc
HOM Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin MARC | IMPC 1.72E-7
Bin2
Bin2em1(IMPC)Wtsi
HOM Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 4.07E-7
Tpcn1
Tpcn1tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 4.66E-7
Zswim1
Zswim1tm1b(KOMP)Mbp
HOM Female postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin MARC | IMPC 5.1E-7
Prkab1
Prkab1em2(IMPC)Mbp
HOM Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin UC Davis | IMPC 6.07E-7
Etaa1
Etaa1em1(IMPC)Marc
HOM Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin MARC | IMPC 6.46E-7
Uqcrq
Uqcrqtm1b(EUCOMM)Hmgu
HET Female postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin MRC Harwell | IMPC 7.75E-7
Sgms1
Sgms1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 8.2E-7
Spata5
Spata5tm1b(KOMP)Wtsi
HET Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin BCM | IMPC 1.16E-6
Rab40c
Rab40ctm1b(KOMP)Wtsi
HET Female postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 1.45E-6
Abcc2
Abcc2tm2b(KOMP)Wtsi
HOM Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin MRC Harwell | IMPC 1.83E-6
Usp21
Usp21tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 1.86E-6
Il27
Il27tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 1.98E-6
Wee1
Wee1tm1b(EUCOMM)Wtsi
HET Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin TCP | IMPC 2.11E-6
Lsm14b
Lsm14btm1b(KOMP)Mbp
HOM Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 2.45E-6
Atp6v0d1
Atp6v0d1tm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin TCP | IMPC 2.66E-6
Dctn4
Dctn4em1(IMPC)Wtsi
HET Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 5.35E-6
Tent5c
Tent5ctm1b(KOMP)Wtsi
HET Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 5.52E-6
Pld3
Pld3tm1e(EUCOMM)Wtsi
HOM Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 6.01E-6
Sqstm1
Sqstm1tm1a(KOMP)Wtsi
HOM Female postnatal decreased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | EuroPhenome 1.04E-5
Slc25a21
Slc25a21tm1d(KOMP)Wtsi
HOM Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 1.09E-5
Hbq1a
Hbq1atm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin RBRC | IMPC 1.31E-5
Rhd
Rhdtm1e(EUCOMM)Wtsi
HOM Female Male postnatal decreased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | EuroPhenome 1.33E-5
Eme1
Eme1tm1.1(KOMP)Wtsi
HOM Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin BCM | IMPC 1.51E-5
Lpin2
Lpin2tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin TCP | IMPC 1.65E-5
Fbxo10
Fbxo10tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin MARC | IMPC 2.22E-5
Trappc10
Trappc10tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 2.25E-5
Rab5a
Rab5atm1b(KOMP)Wtsi
HOM Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 2.49E-5
Smc3
Smc3tm1a(EUCOMM)Wtsi
HET Female Male postnatal decreased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | EuroPhenome 2.78E-5
Reg3d
Reg3dtm1b(EUCOMM)Wtsi
HOM Female postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 2.8E-5
Hsd17b1
Hsd17b1tm1.1(KOMP)Vlcg
HOM Female postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 2.81E-5
Rab5c
Rab5ctm1a(EUCOMM)Wtsi
HET Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 3.61E-5
Fbxo43
Fbxo43em1(IMPC)Marc
HOM Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin MARC | IMPC 3.7E-5
Dhfr
Dhfrtm1b(EUCOMM)Wtsi
HET Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin TCP | IMPC 4.43E-5
Baz1a
Baz1atm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin TCP | IMPC 4.45E-5
Fbxw2
Fbxw2tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin MARC | IMPC 5.21E-5
Elk4
Elk4tm1a(EUCOMM)Wtsi
HOM Male postnatal decreased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | EuroPhenome 6.62E-5
Vps33b
Vps33btm1a(EUCOMM)Wtsi
HET Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 7.0E-5
Cdca5
Cdca5tm1.1(KOMP)Vlcg
HET Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 7.58E-5
Eps15
Eps15tm1a(KOMP)Wtsi
HOM Female postnatal decreased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | EuroPhenome 8.43E-5
Wars
Warstm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin HMGU | IMPC 9.34E-5
Angptl1
Angptl1tm4b(KOMP)Wtsi
HOM Female postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin KMPC | IMPC 9.48E-5
Ttc39a
Ttc39atm1b(KOMP)Mbp
HOM Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin ICS | IMPC 9.5E-5
Rfxank
Rfxanktm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin HMGU | IMPC 9.55E-5

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