Phenotype: increased mean corpuscular hemoglobin

Definition greater than the average levels of hemoglobin contained in an erythrocyte

Synonyms
  • high MCH
  • high MCH
  • increased mean corpuscular haemoglobin
  • increased mean corpuscular haemoglobin
  • hyperchromia
  • increased MCH
  • high mean corpuscular haemoglobin
  • high mean corpuscular hemoglobin
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MP browserMP:0005561

Phenotype associations stats

2.80% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased mean corpuscular hemoglobin (102/3640)

2.52% females (91/3608) 2.68% males (97/3616)

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Gene variants with increased mean corpuscular hemoglobin

Total number of significant genotype-phenotype associations: 190

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Foxo3
Foxo3tm1.1(KOMP)Vlcg
HOM Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 0.0
Hfe2
Hfe2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 0.0
Duoxa2
Duoxa2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 3.13E-37
Knstrn
Knstrntm1b(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin ICS | IMPC 2.58E-35
Fam53b
Fam53btm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin HMGU | IMPC 3.77E-25
Thsd1
Thsd1tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 8.73E-15
Sik3
Sik3tm1a(EUCOMM)Hmgu
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 2.03E-13
Tfr2
Tfr2em1(IMPC)Rbrc
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin RBRC | IMPC 7.58E-13
Rab43
Rab43tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 3.29E-12
Bhlhe40
Bhlhe40tm1b(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 9.3E-12
Dcaf10
Dcaf10tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 2.52E-11
Ppp1cc
Ppp1ccem1(IMPC)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 5.69E-11
Prdm2
Prdm2em1(IMPC)Marc
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin MARC | IMPC 1.1E-10
Zzef1
Zzef1tm2.1(KOMP)Vlcg
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 2.65E-10
Entpd1
Entpd1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | EuroPhenome 6.1E-10
2310057J18Rik
2310057J18Riktm1a(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | EuroPhenome 9.26E-10
Cpa1
Cpa1em1(IMPC)Marc
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin MARC | IMPC 9.38E-10
Elk4
Elk4tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | EuroPhenome 1.59E-9
Chn1
Chn1tm1.1(KOMP)Vlcg
HOM Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 2.55E-9
Cdk5rap2
Cdk5rap2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | EuroPhenome 3.68E-9
Fam160a1
Fam160a1tm1b(EUCOMM)Wtsi
HET Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 6.84E-9
Hbs1l
Hbs1ltm1a(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 1.05E-8
Brcc3
Brcc3em1(IMPC)Marc
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin MARC | IMPC 1.05E-8
Cfh
Cfhtm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | MGP 1.46E-8
Phf5a
Phf5aem2(IMPC)Marc
HET Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin MARC | IMPC 2.26E-8
Vangl1
Vangl1tm1e(KOMP)Wtsi
HET Female Male postnatal increased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | MGP 2.4E-8
Bbc3
Bbc3em1(IMPC)Marc
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin MARC | IMPC 2.65E-8
Tbc1d4
Tbc1d4tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 2.74E-8
Bnip2
Bnip2tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 3.69E-8
Acsf2
Acsf2tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 3.99E-8
Copg1
Copg1tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | MGP 5.24E-8
Fbxl2
Fbxl2em2(IMPC)Marc
HOM Female postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin MARC | IMPC 6.07E-8
Eml1
Eml1em1(IMPC)Wtsi
HOM Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 6.11E-8
Cr1l
Cr1ltm1b(KOMP)Wtsi
HET Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 6.27E-8
Fbxw13
Fbxw13em2(IMPC)Marc
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin MARC | IMPC 1.09E-7
Cd33
Cd33tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 1.16E-7
Rft1
Rft1tm1b(KOMP)Wtsi
HET Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin MRC Harwell | IMPC 1.17E-7
Pex3
Pex3tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | EuroPhenome 1.32E-7
Lsm11
Lsm11tm1a(KOMP)Wtsi
HET Female Male postnatal increased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | EuroPhenome 1.41E-7
Mad2l2
Mad2l2tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | EuroPhenome 2.44E-7
Rab3ip
Rab3iptm1.1(KOMP)Vlcg
HOM Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 2.55E-7
Lmnb1
Lmnb1tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | MGP 2.93E-7
Mst1
Mst1tm1(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | EuroPhenome 4.52E-7
Nfya
NfyaGt(EUCJ0004f10)Hmgu
HET Female Male postnatal increased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | EuroPhenome 5.28E-7
Prpf6
Prpf6tm1.1(KOMP)Vlcg
HET Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 6.82E-7
Abca4
Abca4tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | MGP 8.9E-7
Ripply3
Ripply3tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | EuroPhenome 9.93E-7
Brd2
Brd2em1(IMPC)Wtsi
HET Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 1.07E-6
Fbxo7
Fbxo7tm1a(EUCOMM)Wtsi
HOM Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 2.08E-6
Slc35f6
Slc35f6tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | EuroPhenome 2.48E-6
Clpp
Clpptm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 2.64E-6
Nutm1
Nutm1tm1b(KOMP)Wtsi
HOM Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 2.82E-6
Arrb1
Arrb1tm1b(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 3.82E-6
Elmo1
Elmo1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 3.98E-6
Mtor
Mtortm1a(EUCOMM)Wtsi
HET Female Male postnatal increased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | MGP 4.35E-6
Mylip
Myliptm1.1(KOMP)Vlcg
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 5.79E-6
Ptges2
Ptges2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | EuroPhenome 6.49E-6
Havcr2
Havcr2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin UC Davis | IMPC 8.61E-6
Pitpnm1
Pitpnm1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | EuroPhenome 8.72E-6
Piezo1
Piezo1tm1b(KOMP)Wtsi
HET Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin UC Davis | IMPC 9.97E-6
Mpv17l2
Mpv17l2tm1.1(KOMP)Mbp
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin UC Davis | IMPC 1.05E-5
Osm
Osmtm1b(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 1.14E-5
Tmem136
Tmem136tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 1.2E-5
Ahrr
Ahrrtm1b(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 1.26E-5
Ahrr
Ahrrtm1b(KOMP)Wtsi
HET Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 1.3E-5
Skida1
Skida1tm1(KOMP)Wtsi
HET Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 1.36E-5
Elmod1
Elmod1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin MRC Harwell | IMPC 1.7E-5
Slc4a10
Slc4a10tm1b(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin MRC Harwell | IMPC 2.21E-5
Tbx22
Tbx22tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 2.34E-5
Cdh23
Cdh23tm2b(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 2.64E-5
D930020B18Rik
D930020B18Riktm1.1(KOMP)Vlcg
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin UC Davis | IMPC 2.7E-5
Stag3
Stag3tm1e.1(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 2.85E-5
Anp32e
Anp32etm1e(KOMP)Wtsi
HOM Male postnatal increased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | MGP 2.94E-5
Tmem18
Tmem18tm1b(EUCOMM)Wtsi
HOM Female postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 2.99E-5
Mc1r
Mc1rtm1.1(KOMP)Vlcg
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin UC Davis | IMPC 3.09E-5
Lpar6
Lpar6tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 3.27E-5
Aurka
Aurkatm1b(EUCOMM)Hmgu
HET Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 3.57E-5
Slc25a28
Slc25a28tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 4.08E-5
Rfc1
Rfc1tm1b(KOMP)Mbp
HET Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 4.25E-5
H2-M5
H2-M5tm1(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | EuroPhenome 4.3E-5
Reg3d
Reg3dtm1b(EUCOMM)Wtsi
HOM Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 4.31E-5
Pnpt1
Pnpt1tm1a(KOMP)Wtsi
HET Male postnatal increased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | EuroPhenome 4.4E-5
Arhgap25
Arhgap25tm1a(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | EuroPhenome 4.43E-5
Trim66
Trim66tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | MGP 5.15E-5
Ltbp1
Ltbp1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | MGP 5.15E-5
Ptpn2
Ptpn2tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | EuroPhenome 5.48E-5
Usp11
Usp11tm1(KOMP)Wtsi
HOM Female postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 5.76E-5
Trf
Trfem1(IMPC)Rbrc
HET Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin RBRC | IMPC 5.79E-5
Sar1b
Sar1btm1a(EUCOMM)Wtsi
HET Female Male postnatal increased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | MGP 6.01E-5
Rdx
Rdxtm1.1(KOMP)Vlcg
HET Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 6.6E-5
Usp33
Usp33tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | MGP 6.98E-5
Hook3
Hook3tm1b(NCOM)Mfgc
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin TCP | IMPC 7.0E-5
Vps33b
Vps33btm1a(EUCOMM)Wtsi
HET Female postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 7.0E-5
Mmachc
Mmachctm1.1(NCOM)Mfgc
HET Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin TCP | IMPC 7.08E-5
Apbb2
Apbb2tm1.1(KOMP)Vlcg
HET Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin UC Davis | IMPC 7.45E-5
S100b
S100btm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Haematology test | Mean-corpuscular-haemoglobin WTSI | EuroPhenome 7.82E-5
Palb2
Palb2tm1.1(KOMP)Vlcg
HET Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin JAX | IMPC 8.09E-5
Med22
Med22tm1a(EUCOMM)Wtsi
HET Female postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 8.46E-5
Igfals
Igfalstm1b(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin UC Davis | IMPC 8.48E-5
Morc2a
Morc2aem1(IMPC)Wtsi
HET Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin WTSI | IMPC 8.84E-5
Herpud2
Herpud2tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin UC Davis | IMPC 9.2E-5
Spast
Spasttm1b(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin UC Davis | IMPC 9.76E-5
Sarnp
Sarnptm1b(EUCOMM)Hmgu
HET Female Male postnatal increased mean corpuscular hemoglobin Hematology | Mean corpuscular hemoglobin HMGU | IMPC 9.98E-5

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