Phenotype: increased circulating creatinine level

Definition greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction

Synonyms increased creatinine level

MP browserMP:0005553

Phenotype associations stats

1.12% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased circulating creatinine level (43/3838)

0.87% females (33/3794) 0.87% males (33/3808)

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Gene variants with increased circulating creatinine level

Total number of significant genotype-phenotype associations: 66

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Slc12a1
Slc12a1urehr3
HOM Female Male postnatal increased circulating creatinine level Clinical chemistry (GMC) | Creatinine HMGU | EuroPhenome 1.19E-13
Lmnb2
Lmnb2tm1a(KOMP)Wtsi
HET Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | EuroPhenome 4.18E-13
Camkmt
Camkmttm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 1.03E-10
Cyp17a1
Cyp17a1tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MARC | IMPC 5.47E-10
Slc13a3
Slc13a3tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine UC Davis | IMPC 1.81E-8
Ucn3
Ucn3tm1.1(KOMP)Vlcg
HOM Female postnatal increased circulating creatinine level Clinical Chemistry | Creatinine UC Davis | IMPC 3.35E-8
Mta3
Mta3tm3a(KOMP)Wtsi
HET Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | EuroPhenome 3.93E-8
Kdm4b
Kdm4btm1a(EUCOMM)Wtsi
HET Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | MGP 1.85E-7
Dsg1c
Dsg1cem1(IMPC)Mbp
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine UC Davis | IMPC 3.08E-7
Dctn1
Dctn1tm1a(EUCOMM)Wtsi
HET Female postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 5.4E-7
Nr1i2
Nr1i2
HOM Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine ICS | EuroPhenome 5.47E-7
Cbx6
Cbx6tm1a(EUCOMM)Wtsi
HOM Female postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 6.87E-7
Csmd1
Csmd1em1(IMPC)Wtsi
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 8.24E-7
Gstt1
Gstt1tm1a(EUCOMM)Hmgu
HOM Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine HMGU | IMPC 9.23E-7
Fbxw8
Fbxw8tm1b(EUCOMM)Hmgu
HET Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MARC | IMPC 1.1E-6
Fbxo44
Fbxo44tm1b(KOMP)Wtsi
HOM Female postnatal increased circulating creatinine level Clinical Chemistry | Creatinine UC Davis | IMPC 1.43E-6
Rnf10
Rnf10tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 1.6E-6
Cxcr2
Cxcr2tm1a(EUCOMM)Wtsi
HET Female postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 1.93E-6
Aqp3
Aqp3tm2b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MRC Harwell | IMPC 2.19E-6
Btbd17
Btbd17em1(IMPC)Mbp
HOM Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine UC Davis | IMPC 2.55E-6
Il13
Il13tm1.1(KOMP)Vlcg
HOM Female postnatal increased circulating creatinine level Clinical Chemistry | Creatinine UC Davis | IMPC 2.82E-6
Alkbh6
Alkbh6tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine HMGU | IMPC 3.03E-6
Shisa8
Shisa8em1(IMPC)Mbp
HOM Female postnatal increased circulating creatinine level Clinical Chemistry | Creatinine UC Davis | IMPC 3.41E-6
Ndrg4
Ndrg4tm1b(KOMP)Wtsi
HOM Female postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MRC Harwell | IMPC 5.53E-6
Gbp5
Gbp5em1(IMPC)Wtsi
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 6.76E-6
Prmt1
Prmt1tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | EuroPhenome 8.51E-6
Usp19
Usp19tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 8.77E-6
Gpr22
Gpr22tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MRC Harwell | IMPC 1.22E-5
Srsf4
Srsf4tm1a(EUCOMM)Wtsi
HET Female postnatal increased circulating creatinine level Clinical Chemistry | Creatinine ICS | MGP 1.87E-5
Adipor1
Adipor1tm1b(EUCOMM)Hmgu
HOM Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MRC Harwell | IMPC 2.26E-5
Slc22a8
Slc22a8tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MRC Harwell | IMPC 2.51E-5
Mrps35
Mrps35tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine ICS | MGP 3.75E-5
Slc38a10
Slc38a10tm1a(EUCOMM)Wtsi
HOM Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | EuroPhenome 4.0E-5
Klhl21
Klhl21tm1a(KOMP)Wtsi
HET Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 4.45E-5
Zfp367
Zfp367tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | EuroPhenome 5.1E-5
Celsr1
Celsr1Scy
HET Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MRC Harwell | EuroPhenome 5.32E-5
Jarid2
Jarid2tm1a(KOMP)Wtsi
HET Female postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | EuroPhenome 5.52E-5
Tmem254b
Tmem254btm1a(KOMP)Wtsi
HOM Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 6.22E-5
Dbn1
Dbn1tm1b(KOMP)Wtsi
HET Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 6.56E-5
Usp31
Usp31em1(IMPC)Marc
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MARC | IMPC 7.68E-5
Hpse
Hpsetm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine TCP | IMPC 7.78E-5
Atp5e
Atp5etm1b(EUCOMM)Wtsi
HET Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 8.4E-5
Trim8
Trim8em1(IMPC)Wtsi
HOM Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 8.54E-5

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