Phenotype: increased circulating creatinine level

Definition greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction

Synonyms increased creatinine level

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Phenotype associations stats

1.33% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased circulating creatinine level (46/3451)

1.02% females (35/3416) 1.05% males (36/3418)

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Gene variants with increased circulating creatinine level

Total number of significant genotype-phenotype associations: 71

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Mir28a
Mir28atm1(mirKO)Wtsi
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MARC | IMPC 1.68E-44
Duoxa2
Duoxa2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 2.89E-23
Tmem63a
Tmem63atm1(KOMP)Vlcg
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MARC | IMPC 1.33E-14
Slc12a1
Slc12a1urehr3
HOM Female Male postnatal increased circulating creatinine level Clinical chemistry (GMC) | Creatinine HMGU | EuroPhenome 1.19E-13
Lmnb2
Lmnb2tm1a(KOMP)Wtsi
HET Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | EuroPhenome 4.13E-13
Camkmt
Camkmttm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 8.5E-11
Slc13a3
Slc13a3tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine UC Davis | IMPC 1.81E-8
Ucn3
Ucn3tm1.1(KOMP)Vlcg
HOM Female postnatal increased circulating creatinine level Clinical Chemistry | Creatinine UC Davis | IMPC 3.06E-8
Mta3
Mta3tm3a(KOMP)Wtsi
HET Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | EuroPhenome 3.93E-8
Dnpep
Dnpeptm1e(EUCOMM)Wtsi
HOM Female postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 7.07E-8
Nr1i2
Nr1i2
HOM Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine ICS | EuroPhenome 5.47E-7
Dctn1
Dctn1tm1a(EUCOMM)Wtsi
HET Female postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 5.65E-7
Cbx6
Cbx6tm1a(EUCOMM)Wtsi
HOM Female postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 6.64E-7
Csmd1
Csmd1em1(IMPC)Wtsi
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 7.39E-7
Fbxw8
Fbxw8tm1b(EUCOMM)Hmgu
HET Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MARC | IMPC 7.88E-7
Stk3
Stk3em1(IMPC)H
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MRC Harwell | IMPC 8.02E-7
Kdm4b
Kdm4btm1a(EUCOMM)Wtsi
HET Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | EuroPhenome 9.72E-7
Alkbh6
Alkbh6tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine HMGU | IMPC 1.27E-6
Rnf10
Rnf10tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 1.5E-6
Hexb
Hexbtm1b(EUCOMM)Hmgu
HOM Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MRC Harwell | IMPC 1.54E-6
Fbxo44
Fbxo44tm1b(KOMP)Wtsi
HOM Female postnatal increased circulating creatinine level Clinical Chemistry | Creatinine UC Davis | IMPC 1.57E-6
Cxcr2
Cxcr2tm1a(EUCOMM)Wtsi
HET Female postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 1.97E-6
Ndrg4
Ndrg4tm1b(KOMP)Wtsi
HOM Female postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MRC Harwell | IMPC 4.3E-6
Gbp5
Gbp5em1(IMPC)Wtsi
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 6.39E-6
Usp19
Usp19tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 8.16E-6
Prmt1
Prmt1tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | EuroPhenome 8.49E-6
Gpr22
Gpr22tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MRC Harwell | IMPC 9.66E-6
Srsf4
Srsf4tm1a(EUCOMM)Wtsi
HET Female postnatal increased circulating creatinine level Clinical Chemistry | Creatinine ICS | MGP 1.87E-5
Adipor1
Adipor1tm1b(EUCOMM)Hmgu
HOM Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MRC Harwell | IMPC 2.21E-5
Mrps35
Mrps35tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine ICS | MGP 3.75E-5
Slc38a10
Slc38a10tm1a(EUCOMM)Wtsi
HOM Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | EuroPhenome 3.97E-5
Klhl21
Klhl21tm1a(KOMP)Wtsi
HET Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 4.22E-5
Zfp367
Zfp367tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | EuroPhenome 4.96E-5
Usp31
Usp31em1(IMPC)Marc
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MARC | IMPC 5.02E-5
Trim8
Trim8em1(IMPC)Wtsi
HOM Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 5.09E-5
Celsr1
Celsr1Scy
HET Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MRC Harwell | EuroPhenome 5.32E-5
Jarid2
Jarid2tm1a(KOMP)Wtsi
HET Female postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | EuroPhenome 5.52E-5
Reg3d
Reg3dtm1b(EUCOMM)Wtsi
HOM Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 5.72E-5
Dbn1
Dbn1tm1b(KOMP)Wtsi
HET Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 5.92E-5
Mapk13
Mapk13em1(IMPC)Hmgu
HOM Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine HMGU | IMPC 5.95E-5
Tmem254b
Tmem254btm1a(KOMP)Wtsi
HOM Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 5.98E-5
Col4a5
Col4a5tm1b(EUCOMM)Wtsi
HOM Female postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MRC Harwell | IMPC 6.7E-5
Hpse
Hpsetm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine TCP | IMPC 8.22E-5
Gnao1
Gnao1tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MRC Harwell | IMPC 8.25E-5
Atp5e
Atp5etm1b(EUCOMM)Wtsi
HET Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 8.61E-5
Smpdl3a
Smpdl3aem1(IMPC)Tcp
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine TCP | IMPC 9.16E-5

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