Phenotype: increased circulating creatinine level

Definition greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction

Synonyms increased creatinine level

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Phenotype associations stats

1.47% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased circulating creatinine level (42/2862)

1.26% females (36/2853) 1.13% males (32/2835)

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Gene variants with increased circulating creatinine level

Total number of significant genotype-phenotype associations: 69

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Mir28a
Mir28atm1(mirKO)Wtsi
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MARC | IMPC 0.0
Duoxa2
Duoxa2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 1.53E-25
Lmnb2
Lmnb2tm1a(KOMP)Wtsi
HET Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | EuroPhenome 6.69E-14
Slc12a1
Slc12a1urehr3
HOM Female Male postnatal increased circulating creatinine level Clinical chemistry (GMC) | Creatinine HMGU | EuroPhenome 1.19E-13
Camkmt
Camkmttm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 6.71E-12
Cyp17a1
Cyp17a1tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MARC | IMPC 2.74E-11
Tmem63a
Tmem63atm1(KOMP)Vlcg
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MARC | IMPC 1.12E-10
Dnpep
Dnpeptm1e(EUCOMM)Wtsi
HOM Female postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 2.43E-8
Ucn3
Ucn3tm1.1(KOMP)Vlcg
HOM Female postnatal increased circulating creatinine level Clinical Chemistry | Creatinine UC Davis | IMPC 2.51E-8
Mta3
Mta3tm3a(KOMP)Wtsi
HET Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | EuroPhenome 3.93E-8
Mir141
Mir141tm1(mirKO)Wtsi
HET Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MARC | IMPC 1.57E-7
Kdm4b
Kdm4btm1a(EUCOMM)Wtsi
HET Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | EuroPhenome 2.12E-7
Fbxw8
Fbxw8tm1b(EUCOMM)Hmgu
HET Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MARC | IMPC 2.15E-7
Cbx6
Cbx6tm1a(EUCOMM)Wtsi
HOM Female postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 3.93E-7
Dctn1
Dctn1tm1a(EUCOMM)Wtsi
HET Female postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 4.03E-7
Nr1i2
Nr1i2
HOM Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine ICS | EuroPhenome 5.47E-7
Aqp3
Aqp3tm2b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MRC Harwell | IMPC 7.64E-7
Cxcr2
Cxcr2tm1a(EUCOMM)Wtsi
HET Female postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 9.98E-7
Fbxo44
Fbxo44tm1b(KOMP)Wtsi
HOM Female postnatal increased circulating creatinine level Clinical Chemistry | Creatinine UC Davis | IMPC 1.36E-6
Ndrg4
Ndrg4tm1b(KOMP)Wtsi
HOM Female postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MRC Harwell | IMPC 2.08E-6
Rnf10
Rnf10tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 2.38E-6
Slc22a8
Slc22a8tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MRC Harwell | IMPC 7.16E-6
Gpr22
Gpr22tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MRC Harwell | IMPC 7.8E-6
Prmt1
Prmt1tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | EuroPhenome 8.69E-6
Adipor1
Adipor1tm1b(EUCOMM)Hmgu
HOM Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MRC Harwell | IMPC 1.33E-5
Dbn1
Dbn1tm1b(KOMP)Wtsi
HET Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 1.85E-5
Srsf4
Srsf4tm1a(EUCOMM)Wtsi
HOM Female postnatal increased circulating creatinine level Clinical Chemistry | Creatinine ICS | EuroPhenome 1.87E-5
Srsf4
Srsf4tm1a(EUCOMM)Wtsi
HET Female postnatal increased circulating creatinine level Clinical Chemistry | Creatinine ICS | EuroPhenome 1.87E-5
Usp31
Usp31em1Marc
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MARC | IMPC 2.08E-5
Kctd15
Kctd15tm1b(EUCOMM)Wtsi
HET Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine ICS | IMPC 2.19E-5
Hpse
Hpsetm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine TCP | IMPC 3.03E-5
Klhl21
Klhl21tm1a(KOMP)Wtsi
HET Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 3.71E-5
Mrps35
Mrps35tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine ICS | EuroPhenome 3.75E-5
Sbno1
Sbno1tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MRC Harwell | IMPC 3.92E-5
Pkd1
Pkd1tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MRC Harwell | IMPC 4.0E-5
Gnao1
Gnao1tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MRC Harwell | IMPC 4.13E-5
Frmd6
Frmd6em2H
HET Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MRC Harwell | IMPC 4.36E-5
Zfp367
Zfp367tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | EuroPhenome 5.05E-5
Celsr1
Celsr1Scy
HET Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MRC Harwell | EuroPhenome 5.32E-5
Jarid2
Jarid2tm1a(KOMP)Wtsi
HET Female postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | EuroPhenome 5.52E-5
Col4a5
Col4a5tm1b(EUCOMM)Wtsi
HOM Female postnatal increased circulating creatinine level Clinical Chemistry | Creatinine MRC Harwell | IMPC 6.7E-5
Tmem254b
Tmem254btm1a(KOMP)Wtsi
HOM Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 7.34E-5
Pld3
Pld3tm1e(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating creatinine level Clinical Chemistry | Creatinine WTSI | IMPC 7.79E-5

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