Phenotype: decreased circulating thyroxine level

Definition reduction in the normal blood concentration of the major hormone derived from the thyroid gland that normally affects cellular metabolism

Synonyms
  • decreased circulating level of thyroxine
  • decreased circulating level of thyroxine
  • reduced circulating thyroxine level
  • reduced circulating thyroxine level
  • decreased circulating level of thyroxin
  • decreased circulating level of T4
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MP browserMP:0005478

Phenotype associations stats

0.64% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased circulating thyroxine level (7/1099)

0.49% females (5/1020) 0.58% males (6/1032)



Gene variants with decreased circulating thyroxine level

Total number of significant genotype-phenotype associations: 11

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Gdap2
Gdap2em1(IMPC)Wtsi
HOM Male postnatal decreased circulating thyroxine level Clinical Chemistry | Thyroxine WTSI | IMPC 8.92E-7
Trmt2a
Trmt2atm2b(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating thyroxine level Clinical Chemistry | Thyroxine WTSI | IMPC 4.36E-6
Tmem189
Tmem189tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating thyroxine level Clinical Chemistry | Thyroxine WTSI | IMPC 2.06E-5
Lrrc23
Lrrc23tm1a(EUCOMM)Wtsi
HOM Male postnatal decreased circulating thyroxine level Clinical Chemistry | Thyroxine WTSI | IMPC 3.59E-5
Myl3
Myl3em1(IMPC)Wtsi
HET Female Male postnatal decreased circulating thyroxine level Clinical Chemistry | Thyroxine WTSI | IMPC 6.6E-5
Cxcr2
Cxcr2tm1a(EUCOMM)Wtsi
HOM Female postnatal decreased circulating thyroxine level Clinical Chemistry | Thyroxine WTSI | IMPC 7.58E-5
Dmgdh
Dmgdhtm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating thyroxine level Clinical Chemistry | Thyroxine WTSI | IMPC 8.47E-5

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