Phenotype: decreased circulating thyroxine level

Definition reduction in the normal blood concentration of the major hormone derived from the thyroid gland that normally affects cellular metabolism

Synonyms
  • decreased circulating level of thyroxine
  • decreased circulating level of thyroxine
  • reduced circulating thyroxine level
  • reduced circulating thyroxine level
  • decreased circulating level of thyroxin
  • decreased circulating level of T4
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MP browserMP:0005478

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Phenotype associations stats

0.54% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased circulating thyroxine level (6/1115)

0.48% females (5/1038) 0.48% males (5/1048)



Gene variants with decreased circulating thyroxine level

Total number of significant genotype-phenotype associations: 10

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Duoxa2
Duoxa2tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating thyroxine level Clinical Chemistry | Thyroxine WTSI | IMPC 6.95E-17
Gdap2
Gdap2em1(IMPC)Wtsi
HOM Male postnatal decreased circulating thyroxine level Clinical Chemistry | Thyroxine WTSI | IMPC 1.53E-6
Trmt2a
Trmt2atm2b(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating thyroxine level Clinical Chemistry | Thyroxine WTSI | IMPC 4.82E-6
Tmem189
Tmem189tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating thyroxine level Clinical Chemistry | Thyroxine WTSI | IMPC 2.06E-5
Cxcr2
Cxcr2tm1a(EUCOMM)Wtsi
HOM Female postnatal decreased circulating thyroxine level Clinical Chemistry | Thyroxine WTSI | IMPC 6.76E-5
Dmgdh
Dmgdhtm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating thyroxine level Clinical Chemistry | Thyroxine WTSI | IMPC 7.49E-5

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