Definition
reduction in the normal blood concentration of the major hormone derived from the thyroid gland that normally affects cellular metabolism
Synonyms
reduced circulating thyroxine level,
decreased circulating level of thyroxine,
decreased circulating level of thyroxin,
decreased circulating level of T4
0%
of tested genes
0
significant genes
0
tested genes
IMPC Gene variants with decreased circulating thyroxine level
Total number of significant genotype-phenotype associations: 6
| Gene / Allele | Zygosity | Sex | Life Stage | Phenotype | Parameter | Phenotyping Center |
P Value |
|---|---|---|---|---|---|---|---|
| Duoxa2 Duoxa2tm1b(KOMP)Wtsi |
HOM | Early adult | decreased circulating thyroxine level | Thyroxine Clinical Chemistry |
WTSI IMPC |
0.00 | |
| Gdap2 Gdap2em1(IMPC)Wtsi |
HOM | Early adult | decreased circulating thyroxine level | Thyroxine Clinical Chemistry |
WTSI IMPC |
4.52×10-07 | |
| Cxcr2 Cxcr2tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased circulating thyroxine level | Thyroxine Clinical Chemistry |
WTSI IMPC |
1.58×10-05 | |
| Ncf2 Ncf2tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased circulating thyroxine level | Thyroxine Clinical Chemistry |
WTSI IMPC |
1.63×10-05 | |
| Cand2 Cand2tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased circulating thyroxine level | Thyroxine Clinical Chemistry |
WTSI IMPC |
6.82×10-05 |