Phenotype: decreased heart rate

Definition fewer than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute

Synonyms
  • bradyrhythmia
  • bradyrhythmia
  • reduced heart rate
  • reduced heart rate
  • bradycardia
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Related
Synonyms
sinus bradycardia

MP browserMP:0005333

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Phenotype associations stats

0.63% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased heart rate (18/2871)

0.52% females (15/2864) 0.45% males (12/2689)

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Gene variants with decreased heart rate

Total number of significant genotype-phenotype associations: 27

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Wfdc11
Wfdc11em1Marc
HOM Female Male postnatal decreased heart rate Echo | HR MARC | IMPC 2.74E-24
Trh
Trhem1Tcp
HOM Female Male postnatal decreased heart rate Electrocardiogram (ECG) | HR TCP | IMPC 6.01E-15
Uhrf2
Uhrf2tm1b(EUCOMM)Wtsi
HOM Female postnatal decreased heart rate Electrocardiogram (ECG) | HR TCP | IMPC 3.58E-8
Scarb1
Scarb1tm1b(EUCOMM)Wtsi
HET Female Male postnatal decreased heart rate Electrocardiogram (ECG) | HR BCM | IMPC 1.63E-7
Oplah
Oplahtm1b(KOMP)Wtsi
HOM Female postnatal decreased heart rate Echo | HR HMGU | IMPC 1.71E-7
Rab3gap2
Rab3gap2tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased heart rate Electrocardiogram (ECG) | HR JAX | IMPC 1.95E-7
Bbox1
Bbox1tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 2.63E-7
Ap4e1
Ap4e1tm1b(KOMP)Wtsi
HOM Female postnatal decreased heart rate Echo | HR BCM | IMPC 1.52E-6
Tnfrsf17
Tnfrsf17tm1.1(KOMP)Vlcg
HOM Female postnatal decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 6.92E-6
Ccr6
Ccr6tm1.1(KOMP)Vlcg
HOM Male postnatal decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 1.1E-5
P3h1
P3h1tm1b(EUCOMM)Wtsi
HOM Female postnatal decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 1.29E-5
Wsb2
Wsb2tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased heart rate Echo | HR HMGU | IMPC 2.13E-5
Gpr108
Gpr108tm1b(EUCOMM)Hmgu
HOM Male postnatal decreased heart rate Electrocardiogram (ECG) | HR ICS | IMPC 3.37E-5
Klk4
Klk4tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 5.16E-5
Fbxl16
Fbxl16tm1b(KOMP)Wtsi
HET Male postnatal decreased heart rate Echo | HR BCM | IMPC 5.61E-5
Setbp1
Setbp1tm1e.1(EUCOMM)Wtsi
HET Female Male postnatal decreased heart rate Electrocardiogram (ECG) | HR ICS | IMPC 9.36E-5
Rest
Resttm2b(EUCOMM)Wtsi
HET Female Male postnatal decreased heart rate Electrocardiogram (ECG) | HR HMGU | IMPC 9.52E-5
Unc45a
Unc45atm1b(EUCOMM)Hmgu
HET Female postnatal decreased heart rate Electrocardiogram (ECG) | HR HMGU | IMPC 9.58E-5

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