Phenotype: decreased heart rate

Definition fewer than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute

Synonyms
  • bradyrhythmia
  • bradyrhythmia
  • reduced heart rate
  • reduced heart rate
  • bradycardia
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Related
Synonyms
  • Sinus bradycardia
  • Sinus bradycardia
  • sinus bradycardia
  • sinus bradycardia

MP browserMP:0005333

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Phenotype associations stats

0.71% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased heart rate (23/3228)

0.65% females (21/3207) 0.53% males (16/3032)

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Gene variants with decreased heart rate

Total number of significant genotype-phenotype associations: 37

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Wfdc11
Wfdc11em1(IMPC)Marc
HOM Female Male postnatal decreased heart rate Echo | HR MARC | IMPC 2.74E-24
Trh
Trhem1(IMPC)Tcp
HOM Female Male postnatal decreased heart rate Electrocardiogram (ECG) | HR TCP | IMPC 1.14E-11
Tmem203
Tmem203em1(IMPC)H
HOM Female Male postnatal decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 8.74E-10
Trim55
Trim55tm2b(EUCOMM)Hmgu
HOM Female Male postnatal decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 2.27E-9
Hipk3
Hipk3tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased heart rate Electrocardiogram (ECG) | HR HMGU | IMPC 1.91E-8
Rab3gap2
Rab3gap2tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased heart rate Electrocardiogram (ECG) | HR JAX | IMPC 6.0E-8
Oplah
Oplahtm1b(KOMP)Wtsi
HOM Female postnatal decreased heart rate Echo | HR HMGU | IMPC 9.03E-8
Wsb2
Wsb2tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased heart rate Echo | HR HMGU | IMPC 1.34E-7
Bbox1
Bbox1tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 2.05E-7
Uhrf2
Uhrf2tm1b(EUCOMM)Wtsi
HOM Female postnatal decreased heart rate Electrocardiogram (ECG) | HR TCP | IMPC 3.01E-6
Ap4e1
Ap4e1tm1b(KOMP)Wtsi
HOM Female postnatal decreased heart rate Echo | HR BCM | IMPC 1.05E-5
Sbno1
Sbno1tm1b(EUCOMM)Hmgu
HET Female postnatal decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 1.07E-5
Il18r1
Il18r1em1(IMPC)Mbp
HOM Female postnatal decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 1.12E-5
Tnfrsf17
Tnfrsf17tm1.1(KOMP)Vlcg
HOM Female postnatal decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 1.43E-5
Rab4a
Rab4atm1b(EUCOMM)Hmgu
HOM Male postnatal decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 1.99E-5
Cyp27a1
Cyp27a1tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 2.35E-5
Unc45a
Unc45atm1b(EUCOMM)Hmgu
HET Female postnatal decreased heart rate Electrocardiogram (ECG) | HR HMGU | IMPC 5.51E-5
Ccr6
Ccr6tm1.1(KOMP)Vlcg
HOM Male postnatal decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 7.0E-5
Rest
Resttm2b(EUCOMM)Wtsi
HET Female Male postnatal decreased heart rate Electrocardiogram (ECG) | HR HMGU | IMPC 7.31E-5
Gcsh
Gcshem1(IMPC)H
HET Female Male postnatal decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 7.75E-5
Ccl9
Ccl9tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 7.92E-5
Afap1l2
Afap1l2tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 8.85E-5
Setbp1
Setbp1tm1b(EUCOMM)Wtsi
HET Female Male postnatal decreased heart rate Electrocardiogram (ECG) | HR ICS | IMPC 9.36E-5

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