Phenotype: decreased heart rate

Definition fewer than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute

Synonyms
  • bradyrhythmia
  • bradyrhythmia
  • reduced heart rate
  • reduced heart rate
  • bradycardia
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Related
Synonyms
  • sinus bradycardia
  • sinus bradycardia
  • Sinus bradycardia
  • Sinus bradycardia

MP browserMP:0005333

Phenotype associations stats

0.76% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased heart rate (25/3278)

0.61% females (20/3258) 0.65% males (20/3073)

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Gene variants with decreased heart rate

Total number of significant genotype-phenotype associations: 63

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Trim55
Trim55tm2b(EUCOMM)Hmgu
HOM Female Male postnatal decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 3.82E-10
Trh
Trhem1(IMPC)Tcp
HOM Female Male postnatal decreased heart rate Electrocardiogram (ECG) | HR TCP | IMPC 1.41E-9
Hipk3
Hipk3tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased heart rate Electrocardiogram (ECG) | HR HMGU | IMPC 1.91E-8
Rab4a
Rab4atm1b(EUCOMM)Hmgu
HOM Male postnatal prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 3.62E-8
Maged1
Maged1em1(IMPC)Mbp
HEM Male postnatal prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 4.07E-8
Bbox1
Bbox1tm1a(KOMP)Wtsi
HOM Female Male postnatal prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 5.24E-8
Bbox1
Bbox1tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 9.56E-8
Maged1
Maged1em1(IMPC)Mbp
HEM Male postnatal decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 1.98E-7
Rab3gap2
Rab3gap2tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased heart rate Electrocardiogram (ECG) | HR JAX | IMPC 2.14E-7
Rab3gap2
Rab3gap2tm1b(KOMP)Wtsi
HOM Female Male postnatal prolonged RR interval Electrocardiogram (ECG) | RR JAX | IMPC 2.48E-7
Gcsh
Gcshem1(IMPC)H
HET Female Male postnatal prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 1.14E-6
Wsb2
Wsb2tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased heart rate Echo | HR HMGU | IMPC 1.3E-6
Tnfrsf17
Tnfrsf17tm1.1(KOMP)Vlcg
HOM Female postnatal prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 2.65E-6
Got1
Got1tm1b(EUCOMM)Hmgu
HET Female Male postnatal prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 3.69E-6
Sbno1
Sbno1tm1b(EUCOMM)Hmgu
HET Female postnatal prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 3.73E-6
Sbno1
Sbno1tm1b(EUCOMM)Hmgu
HET Female postnatal decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 4.78E-6
Rab4a
Rab4atm1b(EUCOMM)Hmgu
HOM Male postnatal decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 6.04E-6
Tmem203
Tmem203em1(IMPC)H
HOM Female Male postnatal decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 8.16E-6
Tnfrsf17
Tnfrsf17tm1.1(KOMP)Vlcg
HOM Female postnatal decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 1.61E-5
Mindy2
Mindy2em1(IMPC)H
HOM Male postnatal prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 2.14E-5
Vgf
Vgfem1(IMPC)H
HOM Male postnatal prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 2.18E-5
Cyp27a1
Cyp27a1tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 2.4E-5
Mindy2
Mindy2em1(IMPC)H
HOM Male postnatal decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 2.51E-5
Gcsh
Gcshem1(IMPC)H
HET Female Male postnatal decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 2.84E-5
Ift81
Ift81tm1b(EUCOMM)Wtsi
HET Female Male postnatal decreased heart rate Electrocardiogram (ECG) | HR HMGU | IMPC 4.8E-5
Unc45a
Unc45atm1b(EUCOMM)Hmgu
HET Female postnatal prolonged RR interval Electrocardiogram (ECG) | RR HMGU | IMPC 5.28E-5
Unc45a
Unc45atm1b(EUCOMM)Hmgu
HET Female postnatal decreased heart rate Electrocardiogram (ECG) | HR HMGU | IMPC 5.51E-5
Cyp27a1
Cyp27a1tm1.1(KOMP)Vlcg
HOM Female Male postnatal prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 5.75E-5
Got1
Got1tm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 5.86E-5
Ift81
Ift81tm1b(EUCOMM)Wtsi
HET Female Male postnatal prolonged RR interval Electrocardiogram (ECG) | RR HMGU | IMPC 5.88E-5
Wars
Warstm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased heart rate Echo | HR HMGU | IMPC 6.99E-5
Ccr6
Ccr6tm1.1(KOMP)Vlcg
HOM Male postnatal decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 7.11E-5
Rest
Resttm2b(EUCOMM)Wtsi
HET Female Male postnatal decreased heart rate Electrocardiogram (ECG) | HR HMGU | IMPC 7.31E-5
Afap1l2
Afap1l2tm1b(KOMP)Wtsi
HOM Female Male postnatal prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 8.33E-5
Ap4e1
Ap4e1em2(IMPC)Mbp
HOM Female postnatal prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 8.49E-5
Ccr6
Ccr6tm1.1(KOMP)Vlcg
HOM Male postnatal prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 8.81E-5
Afap1l2
Afap1l2tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 9.16E-5
Rest
Resttm2b(EUCOMM)Wtsi
HET Female Male postnatal prolonged RR interval Electrocardiogram (ECG) | RR HMGU | IMPC 9.18E-5
Il18r1
Il18r1em1(IMPC)Mbp
HOM Female postnatal decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 9.77E-5
Slc29a1
Slc29a1tm2b(NCOM)Mfgc
HOM Female Male postnatal decreased heart rate Electrocardiogram (ECG) | HR TCP | IMPC 9.97E-5

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