Phenotype: decreased circulating cholesterol level

Definition less than the normal amount in the blood of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues

Synonyms
  • low total plasma cholesterol level
  • low total plasma cholesterol level
  • decreased total serum cholesterol level
  • decreased total serum cholesterol level
  • low total serum cholesterol level
  • reduced circulating cholesterol level
  • decreased total plasma cholesterol level
  • hypocholesterolemia
  • decreased total circulating cholesterol level
  • low total circulating cholesterol level
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Related
Synonyms
  • decreased VLDL cholesterol level
  • decreased VLDL cholesterol level
  • decreased circulating VLDL cholesterol level
  • decreased circulating VLDL cholesterol level
  • low VLDL cholesterol level
  • low circulating VLDL cholesterol level
  • reduced VLDL cholesterol level
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Phenotype associations stats

4.05% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased circulating cholesterol level (132/3257)

2.44% females (79/3240) 3.86% males (125/3240)

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Gene variants with decreased circulating cholesterol level

Total number of significant genotype-phenotype associations: 337

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Pcsk9
Pcsk9tm2b(EUCOMM)Hmgu
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol HMGU | IMPC 4.66E-30
Apoc4
Apoc4tm1.1(KOMP)Mbp
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 7.93E-26
Pcsk9
Pcsk9tm2b(EUCOMM)Hmgu
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 3.19E-25
Mir141
Mir141tm1(mirKO)Wtsi
HET Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MARC | IMPC 2.53E-21
Dbn1
Dbn1tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 2.01E-16
Akap9
Akap9tm1a(KOMP)Wtsi
HET Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 3.32E-16
Akap9
Akap9tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 3.32E-16
Ttc28
Ttc28tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol TCP | IMPC 1.1E-15
Plcg2
Plcg2Ali14
HET Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol HMGU | EuroPhenome 1.08E-12
Dbn1
Dbn1tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | EuroPhenome 3.24E-12
Pex3
Pex3tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | EuroPhenome 6.52E-12
Pex3
Pex3tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 1.0E-11
Sec16b
Sec16btm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 1.73E-11
Akap9
Akap9tm1a(KOMP)Wtsi
HET Female Male postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | EuroPhenome 3.43E-11
Akap9
Akap9tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | EuroPhenome 3.43E-11
Acsl5
Acsl5tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol UC Davis | IMPC 4.18E-11
Dlg4
Dlg4tm1e(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 6.26E-11
Sec24a
Sec24atm1a(KOMP)Wtsi
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 1.18E-10
Brd7
Brd7tm3a(EUCOMM)Wtsi
HET Female Male postnatal decreased circulating LDL cholesterol level Fasted Clinical Chemistry | LDL-cholesterol WTSI | EuroPhenome 1.18E-10
Adgrf5
Adgrf5tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol TCP | IMPC 1.4E-10
Prkab1
Prkab1tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | IMPC 1.72E-10
Cyp27b1
Cyp27b1tm1b(EUCOMM)Hmgu
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 1.98E-10
Cyp27b1
Cyp27b1tm1b(EUCOMM)Hmgu
HOM Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol TCP | IMPC 2.14E-10
Tcf19
Tcf19tm1b(EUCOMM)Hmgu
HOM Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol TCP | IMPC 2.82E-10
Akap9
Akap9tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | EuroPhenome 3.85E-10
Akap9
Akap9tm1a(KOMP)Wtsi
HET Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | EuroPhenome 3.85E-10
Setd1a
Setd1atm1a(EUCOMM)Wtsi
HET Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | EuroPhenome 4.25E-10
Vangl2
Vangl2Lp
HET Female Male postnatal decreased circulating cholesterol level Fasted Clinical Chemistry | Total cholesterol MRC Harwell | EuroPhenome 6.6E-10
Sec24a
Sec24atm1a(KOMP)Wtsi
HOM Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | EuroPhenome 7.27E-10
Acsl5
Acsl5tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 7.66E-10
Prkab1
Prkab1tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 8.57E-10
Arhgef4
Arhgef4tm1a(KOMP)Wtsi
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 1.03E-9
Pex3
Pex3tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | EuroPhenome 1.38E-9
Sec16b
Sec16btm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | EuroPhenome 1.68E-9
Krtap17-1
Krtap17-1tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol UC Davis | IMPC 1.71E-9
Krtap17-1
Krtap17-1tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 2.35E-9
BC048403
BC048403tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MARC | IMPC 3.54E-9
Setd1a
Setd1atm1a(EUCOMM)Wtsi
HET Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 3.82E-9
Gc
Gctm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol UC Davis | IMPC 7.14E-9
Rasgrf1
Rasgrf1tm1bNarl
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol MRC Harwell | IMPC 8.04E-9
Adgrf5
Adgrf5tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 1.86E-8
Ltbp1
Ltbp1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | EuroPhenome 2.53E-8
Ahrr
Ahrrtm1b(KOMP)Wtsi
HET Female Male postnatal decreased circulating HDL cholesterol level Plasma Chemistry | HDL cholesterol JAX | IMPC 2.68E-8
Setd1a
Setd1atm1a(EUCOMM)Wtsi
HET Female Male postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | EuroPhenome 2.83E-8
Tfap4
Tfap4tm1.1(KOMP)Vlcg
HET Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol UC Davis | IMPC 3.47E-8
Tfap4
Tfap4tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol UC Davis | IMPC 3.47E-8
Stx8
Stx8tm2a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 3.48E-8
Zfp84
Zfp84tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 3.71E-8
Far2
Far2tm2b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Plasma Chemistry | HDL cholesterol JAX | IMPC 3.72E-8
Nab2
Nab2tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 4.28E-8
Cbx6
Cbx6tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 4.69E-8
Far2
Far2tm2b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating cholesterol level Plasma Chemistry | Total cholesterol JAX | IMPC 4.74E-8
Esco1
Esco1tm1(KOMP)Wtsi
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | EuroPhenome 5.42E-8
Nrxn1
Nrxn1tm1b(KOMP)Wtsi
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 5.76E-8
Nrxn1
Nrxn1tm1b(KOMP)Wtsi
HOM Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol MRC Harwell | IMPC 6.24E-8
Prkab1
Prkab1tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | IMPC 9.15E-8
Arhgef4
Arhgef4tm1a(KOMP)Wtsi
HOM Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | EuroPhenome 1.14E-7
Eif4e3
Eif4e3tm1a(KOMP)Wtsi
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 1.34E-7
Dusp7
Dusp7tm1(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MARC | IMPC 1.4E-7
Slc16a2
Slc16a2tm1a(KOMP)Wtsi
HEM Female Male postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | EuroPhenome 1.42E-7
Elk4
Elk4tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating cholesterol level Fasted Clinical Chemistry | Total cholesterol HMGU | EuroPhenome 1.62E-7
Optn
Optntm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | EuroPhenome 1.68E-7
Cbx6
Cbx6tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | IMPC 1.7E-7
Cygb
Cygbtm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol UC Davis | IMPC 1.72E-7
Sptbn1
Sptbn1tm1a(EUCOMM)Wtsi
HET Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | EuroPhenome 1.87E-7
Elk4
Elk4tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol HMGU | EuroPhenome 2.08E-7
Nab2
Nab2tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol ICS | IMPC 2.15E-7
Sptbn1
Sptbn1tm1a(EUCOMM)Wtsi
HET Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 3.11E-7
Dlg2
Dlg2tm1Dsb
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 3.47E-7
Ewsr1
Ewsr1tm1b(EUCOMM)Wtsi
HET Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol TCP | IMPC 3.73E-7
Ltbp1
Ltbp1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | EuroPhenome 3.73E-7
Sar1b
Sar1btm1a(EUCOMM)Wtsi
HET Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | EuroPhenome 3.74E-7
Sar1b
Sar1btm1a(EUCOMM)Wtsi
HET Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 3.79E-7
Mta1
Mta1tm1a(EUCOMM)Wtsi
HOM Male postnatal decreased circulating LDL cholesterol level Fasted Clinical Chemistry | LDL-cholesterol WTSI | EuroPhenome 6.21E-7
Optn
Optntm1a(EUCOMM)Wtsi
HOM Female postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 6.43E-7
BC048403
BC048403tm1b(KOMP)Wtsi
HOM Female postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol MARC | IMPC 7.08E-7
Ppil3
Ppil3tm1b(EUCOMM)Wtsi
HOM Female postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 7.75E-7
Stx8
Stx8tm2a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating cholesterol level Fasted Clinical Chemistry | Total cholesterol MRC Harwell | EuroPhenome 8.57E-7
Trmt10a
Trmt10atm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 9.89E-7
Dbn1
Dbn1tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | EuroPhenome 1.14E-6
Fam117b
Fam117btm1a(EUCOMM)Wtsi
HOM Female postnatal decreased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 1.18E-6
Hspa5
Hspa5tm1.1(KOMP)Vlcg
HET Male postnatal decreased circulating HDL cholesterol level Plasma Chemistry | HDL cholesterol JAX | IMPC 1.19E-6
Copg1
Copg1tm1a(EUCOMM)Wtsi
HET Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | EuroPhenome 1.31E-6
Dnase1l2
Dnase1l2tm1(KOMP)Wtsi
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol RBRC | IMPC 1.38E-6
Chd7
Chd7Whi
HET Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | EuroPhenome 1.39E-6
Zfp84
Zfp84tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | IMPC 1.46E-6
Esco1
Esco1tm1(KOMP)Wtsi
HOM Female Male postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | EuroPhenome 1.46E-6
Baz1b
Baz1btm2a(KOMP)Wtsi
HET Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | EuroPhenome 1.55E-6
Eif4e3
Eif4e3tm1a(KOMP)Wtsi
HOM Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | EuroPhenome 1.78E-6
Akt2
Akt2tm1Wcs
HOM Male postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | EuroPhenome 1.79E-6
Ltbp1
Ltbp1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 1.88E-6
Gc
Gctm1.1(KOMP)Vlcg
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 1.99E-6
Gpld1
Gpld1tm1.1(KOMP)Vlcg
HOM Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol UC Davis | IMPC 1.99E-6
Miga2
Miga2tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | EuroPhenome 2.0E-6
Wdtc1
Wdtc1tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | IMPC 2.13E-6
Snx5
Snx5tm1a(KOMP)Wtsi
HOM Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | EuroPhenome 2.18E-6
Snx5
Snx5tm1a(KOMP)Wtsi
HOM Male postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | EuroPhenome 2.3E-6
Cyb561
Cyb561tm1a(EUCOMM)Wtsi
HOM Male postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | EuroPhenome 2.5E-6
Slc16a2
Slc16a2tm1a(KOMP)Wtsi
HEM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | EuroPhenome 2.5E-6
Arhgef4
Arhgef4tm1a(KOMP)Wtsi
HOM Male postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | EuroPhenome 2.51E-6
Hells
Hellstm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating LDL cholesterol level Fasted Clinical Chemistry | LDL-cholesterol HMGU | EuroPhenome 2.52E-6
Nfil3
Nfil3tm1.1(KOMP)Vlcg
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 2.72E-6
4930402H24Rik
4930402H24Riktm1b(EUCOMM)Hmgu
HOM Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol TCP | IMPC 2.83E-6
Arhgap22
Arhgap22tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | IMPC 2.85E-6
Igfbp3
Igfbp3tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 2.86E-6
Sec24a
Sec24atm1a(KOMP)Wtsi
HOM Male postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | EuroPhenome 3.02E-6
Rnf10
Rnf10tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating cholesterol level Plasma Chemistry | Total cholesterol JAX | IMPC 3.13E-6
Slc16a2
Slc16a2tm1a(KOMP)Wtsi
HOM Female postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | EuroPhenome 3.16E-6
Xbp1
Xbp1tm1a(EUCOMM)Wtsi
HET Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol HMGU | EuroPhenome 3.19E-6
Optn
Optntm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | EuroPhenome 3.32E-6
Slc16a2
Slc16a2tm1a(KOMP)Wtsi
HOM Female postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | EuroPhenome 3.42E-6
Dmxl2
Dmxl2tm1a(EUCOMM)Wtsi
HET Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | IMPC 3.7E-6
Sar1b
Sar1btm1a(EUCOMM)Wtsi
HET Male postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | EuroPhenome 3.95E-6
Krt7
Krt7tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 4.15E-6
Dync1i2
Dync1i2tm1a(EUCOMM)Wtsi
HET Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | EuroPhenome 4.37E-6
Polr3a
Polr3aem3Tcp
HET Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol TCP | IMPC 4.47E-6
Lactb
Lactbtm1.1(KOMP)Mbp
HOM Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol HMGU | IMPC 4.59E-6
Parvb
Parvbtm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol MRC Harwell | MGP 5.24E-6
Rnf10
Rnf10tm1a(KOMP)Wtsi
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 5.62E-6
Dcaf11
Dcaf11tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | IMPC 5.76E-6
Dlg2
Dlg2tm1Dsb
HOM Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | EuroPhenome 6.09E-6
Slitrk1
Slitrk1tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol UC Davis | IMPC 6.11E-6
Tmprss15
Tmprss15tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 6.17E-6
Cyld
Cyldem2Marc
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MARC | IMPC 6.24E-6
Trmt10a
Trmt10atm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | EuroPhenome 6.58E-6
Slc16a2
Slc16a2tm1a(KOMP)Wtsi
HEM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 7.14E-6
Lactb
Lactbtm1.1(KOMP)Mbp
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 7.64E-6
Atad2b
Atad2btm1b(EUCOMM)Hmgu
HOM Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol ICS | IMPC 8.06E-6
Pabpc4
Pabpc4tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 8.11E-6
Smc5
Smc5tm1b(KOMP)Wtsi
HET Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 8.9E-6
Dusp7
Dusp7tm1(KOMP)Wtsi
HOM Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol MARC | IMPC 9.61E-6
Ncoa1
Ncoa1tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol UC Davis | IMPC 9.64E-6
Psmc2
Psmc2tm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol HMGU | IMPC 9.67E-6
Fto
Ftotm1a(EUCOMM)Wtsi
HOM Male postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | EuroPhenome 1.06E-5
Dlg4
Dlg4tm1e(EUCOMM)Wtsi
HOM Male postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | IMPC 1.07E-5
Emx1
Emx1tm1.1(KOMP)Vlcg
HOM Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol UC Davis | IMPC 1.12E-5
Enc1
Enc1tm1a(EUCOMM)Wtsi
HOM Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | IMPC 1.21E-5
Setbp1
Setbp1tm1e.1(EUCOMM)Wtsi
HET Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol ICS | IMPC 1.35E-5
Miga2
Miga2tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 1.49E-5
Cd300lg
Cd300lgtm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | IMPC 1.54E-5
Tmprss15
Tmprss15tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | EuroPhenome 1.56E-5
Trmt10a
Trmt10atm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | EuroPhenome 1.67E-5
Dcaf11
Dcaf11tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | IMPC 1.67E-5
Sptbn1
Sptbn1tm1a(EUCOMM)Wtsi
HET Male postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | EuroPhenome 1.71E-5
Ttc28
Ttc28tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 1.76E-5
Setd6
Setd6tm1.1(KOMP)Mbp
HOM Male postnatal decreased circulating cholesterol level Plasma Chemistry | Total cholesterol JAX | IMPC 1.92E-5
2010300C02Rik
2010300C02Riktm1b(KOMP)Wtsi
HOM Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | IMPC 1.93E-5
Sorbs2
Sorbs2tm1.1(KOMP)Mbp
HOM Female Male postnatal decreased circulating HDL cholesterol level Plasma Chemistry | HDL cholesterol JAX | IMPC 1.98E-5
Pbx3
Pbx3tm1a(EUCOMM)Wtsi
HOM Female postnatal decreased circulating cholesterol level Fasted Clinical Chemistry | Total cholesterol MRC Harwell | EuroPhenome 2.03E-5
St18
St18tm1a(KOMP)Wtsi
HOM Male postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | EuroPhenome 2.07E-5
Aldh2
Aldh2tm1a(EUCOMM)Wtsi
HOM Male postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | EuroPhenome 2.08E-5
Rhd
Rhdtm1e(EUCOMM)Wtsi
HOM Male postnatal decreased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 2.1E-5
Dusp26
Dusp26tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | EuroPhenome 2.12E-5
Fam234b
Fam234btm1a(EUCOMM)Wtsi
HOM Male postnatal decreased circulating LDL cholesterol level Fasted Clinical Chemistry | LDL-cholesterol HMGU | EuroPhenome 2.12E-5
Slc16a2
Slc16a2tm1a(KOMP)Wtsi
HOM Female postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 2.16E-5
Igfbp3
Igfbp3tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol MRC Harwell | IMPC 2.24E-5
Fam234b
Fam234btm1a(EUCOMM)Wtsi
HOM Male postnatal decreased circulating cholesterol level Fasted Clinical Chemistry | Total cholesterol HMGU | EuroPhenome 2.44E-5
Aldh2
Aldh2tm1a(EUCOMM)Wtsi
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 2.47E-5
Arvcf
Arvcftm1e(EUCOMM)Wtsi
HOM Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | IMPC 2.59E-5
Sec16b
Sec16btm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | EuroPhenome 2.59E-5
Chd7
Chd7Whi
HET Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 2.6E-5
Ide
Idetm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | EuroPhenome 2.61E-5
Txndc5
Txndc5tm1.1(KOMP)Vlcg
HET Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol UC Davis | IMPC 2.81E-5
Cenpo
Cenpotm1b(KOMP)Mbp
HET Female Male postnatal decreased circulating cholesterol level Plasma Chemistry | Total cholesterol JAX | IMPC 2.86E-5
Miga2
Miga2tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | EuroPhenome 2.86E-5
Fbf1
Fbf1tm1a(EUCOMM)Wtsi
HOM Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | IMPC 2.9E-5
Aldh2
Aldh2tm1a(EUCOMM)Wtsi
HOM Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | EuroPhenome 2.93E-5
Slc25a21
Slc25a21tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | EuroPhenome 3.03E-5
Slc35b4
Slc35b4tm1.1(KOMP)Vlcg
HET Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol UC Davis | IMPC 3.2E-5
Dnmt3a
Dnmt3atm1b(KOMP)Wtsi
HET Male postnatal decreased circulating HDL cholesterol level Plasma Chemistry | HDL cholesterol JAX | IMPC 3.22E-5
Rnf10
Rnf10tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 3.27E-5
Cinp
Cinptm1.1(KOMP)Vlcg
HET Male postnatal decreased circulating cholesterol level Plasma Chemistry | Total cholesterol JAX | IMPC 3.38E-5
Tmc6
Tmc6tm1a(EUCOMM)Wtsi
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 3.49E-5
Idh1
Idh1tm1b(EUCOMM)Wtsi
HOM Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol TCP | IMPC 3.57E-5
Vangl2
Vangl2Lp
HET Female Male postnatal decreased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 3.65E-5
Eif4e3
Eif4e3tm1a(KOMP)Wtsi
HOM Male postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | EuroPhenome 3.68E-5
Zfyve28
Zfyve28tm1b(EUCOMM)Wtsi
HOM Male postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | IMPC 3.86E-5
Rab36
Rab36tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating cholesterol level Plasma Chemistry | Total cholesterol JAX | IMPC 4.05E-5
Akt2
Akt2tm1Wcs
HOM Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | EuroPhenome 4.08E-5
Ldha
Ldhatm1a(EUCOMM)Wtsi
HET Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 4.1E-5
1110059G10Rik
1110059G10Riktm1a(KOMP)Wtsi
HOM Female postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | IMPC 4.45E-5
Polr3a
Polr3aem3Tcp
HET Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 4.5E-5
Mtor
Mtortm1a(EUCOMM)Wtsi
HET Male postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | EuroPhenome 4.77E-5
Rnf10
Rnf10tm1a(KOMP)Wtsi
HOM Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | EuroPhenome 4.86E-5
4930402H24Rik
4930402H24Riktm1b(EUCOMM)Hmgu
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 4.89E-5
Txndc5
Txndc5tm1.1(KOMP)Vlcg
HET Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 4.97E-5
Zfp715
Zfp715tm1a(EUCOMM)Hmgu
HOM Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol MRC Harwell | MGP 5.17E-5
Sorbs2
Sorbs2tm1.1(KOMP)Mbp
HOM Female Male postnatal decreased circulating cholesterol level Plasma Chemistry | Total cholesterol JAX | IMPC 5.51E-5
Pigh
Pightm1.1(KOMP)Vlcg
HET Male postnatal decreased circulating HDL cholesterol level Plasma Chemistry | HDL cholesterol JAX | IMPC 5.56E-5
Snx5
Snx5tm1a(KOMP)Wtsi
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 5.63E-5
Abca6
Abca6tm2b(KOMP)Wtsi
HOM Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol TCP | IMPC 6.08E-5
Sgo1
Sgo1tm1a(EUCOMM)Wtsi
HET Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | EuroPhenome 6.1E-5
Agtr2
Agtr2tm1a(EUCOMM)Wtsi
HOM Female postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | EuroPhenome 6.12E-5
Wdr47
Wdr47tm1a(EUCOMM)Wtsi
HOM Male postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | MGP 6.32E-5
Baz1b
Baz1btm2a(KOMP)Wtsi
HET Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 6.47E-5
Psph
Psphtm1.1(KOMP)Vlcg
HET Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 6.56E-5
Lama4
Lama4tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol UC Davis | IMPC 6.6E-5
Pcsk5
Pcsk5tm1b(KOMP)Mbp
HET Male postnatal decreased circulating HDL cholesterol level Plasma Chemistry | HDL cholesterol JAX | IMPC 6.68E-5
Pabpc4
Pabpc4tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | IMPC 6.8E-5
Aak1
Aak1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol ICS | IMPC 6.82E-5
Rhd
Rhdtm1e(EUCOMM)Wtsi
HOM Male postnatal decreased circulating cholesterol level Fasted Clinical Chemistry | Total cholesterol WTSI | EuroPhenome 6.84E-5
Aak1
Aak1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 7.16E-5
Fam117b
Fam117btm1a(EUCOMM)Wtsi
HOM Female postnatal decreased circulating cholesterol level Fasted Clinical Chemistry | Total cholesterol MRC Harwell | EuroPhenome 7.4E-5
Tmem126a
Tmem126atm1a(EUCOMM)Wtsi
HOM Male postnatal decreased circulating LDL cholesterol level Clinical Chemistry | LDL-cholesterol WTSI | IMPC 7.74E-5
Ndufs3
Ndufs3tm1a(EUCOMM)Wtsi
HET Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | EuroPhenome 7.92E-5
Elfn1
Elfn1tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol UC Davis | IMPC 8.0E-5
Rspo1
Rspo1tm1.1(KOMP)Vlcg
HOM Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol UC Davis | IMPC 8.3E-5
Pcsk5
Pcsk5tm1b(KOMP)Mbp
HET Male postnatal decreased circulating cholesterol level Plasma Chemistry | Total cholesterol JAX | IMPC 8.31E-5
March9
March9tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 8.78E-5
Nipa1
Nipa1tm1a(KOMP)Wtsi
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 8.97E-5
Rundc1
Rundc1tm1a(EUCOMM)Wtsi
HET Female postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 9.16E-5
Dhx40
Dhx40tm1(NCOM)Cmhd
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol CMHD | EuroPhenome 9.29E-5
Wrap53
Wrap53tm1b(EUCOMM)Wtsi
HET Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol WTSI | IMPC 9.31E-5
Cyld
Cyldem2Marc
HOM Female Male postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol MARC | IMPC 9.77E-5
Otud7b
Otud7btm1(NCOM)Cmhd
HOM Female postnatal decreased circulating cholesterol level Clinical Chemistry | Total cholesterol CMHD | EuroPhenome 9.81E-5
Mro
Mrotm1H
HOM Female Male postnatal decreased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 9.85E-5

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