Definition
inability or reduced ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max, fractional shortening (FS), velocity of circumferential fiber shortening (Vcfc), peak of aortic outflow velocity (PAV), and ventricular ejection fraction volume
Synonyms
impaired cardiac contractility,
reduced cardiac muscle contractility,
impaired cardiac muscle contractility,
decreased cardiac muscle contraction,
reduced cardiac contractility
0%
of tested genes
0
significant genes
0
tested genes
IMPC Gene variants with decreased cardiac muscle contractility
Total number of significant genotype-phenotype associations: 19
| Gene / Allele | Zygosity | Sex | Life Stage | Phenotype | Parameter | Phenotyping Center |
P Value |
|---|---|---|---|---|---|---|---|
| Zfp280d Zfp280dem1(IMPC)Hmgu |
HOM | Early adult | decreased cardiac muscle contractility | Ejection Fraction Echo |
HMGU IMPC |
2.66×10-32 | |
| Fbxo10 Fbxo10tm1b(KOMP)Wtsi |
HOM | Early adult | decreased cardiac muscle contractility | Fractional Shortening Echo |
MARC IMPC |
5.49×10-09 | |
| Alpk3 Alpk3tm1b(EUCOMM)Hmgu |
HOM | Early adult | decreased cardiac muscle contractility | Ejection Fraction Echo |
MRC Harwell IMPC |
5.90×10-08 | |
| Ints6l Ints6lem1(IMPC)Marc |
HEM | Early adult | decreased cardiac muscle contractility | Fractional Shortening Echo |
MARC IMPC |
3.97×10-07 | |
| Wars1 Wars1tm1b(EUCOMM)Hmgu |
HET | Early adult | decreased cardiac muscle contractility | Ejection Fraction Echo |
HMGU IMPC |
8.24×10-07 | |
| Pex1 Pex1tm1e.1(EUCOMM)Hmgu |
HET | Early adult | decreased cardiac muscle contractility | Ejection Fraction Echo |
HMGU IMPC |
1.03×10-06 | |
| Dsg2 Dsg2tm1b(EUCOMM)Wtsi |
HOM | Early adult | decreased cardiac muscle contractility | Ejection Fraction Echo |
BCM IMPC |
2.12×10-06 | |
| Ufm1 Ufm1em1(IMPC)Marc |
HET | Early adult | decreased cardiac muscle contractility | Ejection Fraction Echo |
MARC IMPC |
2.83×10-06 | |
| Nxn Nxntm1a(EUCOMM)Wtsi |
HET | Early adult | decreased cardiac muscle contractility | Ejection Fraction Echo |
BCM IMPC |
4.43×10-06 | |
| Clec9a Clec9atm1b(KOMP)Wtsi |
HOM | Early adult | decreased cardiac muscle contractility | Fractional Shortening Echo |
ICS IMPC |
5.90×10-06 | |
| Hilpda Hilpdaem1(IMPC)Mhzh |
HOM | Early adult | decreased cardiac muscle contractility | Ejection Fraction Echo |
MARC IMPC |
1.26×10-05 | |
| Sh3tc1 Sh3tc1tm1b(EUCOMM)Hmgu |
HOM | Early adult | decreased cardiac muscle contractility | Fractional Shortening Echo |
ICS IMPC |
2.09×10-05 | |
| Abhd3 Abhd3em1(IMPC)Marc |
HOM | Early adult | decreased cardiac muscle contractility | Ejection Fraction Echo |
MARC IMPC |
2.40×10-05 | |
| Cav1 Cav1em2(IMPC)Ics |
HOM | Early adult | decreased cardiac muscle contractility | Fractional Shortening Echo |
ICS IMPC |
3.40×10-05 | |
| Ncam2 Ncam2tm1b(EUCOMM)Hmgu |
HOM | Early adult | decreased cardiac muscle contractility | Fractional Shortening Echo |
ICS IMPC |
4.17×10-05 | |
| Ndrg4 Ndrg4tm1b(KOMP)Wtsi |
HOM | Early adult | decreased cardiac muscle contractility | Ejection Fraction Echo |
MRC Harwell IMPC |
4.36×10-05 | |
| Wsb2 Wsb2tm1b(EUCOMM)Hmgu |
HOM | Early adult | decreased cardiac muscle contractility | Fractional Shortening Echo |
HMGU IMPC |
4.52×10-05 | |
| Tmprss2 Tmprss2tm2b(EUCOMM)Hmgu |
HOM | Early adult | decreased cardiac muscle contractility | Fractional Shortening Echo |
ICS IMPC |
6.08×10-05 | |
| Kcng2 Kcng2em1(IMPC)Bay |
HOM | Early adult | decreased cardiac muscle contractility | Fractional Shortening Echo |
BCM IMPC |
7.76×10-05 |