Phenotype: decreased lymphocyte cell number

Definition fewer than normal number of the cells involved in adaptive immune reactions of the body in most inflammatory and autoimmune diseases, including B cells, T cells and natural killer cells

Synonyms
  • reduced lymphocyte cell number
  • reduced lymphocyte cell number
  • decreased lymphocyte count
  • decreased lymphocyte count
  • decreased immune cell number
  • reduced lymphocyte count
  • lymphopenia
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Related
Synonyms
  • decreased pre-B cell number
  • decreased pre-B cell number
  • absent B cells
  • absent B cells
  • absent T cells
  • Decreased proportion circulating T-helper cells
  • decreased mature NK cell number
  • absent regulatory T cells
  • absent NK cells
  • decreased thymocyte number
  • decreased mature B cell number
  • decreased T cell number
  • absent immature B cells
  • absent CD8-positive, alpha-beta T cells
  • Decreased proportion of CD3-positive T cells
  • decreased T-helper cell number
  • decreased pre-B cell number
  • decreased NK cell number
  • B lymphocytopenia
  • decreased memory T cell number
  • decreased gamma-delta T cell number
  • decreased activated T cell number
  • decreased memory-marker NK cell number
  • decreased immature NK cell number
  • decreased Ly6C-positive mature NK cell number
  • absent T cells
  • absent CD4-positive, alpha beta T cells
  • decreased KLRG1-positive NK cell number
  • Absence of mature B cells
  • absent NK cells
  • Absence of mature B cells
  • Severe B lymphocytopenia
  • decreased uterine NK cell number
  • Severe B lymphocytopenia
  • absent NK cells
  • decreased immature B cell number
  • decreased memory T cell number
  • absent late pro-B cells
  • Absence of CD8-positive T cells
  • Decreased proportion circulating T-helper cells
  • decreased alpha-beta T cell number
  • decreased B cell number
  • decreased alpha-beta T cell number
  • decreased Ly6C-positive mature NK cell number
  • absent uterine NK cells
  • decreased uterine NK cell number
  • decreased gamma-delta T cell number
  • Decrease in T cell count
  • decreased T-helper cell number
  • absent late pro-B cells
  • absent mature B cells
  • absent double-negative T cells
  • absent B cells
  • absent uterine NK cells
  • decreased single-positive T cell number
  • decreased mature NK cell number
  • decreased thymocyte number
  • decreased activated T cell number
  • Lymphopenia
  • absent NK T cells
  • absent T cells
  • absent lymphocyte
  • decreased Ly6C-positive immature NK cell number
  • absent gamma-delta T cells
  • decreased single-positive T cell number
  • absent uterine NK cells
  • absent mature B cells
  • decreased memory-marker NK cell number
  • decreased regulatory T cell number
  • Severe B lymphocytopenia
  • decreased mature B cell number
  • decreased immature B cell number
  • decreased Ly6C-positive immature NK cell number
  • decreased large unstained cell number
  • decreased immature NK cell number
  • absent B cells
  • Decreased proportion of CD3-positive T cells
  • decreased regulatory T cell number
  • decreased KLRG1-positive NK cell number
  • Reduced natural killer cell count
  • absent immature B cells
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Phenotype associations stats

4.38% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased lymphocyte cell number (122/2786)

3.53% females (95/2688) 4.07% males (111/2729)

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Gene variants with decreased lymphocyte cell number

Total number of significant genotype-phenotype associations: 281

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Cd28
Cd28tm1a(EUCOMM)Hmgu
HOM Female Male postnatal decreased T cell number FACs Analysis | CD25+ percentage of CD4+ T cells MRC Harwell | MGP 3.99E-28
Spns2
Spns2tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD8+ percentage WTSI | 3i 5.59E-25
Elk4
Elk4tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased CD4-positive, alpha beta T cell number FACs Analysis | T cell CD4+ percentage HMGU | EuroPhenome 2.12E-21
Tcf7
Tcf7tm1a(EUCOMM)Wtsi
HOM Male postnatal decreased T cell number FACs Analysis | T cell CD3+ percentage ICS | MGP 4.63E-19
Elk4
Elk4tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased T cell number FACs Analysis | T cell CD3+ percentage HMGU | EuroPhenome 8.19E-19
Lrrk1
Lrrk1tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte differential count MRC Harwell | IMPC 5.52E-16
Pou2af1
Pou2af1tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte differential count UC Davis | IMPC 1.51E-15
Spns2
Spns2tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased CD4-positive, alpha beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD4+ percentage WTSI | 3i 3.26E-15
Hnrnpd
Hnrnpdtm1b(KOMP)Wtsi
HET Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte cell count MARC | IMPC 1.07E-14
Tmem189
Tmem189tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased T cell number Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD3+ percentage WTSI | 3i 2.53E-14
Erf
Erftm1.1(KOMP)Mbp
HET Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte differential count UC Davis | IMPC 5.25E-14
Spns2
Spns2tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased T cell number Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD3+ percentage WTSI | 3i 8.57E-14
Fbxo15
Fbxo15em1(IMPC)Marc
HOM Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte differential count MARC | IMPC 3.07E-13
Elk4
Elk4tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number FACs Analysis | T cell CD8+ percentage HMGU | EuroPhenome 6.01E-13
Tcf7
Tcf7tm1a(EUCOMM)Wtsi
HOM Male postnatal decreased CD4-positive, alpha beta T cell number FACs Analysis | T cell CD4+ percentage ICS | MGP 7.35E-13
Tmem189
Tmem189tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD8+ percentage WTSI | 3i 1.17E-12
Dlgap2
Dlgap2em1(IMPC)Mhzh
HOM Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte differential count MARC | IMPC 1.76E-12
Trim37
Trim37em1(IMPC)Marc
HOM Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte cell count MARC | IMPC 2.49E-12
Lyn
Lyntm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte cell count MRC Harwell | IMPC 9.41E-12
Lepr
Leprtm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte cell count MRC Harwell | IMPC 1.25E-11
Rhbdd1
Rhbdd1tm1.1Mfm
HOM Female Male postnatal decreased B cell number FACs Analysis | B cell CD19+ percentage MRC Harwell | EuroPhenome 2.46E-11
Sgms1
Sgms1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased NK T cell number Buffy coat peripheral blood leukocyte immunophenotyping | NKT cell percentage WTSI | 3i 2.81E-11
Ikzf3
Ikzf3tm1(KOMP)Vlcg
HOM Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte cell count RBRC | IMPC 7.15E-11
Pkn1
Pkn1tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte cell count MRC Harwell | IMPC 8.13E-11
Spns2
Spns2tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased mature B cell number Buffy coat peripheral blood leukocyte immunophenotyping | Mature B cell IgD+ percentage WTSI | 3i 1.35E-10
Rab19
Rab19tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased large unstained cell number Hematology | Large Unstained Cell (LUC) differential count ICS | IMPC 1.89E-10
Tmem189
Tmem189tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased CD4-positive, alpha beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD4+ percentage WTSI | 3i 2.13E-10
Sgms1
Sgms1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD8+ percentage WTSI | 3i 2.18E-10
Nrxn1
Nrxn1tm1b(KOMP)Wtsi
HOM Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte differential count MRC Harwell | IMPC 2.68E-10
Spns2
Spns2tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased B cell number Buffy coat peripheral blood leukocyte immunophenotyping | B cell CD19+ percentage WTSI | 3i 3.1E-10
Dnm2
Dnm2tm1.1(KOMP)Vlcg
HET Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte differential count UC Davis | IMPC 4.93E-10
Pkn1
Pkn1tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased large unstained cell number Hematology | Large Unstained Cell (LUC) count MRC Harwell | IMPC 7.71E-10
Nr1d2
Nr1d2tm1Dgen
HOM Male postnatal decreased T cell number FACs Analysis | T cell CD3+ percentage ICS | EuroPhenome 8.65E-10
Fbxo7
Fbxo7tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased CD4-positive, alpha beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD4+ percentage WTSI | 3i 9.77E-10
Parvb
Parvbtm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased mature B cell number FACs Analysis | Mature B cells IgD+ percentage MRC Harwell | MGP 1.62E-9
Acp2
Acp2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased T cell number FACs Analysis | T cell CD3+ percentage MRC Harwell | EuroPhenome 2.48E-9
Ric1
Ric1tm1a(EUCOMM)Hmgu
HOM Male postnatal decreased mature B cell number FACs Analysis | Mature B cells IgD+ percentage MRC Harwell | EuroPhenome 4.05E-9
Acp2
Acp2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number FACs Analysis | T cell CD8+ percentage MRC Harwell | EuroPhenome 4.26E-9
Parvb
Parvbtm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased T cell number FACs Analysis | CD25+ percentage of CD4+ T cells MRC Harwell | EuroPhenome 6.21E-9
Nr1d2
Nr1d2tm1Dgen
HOM Male postnatal decreased CD8-positive, alpha-beta T cell number FACs Analysis | T cell CD8+ percentage ICS | EuroPhenome 8.97E-9
Fbxo7
Fbxo7tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased T cell number Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD3+ percentage WTSI | 3i 1.83E-8
Usp12
Usp12tm1a(EUCOMM)Hmgu
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number FACs Analysis | T cell CD8+ percentage HMGU | MGP 2.3E-8
Ccdc83
Ccdc83em1(IMPC)Marc
HOM Female postnatal decreased lymphocyte cell number Hematology | Lymphocyte cell count MARC | IMPC 2.3E-8
Arhgef4
Arhgef4tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased T cell number FACs Analysis | CD25+ percentage of CD4+ T cells HMGU | EuroPhenome 3.38E-8
C3ar1
C3ar1tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte differential count UC Davis | IMPC 3.6E-8
Def6
Def6tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased CD4-positive, alpha beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD4+ percentage WTSI | 3i 4.11E-8
Elmo1
Elmo1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased mature B cell number Buffy coat peripheral blood leukocyte immunophenotyping | Mature B cell IgD+ percentage WTSI | 3i 4.27E-8
Cyba
Cybatm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased NK cell number Buffy coat peripheral blood leukocyte immunophenotyping | NK cell percentage WTSI | 3i 8.69E-8
Ppp2r2a
Ppp2r2atm1b(KOMP)Wtsi
HET Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte cell count MARC | IMPC 1.26E-7
Fkbp10
Fkbp10tm2a(EUCOMM)Wtsi
HET Male postnatal decreased B cell number FACs Analysis | B cell CD19+ percentage ICS | MGP 1.33E-7
Gper1
Gper1tm1Dgen
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number FACs Analysis | T cell CD8+ percentage HMGU | EuroPhenome 1.36E-7
Dyrk1b
Dyrk1btm1b(EUCOMM)Wtsi
HET Female Male postnatal decreased large unstained cell number Hematology | Large Unstained Cell (LUC) differential count ICS | IMPC 1.42E-7
Elmod1
Elmod1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte cell count MRC Harwell | IMPC 1.58E-7
Kdm7a
Kdm7atm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD8+ percentage WTSI | 3i 1.65E-7
Ezr
Ezrtm2a(EUCOMM)Wtsi
HET Female Male postnatal decreased NK T cell number Buffy coat peripheral blood leukocyte immunophenotyping | NKT cell percentage WTSI | 3i 1.82E-7
Fam234b
Fam234btm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number FACs Analysis | T cell CD8+ percentage HMGU | EuroPhenome 2.7E-7
Dctn1
Dctn1tm1a(EUCOMM)Wtsi
HET Female postnatal decreased effector memory CD4-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | CD4+CD44+CD62L- percentage WTSI | 3i 3.29E-7
Gsk3a
Gsk3atm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased T cell number FACs Analysis | CD25+ percentage of CD4+ T cells HMGU | MGP 3.32E-7
Ric1
Ric1tm1a(EUCOMM)Hmgu
HOM Male postnatal decreased B cell number FACs Analysis | B cell CD19+ percentage MRC Harwell | EuroPhenome 3.49E-7
Sgms1
Sgms1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased NK cell number Buffy coat peripheral blood leukocyte immunophenotyping | NK cell percentage WTSI | 3i 3.5E-7
Plcg2
Plcg2Ali14
HET Female Male postnatal decreased mature B cell number FACs Analysis | Mature B cells IgD+ percentage HMGU | EuroPhenome 3.86E-7
Fbxo7
Fbxo7tm1a(EUCOMM)Wtsi
HOM Female postnatal decreased CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD8+ percentage WTSI | 3i 3.97E-7
Sgms1
Sgms1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased T cell number Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD3+ percentage WTSI | 3i 3.98E-7
Ninj2
Ninj2tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased NK T cell number Buffy coat peripheral blood leukocyte immunophenotyping | NKT cell percentage WTSI | 3i 4.77E-7
Parvb
Parvbtm1a(EUCOMM)Wtsi
HOM Male postnatal decreased NK cell number FACs Analysis | NK cell percentage MRC Harwell | MGP 5.55E-7
Mcf2l
Mcf2ltm1a(EUCOMM)Hmgu
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD8+ percentage WTSI | 3i 6.05E-7
Abcc5
Abcc5em1(IMPC)H
HOM Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte cell count MRC Harwell | IMPC 6.36E-7
Calhm2
Calhm2tm1b(KOMP)Mbp
HOM Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte differential count UC Davis | IMPC 7.36E-7
Asxl1
Asxl1tm1a(EUCOMM)Wtsi
HET Female postnatal decreased B cell number FACs Analysis | B cell CD19+ percentage HMGU | EuroPhenome 7.41E-7
Stx7
Stx7em1(IMPC)Rbrc
HOM Female Male postnatal decreased large unstained cell number Hematology | Large Unstained Cell (LUC) differential count RBRC | IMPC 7.94E-7
Ccdc129
Ccdc129em1(IMPC)Marc
HOM Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte differential count MARC | IMPC 8.09E-7
Gper1
Gper1tm1Dgen
HOM Female Male postnatal decreased T cell number FACs Analysis | T cell CD3+ percentage HMGU | EuroPhenome 9.33E-7
Tnik
Tniktm3a(EUCOMM)Wtsi
HOM Female Male postnatal decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Buffy coat peripheral blood leukocyte immunophenotyping | Treg cell CD25+ percentage WTSI | 3i 1.32E-6
Tram2
Tram2tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD8+ percentage WTSI | 3i 1.6E-6
Brpf1
Brpf1tm1a(EUCOMM)Wtsi
HET Female Male postnatal decreased T cell number FACs Analysis | T cell CD3+ percentage MRC Harwell | EuroPhenome 1.89E-6
Isg20
Isg20tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased NK T cell number Buffy coat peripheral blood leukocyte immunophenotyping | NKT cell percentage WTSI | 3i 1.9E-6
Nfkbid
Nfkbidtm1a(EUCOMM)Wtsi
HET Female Male postnatal decreased B cell number FACs Analysis | B cell CD19+ percentage HMGU | EuroPhenome 2.29E-6
Atn1
Atn1tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte differential count MRC Harwell | IMPC 2.33E-6
Mcf2l
Mcf2ltm1a(EUCOMM)Hmgu
HOM Female Male postnatal decreased T cell number Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD3+ percentage WTSI | 3i 2.7E-6
Rcc1l
Rcc1ltm1a(EUCOMM)Hmgu
HET Male postnatal decreased T cell number FACs Analysis | CD25+ percentage of CD4+ T cells HMGU | MGP 2.83E-6
Ifitm1
Ifitm1not yet assigned
HOM Male postnatal decreased mature B cell number FACs Analysis | Mature B cells IgD+ percentage HMGU | EuroPhenome 2.9E-6
Mrap2
Mrap2tm1a(EUCOMM)Wtsi
HOM Male postnatal decreased B cell number Buffy coat peripheral blood leukocyte immunophenotyping | B cell CD19+ percentage WTSI | 3i 3.02E-6
Ing4
Ing4em2(IMPC)Tcp
HOM Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte differential count TCP | IMPC 3.3E-6
Setx
Setxtm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte cell count ICS | IMPC 3.34E-6
Sdc4
Sdc4tm2b(KOMP)Wtsi
HOM Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte differential count MRC Harwell | IMPC 3.35E-6
Entpd1
Entpd1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased NK cell number FACs Analysis | NK cell percentage HMGU | MGP 3.43E-6
Ddhd1
Ddhd1tm1a(KOMP)Wtsi
HOM Male postnatal decreased B cell number Buffy coat peripheral blood leukocyte immunophenotyping | B cell CD19+ percentage WTSI | 3i 3.46E-6
Synpo2
Synpo2tm1b(EUCOMM)Wtsi
HET Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte cell count ICS | IMPC 3.48E-6
Acp2
Acp2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased CD4-positive, alpha beta T cell number FACs Analysis | T cell CD4+ percentage MRC Harwell | EuroPhenome 3.53E-6
Arsg
Arsgtm1a(KOMP)Wtsi
HOM Female Male postnatal decreased B cell number Buffy coat peripheral blood leukocyte immunophenotyping | B cell CD19+ percentage WTSI | 3i 3.55E-6
Fabp1
Fabp1tm1b(EUCOMM)Hmgu
HOM Male postnatal decreased large unstained cell number Hematology | Large Unstained Cell (LUC) count MRC Harwell | IMPC 3.57E-6
Emc10
Emc10tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte differential count MRC Harwell | IMPC 3.62E-6
Atg4c
Atg4cem2(IMPC)Marc
HOM Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte differential count MARC | IMPC 3.76E-6
Gper1
Gper1tm1Dgen
HOM Female Male postnatal decreased CD4-positive, alpha beta T cell number FACs Analysis | T cell CD4+ percentage HMGU | EuroPhenome 4.18E-6
Bahd1
Bahd1tm2b(KOMP)Wtsi
HET Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte cell count ICS | IMPC 4.39E-6
Tram2
Tram2tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased T cell number Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD3+ percentage WTSI | 3i 5.48E-6
Il10ra
Il10ratm1b(KOMP)Wtsi
HOM Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte differential count ICS | IMPC 6.04E-6
Col4a5
Col4a5tm1b(EUCOMM)Wtsi
HOM Female postnatal decreased lymphocyte cell number Hematology | Lymphocyte differential count MRC Harwell | IMPC 6.05E-6
Slc25a21
Slc25a21tm1d(KOMP)Wtsi
HOM Male postnatal decreased NK T cell number Buffy coat peripheral blood leukocyte immunophenotyping | NKT cell percentage WTSI | 3i 6.11E-6
Prss50
Prss50tm1a(EUCOMM)Hmgu
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number FACs Analysis | T cell CD8+ percentage MRC Harwell | MGP 6.54E-6
Def6
Def6tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased T cell number Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD3+ percentage WTSI | 3i 6.82E-6
Elmo1
Elmo1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Buffy coat peripheral blood leukocyte immunophenotyping | Treg cell CD25+ percentage WTSI | 3i 8.59E-6
Mmp11
Mmp11tm1a(EUCOMM)Hmgu
HET Female postnatal decreased T cell number FACs Analysis | CD25+ percentage of CD4+ T cells HMGU | EuroPhenome 8.8E-6
Lyn
Lyntm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased large unstained cell number Hematology | Large Unstained Cell (LUC) count MRC Harwell | IMPC 9.45E-6
Ikzf3
Ikzf3tm1(KOMP)Vlcg
HOM Female Male postnatal decreased large unstained cell number Hematology | Large Unstained Cell (LUC) count RBRC | IMPC 1.02E-5
Mysm1
Mysm1tm1a(KOMP)Wtsi
HOM Female postnatal decreased B cell number FACs Analysis | B cell CD19+ percentage HMGU | MGP 1.22E-5
Fndc9
Fndc9tm1.1(KOMP)Vlcg
HOM Female postnatal decreased lymphocyte cell number Hematology | Lymphocyte differential count UC Davis | IMPC 1.3E-5
Pknox1
Pknox1Gt(EUCJ0079d10)Hmgu
HET Female postnatal decreased mature B cell number FACs Analysis | Mature B cells IgD+ percentage HMGU | MGP 1.4E-5
Isg20
Isg20tm1a(KOMP)Wtsi
HOM Male postnatal decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Buffy coat peripheral blood leukocyte immunophenotyping | Treg cell CD25+ percentage WTSI | 3i 1.45E-5
Abca4
Abca4tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased CD4-positive, alpha beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD4+ percentage WTSI | 3i 1.56E-5
Cdkal1
Cdkal1tm2a(EUCOMM)Wtsi
HOM Female Male postnatal decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Buffy coat peripheral blood leukocyte immunophenotyping | Treg cell CD25+ percentage WTSI | 3i 1.72E-5
Pms1
Pms1tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte differential count UC Davis | IMPC 1.85E-5
Mysm1
Mysm1tm1a(KOMP)Wtsi
HOM Female postnatal decreased mature B cell number FACs Analysis | Mature B cells IgD+ percentage HMGU | MGP 1.86E-5
Cidec
Cidectm1a(EUCOMM)Wtsi
HOM Female postnatal decreased CD4-positive, alpha beta T cell number FACs Analysis | T cell CD4+ percentage HMGU | EuroPhenome 1.88E-5
Alox15
Alox15tm1b(KOMP)Mbp
HOM Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte differential count UC Davis | IMPC 1.93E-5
Cstb
Cstbtm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte cell count ICS | IMPC 2.44E-5
5330417C22Rik
5330417C22Riktm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte cell count ICS | IMPC 2.46E-5
Prss50
Prss50tm1a(EUCOMM)Hmgu
HOM Female Male postnatal decreased T cell number FACs Analysis | T cell CD3+ percentage MRC Harwell | EuroPhenome 2.83E-5
Aldh2
Aldh2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number FACs Analysis | T cell CD8+ percentage MRC Harwell | EuroPhenome 2.85E-5
Fbxo7
Fbxo7tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased NK T cell number Buffy coat peripheral blood leukocyte immunophenotyping | NKT cell percentage WTSI | 3i 2.96E-5
Ralb
Ralbtm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased mature B cell number Buffy coat peripheral blood leukocyte immunophenotyping | Mature B cell IgD+ percentage WTSI | 3i 3.01E-5
Abhd3
Abhd3em1(IMPC)Marc
HOM Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte cell count MARC | IMPC 3.01E-5
Itch
Itchtm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte differential count MRC Harwell | IMPC 3.16E-5
Ddx52
Ddx52tm1a(EUCOMM)Wtsi
HET Male postnatal decreased NK cell number FACs Analysis | NK cell percentage ICS | MGP 3.26E-5
Fam96a
Fam96atm2a(EUCOMM)Wtsi
HOM Male postnatal decreased effector memory CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | CD8+CD44+CD62L- percentage WTSI | 3i 3.27E-5
Rspo1
Rspo1tm2b(KOMP)Wtsi
HOM Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte cell count ICS | IMPC 3.29E-5
Aldh2
Aldh2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased CD4-positive, alpha beta T cell number FACs Analysis | T cell CD4+ percentage MRC Harwell | EuroPhenome 3.3E-5
Eftud2
Eftud2tm1b(KOMP)Wtsi
HET Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte cell count ICS | IMPC 3.39E-5
Lgals7
Lgals7tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased effector memory CD4-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | CD4+CD44+CD62L- percentage WTSI | 3i 3.46E-5
Wdr37
Wdr37tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased B cell number Buffy coat peripheral blood leukocyte immunophenotyping | B cell CD19+ percentage WTSI | 3i 3.52E-5
March9
March9tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased B cell number FACs Analysis | B cell CD19+ percentage MRC Harwell | EuroPhenome 3.97E-5
Elk4
Elk4tm1a(EUCOMM)Wtsi
HOM Female postnatal decreased mature B cell number FACs Analysis | Mature B cells IgD+ percentage HMGU | EuroPhenome 4.09E-5
Chst12
Chst12em1(IMPC)Marc
HOM Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte cell count MARC | IMPC 4.2E-5
Coro1a
Coro1atm1.1(KOMP)Vlcg
HOM Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte differential count UC Davis | IMPC 4.25E-5
Pknox1
Pknox1Gt(EUCJ0079d10)Hmgu
HET Female Male postnatal decreased B cell number FACs Analysis | B cell CD19+ percentage HMGU | MGP 4.37E-5
Scaper
Scapertm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased large unstained cell number Hematology | Large Unstained Cell (LUC) differential count ICS | IMPC 4.5E-5
Il10rb
Il10rbtm1a(KOMP)Wtsi
HOM Male postnatal decreased B cell number Buffy coat peripheral blood leukocyte immunophenotyping | B cell CD19+ percentage WTSI | 3i 4.83E-5
Serf1
Serf1tm1a(EUCOMM)Hmgu
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number FACs Analysis | T cell CD8+ percentage MRC Harwell | EuroPhenome 4.87E-5
Zfp595
Zfp595tm1b(KOMP)Wtsi
HOM Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte cell count MRC Harwell | IMPC 5.1E-5
Lyplal1
Lyplal1tm1a(KOMP)Wtsi
HOM Female postnatal decreased NK T cell number Buffy coat peripheral blood leukocyte immunophenotyping | NKT cell percentage WTSI | 3i 5.11E-5
Xbp1
Xbp1tm1a(EUCOMM)Wtsi
HET Male postnatal decreased T cell number FACs Analysis | CD25+ percentage of CD4+ T cells HMGU | EuroPhenome 5.13E-5
Wrnip1
Wrnip1tm1a(EUCOMM)Wtsi
HOM Female postnatal decreased T cell number FACs Analysis | T cell CD3+ percentage HMGU | EuroPhenome 5.35E-5
Wrnip1
Wrnip1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased CD8-positive, alpha-beta T cell number FACs Analysis | T cell CD8+ percentage HMGU | EuroPhenome 5.37E-5
Fkbp10
Fkbp10tm2a(EUCOMM)Wtsi
HET Male postnatal decreased mature B cell number FACs Analysis | Mature B cells IgD+ percentage ICS | MGP 5.77E-5
Tnfrsf1b
Tnfrsf1btm1a(EUCOMM)Wtsi
HOM Female postnatal decreased T cell number FACs Analysis | T cell CD3+ percentage ICS | MGP 5.91E-5
Nodal
Nodaltm1Rob
HET Male postnatal decreased B cell number FACs Analysis | B cell CD19+ percentage MRC Harwell | EuroPhenome 6.35E-5
Taf8
Taf8tm2b(EUCOMM)Wtsi
HET Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte differential count UC Davis | IMPC 6.36E-5
Cbx6
Cbx6tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased T cell number Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD3+ percentage WTSI | 3i 6.48E-5
Nbeal2
Nbeal2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased NK cell number Buffy coat peripheral blood leukocyte immunophenotyping | NK cell percentage WTSI | 3i 6.7E-5
Tiparp
Tiparptm1b(EUCOMM)Wtsi
HET Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte differential count UC Davis | IMPC 6.76E-5
Aldh2
Aldh2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased T cell number FACs Analysis | T cell CD3+ percentage MRC Harwell | EuroPhenome 7.44E-5
Dtwd1
Dtwd1em1(IMPC)Marc
HOM Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte cell count MARC | IMPC 7.57E-5
Avp
Avptm1b(EUCOMM)Wtsi
HET Male postnatal decreased large unstained cell number Hematology | Large Unstained Cell (LUC) count MRC Harwell | IMPC 7.88E-5
Stat1
Stat1tm2b(EUCOMM)Wtsi
HOM Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte differential count ICS | IMPC 8.04E-5
Nr1d2
Nr1d2tm1Dgen
HOM Male postnatal decreased CD4-positive, alpha beta T cell number FACs Analysis | T cell CD4+ percentage ICS | EuroPhenome 8.5E-5
Cd55b
Cd55btm1a(KOMP)Wtsi
HOM Female Male postnatal decreased CD4-positive, alpha beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | T cell CD4+ percentage WTSI | 3i 8.54E-5
Cidec
Cidectm1a(EUCOMM)Wtsi
HOM Female postnatal decreased T cell number FACs Analysis | T cell CD3+ percentage HMGU | EuroPhenome 8.7E-5
Bud23
Bud23em2(IMPC)H
HET Female postnatal decreased lymphocyte cell number Hematology | Lymphocyte differential count MRC Harwell | IMPC 9.03E-5
Cd22
Cd22tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte differential count UC Davis | IMPC 9.13E-5
Pknox1
Pknox1Gt(EUCJ0079d10)Hmgu
HET Female Male postnatal decreased T cell number FACs Analysis | CD25+ percentage of CD4+ T cells HMGU | MGP 9.16E-5
Edc4
Edc4tm1a(EUCOMM)Wtsi
HET Female Male postnatal decreased NK cell number Buffy coat peripheral blood leukocyte immunophenotyping | NK cell percentage WTSI | 3i 9.2E-5
Elmo1
Elmo1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased NK T cell number Buffy coat peripheral blood leukocyte immunophenotyping | NKT cell percentage WTSI | 3i 9.3E-5
Got1
Got1tm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte cell count MRC Harwell | IMPC 9.31E-5
Dnmt3a
Dnmt3atm1a(KOMP)Wtsi
HOM Male postnatal decreased effector memory CD8-positive, alpha-beta T cell number Buffy coat peripheral blood leukocyte immunophenotyping | CD8+CD44+CD62L- percentage WTSI | 3i 9.38E-5
Gatad2b
Gatad2btm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased lymphocyte cell number Hematology | Lymphocyte differential count ICS | IMPC 9.46E-5
Serf1
Serf1tm1a(EUCOMM)Hmgu
HOM Female Male postnatal decreased T cell number FACs Analysis | T cell CD3+ percentage MRC Harwell | MGP 9.87E-5

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