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Phenotype: increased B cell number

Definition
greater than normal number of cells that are formed in the bone marrow, migrate to the peripheral lymphatic system, and mature into plasma cells or memory cells; these cells are involved in humoral immunity
Synonyms
increased B lymphocyte number,  increased B cell count,  increased B lymphocyte count,  increased B-cell count
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with increased B cell number

Total number of significant genotype-phenotype associations: 32

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Aicda
Aicdatm1b(EUCOMM)Hmgu 		HOM   Early adult increased early germinal center B cell number Early germinal centre B cells - % of GC cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Aicda
Aicdatm1b(EUCOMM)Hmgu 		HOM   Early adult increased germinal center B cell number Germinal centre B cells - % of B2 cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Arhgap17
Arhgap17tm1b(EUCOMM)Wtsi 		HOM   Early adult increased transitional stage T1 B cell number Transitional 1 B cells - % of B2 cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi 		HOM   Early adult increased plasma cell number Plasma cells - % of B2 cells
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Bach2
Bach2tm1a(EUCOMM)Wtsi 		HOM   Early adult increased immature B cell number Immature B cells (Hardy fraction E) - % of B220+
Bone marrow immunophenotyping		 WTSI
3i		 0.00
Clpp
Clpptm1a(EUCOMM)Wtsi 		HOM Early adult increased B cell number B cell number
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Clpp
Clpptm1a(EUCOMM)Wtsi 		HOM   Early adult increased mature B cell number IgD+ mature B cell number
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Cog6
Cog6tm1a(EUCOMM)Wtsi 		HOM   Early adult increased B-2 B cell number Total B2 cells - % of CD45+
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Cog6
Cog6tm1a(EUCOMM)Wtsi 		HOM   Early adult increased follicular B cell number Follicular B cells - % of B2 cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Cog6
Cog6tm1a(EUCOMM)Wtsi 		HOM   Early adult increased plasma cell number Plasma cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Cttnbp2
Cttnbp2tm1b(KOMP)Wtsi 		HOM   Early adult increased plasma cell number Plasma cells - % of CD45+
Bone marrow immunophenotyping		 WTSI
3i		 0.00
Dph6
Dph6tm1a(KOMP)Wtsi 		HOM   Early adult increased marginal zone B cell number Marginal zone B cells - % of B2 cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Dph6
Dph6tm1a(KOMP)Wtsi 		HOM   Early adult increased plasma cell number Plasma cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Sik3
Sik3tm1a(EUCOMM)Hmgu 		HOM   Early adult increased follicular B cell number Follicular B cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Ydjc
Ydjctm1(KOMP)Wtsi 		HOM   Early adult increased germinal center B cell number Germinal centre B cells - % of B2 cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
2310022B05Rik
2310022B05Riktm1a(EUCOMM)Hmgu 		HOM Early adult increased B cell number B cell CD19+ percentage
FACs Analysis		 MRC Harwell
EuroPhenome		 7.84×10-11
Elk4
Elk4tm1a(EUCOMM)Wtsi 		HOM Early adult increased B cell number B cell CD19+ percentage
FACs Analysis		 HMGU
EuroPhenome		 1.33×10-07
Nr1d2
Nr1d2tm1Dgen 		HOM Early adult increased B cell number B cell CD19+ percentage
FACs Analysis		 ICS
EuroPhenome		 5.52×10-07
Klrb1
Klrb1tm1b(EUCOMM)Wtsi 		HOM Late adult increased follicular B cell number Follicular B Cells
Immunophenotyping		 HMGU
IMPC		 4.70×10-06
Acp2
Acp2tm1a(EUCOMM)Wtsi 		HOM Early adult increased B cell number B cell CD19+ percentage
FACs Analysis		 MRC Harwell
EuroPhenome		 5.80×10-06
Arhgef4
Arhgef4tm1a(KOMP)Wtsi 		HOM Early adult increased mature B cell number Mature B cells IgD+ percentage
FACs Analysis		 HMGU
EuroPhenome		 1.38×10-05
Pja1
Pja1PJA1 		HEM Early adult increased B cell number B cell CD19+ percentage
FACs Analysis		 ICS
EuroPhenome		 1.80×10-05
Lratd2
Lratd2em1(IMPC)Ccpcz 		HOM Early adult increased B-2 B cell number B2B Cells
Immunophenotyping		 CCP-IMG
IMPC		 2.00×10-05
Kdm4c
Kdm4ctm1a(KOMP)Wtsi 		HET Early adult increased B cell number B cell CD19+ percentage
FACs Analysis		 HMGU
EuroPhenome		 2.47×10-05
Timp2
Timp2em1(IMPC)Hmgu 		HOM Late adult increased follicular B cell number Follicular B Cells
Immunophenotyping		 HMGU
IMPC		 3.56×10-05
Rhbdf2
Rhbdf2tm1.1Mfm 		HOM Early adult increased B cell number B cell CD19+ percentage
FACs Analysis		 MRC Harwell
EuroPhenome		 3.82×10-05
Fam234b
Fam234btm1a(EUCOMM)Wtsi 		HOM Early adult increased B cell number B cell CD19+ percentage
FACs Analysis		 HMGU
EuroPhenome		 6.95×10-05
Timp2
Timp2em1(IMPC)Hmgu 		HOM Late adult increased B-2 B cell number B2B Cells
Immunophenotyping		 HMGU
IMPC		 7.20×10-05
Timp2
Timp2em1(IMPC)Hmgu 		HOM Late adult increased B cell number B Cells
Immunophenotyping		 HMGU
IMPC		 7.63×10-05
Myoz1
Myoz1tm1b(EUCOMM)Hmgu 		HOM   Late adult increased marginal zone B cell number MZB (CD21/35 high)
Immunophenotyping		 HMGU
IMPC		 8.45×10-05
Tnfrsf1b
Tnfrsf1btm1a(EUCOMM)Wtsi 		HOM Early adult increased B cell number B cell CD19+ percentage
FACs Analysis		 ICS
EuroPhenome		 9.42×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Immunophenotyping
Bone marrow immunophenotyping
Buffy coat peripheral blood leukocyte immunophenotyping
FACS
FACs Analysis
Mesenteric Lymph Node Immunophenotyping
Spleen Immunophenotyping
Whole blood peripheral blood leukocyte immunophenotyping

 Phenotype associations stats

3.10% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased B cell number (24/773)

1.71% females (5/292) 2.74% males (9/328)

Select a parameter    



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