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Phenotype: increased spleen weight

Definition
greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets
Synonyms
increased splenic weight
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with increased spleen weight

Total number of significant genotype-phenotype associations: 133

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
C9orf72
C9orf72tm1.1(KOMP)Mbp 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 0.00
Fbn1
Fbn1em1(IMPC)H 		HET Early adult increased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 0.00
Itch
Itchtm1b(EUCOMM)Hmgu 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 0.00
Tnip1
Tnip1tm1b(EUCOMM)Hmgu 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 0.00
Mlh1
Mlh1tm1b(EUCOMM)Hmgu 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 1.70×10-38
Hmox2
Hmox2tm1b(EUCOMM)Hmgu 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 2.04×10-37
Shmt2
Shmt2em1(IMPC)Bay 		HET Early adult increased spleen weight Spleen weight
Organ Weight		 BCM
IMPC		 1.76×10-35
Ctsa
Ctsatm2b(EUCOMM)Hmgu 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 2.48×10-32
Mettl25
Mettl25em1(IMPC)Bay 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 BCM
IMPC		 7.53×10-27
Junb
Junbtm1b(EUCOMM)Hmgu 		HET Early adult increased spleen weight Spleen weight
Organ Weight		 BCM
IMPC		 2.66×10-26
Knop1
Knop1tm1b(EUCOMM)Wtsi 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 BCM
IMPC		 1.01×10-25
Slc3a1
Slc3a1tm1.1(KOMP)Vlcg 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 2.29×10-24
Nemp1
Nemp1em1(IMPC)Mbp 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 3.68×10-24
Spred1
Spred1em1(IMPC)Ccpcz 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 CCP-IMG
IMPC		 6.88×10-24
Cdkn1b
Cdkn1bem2(IMPC)H 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 5.21×10-23
Mgrn1
Mgrn1em1(IMPC)Tcp 		HET Early adult increased spleen weight Spleen weight
Organ Weight		 TCP
IMPC		 1.45×10-22
Sirpa
Sirpatm1b(EUCOMM)Hmgu 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 BCM
IMPC		 2.29×10-20
Snca
Sncaem1(IMPC)H 		HOM Late adult increased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 3.88×10-20
Ccl17
Ccl17em1(IMPC)H 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 1.45×10-19
Lyn
Lyntm1b(EUCOMM)Hmgu 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 2.58×10-18
Prkab1
Prkab1tm1b(KOMP)Wtsi 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 7.16×10-18
Fer
Ferem1(IMPC)Tcp 		HET Early adult increased spleen weight Spleen weight
Organ Weight		 TCP
IMPC		 6.24×10-17
Epg5
Epg5em1(IMPC)H 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 1.41×10-16
Gngt2
Gngt2em1(IMPC)Bay 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 BCM
IMPC		 3.10×10-16
Havcr2
Havcr2tm1b(KOMP)Wtsi 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 5.87×10-16
Ryr1
Ryr1tm1b(EUCOMM)Hmgu 		HET Early adult increased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 9.20×10-16
Irag1
Irag1em1(IMPC)Ccpcz 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 CCP-IMG
IMPC		 1.61×10-15
Etfb
Etfbem1(IMPC)Hmgu 		HET Early adult increased spleen weight Spleen weight
Organ Weight		 HMGU
IMPC		 3.15×10-14
Rab2a
Rab2aem2(IMPC)Tcp 		HET Early adult increased spleen weight Spleen weight
Organ Weight		 TCP
IMPC		 3.78×10-14
Abcb4
Abcb4em1(IMPC)H 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 2.02×10-13
Ppia
Ppiaem1(IMPC)Mbp 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 4.32×10-13
Peli1
Peli1tm1b(EUCOMM)Wtsi 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 5.52×10-13
Glrb
Glrbem1(IMPC)Tcp 		HET Early adult increased spleen weight Spleen weight
Organ Weight		 TCP
IMPC		 6.16×10-13
Mllt6
Mllt6em1(IMPC)Tcp 		HOM Late adult increased spleen weight Spleen weight
Organ Weight		 TCP
IMPC		 1.21×10-12
Tox
Toxtm1b(KOMP)Wtsi 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 6.59×10-11
Rnaseh2a
Rnaseh2aem1(IMPC)Tcp 		HET Early adult increased spleen weight Spleen weight
Organ Weight		 TCP
IMPC		 1.97×10-10
Mpig6b
Mpig6btm1.1(KOMP)Vlcg 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 2.22×10-10
Serpinb10
Serpinb10em1(IMPC)Mbp 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 2.45×10-10
Vps4a
Vps4atm1b(EUCOMM)Hmgu 		HET Early adult increased spleen weight Spleen weight
Organ Weight		 BCM
IMPC		 3.94×10-10
Bcl2l12
Bcl2l12tm1.1(KOMP)Vlcg 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 1.22×10-09
Prdm13
Prdm13em1(IMPC)Tcp 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 TCP
IMPC		 2.60×10-09
Trpc1
Trpc1em1(IMPC)H 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 3.14×10-09
Lbp
Lbptm1b(EUCOMM)Hmgu 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 1.13×10-08
Pdik1l
Pdik1lem1(IMPC)Mbp 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 2.04×10-08
Col4a5
Col4a5tm1b(EUCOMM)Wtsi 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 2.92×10-08
Foxred1
Foxred1em1(IMPC)Bay 		HET Early adult increased spleen weight Spleen weight
Organ Weight		 BCM
IMPC		 3.34×10-08
Rnf115
Rnf115em1(IMPC)H 		HOM Late adult increased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 6.53×10-08
Aif1l
Aif1ltm1b(EUCOMM)Wtsi 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 BCM
IMPC		 7.22×10-08
Panx2
Panx2tm1b(KOMP)Wtsi 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 8.06×10-08
Mapkbp1
Mapkbp1tm1b(EUCOMM)Hmgu 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 1.11×10-07
Scarb1
Scarb1tm1b(EUCOMM)Wtsi 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 BCM
IMPC		 1.19×10-07
Prkab1
Prkab1em1(IMPC)Bay 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 BCM
IMPC		 1.20×10-07
Ngp
Ngptm1b(KOMP)Wtsi 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 BCM
IMPC		 1.74×10-07
Gpr146
Gpr146em1(IMPC)H 		HOM Late adult increased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 1.84×10-07
Cdk12
Cdk12em1(IMPC)Tcp 		HET Early adult increased spleen weight Spleen weight
Organ Weight		 TCP
IMPC		 2.04×10-07
Gpr182
Gpr182tm2b(KOMP)Wtsi 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 4.64×10-07
Npy2r
Npy2rem1(IMPC)H 		HOM Late adult increased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 5.23×10-07
Mri1
Mri1em1(IMPC)Bay 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 BCM
IMPC		 5.44×10-07
Vps33a
Vps33aem2(IMPC)Tcp 		HET Early adult increased spleen weight Spleen weight
Organ Weight		 TCP
IMPC		 9.95×10-07
Ppbp
Ppbptm1.1(KOMP)Vlcg 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 1.13×10-06
Dusp16
Dusp16em1(IMPC)Tcp 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 TCP
IMPC		 1.32×10-06
Mettl23
Mettl23em1(IMPC)Hmgu 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 HMGU
IMPC		 1.74×10-06
Phf20l1
Phf20l1em1(IMPC)Tcp 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 TCP
IMPC		 1.75×10-06
Pld4
Pld4em1(IMPC)Mbp 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 2.13×10-06
Etv6
Etv6em1(IMPC)Rbrc 		HET Late adult increased spleen weight Spleen weight
Organ Weight		 RBRC
IMPC		 2.26×10-06
Tnr
Tnrem1(IMPC)Rbrc 		HOM Late adult increased spleen weight Spleen weight
Organ Weight		 RBRC
IMPC		 2.67×10-06
Loricrin
Loricrintm1.1(KOMP)Vlcg 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 2.99×10-06
Cul5
Cul5tm1.1(KOMP)Vlcg 		HET Early adult increased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 3.34×10-06
Dock2
Dock2tm1b(EUCOMM)Wtsi 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 BCM
IMPC		 3.37×10-06
Kcnn4
Kcnn4em1(IMPC)Ccpcz 		HOM   Early adult increased spleen weight Spleen weight
Organ Weight		 CCP-IMG
IMPC		 4.05×10-06
Ctdspl2
Ctdspl2tm2b(KOMP)Wtsi 		HET Early adult increased spleen weight Spleen weight
Organ Weight		 BCM
IMPC		 4.40×10-06
Bcl2l11
Bcl2l11em1(IMPC)H 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 4.42×10-06
Id3
Id3em1(IMPC)Mbp 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 4.61×10-06
Nhlh2
Nhlh2tm1b(KOMP)Mbp 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 4.64×10-06
Apbb1ip
Apbb1ipem1(IMPC)Ccpcz 		HOM   Early adult increased spleen weight Spleen weight
Organ Weight		 CCP-IMG
IMPC		 4.74×10-06
Dnase1l3
Dnase1l3em1(IMPC)Mbp 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 5.35×10-06
Btbd16
Btbd16tm2b(EUCOMM)Hmgu 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 BCM
IMPC		 5.37×10-06
Cybb
Cybbtm2b(KOMP)Wtsi 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 5.99×10-06
Cd5
Cd5tm1.1(KOMP)Mbp 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 8.06×10-06
Gigyf2
Gigyf2tm1b(EUCOMM)Wtsi 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 8.40×10-06
Zcchc17
Zcchc17em1(IMPC)Hmgu 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 HMGU
IMPC		 9.04×10-06
Bcl3
Bcl3tm1b(EUCOMM)Wtsi 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 9.14×10-06
Plekha5
Plekha5em1(IMPC)Tcp 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 TCP
IMPC		 9.16×10-06
Timd6
Timd6tm1b(KOMP)Wtsi 		HET Early adult increased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 9.65×10-06
Eif2ak1
Eif2ak1em1(IMPC)Bay 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 BCM
IMPC		 9.81×10-06
Ccl25
Ccl25em1(IMPC)H 		HOM Late adult increased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 1.03×10-05
Rgs4
Rgs4em1(IMPC)H 		HOM Late adult increased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 1.20×10-05
Nelfa
Nelfaem1(IMPC)Tcp 		HET Early adult increased spleen weight Spleen weight
Organ Weight		 TCP
IMPC		 1.22×10-05
Nfil3
Nfil3tm1.1(KOMP)Vlcg 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 1.44×10-05
Tmem138
Tmem138tm1b(EUCOMM)Wtsi 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 BCM
IMPC		 1.50×10-05
Irf4
Irf4em1(IMPC)Mbp 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 1.52×10-05
Kiss1r
Kiss1rtm1.1(KOMP)Vlcg 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 1.67×10-05
Rpusd2
Rpusd2tm1b(KOMP)Wtsi 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 BCM
IMPC		 1.74×10-05
Scn8a
Scn8aem1(IMPC)Bay 		HET Early adult increased spleen weight Spleen weight
Organ Weight		 BCM
IMPC		 1.87×10-05
Raver1
Raver1em1(IMPC)Hmgu 		HOM   Early adult increased spleen weight Spleen weight
Organ Weight		 HMGU
IMPC		 1.94×10-05
Pomk
Pomkem1(IMPC)Hmgu 		HET Early adult increased spleen weight Spleen weight
Organ Weight		 HMGU
IMPC		 2.26×10-05
Fdx2
Fdx2em1(IMPC)Rbrc 		HOM Late adult increased spleen weight Spleen weight
Organ Weight		 RBRC
IMPC		 3.07×10-05
Agtr1a
Agtr1aem1(IMPC)Rbrc 		HOM Late adult increased spleen weight Spleen weight
Organ Weight		 RBRC
IMPC		 3.24×10-05
Slc29a3
Slc29a3em1(IMPC)Mbp 		HOM   Early adult increased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 3.30×10-05
Bhmt
Bhmttm1b(EUCOMM)Hmgu 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 BCM
IMPC		 3.41×10-05
Mettl5
Mettl5em1(IMPC)Hmgu 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 HMGU
IMPC		 3.55×10-05
Arf4
Arf4tm1b(KOMP)Wtsi 		HET Early adult increased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 3.89×10-05
Sell
Selltm1b(EUCOMM)Hmgu 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 4.38×10-05
Cacna2d2
Cacna2d2em1(IMPC)Mbp 		HET Early adult increased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 4.99×10-05
Spo11
Spo11tm2b(KOMP)Wtsi 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 BCM
IMPC		 5.09×10-05
Acsl5
Acsl5tm1.1(KOMP)Vlcg 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 5.80×10-05
Notch3
Notch3tm1.1(KOMP)Vlcg 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 6.04×10-05
Gpld1
Gpld1tm1.1(KOMP)Vlcg 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 6.11×10-05
Mtarc1
Mtarc1em1(IMPC)H 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 6.11×10-05
Dhx40
Dhx40tm1b(KOMP)Wtsi 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 BCM
IMPC		 7.04×10-05
Socs2
Socs2em1(IMPC)H 		HOM   Early adult increased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 7.57×10-05
Ilrun
IlrunGt(IST12471H5)Tigm 		HOM   Early adult increased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 7.67×10-05
Chst10
Chst10em1(IMPC)Hmgu 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 HMGU
IMPC		 8.37×10-05
Rap1gap
Rap1gapem1(IMPC)H 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 8.58×10-05
Cox6b1
Cox6b1em1(IMPC)Tcp 		HET Early adult increased spleen weight Spleen weight
Organ Weight		 TCP
IMPC		 8.62×10-05
Hspbap1
Hspbap1tm1b(EUCOMM)Hmgu 		HOM Early adult increased spleen weight Spleen weight
Organ Weight		 BCM
IMPC		 9.35×10-05
Lcmt1
Lcmt1em1(IMPC)Rbrc 		HET Late adult increased spleen weight Spleen weight
Organ Weight		 RBRC
IMPC		 9.66×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Organ Weight

 Phenotype associations stats

3.56% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased spleen weight (116/3255)

1.88% females (49/2611) 2.40% males (77/3210)

Select a parameter    



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