Total number of significant genotype-phenotype associations: 76

Gene / Allele	Zygosity	Sex	Life Stage	Phenotype	Parameter	Phenotyping Center	P Value
Sik3 Sik3tm1a(EUCOMM)Hmgu	HOM		Early adult	abnormal spine curvature	Shape of spine X-ray	WTSI IMPC	2.50×10-11
Ccnd2 Ccnd2tm1b(KOMP)Mbp	HOM		Early adult	abnormal spine curvature	Shape of spine X-ray	MRC Harwell IMPC	1.18×10-10
Sik3 Sik3tm1a(EUCOMM)Hmgu	HOM		Early adult	kyphosis	Kyphosis X-ray	WTSI IMPC	2.71×10-10
Uchl1 Uchl1tm1b(EUCOMM)Hmgu	HET		Early adult	abnormal spine curvature	Shape of spine X-ray	MRC Harwell IMPC	1.77×10-08
Slc20a2 Slc20a2tm1a(EUCOMM)Wtsi	HOM		Early adult	kyphosis	Kyphosis X-ray	WTSI IMPC	5.58×10-08
Fgf14 Fgf14em1(IMPC)Ccpcz	HOM		Early adult	kyphosis	Kyphosis X-ray	CCP-IMG IMPC	2.11×10-07
Krtap8-1 Krtap8-1em1(IMPC)Ccpcz	HOM		Early adult	lordosis	Lordosis X-ray	CCP-IMG IMPC	2.24×10-07
Cer1 Cer1em1(IMPC)Ccpcz	HOM		Early adult	kyphosis	Kyphosis X-ray	CCP-IMG IMPC	3.05×10-07
Krt27 Krt27em1(IMPC)Ccpcz	HOM		Early adult	lordosis	Lordosis X-ray	CCP-IMG IMPC	5.77×10-07
Slc20a2 Slc20a2tm1a(EUCOMM)Wtsi	HOM		Early adult	abnormal spine curvature	Shape of spine X-ray	WTSI IMPC	6.47×10-07
Prss35 Prss35em1(IMPC)Ccpcz	HOM		Early adult	lordosis	Lordosis X-ray	CCP-IMG IMPC	6.86×10-07
Ccnd2 Ccnd2tm1b(KOMP)Mbp	HOM		Late adult	abnormal spine curvature	Shape of spine X-ray	MRC Harwell IMPC	1.61×10-06
Ddi2 Ddi2tm1b(EUCOMM)Hmgu	HET		Early adult	abnormal spine curvature	Shape of spine X-ray	CCP-IMG IMPC	1.96×10-06
Tent5a Tent5aem1(IMPC)Ccpcz	HOM		Early adult	abnormal spine curvature	Shape of spine X-ray	CCP-IMG IMPC	1.96×10-06
Rnf14 Rnf14em1(IMPC)Ccpcz	HOM		Early adult	lordosis	Lordosis X-ray	CCP-IMG IMPC	2.13×10-06
Calb1 Calb1em1(IMPC)Ccpcz	HOM		Early adult	kyphosis	Kyphosis X-ray	CCP-IMG IMPC	2.35×10-06
Mfng Mfngem1(IMPC)Ccpcz	HOM		Early adult	kyphosis	Kyphosis X-ray	CCP-IMG IMPC	2.35×10-06
Tram2 Tram2tm1a(KOMP)Wtsi	HOM		Early adult	kyphosis	Kyphosis X-ray	WTSI IMPC	2.92×10-06
Bbip1 Bbip1em1(IMPC)Ccpcz	HET		Early adult	kyphosis	Kyphosis X-ray	CCP-IMG IMPC	3.11×10-06
Bmp6 Bmp6em1(IMPC)Ccpcz	HOM		Early adult	kyphosis	Kyphosis X-ray	CCP-IMG IMPC	3.11×10-06
Zc3h8 Zc3h8em1(IMPC)Ccpcz	HET		Early adult	lordosis	Lordosis X-ray	CCP-IMG IMPC	3.61×10-06
Ak7 Ak7em1(IMPC)Ccpcz	HET		Early adult	kyphosis	Kyphosis X-ray	CCP-IMG IMPC	3.90×10-06
Nisch Nischtm1b(EUCOMM)Hmgu	HOM		Early adult	abnormal spine curvature	Shape of spine X-ray	MRC Harwell IMPC	4.45×10-06
Bbip1 Bbip1em1(IMPC)Ccpcz	HET		Early adult	abnormal spine curvature	Shape of spine X-ray	CCP-IMG IMPC	6.29×10-06
Bmp6 Bmp6em1(IMPC)Ccpcz	HOM		Early adult	abnormal spine curvature	Shape of spine X-ray	CCP-IMG IMPC	6.29×10-06
Mir129-2 Mir129-2em1(IMPC)Kmpc	HOM		Late adult	abnormal spine curvature	Shape of spine X-ray	KMPC IMPC	7.30×10-06
Rnf168 Rnf168tm2b(EUCOMM)Hmgu	HOM		Early adult	abnormal spine curvature	Shape of spine X-ray	CCP-IMG IMPC	7.34×10-06
Ropn1l Ropn1ltm1b(EUCOMM)Wtsi	HOM		Early adult	kyphosis	Kyphosis X-ray	WTSI IMPC	7.53×10-06
Wdr37 Wdr37tm1a(KOMP)Wtsi	HOM		Early adult	kyphosis	Kyphosis X-ray	WTSI IMPC	7.53×10-06
Arg2 Arg2em1(IMPC)Ccpcz	HOM		Early adult	abnormal spine curvature	Shape of spine X-ray	CCP-IMG IMPC	8.98×10-06
Cer1 Cer1em1(IMPC)Ccpcz	HOM		Early adult	abnormal spine curvature	Shape of spine X-ray	CCP-IMG IMPC	8.98×10-06
Arg2 Arg2em1(IMPC)Ccpcz	HOM		Early adult	lordosis	Lordosis X-ray	CCP-IMG IMPC	9.21×10-06
Brinp3 Brinp3em1(IMPC)Ccpcz	HOM		Early adult	lordosis	Lordosis X-ray	CCP-IMG IMPC	9.21×10-06
Btbd7 Btbd7em1(IMPC)Ccpcz	HOM		Early adult	lordosis	Lordosis X-ray	CCP-IMG IMPC	9.21×10-06
Prss54 Prss54em1(IMPC)Ccpcz	HOM		Early adult	kyphosis	Kyphosis X-ray	CCP-IMG IMPC	9.72×10-06
Tram2 Tram2tm1a(KOMP)Wtsi	HOM		Early adult	abnormal spine curvature	Shape of spine X-ray	WTSI IMPC	1.08×10-05
Zc2hc1c Zc2hc1cem1(IMPC)Ccpcz	HOM		Early adult	kyphosis	Kyphosis X-ray	CCP-IMG IMPC	1.16×10-05
Pstpip1 Pstpip1em1(IMPC)Ccpcz	HOM		Early adult	lordosis	Lordosis X-ray	CCP-IMG IMPC	1.29×10-05
Prss21 Prss21em1(IMPC)Ccpcz	HET		Early adult	kyphosis	Kyphosis X-ray	CCP-IMG IMPC	1.43×10-05
Tpte Tpteem1(IMPC)Kmpc	HOM		Early adult	kyphosis	Kyphosis X-ray	KMPC IMPC	1.51×10-05
Tpte Tpteem1(IMPC)Kmpc	HOM		Early adult	abnormal spine curvature	Shape of spine X-ray	KMPC IMPC	1.51×10-05
Kcnv2 Kcnv2tm1Wtsi	HOM		Early adult	kyphosis	Kyphosis X-ray	WTSI IMPC	1.79×10-05
Fam53a Fam53aem1(IMPC)Ccpcz	HOM		Early adult	abnormal spine curvature	Shape of spine X-ray	CCP-IMG IMPC	1.85×10-05
Prss54 Prss54em1(IMPC)Ccpcz	HOM		Early adult	abnormal spine curvature	Shape of spine X-ray	CCP-IMG IMPC	1.85×10-05
Mbd1 Mbd1em1(IMPC)Wtsi	HOM		Early adult	lordosis	Lordosis X-ray	WTSI IMPC	1.90×10-05
Krt72 Krt72em1(IMPC)Ccpcz	HOM		Early adult	kyphosis	Kyphosis X-ray	CCP-IMG IMPC	2.05×10-05
Rnf148 Rnf148em1(IMPC)Ccpcz	HOM		Early adult	kyphosis	Kyphosis X-ray	CCP-IMG IMPC	2.05×10-05
Calb1 Calb1em1(IMPC)Ccpcz	HOM		Early adult	abnormal spine curvature	Shape of spine X-ray	CCP-IMG IMPC	2.51×10-05
Mfng Mfngem1(IMPC)Ccpcz	HOM		Early adult	abnormal spine curvature	Shape of spine X-ray	CCP-IMG IMPC	2.51×10-05
Krt72 Krt72em1(IMPC)Ccpcz	HOM		Early adult	abnormal spine curvature	Shape of spine X-ray	CCP-IMG IMPC	2.64×10-05
Rnf148 Rnf148em1(IMPC)Ccpcz	HOM		Early adult	abnormal spine curvature	Shape of spine X-ray	CCP-IMG IMPC	2.64×10-05
Prss21 Prss21em1(IMPC)Ccpcz	HET		Early adult	abnormal spine curvature	Shape of spine X-ray	CCP-IMG IMPC	2.70×10-05
Klhl1 Klhl1em1(IMPC)Ccpcz	HOM		Early adult	abnormal spine curvature	Shape of spine X-ray	CCP-IMG IMPC	2.86×10-05
Adk Adkem1(IMPC)Ccpcz	HET		Early adult	abnormal spine curvature	Shape of spine X-ray	CCP-IMG IMPC	3.04×10-05
Fam221a Fam221aem1(IMPC)Ccpcz	HOM		Early adult	kyphosis	Kyphosis X-ray	CCP-IMG IMPC	3.04×10-05
Fgf14 Fgf14em1(IMPC)Ccpcz	HOM		Early adult	abnormal spine curvature	Shape of spine X-ray	CCP-IMG IMPC	3.67×10-05
Prss35 Prss35em1(IMPC)Ccpcz	HOM		Early adult	kyphosis	Kyphosis X-ray	CCP-IMG IMPC	3.71×10-05
Tent5a Tent5aem1(IMPC)Ccpcz	HOM		Early adult	scoliosis	Scoliosis X-ray	CCP-IMG IMPC	4.35×10-05
Dnase1l2 Dnase1l2tm1.1(KOMP)Wtsi	HOM		Early adult	abnormal spine curvature	Shape of spine X-ray	WTSI IMPC	5.04×10-05
H2-Eb1 H2-Eb1b-tm1a(KOMP)Wtsi	HOM		Early adult	abnormal spine curvature	Shape of spine X-ray	WTSI IMPC	5.04×10-05
Pabpc4 Pabpc4tm1a(KOMP)Wtsi	HOM		Early adult	abnormal spine curvature	Shape of spine X-ray	WTSI IMPC	5.04×10-05
Ropn1l Ropn1ltm1b(EUCOMM)Wtsi	HOM		Early adult	abnormal spine curvature	Shape of spine X-ray	WTSI IMPC	5.04×10-05
Selenok Selenoktm1b(EUCOMM)Wtsi	HOM		Early adult	abnormal spine curvature	Shape of spine X-ray	WTSI IMPC	5.04×10-05
Wdr37 Wdr37tm1a(KOMP)Wtsi	HOM		Early adult	abnormal spine curvature	Shape of spine X-ray	WTSI IMPC	5.04×10-05
Fnip1 Fnip1em1(IMPC)Ccpcz	HOM		Early adult	abnormal spine curvature	Shape of spine X-ray	CCP-IMG IMPC	5.36×10-05
Fam221a Fam221aem1(IMPC)Ccpcz	HOM		Early adult	abnormal spine curvature	Shape of spine X-ray	CCP-IMG IMPC	5.71×10-05
Prss21 Prss21em1(IMPC)Ccpcz	HET		Early adult	lordosis	Lordosis X-ray	CCP-IMG IMPC	7.34×10-05
Arg2 Arg2em1(IMPC)Ccpcz	HOM		Early adult	kyphosis	Kyphosis X-ray	CCP-IMG IMPC	7.66×10-05
Klhl1 Klhl1em1(IMPC)Ccpcz	HOM		Early adult	kyphosis	Kyphosis X-ray	CCP-IMG IMPC	7.66×10-05
Ak7 Ak7em1(IMPC)Ccpcz	HET		Early adult	abnormal spine curvature	Shape of spine X-ray	CCP-IMG IMPC	8.11×10-05
Vgll3 Vgll3em1(IMPC)H	HOM		Early adult	abnormal spine curvature	Shape of spine X-ray	MRC Harwell IMPC	9.20×10-05
Zc2hc1c Zc2hc1cem1(IMPC)Ccpcz	HOM		Early adult	abnormal spine curvature	Shape of spine X-ray	CCP-IMG IMPC	9.29×10-05