Phenotype: decreased heart rate variability

Definition reduced variation of beat-to-beat intervals of the heart that occurs in conjunction with the respiratory cycle

Synonyms
  • decreased respiratory sinus arrhythmia
  • decreased respiratory sinus arrhythmia
  • reduced heart rate variability
  • reduced heart rate variability

MP browserMP:0003929

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Phenotype associations stats

0.94% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased heart rate variability (18/1913)

0.96% females (18/1869) 0.85% males (16/1877)



Gene variants with decreased heart rate variability

Total number of significant genotype-phenotype associations: 34

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Sgip1
Sgip1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased heart rate variability Electrocardiogram (ECG) | HRV HMGU | IMPC 3.56E-10
Casq2
Casq2tm1b(KOMP)Wtsi
HET Female Male postnatal decreased heart rate variability Electrocardiogram (ECG) | HRV TCP | IMPC 2.74E-9
Gja8
Gja8tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased heart rate variability Electrocardiogram (ECG) | HRV MRC Harwell | IMPC 3.15E-7
Slc44a4
Slc44a4tm1b(EUCOMM)Hmgu
HOM Female postnatal decreased heart rate variability Electrocardiogram (ECG) | HRV HMGU | IMPC 9.87E-7
Trip13
Trip13tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased heart rate variability Electrocardiogram (ECG) | HRV JAX | IMPC 3.17E-6
Aif1
Aif1tm1.1(KOMP)Wtsi
HOM Female Male postnatal decreased heart rate variability Electrocardiogram (ECG) | HRV HMGU | IMPC 6.08E-6
Lactb
Lactbtm1.1(KOMP)Mbp
HOM Female Male postnatal decreased heart rate variability Electrocardiogram (ECG) | HRV HMGU | IMPC 7.89E-6
Atrip
Atriptm1b(KOMP)Wtsi
HET Female Male postnatal decreased heart rate variability Electrocardiogram (ECG) | HRV JAX | IMPC 1.11E-5
Far2
Far2tm2b(KOMP)Wtsi
HOM Female Male postnatal decreased heart rate variability Electrocardiogram (ECG) | HRV JAX | IMPC 1.17E-5
Bbs5
Bbs5tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased heart rate variability Electrocardiogram (ECG) | HRV MRC Harwell | IMPC 1.43E-5
Trib2
Trib2tm1b(KOMP)Wtsi
HET Female postnatal decreased heart rate variability Electrocardiogram (ECG) | HRV BCM | IMPC 2.64E-5
Klkb1
Klkb1tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased heart rate variability Electrocardiogram (ECG) | HRV HMGU | IMPC 2.95E-5
Kcnh3
Kcnh3tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased heart rate variability Electrocardiogram (ECG) | HRV JAX | IMPC 5.71E-5
Ism2
Ism2tm3b(EUCOMM)Hmgu
HOM Female Male postnatal decreased heart rate variability Electrocardiogram (ECG) | HRV BCM | IMPC 5.75E-5
Vsig8
Vsig8tm1.1(KOMP)Mbp
HOM Female Male postnatal decreased heart rate variability Electrocardiogram (ECG) | HRV JAX | IMPC 6.31E-5
Lrp1
Lrp1tm1.1(KOMP)Wtsi
HET Female Male postnatal decreased heart rate variability Electrocardiogram (ECG) | HRV JAX | IMPC 7.09E-5
C9
C9tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased heart rate variability Electrocardiogram (ECG) | HRV JAX | IMPC 8.25E-5
Fam161a
Fam161atm1b(KOMP)Wtsi
HOM Female Male postnatal decreased heart rate variability Electrocardiogram (ECG) | HRV JAX | IMPC 8.36E-5

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