Phenotype: increased circulating chloride level

Phenotype associations stats

1.30% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased circulating chloride level (39/3003)

1.11% females (33/2974) 1.28% males (38/2973)

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Gene variants with increased circulating chloride level

Total number of significant genotype-phenotype associations: 71

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Cdh23
Cdh23tm2b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | IMPC 1.53E-18
Rrp8
Rrp8tm1.1(KOMP)Vlcg
HET Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride JAX | IMPC 6.1E-10
Gar1
Gar1tm1a(EUCOMM)Wtsi
HET Male postnatal increased circulating chloride level Clinical Chemistry | Chloride ICS | MGP 1.11E-9
Tppp
Tppptm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride JAX | IMPC 1.92E-9
Ush1c
Ush1ctm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | IMPC 5.74E-9
Cbx6
Cbx6tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | IMPC 8.08E-9
Dach1
Dach1tm1b(KOMP)Wtsi
HET Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride JAX | IMPC 4.34E-8
Clvs1
Clvs1tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride JAX | IMPC 5.02E-8
Herc1
Herc1em3(IMPC)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | IMPC 6.37E-8
Dbn1
Dbn1tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | EuroPhenome 7.44E-8
Srp9
Srp9tm1.1(KOMP)Vlcg
HET Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride JAX | IMPC 2.69E-7
Gad2
Gad2tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride HMGU | IMPC 2.96E-7
Entpd1
Entpd1tm1b(EUCOMM)Wtsi
HET Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride HMGU | IMPC 3.64E-7
Elmod1
Elmod1tm1a(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride MRC Harwell | EuroPhenome 4.76E-7
4932438A13Rik
4932438A13Riktm1b(EUCOMM)Hmgu
HET Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride JAX | IMPC 8.47E-7
Cdca5
Cdca5tm1.1(KOMP)Vlcg
HET Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride JAX | IMPC 1.19E-6
Mysm1
Mysm1tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | EuroPhenome 1.35E-6
Rnf7
Rnf7tm1a(EUCOMM)Wtsi
HET Male postnatal increased circulating chloride level Clinical Chemistry | Chloride MRC Harwell | EuroPhenome 1.59E-6
Mybpc3
Mybpc3tm1a(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride MRC Harwell | EuroPhenome 2.03E-6
Usp20
Usp20tm1a(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | IMPC 4.03E-6
Ehd1
Ehd1tm1a(EUCOMM)Wtsi
HET Female postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | EuroPhenome 6.79E-6
Izumo1r
Izumo1rtm2a(KOMP)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | IMPC 8.28E-6
Cpgi5563
Cpgi5563tm1.1(NCC)WCS
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | IMPC 1.3E-5
Arl4a
Arl4atm1Asch
HOM Male postnatal increased circulating chloride level Clinical chemistry (GMC) | Chloride HMGU | EuroPhenome 1.51E-5
Htr7
Htr7tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride JAX | IMPC 1.55E-5
Ift20
Ift20tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride ICS | MGP 1.59E-5
Prune2
Prune2tm1e(KOMP)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | IMPC 1.67E-5
Adgrb1
Adgrb1tm2a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | IMPC 1.87E-5
Kif1b
Kif1btm1b(KOMP)Wtsi
HET Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride JAX | IMPC 2.39E-5
Clk1
Clk1tm1a(EUCOMM)Wtsi
HOM Male postnatal increased circulating chloride level Clinical Chemistry | Chloride ICS | MGP 2.82E-5
D1Ertd622e
D1Ertd622etm1.1(KOMP)Vlcg
HET Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride JAX | IMPC 3.92E-5
Vim
Vimtm2Cba
HOM Female Male postnatal increased circulating chloride level Clinical chemistry (GMC) | Chloride HMGU | EuroPhenome 6.16E-5
Zfp341
Zfp341tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | IMPC 6.33E-5
Irf8
Irf8tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride JAX | IMPC 6.35E-5
Begain
Begaintm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | IMPC 6.44E-5
Rnf10
Rnf10tm1b(KOMP)Wtsi
HOM Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | IMPC 7.4E-5
Rxfp2
Rxfp2tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride HMGU | IMPC 8.14E-5
Inpp1
Inpp1tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | EuroPhenome 9.1E-5
Taf11
Taf11tm1a(EUCOMM)Wtsi
HET Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | IMPC 9.92E-5

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