Phenotype: increased circulating chloride level

Phenotype associations stats

1.73% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased circulating chloride level (44/2545)

1.42% females (36/2537) 1.71% males (43/2517)

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Gene variants with increased circulating chloride level

Total number of significant genotype-phenotype associations: 80

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Klhl3
Klhl3tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride MRC Harwell | IMPC 5.23E-14
Rrp8
Rrp8tm1.1(KOMP)Vlcg
HET Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride JAX | IMPC 5.83E-10
Ehd1
Ehd1tm1a(EUCOMM)Wtsi
HET Female postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | EuroPhenome 7.64E-10
Ehd1
Ehd1tm1a(EUCOMM)Wtsi
HOM Female postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | EuroPhenome 7.64E-10
Gar1
Gar1tm1a(EUCOMM)Wtsi
HET Male postnatal increased circulating chloride level Clinical Chemistry | Chloride ICS | EuroPhenome 1.11E-9
Tppp
Tppptm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride JAX | IMPC 1.92E-9
Ush1c
Ush1ctm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | IMPC 5.06E-9
Cbx6
Cbx6tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | IMPC 1.44E-8
Dach1
Dach1tm1b(KOMP)Wtsi
HET Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride JAX | IMPC 4.29E-8
Clvs1
Clvs1tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride JAX | IMPC 4.98E-8
Srp9
Srp9tm1.1(KOMP)Vlcg
HET Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride JAX | IMPC 2.64E-7
Gad2
Gad2tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride HMGU | IMPC 3.65E-7
Entpd1
Entpd1tm1b(EUCOMM)Wtsi
HET Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride HMGU | IMPC 3.81E-7
Elmod1
Elmod1tm1a(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride MRC Harwell | MGP 4.76E-7
Dbn1
Dbn1tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | EuroPhenome 5.46E-7
4932438A13Rik
4932438A13Riktm1b(EUCOMM)Hmgu
HET Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride JAX | IMPC 8.3E-7
Mysm1
Mysm1tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | EuroPhenome 1.35E-6
Rnf7
Rnf7tm1a(EUCOMM)Wtsi
HET Male postnatal increased circulating chloride level Clinical Chemistry | Chloride MRC Harwell | EuroPhenome 1.59E-6
Mybpc3
Mybpc3tm1a(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride MRC Harwell | EuroPhenome 2.03E-6
Pkd1
Pkd1tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride MRC Harwell | IMPC 3.56E-6
Myl12b
Myl12btm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | EuroPhenome 3.66E-6
Cacna1b
Cacna1btm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride MRC Harwell | IMPC 4.42E-6
Izumo1r
Izumo1rtm2a(KOMP)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | IMPC 6.66E-6
Cdca5
Cdca5tm1.1(KOMP)Vlcg
HET Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride JAX | IMPC 8.15E-6
Ddost
Ddosttm1.1(KOMP)Vlcg
HET Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride TCP | IMPC 8.74E-6
Ndrg4
Ndrg4tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride MRC Harwell | IMPC 1.23E-5
Usmg5
Usmg5tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride MRC Harwell | IMPC 1.25E-5
Adgrb1
Adgrb1tm2a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | IMPC 1.47E-5
Htr7
Htr7tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride JAX | IMPC 1.55E-5
Ift20
Ift20tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride ICS | EuroPhenome 1.59E-5
Cdca8
Cdca8tm1a(KOMP)Wtsi
HET Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | EuroPhenome 1.65E-5
Kif1b
Kif1btm1b(KOMP)Wtsi
HET Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride JAX | IMPC 2.34E-5
Arl4a
Arl4atm1Asch
HOM Male postnatal increased circulating chloride level Clinical chemistry (GMC) | Chloride HMGU | EuroPhenome 2.44E-5
Clk1
Clk1tm1a(EUCOMM)Wtsi
HOM Male postnatal increased circulating chloride level Clinical Chemistry | Chloride ICS | EuroPhenome 2.82E-5
Tmprss15
Tmprss15tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | EuroPhenome 3.15E-5
Tulp3
Tulp3tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride MRC Harwell | IMPC 3.26E-5
Nrxn1
Nrxn1tm1b(KOMP)Wtsi
HOM Male postnatal increased circulating chloride level Clinical Chemistry | Chloride MRC Harwell | IMPC 3.58E-5
D1Ertd622e
D1Ertd622etm1.1(KOMP)Vlcg
HET Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride JAX | IMPC 3.91E-5
Dlg4
Dlg4tm1e(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | IMPC 4.84E-5
Ubr4
Ubr4tm1b(EUCOMM)Hmgu
HET Male postnatal increased circulating chloride level Clinical Chemistry | Chloride MRC Harwell | IMPC 5.05E-5
Sesn3
Sesn3tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | EuroPhenome 5.23E-5
Gys2
Gys2tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | MGP 5.23E-5
Irf8
Irf8tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride JAX | IMPC 6.15E-5
Vim
Vimtm2Cba
HOM Female Male postnatal increased circulating chloride level Clinical chemistry (GMC) | Chloride HMGU | EuroPhenome 6.16E-5
Rnf10
Rnf10tm1b(KOMP)Wtsi
HOM Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | IMPC 7.13E-5

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