Phenotype: increased circulating chloride level

Phenotype associations stats

1.70% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased circulating chloride level (47/2758)

1.39% females (38/2730) 1.65% males (45/2728)

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Gene variants with increased circulating chloride level

Total number of significant genotype-phenotype associations: 83

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Klhl3
Klhl3tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride MRC Harwell | IMPC 1.23E-13
Rrp8
Rrp8tm1.1(KOMP)Vlcg
HET Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride JAX | IMPC 5.85E-10
Ehd1
Ehd1tm1a(EUCOMM)Wtsi
HET Female postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | EuroPhenome 7.64E-10
Gar1
Gar1tm1a(EUCOMM)Wtsi
HET Male postnatal increased circulating chloride level Clinical Chemistry | Chloride ICS | MGP 1.11E-9
Tppp
Tppptm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride JAX | IMPC 1.92E-9
Ush1c
Ush1ctm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | IMPC 8.33E-9
Cbx6
Cbx6tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | IMPC 1.16E-8
Dach1
Dach1tm1b(KOMP)Wtsi
HET Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride JAX | IMPC 4.29E-8
Clvs1
Clvs1tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride JAX | IMPC 4.98E-8
Ddost
Ddosttm1.1(KOMP)Vlcg
HET Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride TCP | IMPC 4.99E-8
Srp9
Srp9tm1.1(KOMP)Vlcg
HET Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride JAX | IMPC 2.64E-7
Gad2
Gad2tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride HMGU | IMPC 3.0E-7
Entpd1
Entpd1tm1b(EUCOMM)Wtsi
HET Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride HMGU | IMPC 3.69E-7
Elmod1
Elmod1tm1a(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride MRC Harwell | EuroPhenome 4.76E-7
Dbn1
Dbn1tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | EuroPhenome 5.46E-7
4932438A13Rik
4932438A13Riktm1b(EUCOMM)Hmgu
HET Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride JAX | IMPC 8.31E-7
Mysm1
Mysm1tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | EuroPhenome 1.35E-6
Rnf7
Rnf7tm1a(EUCOMM)Wtsi
HET Male postnatal increased circulating chloride level Clinical Chemistry | Chloride MRC Harwell | EuroPhenome 1.59E-6
Mybpc3
Mybpc3tm1a(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride MRC Harwell | EuroPhenome 2.03E-6
Myl12b
Myl12btm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | EuroPhenome 3.66E-6
Pkd1
Pkd1tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride MRC Harwell | IMPC 3.67E-6
Cacna1b
Cacna1btm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride MRC Harwell | IMPC 4.46E-6
Cacna1i
Cacna1itm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride BCM | IMPC 5.05E-6
Stk3
Stk3em1(IMPC)H
HOM Male postnatal increased circulating chloride level Clinical Chemistry | Chloride MRC Harwell | IMPC 5.17E-6
Cdca5
Cdca5tm1.1(KOMP)Vlcg
HET Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride JAX | IMPC 8.08E-6
Izumo1r
Izumo1rtm2a(KOMP)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | IMPC 9.57E-6
Arl4a
Arl4atm1Asch
HOM Male postnatal increased circulating chloride level Clinical chemistry (GMC) | Chloride HMGU | EuroPhenome 1.51E-5
Htr7
Htr7tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride JAX | IMPC 1.55E-5
Fbxw9
Fbxw9tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride BCM | IMPC 1.55E-5
Ift20
Ift20tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride ICS | MGP 1.59E-5
Cdca8
Cdca8tm1a(KOMP)Wtsi
HET Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | EuroPhenome 1.65E-5
Ndrg4
Ndrg4tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride MRC Harwell | IMPC 1.69E-5
Usmg5
Usmg5tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride MRC Harwell | IMPC 2.09E-5
Adgrb1
Adgrb1tm2a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | IMPC 2.22E-5
Kif1b
Kif1btm1b(KOMP)Wtsi
HET Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride JAX | IMPC 2.35E-5
Clk1
Clk1tm1a(EUCOMM)Wtsi
HOM Male postnatal increased circulating chloride level Clinical Chemistry | Chloride ICS | MGP 2.82E-5
Tmprss15
Tmprss15tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | EuroPhenome 3.15E-5
D1Ertd622e
D1Ertd622etm1.1(KOMP)Vlcg
HET Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride JAX | IMPC 3.91E-5
Tulp3
Tulp3tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride MRC Harwell | IMPC 4.05E-5
Nrxn1
Nrxn1tm1b(KOMP)Wtsi
HOM Male postnatal increased circulating chloride level Clinical Chemistry | Chloride MRC Harwell | IMPC 4.41E-5
Ubr4
Ubr4tm1b(EUCOMM)Hmgu
HET Male postnatal increased circulating chloride level Clinical Chemistry | Chloride MRC Harwell | IMPC 5.01E-5
Sesn3
Sesn3tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | EuroPhenome 5.23E-5
Gys2
Gys2tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | EuroPhenome 5.23E-5
Vim
Vimtm2Cba
HOM Female Male postnatal increased circulating chloride level Clinical chemistry (GMC) | Chloride HMGU | EuroPhenome 6.16E-5
Irf8
Irf8tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating chloride level Clinical Chemistry | Chloride JAX | IMPC 6.16E-5
Rnf10
Rnf10tm1b(KOMP)Wtsi
HOM Male postnatal increased circulating chloride level Clinical Chemistry | Chloride WTSI | IMPC 6.54E-5
Acat2
Acat2tm1b(KOMP)Wtsi
HET Female postnatal increased circulating chloride level Clinical Chemistry | Chloride BCM | IMPC 7.36E-5

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