banner
Genes Phenotypes Help, News, Blog

Phenotype: decreased circulating alanine transaminase level

Definition
decreased concentration in the blood of the enzyme which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction
Synonyms
reduced circulating alanine transaminase level
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with decreased circulating alanine transaminase level

Total number of significant genotype-phenotype associations: 28

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Secisbp2l
Secisbp2lem1(IMPC)J 		HOM Late adult decreased circulating alanine transaminase level Alanine aminotransferase
Clinical Chemistry		 JAX
IMPC		 5.09×10-11
Fbrs
Fbrsem1(IMPC)J 		HET Early adult decreased circulating alanine transaminase level Alanine aminotransferase
Clinical Chemistry		 JAX
IMPC		 7.74×10-10
Fbxo42
Fbxo42em1(IMPC)J 		HET Early adult decreased circulating alanine transaminase level Alanine aminotransferase
Clinical Chemistry		 JAX
IMPC		 4.03×10-08
Ano3
Ano3em2(IMPC)Mbp 		HOM Early adult decreased circulating alanine transaminase level Alanine aminotransferase
Clinical Chemistry		 UC Davis
IMPC		 5.44×10-08
Phactr1
Phactr1em1(IMPC)Mbp 		HOM Late adult decreased circulating alanine transaminase level Alanine aminotransferase
Clinical Chemistry		 UC Davis
IMPC		 2.45×10-07
Camk1
Camk1tm2b(EUCOMM)Hmgu 		HOM Early adult decreased circulating alanine transaminase level Alanine aminotransferase
Clinical Chemistry		 BCM
IMPC		 3.10×10-07
Nos1ap
Nos1aptm1b(KOMP)Wtsi 		HOM Early adult decreased circulating alanine transaminase level Alanine aminotransferase
Clinical Chemistry		 BCM
IMPC		 8.49×10-07
Amfr
Amfrtm1a(KOMP)Wtsi 		HOM Early adult decreased circulating alanine transaminase level Alanine aminotransferase
Clinical Chemistry		 WTSI
MGP		 9.01×10-07
Prss3b
Prss3btm1b(KOMP)Wtsi 		HOM Early adult decreased circulating alanine transaminase level Alanine aminotransferase
Clinical Chemistry		 BCM
IMPC		 1.01×10-06
Mcm10
Mcm10tm1(NCOM)Cmhd 		HET Early adult decreased circulating alanine transaminase level Alanine aminotransferase
Clinical Chemistry		 CMHD
EuroPhenome		 2.51×10-06
Zfp532
Zfp532em1(IMPC)J 		HET Early adult decreased circulating alanine transaminase level Alanine aminotransferase
Clinical Chemistry		 JAX
IMPC		 3.29×10-06
Fto
Ftotm1a(EUCOMM)Wtsi 		HOM   Early adult decreased circulating alanine transaminase level Alanine aminotransferase
Clinical Chemistry		 WTSI
EuroPhenome		 3.76×10-06
Gmeb2
Gmeb2em1(IMPC)J 		HET Early adult decreased circulating alanine transaminase level Alanine aminotransferase
Clinical Chemistry		 JAX
IMPC		 6.87×10-06
Chdh
Chdhtm1b(KOMP)Mbp 		HOM Early adult decreased circulating alanine transaminase level Alanine aminotransferase
Clinical Chemistry		 UC Davis
IMPC		 9.36×10-06
Taco1
Taco1em1(IMPC)J 		HOM Late adult decreased circulating alanine transaminase level Alanine aminotransferase
Clinical Chemistry		 JAX
IMPC		 1.04×10-05
Ap4e1
Ap4e1tm1a(KOMP)Wtsi 		HOM Early adult decreased circulating alanine transaminase level Alanine aminotransferase
Clinical Chemistry		 WTSI
MGP		 1.22×10-05
Fam171a1
Fam171a1em1(IMPC)J 		HOM   Early adult decreased circulating alanine transaminase level Alanine aminotransferase
Clinical Chemistry		 JAX
IMPC		 2.09×10-05
Smyd2
Smyd2tm1a(KOMP)Wtsi 		HOM Early adult decreased circulating alanine transaminase level Alanine aminotransferase
Clinical Chemistry		 WTSI
EuroPhenome		 2.12×10-05
Abhd17c
Abhd17cem1(IMPC)Mbp 		HOM Late adult decreased circulating alanine transaminase level Alanine aminotransferase
Clinical Chemistry		 UC Davis
IMPC		 2.67×10-05
Ftsj1
Ftsj1tm1b(EUCOMM)Wtsi 		HEM Early adult decreased circulating alanine transaminase level Alanine aminotransferase
Clinical Chemistry		 BCM
IMPC		 3.85×10-05
Rhbg
Rhbgem1(IMPC)Hmgu 		HOM   Early adult decreased circulating alanine transaminase level Alanine aminotransferase
Clinical Chemistry		 HMGU
IMPC		 4.23×10-05
Lhfpl4
Lhfpl4em1(IMPC)H 		HET Early adult decreased circulating alanine transaminase level Alanine aminotransferase
Clinical Chemistry		 MRC Harwell
IMPC		 7.84×10-05
Zfp423
Zfp423em1(IMPC)J 		HET Early adult decreased circulating alanine transaminase level Alanine aminotransferase
Clinical Chemistry		 JAX
IMPC		 8.34×10-05
Sar1b
Sar1btm1a(EUCOMM)Wtsi 		HET Early adult decreased circulating alanine transaminase level Alanine aminotransferase
Clinical Chemistry		 WTSI
MGP		 9.26×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Clinical Blood Chemistry
Clinical Chemistry
Clinical chemistry (GMC)
Fasted Bleed
Terminal Bleed

 Phenotype associations stats

0.33% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased circulating alanine transaminase level (24/7300)

0.08% females (6/7211) 0.26% males (19/7183)

Select a parameter    



The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter