Phenotype: decreased hemoglobin content

Phenotype associations stats

2.18% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased hemoglobin content (75/3443)

1.75% females (60/3423) 2.01% males (69/3438)

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Gene variants with decreased hemoglobin content

Total number of significant genotype-phenotype associations: 144

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Mysm1
Mysm1tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased hemoglobin content Haematology | Haemoglobin WTSI | EuroPhenome 2.95E-33
Ric1
Ric1tm1a(EUCOMM)Hmgu
HOM Female Male postnatal decreased hemoglobin content Haematology | Haemoglobin MRC Harwell | EuroPhenome 9.35E-27
Gna11
Gna11tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin MRC Harwell | IMPC 1.01E-24
Gna11
Gna11tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased hemoglobin content Haematology | Haemoglobin MRC Harwell | EuroPhenome 4.42E-24
Prkab1
Prkab1tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased hemoglobin content Haematology test | Haemoglobin WTSI | MGP 4.15E-19
Fbxo7
Fbxo7tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin WTSI | IMPC 5.02E-19
Vrk3
Vrk3em1Mbp
HOM Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin UC Davis | IMPC 7.92E-18
Mecom
MecomJbo
HET Female Male postnatal decreased hemoglobin content Haematology | Haemoglobin MRC Harwell | EuroPhenome 1.95E-17
Prkab1
Prkab1tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin TCP | IMPC 1.36E-16
Adgrf5
Adgrf5tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin TCP | IMPC 7.25E-16
5430419D17Rik
5430419D17Rikem1Mbp
HOM Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin UC Davis | IMPC 3.27E-14
Pdik1l
Pdik1lem1Mbp
HOM Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin UC Davis | IMPC 4.63E-14
Comt
Comttm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin MRC Harwell | IMPC 3.74E-13
Cp
Cptm1b(KOMP)Wtsi
HOM Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin JAX | IMPC 6.52E-13
Tas2r139
Tas2r139em1Mbp
HOM Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin UC Davis | IMPC 1.52E-12
Nalcn
Nalcnem1Mbp
HET Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin UC Davis | IMPC 1.13E-11
Atp6v1b2
Atp6v1b2tm1b(KOMP)Wtsi
HET Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin TCP | IMPC 1.36E-11
Tmem189
Tmem189tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin WTSI | IMPC 2.01E-11
Caskin1
Caskin1em1Mbp
HOM Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin UC Davis | IMPC 3.79E-11
Fbxo11
Fbxo11tm2b(EUCOMM)Wtsi
HET Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin MRC Harwell | IMPC 9.86E-11
Slc38a10
Slc38a10tm2a(EUCOMM)Wtsi
HOM Female Male postnatal decreased hemoglobin content Haematology | Haemoglobin MRC Harwell | EuroPhenome 1.1E-10
Smurf2
Smurf2tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin MRC Harwell | IMPC 1.26E-10
Etaa1
Etaa1em1Marc
HOM Male postnatal decreased hemoglobin content Hematology | Hemoglobin MARC | IMPC 3.83E-10
Dpy19l1
Dpy19l1em1Mbp
HET Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin UC Davis | IMPC 5.23E-10
Dpy19l1
Dpy19l1em1Mbp
HOM Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin UC Davis | IMPC 5.23E-10
Epas1
Epas1tm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin MRC Harwell | IMPC 6.27E-10
Syce1l
Syce1ltm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin JAX | IMPC 7.0E-10
Syce1l
Syce1ltm1.1(KOMP)Vlcg
HET Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin JAX | IMPC 7.0E-10
Asxl1
Asxl1tm1a(EUCOMM)Wtsi
HET Female Male postnatal decreased hemoglobin content Haematology test | Haemoglobin WTSI | MGP 3.0E-9
Spata46
Spata46em1Mbp
HOM Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin UC Davis | IMPC 3.24E-9
H1foo
H1footm1b(KOMP)Wtsi
HOM Female postnatal decreased hemoglobin content Hematology | Hemoglobin UC Davis | IMPC 3.41E-9
Myl12b
Myl12btm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased hemoglobin content Haematology test | Haemoglobin WTSI | MGP 4.75E-9
Sec61b
Sec61bem1Mbp
HOM Male postnatal decreased hemoglobin content Hematology | Hemoglobin UC Davis | IMPC 9.31E-9
Lrrc8c
Lrrc8cem1Mbp
HOM Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin UC Davis | IMPC 1.02E-8
Gigyf2
Gigyf2tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin MRC Harwell | IMPC 1.27E-8
Olfr392
Olfr392em1Mbp
HOM Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin UC Davis | IMPC 2.63E-8
Mta3
Mta3tm3a(KOMP)Wtsi
HET Female Male postnatal decreased hemoglobin content Haematology | Mean cell haemoglobin concentration WTSI | EuroPhenome 6.43E-8
Thrb
Thrbtm2a(EUCOMM)Wtsi
HOM Female Male postnatal decreased hemoglobin content Haematology | Haemoglobin MRC Harwell | EuroPhenome 6.45E-8
Lyn
Lyntm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin MRC Harwell | IMPC 1.17E-7
Slc25a14
Slc25a14em1Mbp
HOM Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin UC Davis | IMPC 2.19E-7
Duoxa2
Duoxa2tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin WTSI | IMPC 2.38E-7
Klhl3
Klhl3tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin MRC Harwell | IMPC 2.44E-7
Plekhm2
Plekhm2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased hemoglobin content Haematology test | Haemoglobin WTSI | MGP 2.95E-7
Mysm1
Mysm1tm1a(KOMP)Wtsi
HET Female Male postnatal decreased hemoglobin content Haematology | Mean cell haemoglobin concentration MRC Harwell | EuroPhenome 3.73E-7
Kcna10
Kcna10em3Mbp
HET Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin UC Davis | IMPC 5.36E-7
Dnase1l2
Dnase1l2em2Mbp
HOM Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin UC Davis | IMPC 5.78E-7
Dpy19l3
Dpy19l3tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased hemoglobin content Haematology | Haemoglobin ICS | EuroPhenome 7.15E-7
Chd2
Chd2tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin TCP | IMPC 1.03E-6
Usmg5
Usmg5tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin MRC Harwell | IMPC 1.24E-6
Ghrhr
Ghrhrtm1.1(KOMP)Vlcg
HOM Female postnatal decreased hemoglobin content Hematology | Hemoglobin JAX | IMPC 1.84E-6
Kdm2b
Kdm2bem1Marc
HET Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin MARC | IMPC 2.8E-6
Smurf2
Smurf2tm1b(EUCOMM)Wtsi
HET Male postnatal decreased hemoglobin content Hematology | Hemoglobin MRC Harwell | IMPC 2.86E-6
Col4a5
Col4a5tm1b(EUCOMM)Wtsi
HOM Female postnatal decreased hemoglobin content Hematology | Hemoglobin MRC Harwell | IMPC 4.22E-6
Irf8
Irf8tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin JAX | IMPC 7.67E-6
Osm
Osmtm1b(KOMP)Wtsi
HOM Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin JAX | IMPC 8.12E-6
Cwc22
Cwc22em1Mbp
HET Female postnatal decreased hemoglobin content Hematology | Hemoglobin UC Davis | IMPC 9.43E-6
Gbx1
Gbx1
HOM Female postnatal decreased hemoglobin content Haematology | Mean cell haemoglobin concentration ICS | EuroPhenome 1.03E-5
Prkab1
Prkab1em2Mbp
HOM Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin UC Davis | IMPC 1.1E-5
Phactr1
Phactr1em1Mbp
HOM Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin UC Davis | IMPC 1.28E-5
Sgtb
Sgtbem1Mbp
HOM Male postnatal decreased hemoglobin content Hematology | Hemoglobin UC Davis | IMPC 1.42E-5
Ap4e1
Ap4e1tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased hemoglobin content Haematology test | Haemoglobin WTSI | MGP 1.42E-5
Rnf10
Rnf10tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin RBRC | IMPC 1.44E-5
Plcg2
Plcg2Ali14
HET Male postnatal decreased hemoglobin content Haematology | Haemoglobin HMGU | EuroPhenome 1.61E-5
Nagk
Nagktm1b(EUCOMM)Hmgu
HOM Male postnatal decreased hemoglobin content Hematology | Hemoglobin MRC Harwell | IMPC 1.66E-5
Slc38a10
Slc38a10tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased hemoglobin content Haematology test | Haemoglobin WTSI | MGP 1.67E-5
Rbm11
Rbm11em1Marc
HOM Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin MARC | IMPC 1.73E-5
Olfr380
Olfr380em1Mbp
HOM Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin UC Davis | IMPC 1.95E-5
Sytl1
Sytl1tm1a(KOMP)Wtsi
HOM Male postnatal decreased hemoglobin content Haematology | Mean cell haemoglobin concentration WTSI | EuroPhenome 2.05E-5
Asns
Asnstm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased hemoglobin content Haematology | Haemoglobin MRC Harwell | EuroPhenome 2.63E-5
Umod
Umodurehr4
HOM Female Male postnatal decreased hemoglobin content Haematology | Haemoglobin HMGU | EuroPhenome 2.82E-5
Wdr47
Wdr47tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased hemoglobin content Haematology test | Haemoglobin WTSI | MGP 3.28E-5
Aldh3a2
Aldh3a2tm1a(EUCOMM)Wtsi
HOM Male postnatal decreased hemoglobin content Haematology | Haemoglobin ICS | EuroPhenome 3.3E-5
Dph6
Dph6tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased hemoglobin content Hematology | Hemoglobin WTSI | IMPC 3.49E-5
Zfp13
Zfp13tm1a(EUCOMM)Hmgu
HOM Male postnatal decreased hemoglobin content Haematology | Mean cell haemoglobin concentration ICS | EuroPhenome 3.94E-5
Miga2
Miga2tm1a(KOMP)Wtsi
HOM Male postnatal decreased hemoglobin content Haematology test | Haemoglobin WTSI | MGP 4.83E-5
Arhgef4
Arhgef4tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased hemoglobin content Haematology | Mean cell haemoglobin concentration HMGU | EuroPhenome 5.34E-5
Retreg3
Retreg3tm2a(EUCOMM)Wtsi
HOM Male postnatal decreased hemoglobin content Haematology | Mean cell haemoglobin concentration ICS | EuroPhenome 5.93E-5
Elmod1
Elmod1tm1a(EUCOMM)Hmgu
HOM Male postnatal decreased hemoglobin content Haematology | Haemoglobin MRC Harwell | EuroPhenome 6.94E-5
Kat14
Kat14tm1a(KOMP)Wtsi
HOM Female postnatal decreased hemoglobin content Haematology test | Haemoglobin WTSI | MGP 7.85E-5
Cln6
Cln6tm1b(EUCOMM)Hmgu
HOM Male postnatal decreased hemoglobin content Hematology | Hemoglobin TCP | IMPC 8.16E-5
Eef2kmt
Eef2kmttm1e(EUCOMM)Wtsi
HOM Male postnatal decreased hemoglobin content Haematology | Mean cell haemoglobin concentration HMGU | EuroPhenome 8.42E-5
Slc12a1
Slc12a1urehr3
HOM Male postnatal decreased hemoglobin content Haematology (GMC) | Hemoglobin HMGU | EuroPhenome 9.01E-5
B3galt1
B3galt1em1Marc
HOM Male postnatal decreased hemoglobin content Hematology | Hemoglobin MARC | IMPC 9.29E-5

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