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Phenotype: abnormal righting response

Definition
altered ability or changed amount of time needed to recover from an unnatural position to a normal position and/or to resist any force acting to place an organism into a false position
Synonyms
altered righting response
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal righting response

Total number of significant genotype-phenotype associations: 67

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Ush1c
Ush1ctm1a(KOMP)Wtsi 		HOM Early adult impaired righting response Contact righting reflex
Combined SHIRPA and Dysmorphology		 WTSI
IMPC		 2.82×10-23
Lepr
Leprtm1b(EUCOMM)Wtsi 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 MRC Harwell
IMPC		 5.41×10-22
Mir96
Mir96tm3.2(IMPC)Wtsi 		HOM Early adult impaired righting response Contact righting reflex
Combined SHIRPA and Dysmorphology		 WTSI
IMPC		 8.76×10-21
Cyba
Cybatm1a(EUCOMM)Wtsi 		HOM Early adult impaired righting response Contact righting reflex
Combined SHIRPA and Dysmorphology		 WTSI
IMPC		 2.23×10-17
Cdh23
Cdh23tm2b(EUCOMM)Wtsi 		HOM Early adult impaired righting response Contact righting reflex
Combined SHIRPA and Dysmorphology		 WTSI
IMPC		 2.69×10-14
Kcne1
Kcne1tm1b(EUCOMM)Hmgu 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 ICS
IMPC		 2.96×10-11
Hsd17b1
Hsd17b1tm1.1(KOMP)Vlcg 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 3.26×10-11
Abcg8
Abcg8tm1b(KOMP)Wtsi 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 CCP-IMG
IMPC		 2.11×10-10
Pfdn6
Pfdn6tm1.1(KOMP)Vlcg 		HET Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 4.53×10-10
Myo7a
Myo7atm1a(EUCOMM)Wtsi 		HOM Early adult impaired righting response Contact righting reflex
Combined SHIRPA and Dysmorphology		 WTSI
IMPC		 1.38×10-08
Kcnj6
Kcnj6em1(IMPC)H 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 MRC Harwell
IMPC		 3.49×10-08
Dll1
Dll1tm1Gos 		HET Early adult abnormal righting response Contact Righting Reflex
Shirpa (GMC)		 HMGU
EuroPhenome		 4.09×10-08
Pkp4
Pkp4tm1b(EUCOMM)Wtsi 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 8.87×10-08
Tpo
Tpoem1(IMPC)H 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 MRC Harwell
IMPC		 1.07×10-07
Eef1b2
Eef1b2em1(IMPC)J 		HOM Late adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 1.74×10-07
Polr1c
Polr1cem1(IMPC)J 		HET Late adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 1.74×10-07
Hapln1
Hapln1tm1.1(KOMP)Mbp 		HET Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 1.76×10-07
Slc8b1
Slc8b1em1(IMPC)J 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 1.76×10-07
Igsf11
Igsf11tm1b(KOMP)Wtsi 		HOM Late adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 2.02×10-07
Srbd1
Srbd1em1(IMPC)J 		HET Late adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 2.02×10-07
Utp4
Utp4em1(IMPC)J 		HET Late adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 2.02×10-07
Epgn
Epgntm1b(KOMP)Wtsi 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 3.15×10-07
Tent5a
Tent5aem1(IMPC)Ccpcz 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 CCP-IMG
IMPC		 3.52×10-07
Hecw1
Hecw1tm2b(EUCOMM)Hmgu 		HOM Middle aged adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 MRC Harwell
IMPC		 3.82×10-07
Prss2
Prss2tm1.1(KOMP)Vlcg 		HOM Late adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 7.32×10-07
AU040320
AU040320em1(IMPC)J 		HOM Late adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 8.83×10-07
Yeats2
Yeats2em1(IMPC)J 		HET Late adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 8.83×10-07
Rxylt1
Rxylt1em1(IMPC)J 		HET Late adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 3.16×10-06
Serpinb5
Serpinb5tm1b(KOMP)Wtsi 		HOM   Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 3.49×10-06
Mfsd4b4
Mfsd4b4em1(IMPC)J 		HOM Late adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 4.31×10-06
Avp
Avptm1b(EUCOMM)Wtsi 		HET Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 MRC Harwell
IMPC		 4.47×10-06
Fgf7
Fgf7tm1e.1(EUCOMM)Hmgu 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 MRC Harwell
IMPC		 4.47×10-06
Gnao1
Gnao1tm1b(EUCOMM)Hmgu 		HET Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 MRC Harwell
IMPC		 4.47×10-06
Mcub
Mcubtm1b(KOMP)Mbp 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 MRC Harwell
IMPC		 4.47×10-06
Ky
Kyem1(IMPC)J 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 5.30×10-06
Epha10
Epha10tm1.1(KOMP)Vlcg 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 1.11×10-05
Stat1
Stat1tm2b(EUCOMM)Wtsi 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 ICS
IMPC		 1.12×10-05
Trf
Trfem1(IMPC)J 		HET Late adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 1.53×10-05
Ipp
Ipptm1.1(KOMP)Vlcg 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 1.77×10-05
Rnf25
Rnf25tm1.1(KOMP)Vlcg 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 1.77×10-05
Mir96
Mir96tm2.2(IMPC)Wtsi 		HOM Early adult impaired righting response Contact righting reflex
Combined SHIRPA and Dysmorphology		 WTSI
IMPC		 1.78×10-05
Inhbb
Inhbbtm1b(EUCOMM)Hmgu 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 MRC Harwell
IMPC		 2.19×10-05
Svop
Svopem1(IMPC)H 		HOM Late adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 MRC Harwell
IMPC		 2.47×10-05
Samm50
Samm50em1(IMPC)Hmgu 		HET Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 HMGU
IMPC		 3.43×10-05
Wars1
Wars1tm1b(EUCOMM)Hmgu 		HET Late adult impaired righting response Contact righting
SHIRPA		 HMGU
IMPC		 4.59×10-05
Klf7
Klf7tm1b(EUCOMM)Hmgu 		HET Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 MRC Harwell
IMPC		 4.63×10-05
Fastkd5
Fastkd5em1(IMPC)J 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 4.66×10-05
Zfp689
Zfp689tm1.1(KOMP)Vlcg 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 JAX
IMPC		 4.66×10-05
Car3
Car3em1(IMPC)Hmgu 		HET   Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 HMGU
IMPC		 8.07×10-05
Cimap1d
Cimap1dtm1.1(KOMP)Vlcg 		HET Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 UC Davis
IMPC		 8.89×10-05
Grm7
Grm7em1(IMPC)H 		HOM Early adult impaired righting response Contact righting
Combined SHIRPA and Dysmorphology		 MRC Harwell
IMPC		 9.31×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Combined SHIRPA and Dysmorphology
Click-box
Modified SHIRPA
SHIRPA
Shirpa (GMC)

 Phenotype associations stats

1.33% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal righting response (50/3749)

0.88% females (33/3762) 0.82% males (31/3766)

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