Phenotype: decreased heart weight

Definition less than average weight of the heart compared to controls

Synonyms reduced heart weight
Related
Synonyms
  • decreased heart left atrium weight
  • decreased heart left atrium weight
  • decreased heart right atrium weight
  • decreased heart right atrium weight
  • decreased heart right ventricle weight
  • decreased heart left ventricle weight
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Phenotype associations stats

0.95% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased heart weight (37/3904)

0.73% females (28/3855) 0.83% males (32/3875)

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Gene variants with decreased heart weight

Total number of significant genotype-phenotype associations: 60

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Lepr
Leprtm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 1.61E-43
Duoxa2
Duoxa2tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased heart weight Heart Weight | Heart weight WTSI | IMPC 5.27E-11
Il2ra
Il2ratm1b(EUCOMM)Wtsi
HOM Male postnatal decreased heart weight Heart Weight | Heart weight ICS | IMPC 8.53E-9
Cyp17a1
Cyp17a1tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased heart weight Heart Weight | Heart weight MARC | IMPC 3.01E-8
Ghrhr
Ghrhrtm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased heart weight Heart Weight | Heart weight JAX | IMPC 4.44E-8
Hrh4
Hrh4tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased heart weight Heart Weight | Heart weight ICS | IMPC 7.72E-8
Kiss1r
Kiss1rtm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased heart weight Heart Weight | Heart weight UC Davis | IMPC 1.15E-7
Trh
Trhem1(IMPC)Tcp
HOM Female Male postnatal decreased heart weight Heart Weight | Heart weight TCP | IMPC 1.31E-7
Mtmr12
Mtmr12tm1b(KOMP)Wtsi
HOM Male postnatal decreased heart weight Heart Weight | Heart weight ICS | IMPC 1.08E-6
Tlr4
Tlr4tm1.1(KOMP)Vlcg
HOM Male postnatal decreased heart weight Heart Weight | Heart weight UC Davis | IMPC 1.79E-6
Snip1
Snip1tm1a(EUCOMM)Wtsi
HET Female postnatal decreased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 9.07E-6
Acsl4
Acsl4tm1a(EUCOMM)Wtsi
HET Female postnatal decreased heart weight Heart Dissection | Heart weight WTSI | EuroPhenome 9.41E-6
Coq2
Coq2tm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 1.02E-5
Romo1
Romo1em1(IMPC)KMPC
HET Male postnatal decreased heart weight Heart Weight | Heart weight KMPC | IMPC 1.08E-5
Grin2d
Grin2dtm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 1.25E-5
Gpr61
Gpr61em1(IMPC)Bay
HOM Female Male postnatal decreased heart weight Heart Weight | Heart weight BCM | IMPC 1.34E-5
Cybrd1
Cybrd1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 1.57E-5
Ly6g6d
Ly6g6dtm1b(EUCOMM)Hmgu
HOM Male postnatal decreased heart weight Heart Weight | Heart weight HMGU | IMPC 1.82E-5
Hnrnpr
Hnrnprem1(IMPC)Marc
HOM Female Male postnatal decreased heart weight Heart Weight | Heart weight MARC | IMPC 1.85E-5
Pink1
Pink1tm1b(EUCOMM)Wtsi
HOM Female postnatal decreased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 2.01E-5
Slc38a10
Slc38a10tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased heart weight Heart Weight | Heart weight WTSI | IMPC 2.83E-5
Nr1h3
Nr1h3tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased heart weight Heart Weight | Heart weight UC Davis | IMPC 2.87E-5
Fndc9
Fndc9tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased heart weight Heart Weight | Heart weight UC Davis | IMPC 3.03E-5
Kctd15
Kctd15tm1b(EUCOMM)Wtsi
HET Female Male postnatal decreased heart weight Heart Weight | Heart weight ICS | IMPC 3.22E-5
Dnd1
Dnd1em1(IMPC)Bay
HOM Female Male postnatal decreased heart weight Heart Weight | Heart weight BCM | IMPC 3.25E-5
Sparc
Sparctm1a(EUCOMM)Wtsi
HOM Male postnatal decreased heart weight Heart weight/tibia length | Heart weight WTSI | EuroPhenome 3.3E-5
Bbs5
Bbs5tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 3.75E-5
P2rx4
P2rx4tm1b(EUCOMM)Wtsi
HOM Male postnatal decreased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 4.93E-5
Wdr81
Wdr81em1(IMPC)J
HET Male postnatal decreased heart weight Heart Weight | Heart weight JAX | IMPC 5.23E-5
Mbtd1
Mbtd1tm2a(EUCOMM)Wtsi
HET Female Male postnatal decreased heart weight Heart Dissection | Heart weight WTSI | EuroPhenome 5.35E-5
Ap4e1
Ap4e1tm1b(KOMP)Wtsi
HOM Female postnatal decreased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 5.77E-5
Tex45
Tex45tm3b(KOMP)Wtsi
HOM Female Male postnatal decreased heart weight Heart Weight | Heart weight BCM | IMPC 7.49E-5
Il31ra
Il31ratm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 7.6E-5
Prf1
Prf1tm1.1(KOMP)Vlcg
HOM Male postnatal decreased heart weight Heart Weight | Heart weight UC Davis | IMPC 7.76E-5
Ppp2r5e
Ppp2r5eem1(IMPC)Marc
HOM Female Male postnatal decreased heart weight Heart Weight | Heart weight MARC | IMPC 8.46E-5
Vwa1
Vwa1tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased heart weight Heart Weight | Heart weight UC Davis | IMPC 8.7E-5
Ap1g1
Ap1g1tm1b(EUCOMM)Hmgu
HET Female postnatal decreased heart weight Heart Weight | Heart weight JAX | IMPC 8.88E-5

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