Phenotype: decreased heart weight

Definition less than average weight of the heart compared to controls

Synonyms reduced heart weight
Related
Synonyms
  • decreased heart left atrium weight
  • decreased heart left atrium weight
  • decreased heart left ventricle weight
  • decreased heart left ventricle weight
  • decreased heart right atrium weight
  • decreased heart right ventricle weight
  • decreased left ventricle weight
  • decreased right ventricle weight
  • reduced heart left atrium weight
  • reduced heart right atrium weight
  • reduced left ventricle weight
  • reduced right ventricle weight
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Phenotype associations stats

0.76% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased heart weight (27/3550)

0.57% females (20/3516) 0.68% males (24/3528)

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Gene variants with decreased heart weight

Total number of significant genotype-phenotype associations: 46

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Lepr
Leprtm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 1.23E-42
Duoxa2
Duoxa2tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased heart weight Heart Weight | Heart weight WTSI | IMPC 6.26E-11
Cyp17a1
Cyp17a1tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased heart weight Heart Weight | Heart weight MARC | IMPC 2.55E-9
Kiss1r
Kiss1rtm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased heart weight Heart Weight | Heart weight UC Davis | IMPC 1.11E-7
Ghrhr
Ghrhrtm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased heart weight Heart Weight | Heart weight JAX | IMPC 2.18E-7
Mtmr12
Mtmr12tm1b(KOMP)Wtsi
HOM Male postnatal decreased heart weight Heart Weight | Heart weight ICS | IMPC 1.16E-6
Tlr4
Tlr4tm1.1(KOMP)Vlcg
HOM Male postnatal decreased heart weight Heart Weight | Heart weight UC Davis | IMPC 1.6E-6
Ppp2r5e
Ppp2r5eem1Marc
HOM Female Male postnatal decreased heart weight Heart Weight | Heart weight MARC | IMPC 2.18E-6
Gpr61
Gpr61em1Bay
HOM Female Male postnatal decreased heart weight Heart Weight | Heart weight BCM | IMPC 2.67E-6
Acsl4
Acsl4tm1a(EUCOMM)Wtsi
HET Female postnatal decreased heart weight Heart Dissection | Heart weight WTSI | MGP 9.41E-6
Coq2
Coq2tm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 9.72E-6
Il2ra
Il2ratm1b(EUCOMM)Wtsi
HOM Male postnatal decreased heart weight Heart Weight | Heart weight ICS | IMPC 9.76E-6
Grin2d
Grin2dtm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 1.25E-5
Pink1
Pink1tm1b(EUCOMM)Wtsi
HOM Female postnatal decreased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 1.83E-5
Cybrd1
Cybrd1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 1.95E-5
Fndc9
Fndc9tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased heart weight Heart Weight | Heart weight UC Davis | IMPC 2.71E-5
Sparc
Sparctm1a(EUCOMM)Wtsi
HOM Male postnatal decreased heart weight Heart weight/tibia length | Heart weight WTSI | EuroPhenome 3.3E-5
Kctd15
Kctd15tm1b(EUCOMM)Wtsi
HET Female Male postnatal decreased heart weight Heart Weight | Heart weight ICS | IMPC 3.44E-5
Bbs5
Bbs5tm1b(EUCOMM)Wtsi
HET Female Male postnatal decreased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 3.59E-5
Bbs5
Bbs5tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 3.59E-5
Ap4e1
Ap4e1tm1b(KOMP)Wtsi
HOM Female postnatal decreased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 4.93E-5
Mbtd1
Mbtd1tm2a(EUCOMM)Wtsi
HET Female Male postnatal decreased heart weight Heart Dissection | Heart weight WTSI | MGP 5.35E-5
Hnrnpr
Hnrnprem1Marc
HOM Female Male postnatal decreased heart weight Heart Weight | Heart weight MARC | IMPC 5.45E-5
P2rx4
P2rx4tm1b(EUCOMM)Wtsi
HOM Male postnatal decreased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 5.75E-5
Vwa1
Vwa1tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased heart weight Heart Weight | Heart weight UC Davis | IMPC 7.6E-5
Prf1
Prf1tm1.1(KOMP)Vlcg
HOM Male postnatal decreased heart weight Heart Weight | Heart weight UC Davis | IMPC 7.76E-5
Nr1h3
Nr1h3tm1.1(KOMP)Vlcg
HOM Male postnatal decreased heart weight Heart Weight | Heart weight UC Davis | IMPC 8.43E-5
Il31ra
Il31ratm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 8.48E-5

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