Phenotype: decreased circulating triglyceride level

Definition reduced concentration of naturally occurring esters of three fatty acids and glycerol in the blood; triglycerides are widespread in adipose tissue, commonly circulate in the blood in the form of lipoproteins, and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liver

Synonyms
  • low serum triacylglycerol level
  • low serum triacylglycerol level
  • reduced circulating triglyceride level
  • reduced circulating triglyceride level
  • low plasma triglyceride level
  • low serum triglyceride level
  • low plasma triacylglycerol level
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Related
Synonyms
decreased circulating VLDL triglyceride level

MP browserMP:0002644

Phenotype associations stats

2.84% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased circulating triglyceride level (109/3835)

1.80% females (68/3783) 2.78% males (106/3811)

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Gene variants with decreased circulating triglyceride level

Total number of significant genotype-phenotype associations: 175

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Akt2
Akt2tm1Wcs
HOM Male postnatal decreased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides WTSI | EuroPhenome 3.67E-11
Hells
Hellstm1a(EUCOMM)Wtsi
HOM Male postnatal decreased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides HMGU | EuroPhenome 1.77E-9
Acbd3
Acbd3tm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides HMGU | IMPC 5.69E-9
Cpgi5563
Cpgi5563tm1.1(NCC)WCS
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 1.06E-8
Diaph3
Diaph3tm1b(KOMP)Mbp
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides JAX | IMPC 2.13E-8
Rnf10
Rnf10tm1b(KOMP)Wtsi
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides TCP | IMPC 3.04E-8
Arhgef4
Arhgef4tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides HMGU | EuroPhenome 3.75E-8
Pde6b
Pde6b
HOM Male postnatal decreased circulating triglyceride level Clinical chemistry (GMC) | Triglyceride HMGU | EuroPhenome 3.78E-8
Slc38a10
Slc38a10tm2a(EUCOMM)Wtsi
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride MRC Harwell | EuroPhenome 4.63E-8
Fam234b
Fam234btm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides HMGU | EuroPhenome 5.52E-8
Tfap4
Tfap4tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides UC Davis | IMPC 6.64E-8
Elk4
Elk4tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides HMGU | EuroPhenome 6.92E-8
Acsl5
Acsl5tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides UC Davis | IMPC 1.02E-7
Mysm1
Mysm1tm1a(KOMP)Wtsi
HET Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride MRC Harwell | EuroPhenome 1.13E-7
Ppp5c
Ppp5ctm1a(EUCOMM)Wtsi
HOM Male postnatal decreased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides WTSI | EuroPhenome 1.41E-7
Grin2d
Grin2dtm1a(EUCOMM)Wtsi
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride MRC Harwell | EuroPhenome 1.7E-7
Wrnip1
Wrnip1tm1a(EUCOMM)Wtsi
HOM Male postnatal decreased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides HMGU | EuroPhenome 1.75E-7
Arih2
Arih2tm1.1(KOMP)Vlcg
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides UC Davis | IMPC 1.84E-7
Tcerg1l
Tcerg1ltm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 2.68E-7
Hmx3
Hmx3tm1Ebo
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride WTSI | EuroPhenome 3.77E-7
Tial1
Tial1tm1b(EUCOMM)Wtsi
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 4.97E-7
Erf
Erftm1.1(KOMP)Mbp
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides UC Davis | IMPC 6.17E-7
Psg27
Psg27em1(IMPC)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 6.58E-7
Podxl2
Podxl2tm1.1(KOMP)Vlcg
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides UC Davis | IMPC 7.34E-7
Nbas
Nbastm1b(EUCOMM)Hmgu
HET Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides HMGU | IMPC 7.89E-7
Peli1
Peli1tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides UC Davis | IMPC 9.11E-7
Gc
Gctm1.1(KOMP)Vlcg
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides UC Davis | IMPC 1.0E-6
Cyp4b1
Cyp4b1tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides HMGU | IMPC 1.01E-6
Gna11
Gna11tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride MRC Harwell | EuroPhenome 1.06E-6
Eif1b
Eif1btm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides JAX | IMPC 1.36E-6
Dhcr24
Dhcr24tm1a(EUCOMM)Wtsi
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride WTSI | EuroPhenome 1.49E-6
Dpp9
Dpp9tm1a(EUCOMM)Hmgu
HET Female Male postnatal decreased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides HMGU | EuroPhenome 1.55E-6
Sik3
Sik3tm1a(EUCOMM)Hmgu
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 1.56E-6
Rab4a
Rab4atm1b(EUCOMM)Hmgu
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides MRC Harwell | IMPC 1.7E-6
Trbv19
Trbv19em1(IMPC)Wtsi
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 1.74E-6
Phex
Phexnot yet available
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride HMGU | EuroPhenome 1.85E-6
C2cd4b
C2cd4bem1(IMPC)Wtsi
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 1.9E-6
Ube2b
Ube2btm1a(EUCOMM)Wtsi
HET Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride ICS | MGP 1.94E-6
Gbp3
Gbp3tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 1.97E-6
Psph
Psphtm1.1(KOMP)Vlcg
HET Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides TCP | IMPC 2.46E-6
Grhl3
Grhl3tm1a(EUCOMM)Wtsi
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride ICS | MGP 2.77E-6
Mmp11
Mmp11tm1a(EUCOMM)Hmgu
HET Female Male postnatal decreased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides HMGU | EuroPhenome 3.03E-6
Cpgi15344
Cpgi15344tm1.1(NCC)WCS
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 3.15E-6
Serpina3c
Serpina3ctm1a(KOMP)Wtsi
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 3.73E-6
Tbc1d22a
Tbc1d22atm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 3.83E-6
Phactr1
Phactr1em1(IMPC)Mbp
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides UC Davis | IMPC 4.17E-6
Pitx3
Pitx3eyl
HOM Female Male postnatal decreased circulating triglyceride level Clinical chemistry (GMC) | Triglyceride HMGU | EuroPhenome 4.71E-6
Dclk1
Dclk1tm1a(EUCOMM)Wtsi
HET Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 4.97E-6
Rab5a
Rab5atm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides JAX | IMPC 4.99E-6
Mysm1
Mysm1tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride HMGU | EuroPhenome 5.26E-6
Cap2
Cap2tm1e(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides HMGU | EuroPhenome 5.51E-6
Myo6
Myo6Tlc
HET Male postnatal decreased circulating triglyceride level Clinical chemistry (GMC) | Triglyceride HMGU | EuroPhenome 6.19E-6
Wrap53
Wrap53tm1b(EUCOMM)Wtsi
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 6.22E-6
Plcg2
Plcg2Ali14
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride HMGU | EuroPhenome 6.45E-6
Ntf5
Ntf5tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides ICS | IMPC 6.61E-6
Angptl4
Angptl4tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides MRC Harwell | IMPC 6.64E-6
Ube2d1
Ube2d1tm3e(EUCOMM)Wtsi
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 7.41E-6
Trpc3
Trpc3Mwk
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride MRC Harwell | EuroPhenome 7.61E-6
Setd4
Setd4tm1a(KOMP)Wtsi
HOM Female postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 8.32E-6
Elmod1
Elmod1tm1b(EUCOMM)Hmgu
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides MRC Harwell | IMPC 8.38E-6
Crispld2
Crispld2tm1.1(KOMP)Vlcg
HET Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides TCP | IMPC 9.54E-6
Bnip2
Bnip2tm1b(EUCOMM)Wtsi
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 1.04E-5
Hook3
Hook3tm1b(NCOM)Mfgc
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides TCP | IMPC 1.05E-5
D630045J12Rik
D630045J12Riktm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides TCP | IMPC 1.17E-5
Cyba
Cybatm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 1.19E-5
Klk14
Klk14tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides JAX | IMPC 1.2E-5
Serpinb9b
Serpinb9bem1(IMPC)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 1.24E-5
Elfn1
Elfn1tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides UC Davis | IMPC 1.28E-5
Osm
Osmtm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Plasma Chemistry | Triglycerides JAX | IMPC 1.41E-5
Nfil3
Nfil3tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides UC Davis | IMPC 1.55E-5
Esr2
Esr2em1(IMPC)Marc
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides MARC | IMPC 1.72E-5
Slc46a1
Slc46a1tm1b(KOMP)Mbp
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides JAX | IMPC 1.73E-5
Nr1h3
Nr1h3tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides UC Davis | IMPC 1.86E-5
Mag
Magtm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides JAX | IMPC 1.87E-5
Fam117b
Fam117btm1a(EUCOMM)Wtsi
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride MRC Harwell | EuroPhenome 2.53E-5
Ephx1
Ephx1
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride ICS | MGP 2.72E-5
Hbp1
Hbp1Gt(EUCJ0053g09)Hmgu
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride MRC Harwell | EuroPhenome 3.15E-5
Rnf7
Rnf7tm1a(EUCOMM)Wtsi
HET Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride MRC Harwell | EuroPhenome 3.27E-5
Ndufs1
Ndufs1tm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides HMGU | IMPC 4.09E-5
Pmch
Pmchtm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides UC Davis | IMPC 4.22E-5
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 4.3E-5
Farp2
Farp2tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride WTSI | EuroPhenome 4.38E-5
Ppp6c
Ppp6ctm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides ICS | IMPC 4.49E-5
Umod
Umodurehr4
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride HMGU | EuroPhenome 4.65E-5
Pknox1
Pknox1Gt(EUCJ0079d10)Hmgu
HET Male postnatal decreased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides HMGU | EuroPhenome 4.92E-5
Ush1c
Ush1ctm1a(KOMP)Wtsi
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 4.95E-5
Cdh23
Cdh23tm2b(EUCOMM)Wtsi
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 5.33E-5
Ushbp1
Ushbp1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 5.35E-5
Fam83g
Fam83gtm1a(EUCOMM)Wtsi
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride MRC Harwell | EuroPhenome 5.54E-5
Igsf8
Igsf8em1(IMPC)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 5.74E-5
4932438A13Rik
4932438A13Riktm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides JAX | IMPC 5.87E-5
Cldn19
Cldn19tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating triglyceride level Plasma Chemistry | Triglycerides JAX | IMPC 5.88E-5
Rbpj
Rbpjtm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides JAX | IMPC 6.11E-5
Nfkbid
Nfkbidtm1a(EUCOMM)Wtsi
HET Male postnatal decreased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides HMGU | EuroPhenome 6.34E-5
Eps8l2
Eps8l2tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides MRC Harwell | IMPC 6.36E-5
Clec4a3
Clec4a3tm1b(KOMP)Wtsi
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 6.64E-5
Asxl1
Asxl1tm1a(EUCOMM)Wtsi
HET Female Male postnatal decreased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides HMGU | EuroPhenome 6.69E-5
Pex26
Pex26tm1.1(KOMP)Vlcg
HET Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides TCP | IMPC 6.71E-5
Drg2
Drg2tm1a(EUCOMM)Wtsi
HET Female Male postnatal decreased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides ICS | EuroPhenome 6.75E-5
Gm5134
Gm5134tm1a(EUCOMM)Hmgu
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride MRC Harwell | EuroPhenome 6.82E-5
Xbp1
Xbp1tm1a(EUCOMM)Wtsi
HET Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride HMGU | EuroPhenome 6.88E-5
Hnrnpr
Hnrnprem1(IMPC)Marc
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides MARC | IMPC 7.03E-5
Slc35f6
Slc35f6tm1a(EUCOMM)Wtsi
HOM Male postnatal decreased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides HMGU | EuroPhenome 7.05E-5
Snx15
Snx15tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides JAX | IMPC 7.54E-5
Riok2
Riok2tm1b(KOMP)Wtsi
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides UC Davis | IMPC 7.76E-5
Lsm14a
Lsm14atm1b(KOMP)Wtsi
HET Female postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides MARC | IMPC 7.82E-5
Il18rap
Il18rapem1(IMPC)Wtsi
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 7.94E-5
AU021092
AU021092tm1b(KOMP)Wtsi
HET Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides UC Davis | IMPC 8.08E-5
Ttc39b
Ttc39btm1e(EUCOMM)Wtsi
HET Female postnatal decreased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides WTSI | EuroPhenome 9.08E-5
Lmbrd1
Lmbrd1tm1b(EUCOMM)Hmgu
HET Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides TCP | IMPC 9.77E-5

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