Phenotype: decreased circulating triglyceride level

Definition reduced concentration of naturally occurring esters of three fatty acids and glycerol in the blood; triglycerides are widespread in adipose tissue, commonly circulate in the blood in the form of lipoproteins, and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liver

Synonyms
  • reduced circulating triglyceride level
  • reduced circulating triglyceride level
  • low serum triacylglycerol level
  • low serum triacylglycerol level
  • low plasma triglyceride level
  • low serum triglyceride level
  • low plasma triacylglycerol level
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Related
Synonyms
  • decreased circulating VLDL triglyceride level
  • decreased circulating VLDL triglyceride level
  • reduced circulating VLDL triglyceride level
  • reduced circulating VLDL triglyceride level

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Phenotype associations stats

2.64% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased circulating triglyceride level (86/3254)

1.77% females (57/3227) 2.63% males (85/3234)

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Gene variants with decreased circulating triglyceride level

Total number of significant genotype-phenotype associations: 150

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Hells
Hellstm1a(EUCOMM)Wtsi
HOM Male postnatal decreased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides HMGU | EuroPhenome 1.03E-11
Akt2
Akt2tm1Wcs
HOM Male postnatal decreased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides WTSI | EuroPhenome 3.67E-11
Acbd3
Acbd3tm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides HMGU | IMPC 8.63E-9
Nbas
Nbastm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides HMGU | IMPC 1.87E-8
Diaph3
Diaph3tm1b(KOMP)Mbp
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides JAX | IMPC 3.4E-8
Arhgef4
Arhgef4tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides HMGU | EuroPhenome 3.75E-8
Pde6b
Pde6b
HOM Male postnatal decreased circulating triglyceride level Clinical chemistry (GMC) | Triglyceride HMGU | EuroPhenome 3.78E-8
Slc38a10
Slc38a10tm2a(EUCOMM)Wtsi
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride MRC Harwell | EuroPhenome 4.63E-8
Fam234b
Fam234btm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides HMGU | EuroPhenome 5.52E-8
Elk4
Elk4tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides HMGU | EuroPhenome 6.92E-8
Tfap4
Tfap4tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides UC Davis | IMPC 8.46E-8
Tfap4
Tfap4tm1.1(KOMP)Vlcg
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides UC Davis | IMPC 8.46E-8
Acsl5
Acsl5tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides UC Davis | IMPC 1.04E-7
Mysm1
Mysm1tm1a(KOMP)Wtsi
HET Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride MRC Harwell | EuroPhenome 1.13E-7
Ppp5c
Ppp5ctm1a(EUCOMM)Wtsi
HOM Male postnatal decreased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides WTSI | EuroPhenome 1.41E-7
Grin2d
Grin2dtm1a(EUCOMM)Wtsi
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride MRC Harwell | EuroPhenome 1.7E-7
Wrnip1
Wrnip1tm1a(EUCOMM)Wtsi
HOM Male postnatal decreased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides HMGU | EuroPhenome 1.75E-7
Arih2
Arih2tm1.1(KOMP)Vlcg
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides UC Davis | IMPC 3.06E-7
Hmx3
Hmx3tm1Ebo
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride WTSI | EuroPhenome 3.77E-7
Zfp760
Zfp760tm1a(EUCOMM)Hmgu
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride HMGU | EuroPhenome 3.99E-7
Wrap53
Wrap53tm1b(EUCOMM)Wtsi
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 4.65E-7
Tbc1d22a
Tbc1d22atm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 4.81E-7
Erf
Erftm1.1(KOMP)Mbp
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides UC Davis | IMPC 6.31E-7
Gna11
Gna11tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride MRC Harwell | MGP 1.06E-6
Dhcr24
Dhcr24tm1a(EUCOMM)Wtsi
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride WTSI | EuroPhenome 1.22E-6
Eif1b
Eif1btm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides JAX | IMPC 1.36E-6
Gc
Gctm1.1(KOMP)Vlcg
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides UC Davis | IMPC 1.4E-6
Cyp4b1
Cyp4b1tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides HMGU | IMPC 1.46E-6
Dpp9
Dpp9tm1a(EUCOMM)Hmgu
HET Female Male postnatal decreased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides HMGU | EuroPhenome 1.55E-6
Phex
Phexnot yet available
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride HMGU | EuroPhenome 1.85E-6
Serpina3c
Serpina3ctm1a(KOMP)Wtsi
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 2.21E-6
Grhl3
Grhl3tm1a(EUCOMM)Wtsi
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride ICS | EuroPhenome 2.77E-6
Rab5a
Rab5atm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides JAX | IMPC 3.5E-6
Bnip2
Bnip2tm1b(EUCOMM)Wtsi
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 3.59E-6
Angptl4
Angptl4tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides MRC Harwell | IMPC 4.44E-6
Dnajc8
Dnajc8tm1b(KOMP)Wtsi
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 4.64E-6
Pitx3
Pitx3eyl
HOM Female Male postnatal decreased circulating triglyceride level Clinical chemistry (GMC) | Triglyceride HMGU | EuroPhenome 4.71E-6
Ntf5
Ntf5tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides ICS | IMPC 5.12E-6
Cyba
Cybatm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 6.03E-6
Myo6
Myo6Tlc
HET Male postnatal decreased circulating triglyceride level Clinical chemistry (GMC) | Triglyceride HMGU | EuroPhenome 6.19E-6
Plcg2
Plcg2Ali14
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride HMGU | EuroPhenome 6.45E-6
Trpc3
Trpc3Mwk
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride MRC Harwell | EuroPhenome 7.61E-6
Ushbp1
Ushbp1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 8.36E-6
Mmp11
Mmp11tm1a(EUCOMM)Hmgu
HET Female Male postnatal decreased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides HMGU | EuroPhenome 8.53E-6
Ush1c
Ush1ctm1a(KOMP)Wtsi
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 1.03E-5
Elmod1
Elmod1tm1b(EUCOMM)Hmgu
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides MRC Harwell | IMPC 1.17E-5
Klk14
Klk14tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides JAX | IMPC 1.34E-5
Peli1
Peli1tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides UC Davis | IMPC 1.35E-5
Osm
Osmtm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Plasma Chemistry | Triglycerides JAX | IMPC 1.41E-5
Nol8
Nol8tm1b(EUCOMM)Hmgu
HET Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides ICS | IMPC 1.45E-5
Elfn1
Elfn1tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides UC Davis | IMPC 1.59E-5
Nfil3
Nfil3tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides UC Davis | IMPC 1.61E-5
Slc46a1
Slc46a1tm1b(KOMP)Mbp
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides JAX | IMPC 1.78E-5
Phactr1
Phactr1em1Mbp
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides UC Davis | IMPC 1.79E-5
Rnf10
Rnf10tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides TCP | IMPC 1.84E-5
Rnf10
Rnf10tm1b(KOMP)Wtsi
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides TCP | IMPC 1.84E-5
Scaper
Scapertm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides ICS | IMPC 1.95E-5
Sgsm1
Sgsm1tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 2.2E-5
Hnrnpr
Hnrnprem1Marc
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides MARC | IMPC 2.27E-5
Mag
Magtm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides JAX | IMPC 2.32E-5
Xbp1
Xbp1tm1a(EUCOMM)Wtsi
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride HMGU | EuroPhenome 2.33E-5
Ephx1
Ephx1
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride ICS | EuroPhenome 2.42E-5
Fam117b
Fam117btm1a(EUCOMM)Wtsi
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride MRC Harwell | EuroPhenome 2.53E-5
Hbp1
Hbp1Gt(EUCJ0053g09)Hmgu
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride MRC Harwell | EuroPhenome 3.15E-5
Rnf7
Rnf7tm1a(EUCOMM)Wtsi
HET Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride MRC Harwell | EuroPhenome 3.27E-5
Cmtm5
Cmtm5tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 3.57E-5
Ppp6c
Ppp6ctm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides ICS | IMPC 3.8E-5
Farp2
Farp2tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride WTSI | EuroPhenome 4.16E-5
D630045J12Rik
D630045J12Riktm1b(KOMP)Wtsi
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides TCP | IMPC 4.39E-5
Rfc1
Rfc1tm1b(KOMP)Mbp
HET Female Male postnatal decreased circulating triglyceride level Plasma Chemistry | Triglycerides JAX | IMPC 4.64E-5
Umod
Umodurehr4
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride HMGU | EuroPhenome 4.65E-5
Plxnb2
Plxnb2tm1a(EUCOMM)Wtsi
HET Female Male postnatal decreased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides HMGU | EuroPhenome 4.67E-5
Hook3
Hook3tm1b(NCOM)Mfgc
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides TCP | IMPC 4.68E-5
Hook3
Hook3tm1b(NCOM)Mfgc
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides TCP | IMPC 4.68E-5
Pknox1
Pknox1Gt(EUCJ0079d10)Hmgu
HET Male postnatal decreased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides HMGU | EuroPhenome 4.92E-5
Ndfip2
Ndfip2tm1a(EUCOMM)Hmgu
HOM Male postnatal decreased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides HMGU | EuroPhenome 5.49E-5
Fam83g
Fam83gtm1a(EUCOMM)Wtsi
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride MRC Harwell | EuroPhenome 5.54E-5
4932438A13Rik
4932438A13Riktm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides JAX | IMPC 5.54E-5
Cldn19
Cldn19tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating triglyceride level Plasma Chemistry | Triglycerides JAX | IMPC 5.88E-5
Ube2b
Ube2btm1a(EUCOMM)Wtsi
HET Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride ICS | EuroPhenome 6.12E-5
Nfkbid
Nfkbidtm1a(EUCOMM)Wtsi
HET Male postnatal decreased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides HMGU | EuroPhenome 6.34E-5
Crispld2
Crispld2tm1.1(KOMP)Vlcg
HET Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides TCP | IMPC 6.67E-5
Drg2
Drg2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides ICS | EuroPhenome 6.75E-5
Drg2
Drg2tm1a(EUCOMM)Wtsi
HET Female Male postnatal decreased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides ICS | EuroPhenome 6.75E-5
Gm5134
Gm5134tm1a(EUCOMM)Hmgu
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglyceride MRC Harwell | MGP 6.82E-5
Snx15
Snx15tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides JAX | IMPC 6.96E-5
Esr2
Esr2em1Marc
HOM Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides MARC | IMPC 8.12E-5
Ndufs1
Ndufs1tm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides HMGU | IMPC 8.12E-5
AU021092
AU021092tm1b(KOMP)Wtsi
HET Male postnatal decreased circulating triglyceride level Clinical Chemistry | Triglycerides UC Davis | IMPC 8.37E-5
Ttc39b
Ttc39btm1e(EUCOMM)Wtsi
HET Female postnatal decreased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides WTSI | EuroPhenome 9.08E-5

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