Phenotype: increased mean platelet volume

Definition increased average content of platelet cells over normal

Synonyms
  • increased MPV
  • increased MPV
  • high mean platelet volume
  • high mean platelet volume
  • increased platelet size
  • large platelets
  • large platelet size
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Related
Synonyms
  • Giant platelets
  • Giant platelets
  • Macrothrombocytopenia
  • Macrothrombocytopenia
  • giant platelets
Show more

MP browserMP:0002599

Phenotype associations stats

2.12% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased mean platelet volume (62/2926)

1.89% females (54/2852) 1.99% males (57/2861)



Gene variants with increased mean platelet volume

Total number of significant genotype-phenotype associations: 111

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Tardbp
Tardbptm1b(EUCOMM)Wtsi
HET Male postnatal increased mean platelet volume Hematology | Mean platelet volume MRC Harwell | IMPC 1.74E-28
Zdhhc5
Zdhhc5tm1e.1(EUCOMM)Hmgu
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume HMGU | IMPC 6.5E-25
Gp9
Gp9tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume UC Davis | IMPC 1.8E-19
Bin2
Bin2em1(IMPC)Wtsi
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume WTSI | IMPC 2.51E-18
Nbeal2
Nbeal2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume WTSI | IMPC 2.09E-17
Phf5a
Phf5aem2(IMPC)Marc
HET Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume MARC | IMPC 9.42E-17
Ly6g6d
Ly6g6dtm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume HMGU | IMPC 2.1E-15
Sgms1
Sgms1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume WTSI | IMPC 4.3E-14
Trappc10
Trappc10tm1b(KOMP)Wtsi
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume WTSI | IMPC 2.0E-12
Polr3a
Polr3aem2(IMPC)Tcp
HET Male postnatal increased mean platelet volume Hematology | Mean platelet volume TCP | IMPC 9.47E-12
Lepr
Leprtm1b(EUCOMM)Wtsi
HOM Male postnatal increased mean platelet volume Hematology | Mean platelet volume MRC Harwell | IMPC 1.58E-11
Mpig6b
Mpig6btm1.1(KOMP)Vlcg
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume UC Davis | IMPC 2.16E-11
Lpin2
Lpin2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume TCP | IMPC 5.37E-11
Tmem189
Tmem189tm1a(KOMP)Wtsi
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume WTSI | IMPC 6.11E-11
Pbrm1
Pbrm1tm1b(EUCOMM)Wtsi
HET Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume HMGU | IMPC 3.95E-10
Baz1a
Baz1atm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume TCP | IMPC 5.27E-9
Zswim1
Zswim1tm1b(KOMP)Mbp
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume MARC | IMPC 1.16E-8
Kcnj10
Kcnj10tm1b(KOMP)Wtsi
HET Male postnatal increased mean platelet volume Hematology | Mean platelet volume MRC Harwell | IMPC 1.9E-8
Fbxo38
Fbxo38em2(IMPC)Marc
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume MARC | IMPC 1.05E-7
Ube2z
Ube2zem1(IMPC)Marc
HET Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume MARC | IMPC 1.19E-7
Ahcyl1
Ahcyl1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume WTSI | IMPC 1.62E-7
Etaa1
Etaa1em1(IMPC)Marc
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume MARC | IMPC 2.05E-7
Brcc3
Brcc3em1(IMPC)Marc
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume MARC | IMPC 3.18E-7
Herc1
Herc1em3(IMPC)Wtsi
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume WTSI | IMPC 5.67E-7
C2cd4a
C2cd4aem1(IMPC)H
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume MRC Harwell | IMPC 7.11E-7
Cpt1a
Cpt1atm1.2(IMPC)Wtsi
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume WTSI | IMPC 7.74E-7
Cers1
Cers1tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume MRC Harwell | IMPC 8.09E-7
Cog6
Cog6tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume WTSI | IMPC 9.9E-7
Ampd1
Ampd1tm1b(KOMP)Wtsi
HET Female postnatal increased mean platelet volume Hematology | Mean platelet volume TCP | IMPC 1.0E-6
Usp15
Usp15em1(IMPC)Marc
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume MARC | IMPC 2.17E-6
Ehmt1
Ehmt1tm1b(EUCOMM)Hmgu
HET Male postnatal increased mean platelet volume Hematology | Mean platelet volume MARC | IMPC 3.23E-6
Hbs1l
Hbs1ltm1a(KOMP)Wtsi
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume WTSI | IMPC 3.57E-6
Grm7
Grm7em1(IMPC)H
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume MRC Harwell | IMPC 3.73E-6
Cd300a
Cd300atm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume MRC Harwell | IMPC 4.69E-6
Ncf2
Ncf2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume WTSI | IMPC 5.48E-6
Camkmt
Camkmttm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume WTSI | IMPC 8.04E-6
Prkaa2
Prkaa2tm1b(EUCOMM)Hmgu
HOM Male postnatal increased mean platelet volume Hematology | Mean platelet volume MRC Harwell | IMPC 8.37E-6
Abhd3
Abhd3em1(IMPC)Marc
HOM Female postnatal increased mean platelet volume Hematology | Mean platelet volume MARC | IMPC 8.66E-6
Slc38a10
Slc38a10tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume WTSI | IMPC 8.79E-6
Prkab1
Prkab1tm1b(KOMP)Wtsi
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume WTSI | IMPC 1.15E-5
Pak2
Pak2em1(IMPC)H
HET Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume MRC Harwell | IMPC 1.72E-5
Stard10
Stard10tm1b(KOMP)Wtsi
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume MRC Harwell | IMPC 2.07E-5
Fbxo7
Fbxo7tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume WTSI | IMPC 2.29E-5
4930404H24Rik
4930404H24Riktm1a(KOMP)Wtsi
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume WTSI | IMPC 2.78E-5
Hnrnph1
Hnrnph1tm1b(KOMP)Wtsi
HET Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume MARC | IMPC 3.73E-5
Nhp2
Nhp2tm1a(KOMP)Wtsi
HET Male postnatal increased mean platelet volume Hematology | Mean platelet volume WTSI | IMPC 3.77E-5
Sorcs2
Sorcs2em1(IMPC)Marc
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume MARC | IMPC 4.11E-5
Gpr107
Gpr107tm1a(KOMP)Wtsi
HET Female postnatal increased mean platelet volume Hematology | Mean platelet volume WTSI | IMPC 4.24E-5
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume WTSI | IMPC 4.76E-5
Gpsm2
Gpsm2tm1b(EUCOMM)Wtsi
HET Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume HMGU | IMPC 4.82E-5
Hecw2
Hecw2tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume WTSI | IMPC 4.84E-5
Wac
Wactm2b(EUCOMM)Wtsi
HET Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume WTSI | IMPC 4.93E-5
Fbxl20
Fbxl20tm1b(KOMP)Wtsi
HET Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume MRC Harwell | IMPC 5.14E-5
Zfp420
Zfp420tm1b(EUCOMM)Hmgu
HOM Male postnatal increased mean platelet volume Hematology | Mean platelet volume MRC Harwell | IMPC 5.69E-5
Mlec
Mlectm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume WTSI | IMPC 6.41E-5
Smoc1
Smoc1tm1b(EUCOMM)Wtsi
HET Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume MRC Harwell | IMPC 7.01E-5
Abraxas2
Abraxas2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume WTSI | IMPC 7.46E-5
Gp1bb
Gp1bbtm1.1(KOMP)Vlcg
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume UC Davis | IMPC 7.67E-5
Ube2e1
Ube2e1em1(IMPC)Marc
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume MARC | IMPC 8.04E-5
Usp26
Usp26em1(IMPC)Marc
HOM Female postnatal increased mean platelet volume Hematology | Mean platelet volume MARC | IMPC 8.34E-5
Acaa1a
Acaa1atm1a(KOMP)Wtsi
HOM Female postnatal increased mean platelet volume Hematology | Mean platelet volume WTSI | IMPC 8.37E-5
Pkn1
Pkn1tm1b(KOMP)Wtsi
HOM Female Male postnatal increased mean platelet volume Hematology | Mean platelet volume MRC Harwell | IMPC 9.76E-5

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