Phenotype: decreased mean corpuscular volume

Definition less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices

Synonyms
  • reduced mean corpuscular volume
  • reduced mean corpuscular volume
  • low MCV
  • low MCV
  • decreased MCV
  • low mean corpuscular volume
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Related
Synonyms
  • Hypochromic microcytic anemia
  • Hypochromic microcytic anemia
  • Microcytic anemia
  • Microcytic anemia
  • Normochromic microcytic anemia
  • hypochromic microcytic anemia
  • microcytic anemia
Show more

MP browserMP:0002591

Phenotype associations stats

2.16% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased mean corpuscular volume (88/4080)

2.01% females (81/4033) 1.76% males (71/4036)

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Gene variants with decreased mean corpuscular volume

Total number of significant genotype-phenotype associations: 156

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Cp
Cptm1b(KOMP)Wtsi
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 0.0
Pacsin2
Pacsin2tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 0.0
Prkab1
Prkab1tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 0.0
Fbxo36
Fbxo36tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume MARC | IMPC 5.43E-29
AW112010
AW112010em1(IMPC)Marc
HOM Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume MARC | IMPC 3.15E-18
Gimap6
Gimap6tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 1.79E-14
Epb41
Epb41tm1b(KOMP)Mbp
HET Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 4.87E-12
Mul1
Mul1em1(IMPC)H
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 1.26E-11
Arl6ip1
Arl6ip1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 1.06E-10
Fbxw2
Fbxw2tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume MARC | IMPC 4.39E-10
Fcho2
Fcho2tm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume WTSI | IMPC 7.02E-10
Ctsm
Ctsmtm1(KOMP)Wtsi
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume MARC | IMPC 8.44E-10
Rhd
Rhdtm1e(EUCOMM)Wtsi
HOM Female Male postnatal decreased mean corpuscular volume Haematology | Mean cell volume WTSI | EuroPhenome 2.2E-9
Usp2
Usp2tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 2.21E-9
Prkab1
Prkab1em2(IMPC)Mbp
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume UC Davis | IMPC 3.06E-9
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume WTSI | IMPC 4.74E-9
Adgrf5
Adgrf5tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume TCP | IMPC 7.78E-9
Myl12b
Myl12btm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased mean corpuscular volume Haematology test | Mean-cell-volume WTSI | EuroPhenome 8.23E-9
Unk
Unktm1a(KOMP)Wtsi
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume WTSI | IMPC 1.41E-8
Myl2
Myl2tm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume HMGU | IMPC 4.45E-8
Slc25a21
Slc25a21tm1d(KOMP)Wtsi
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume WTSI | IMPC 8.77E-8
Eif2b5
Eif2b5tm1a(EUCOMM)Wtsi
HET Female postnatal decreased mean corpuscular volume Haematology | Mean cell volume ICS | MGP 1.09E-7
Usp31
Usp31em1(IMPC)Marc
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume MARC | IMPC 1.11E-7
Ccdc57
Ccdc57tm1a(EUCOMM)Wtsi
HET Female Male postnatal decreased mean corpuscular volume Haematology test | Mean-cell-volume WTSI | EuroPhenome 1.17E-7
Lsm14b
Lsm14btm1b(KOMP)Mbp
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume WTSI | IMPC 1.4E-7
Prdm2
Prdm2em1(IMPC)Marc
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume MARC | IMPC 2.26E-7
Emc10
Emc10tm1b(EUCOMM)Wtsi
HOM Female postnatal decreased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 3.22E-7
Cntf
Cntftm1b(KOMP)Wtsi
HOM Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume UC Davis | IMPC 3.29E-7
Umod
Umodurehr4
HOM Female Male postnatal decreased mean corpuscular volume Haematology | Mean cell volume HMGU | EuroPhenome 4.4E-7
Hspbap1
Hspbap1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume BCM | IMPC 4.43E-7
Bola2
Bola2tm1(KOMP)Wtsi
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume MARC | IMPC 5.72E-7
Irgm1
Irgm1em1(IMPC)Wtsi
HOM Female postnatal decreased mean corpuscular volume Hematology | Mean cell volume WTSI | IMPC 8.01E-7
Trpm6
Trpm6tm1b(KOMP)Wtsi
HET Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume ICS | IMPC 8.92E-7
Aldh3a2
Aldh3a2tm1a(EUCOMM)Wtsi
HOM Female postnatal decreased mean corpuscular volume Haematology | Mean cell volume ICS | MGP 1.28E-6
Hsf1
Hsf1tm1.1(KOMP)Vlcg
HET Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 1.36E-6
Ecm1
Ecm1tm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 1.5E-6
Fkbp10
Fkbp10tm2a(EUCOMM)Wtsi
HET Male postnatal decreased mean corpuscular volume Haematology | Mean cell volume ICS | MGP 1.53E-6
Ints9
Ints9tm1b(KOMP)Wtsi
HET Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume WTSI | IMPC 1.69E-6
Rcc2
Rcc2tm1b(EUCOMM)Wtsi
HOM Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 1.73E-6
Prom2
Prom2tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 2.65E-6
Bbc3
Bbc3em1(IMPC)Marc
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume MARC | IMPC 2.84E-6
Cldn13
Cldn13tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 2.89E-6
Cd276
Cd276tm2b(EUCOMM)Hmgu
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume ICS | IMPC 3.54E-6
Slc15a3
Slc15a3tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 3.54E-6
Rxrg
Rxrg
HOM Female Male postnatal decreased mean corpuscular volume Haematology | Mean cell volume ICS | EuroPhenome 4.04E-6
Ahrr
Ahrrtm1b(KOMP)Wtsi
HET Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 5.25E-6
Diaph3
Diaph3tm1b(KOMP)Mbp
HET Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 7.5E-6
Tpcn1
Tpcn1tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 8.05E-6
Uqcrq
Uqcrqtm1b(EUCOMM)Hmgu
HET Female postnatal decreased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 8.68E-6
Plac9a
Plac9atm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 1.12E-5
Wars
Warstm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume HMGU | IMPC 1.14E-5
Rbl1
Rbl1tm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume HMGU | IMPC 1.2E-5
Stat1
Stat1tm2b(EUCOMM)Wtsi
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume ICS | IMPC 1.45E-5
Bag1
Bag1tm1a(EUCOMM)Hmgu
HOM Female postnatal decreased mean corpuscular volume Haematology | Mean cell volume ICS | MGP 1.55E-5
Fam210a
Fam210atm1b(EUCOMM)Wtsi
HET Female postnatal decreased mean corpuscular volume Hematology | Mean cell volume TCP | IMPC 1.73E-5
Dbn1
Dbn1tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased mean corpuscular volume Haematology test | Mean-cell-volume WTSI | MGP 1.74E-5
Abcc2
Abcc2tm2b(KOMP)Wtsi
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 1.77E-5
Ehmt1
Ehmt1tm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume WTSI | IMPC 1.77E-5
Bin2
Bin2em1(IMPC)Wtsi
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume WTSI | IMPC 1.85E-5
Crlf3
Crlf3tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume WTSI | IMPC 1.86E-5
Atp6v1b2
Atp6v1b2tm1b(KOMP)Wtsi
HET Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume TCP | IMPC 1.93E-5
Nrbp2
Nrbp2tm2b(EUCOMM)Wtsi
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 1.97E-5
Sufu
Sufutm1b(KOMP)Wtsi
HET Female postnatal decreased mean corpuscular volume Hematology | Mean cell volume TCP | IMPC 2.14E-5
Hemgn
Hemgntm1.1(KOMP)Vlcg
HOM Female postnatal decreased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 2.23E-5
Trub1
Trub1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 2.64E-5
Rasal3
Rasal3tm1b(EUCOMM)Hmgu
HOM Female postnatal decreased mean corpuscular volume Hematology | Mean cell volume ICS | IMPC 3.12E-5
Zfp36
Zfp36tm1(KOMP)Vlcg
HET Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume MARC | IMPC 3.8E-5
Cab39l
Cab39ltm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 3.85E-5
Ints12
Ints12tm1b(EUCOMM)Wtsi
HET Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 4.06E-5
Abca13
Abca13tm1b(EUCOMM)Wtsi
HOM Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume BCM | IMPC 4.98E-5
Sept8
Sept8tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased mean corpuscular volume Haematology | Mean cell volume ICS | MGP 5.52E-5
Stradb
Stradbtm1b(KOMP)Wtsi
HOM Female postnatal decreased mean corpuscular volume Hematology | Mean cell volume ICS | IMPC 5.62E-5
Fbxo10
Fbxo10tm1b(KOMP)Wtsi
HOM Female postnatal decreased mean corpuscular volume Hematology | Mean cell volume MARC | IMPC 5.73E-5
Ces2e
Ces2eem1(IMPC)Marc
HOM Female postnatal decreased mean corpuscular volume Hematology | Mean cell volume MARC | IMPC 5.99E-5
Scarb2
Scarb2em2(IMPC)Tcp
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume TCP | IMPC 6.75E-5
Zfp207
Zfp207tm1b(EUCOMM)Hmgu
HET Female postnatal decreased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 6.81E-5
Slc23a4
Slc23a4tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased mean corpuscular volume Haematology test | Mean-cell-volume WTSI | EuroPhenome 6.85E-5
Setd6
Setd6tm1.1(KOMP)Mbp
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 7.51E-5
Epha5
Epha5tm1b(NCOM)Mfgc
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume TCP | IMPC 7.56E-5
Itch
Itchtm1b(EUCOMM)Hmgu
HOM Female postnatal decreased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 7.6E-5
Plpp3
Plpp3tm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 7.81E-5
Crisp3
Crisp3em1(IMPC)Mhzh
HOM Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume MARC | IMPC 7.83E-5
Gpnmb
Gpnmbtm1.1(KOMP)Vlcg
HET Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 8.05E-5
Prkab1
Prkab1tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased mean corpuscular volume Haematology test | Mean-cell-volume WTSI | EuroPhenome 8.32E-5
Mepce
Mepcetm1.1(KOMP)Vlcg
HOM Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 8.37E-5
F2
F2tm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 8.56E-5
Macrod2
Macrod2tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 8.59E-5
Kcnh3
Kcnh3tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 9.15E-5
Dnm2
Dnm2
HET Female postnatal decreased mean corpuscular volume Haematology | Mean cell volume ICS | EuroPhenome 9.18E-5
Nsun2
Nsun2tm1a(EUCOMM)Wtsi
HET Female postnatal decreased mean corpuscular volume Haematology test | Mean-cell-volume WTSI | EuroPhenome 9.8E-5

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