Phenotype: increased mean corpuscular volume

Definition greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices

Synonyms
  • increased MCV
  • increased MCV
  • high mean corpuscular volume
  • high mean corpuscular volume
  • high MCV
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Related
Synonyms
  • Folate-responsive megaloblastic anemia
  • Folate-responsive megaloblastic anemia
  • Folate-unresponsive megaloblastic anemia
  • Folate-unresponsive megaloblastic anemia
  • Hyperchromic macrocytic anemia
  • Macrocytic anemia
  • Macrocytic dyserythropoietic anemia
  • Megaloblastic anemia
  • Pyrimidine-responsive megaloblastic anemia
  • Refractory macrocytic anemia
  • Thiamine-responsive megaloblastic anemia
  • hyperchromic macrocytic anemia
  • hypochromic macrocytic anemia
  • macrocytic anemia
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MP browserMP:0002590

Phenotype associations stats

2.70% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased mean corpuscular volume (110/4080)

2.28% females (92/4033) 2.43% males (98/4036)

Select a parameter    



Gene variants with increased mean corpuscular volume

Total number of significant genotype-phenotype associations: 192

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Fam53b
Fam53btm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume HMGU | IMPC 0.0
Knstrn
Knstrntm1b(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume ICS | IMPC 0.0
Mysm1
Mysm1tm1a(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Haematology | Mean cell volume WTSI | EuroPhenome 0.0
Ube2e1
Ube2e1em1(IMPC)Marc
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MARC | IMPC 8.41E-45
Hnrnph1
Hnrnph1tm1b(KOMP)Wtsi
HET Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MARC | IMPC 6.11E-33
Slc29a1
Slc29a1tm2b(NCOM)Mfgc
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume TCP | IMPC 8.82E-31
Hjv
Hjvtm1b(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 1.41E-19
Ppp1cc
Ppp1ccem1(IMPC)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume WTSI | IMPC 1.01E-18
Csnk1g2
Csnk1g2tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume HMGU | IMPC 3.47E-18
Trim8
Trim8em1(IMPC)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume WTSI | IMPC 5.76E-17
Pnpt1
Pnpt1tm1a(KOMP)Wtsi
HET Male postnatal increased mean corpuscular volume Haematology test | Mean-cell-volume WTSI | EuroPhenome 8.48E-16
Rft1
Rft1tm1b(KOMP)Wtsi
HET Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 6.92E-14
Fbxw13
Fbxw13em2(IMPC)Marc
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MARC | IMPC 2.63E-13
Ppp2r5e
Ppp2r5eem1(IMPC)Marc
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MARC | IMPC 1.29E-12
Mysm1
Mysm1tm1a(KOMP)Wtsi
HET Female Male postnatal increased mean corpuscular volume Haematology | Mean cell volume MRC Harwell | EuroPhenome 1.47E-12
Brcc3
Brcc3em1(IMPC)Marc
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MARC | IMPC 7.89E-12
Cdh23
Cdh23tm2b(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume WTSI | IMPC 9.17E-12
Klk5
Klk5tm2b(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume HMGU | IMPC 9.87E-12
Cpa1
Cpa1em1(IMPC)Marc
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MARC | IMPC 4.33E-11
Tfr2
Tfr2em1(IMPC)Rbrc
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume RBRC | IMPC 5.58E-11
Dkk3
Dkk3tm1Cni
HOM Male postnatal increased mean corpuscular volume Haematology (GMC) | Mean corpuscular volume HMGU | EuroPhenome 1.22E-10
Hnrnpr
Hnrnprem1(IMPC)Marc
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MARC | IMPC 4.55E-10
Bbs5
Bbs5tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 4.67E-10
Usp15
Usp15tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume WTSI | IMPC 1.46E-9
Gm4922
Gm4922em1(IMPC)Tcp
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume TCP | IMPC 2.28E-9
Atp5md
Atp5mdtm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 3.86E-9
Slc44a5
Slc44a5tm1a(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Haematology test | Mean-cell-volume WTSI | MGP 6.83E-9
Bhlhe40
Bhlhe40tm1b(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume WTSI | IMPC 7.85E-9
Ric1
Ric1tm1a(EUCOMM)Hmgu
HOM Female Male postnatal increased mean corpuscular volume Haematology | Mean cell volume MRC Harwell | EuroPhenome 1.6E-8
Osm
Osmtm1b(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 3.06E-8
Fbxl20
Fbxl20tm1b(KOMP)Wtsi
HET Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 3.94E-8
Atp6v1c1
Atp6v1c1tm1b(NCOM)Mfgc
HET Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume TCP | IMPC 4.07E-8
Pde6b
Pde6b
HOM Female Male postnatal increased mean corpuscular volume Haematology (GMC) | Mean corpuscular volume HMGU | EuroPhenome 4.37E-8
Itch
Itchtm1(NCOM)Cmhd
HET Female postnatal increased mean corpuscular volume Haematology | Mean cell volume CMHD | EuroPhenome 7.59E-8
Bmp7
Bmp7tm1a(EUCOMM)Hmgu
HET Female Male postnatal increased mean corpuscular volume Haematology | Mean cell volume MRC Harwell | EuroPhenome 1.05E-7
Gpr182
Gpr182tm2b(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume UC Davis | IMPC 1.59E-7
Tbc1d4
Tbc1d4tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 1.71E-7
Tatdn2
Tatdn2tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume BCM | IMPC 2.08E-7
Elmod1
Elmod1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 2.12E-7
Adprhl2
Adprhl2em1(IMPC)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume WTSI | IMPC 2.78E-7
Serpinb5
Serpinb5tm1b(KOMP)Wtsi
HOM Male postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 3.16E-7
Phf5a
Phf5aem2(IMPC)Marc
HET Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MARC | IMPC 4.22E-7
Sacs
Sacsem1(IMPC)Tcp
HET Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume TCP | IMPC 4.99E-7
Nutm1
Nutm1tm1b(KOMP)Wtsi
HOM Male postnatal increased mean corpuscular volume Hematology | Mean cell volume WTSI | IMPC 5.55E-7
Nmnat1
Nmnat1tm1a(EUCOMM)Wtsi
HET Male postnatal increased mean corpuscular volume Haematology | Mean cell volume MRC Harwell | EuroPhenome 8.01E-7
Aspa
Aspatm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume HMGU | IMPC 8.2E-7
Kif20a
Kif20atm1b(EUCOMM)Hmgu
HET Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume HMGU | IMPC 8.54E-7
Parl
Parltm1a(EUCOMM)Hmgu
HET Female Male postnatal increased mean corpuscular volume Haematology | Mean cell volume MRC Harwell | EuroPhenome 9.49E-7
Slc38a10
Slc38a10tm2a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Haematology | Mean cell volume MRC Harwell | EuroPhenome 1.03E-6
Arpc4
Arpc4tm1a(EUCOMM)Wtsi
HET Male postnatal increased mean corpuscular volume Haematology test | Mean-cell-volume WTSI | EuroPhenome 1.04E-6
Nr1i2
Nr1i2
HOM Male postnatal increased mean corpuscular volume Haematology | Mean cell volume ICS | EuroPhenome 1.18E-6
Aldh3a2
Aldh3a2tm1a(EUCOMM)Wtsi
HOM Male postnatal increased mean corpuscular volume Haematology | Mean cell volume ICS | MGP 1.28E-6
Rab43
Rab43tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 1.42E-6
Castor1
Castor1tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume UC Davis | IMPC 1.63E-6
Foxo3
Foxo3tm1.1(KOMP)Vlcg
HOM Male postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 1.86E-6
Kcnb1
Kcnb1tm1b(EUCOMM)Hmgu
HOM Female postnatal increased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 2.46E-6
Spns2
Spns2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume WTSI | IMPC 2.56E-6
Aak1
Aak1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume ICS | IMPC 2.65E-6
Tmem189
Tmem189tm1a(KOMP)Wtsi
HOM Female postnatal increased mean corpuscular volume Hematology | Mean cell volume WTSI | IMPC 2.74E-6
Gcsh
Gcshem1(IMPC)H
HET Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 3.13E-6
Thsd1
Thsd1tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 4.16E-6
Sox13
Sox13tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Haematology | Mean cell volume ICS | MGP 5.03E-6
Itsn2
Itsn2tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume UC Davis | IMPC 6.02E-6
Fgf11
Fgf11tm1a(EUCOMM)Wtsi
HOM Female postnatal increased mean corpuscular volume Haematology | Mean cell volume MRC Harwell | EuroPhenome 7.32E-6
Nptn
Nptntm1b(EUCOMM)Hmgu
HOM Female postnatal increased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 8.0E-6
Tbc1d5
Tbc1d5em1(IMPC)J
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 8.15E-6
Esyt3
Esyt3tm1b(EUCOMM)Wtsi
HOM Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 9.24E-6
Ceacam3
Ceacam3em1(IMPC)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume WTSI | IMPC 9.77E-6
Btrc
Btrctm1b(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 1.2E-5
Epb41l5
Epb41l5tm1a(EUCOMM)Hmgu
HET Female Male postnatal increased mean corpuscular volume Haematology | Mean cell volume MRC Harwell | EuroPhenome 1.66E-5
Fes
Festm1b(EUCOMM)Hmgu
HOM Female postnatal increased mean corpuscular volume Hematology | Mean cell volume WTSI | IMPC 1.72E-5
Fam210a
Fam210atm1b(EUCOMM)Wtsi
HET Male postnatal increased mean corpuscular volume Hematology | Mean cell volume TCP | IMPC 1.73E-5
Plin2
Plin2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Haematology test | Mean-cell-volume WTSI | EuroPhenome 1.91E-5
Lyst
Lysttm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume TCP | IMPC 2.17E-5
Pa2g4
Pa2g4tm1a(EUCOMM)Wtsi
HET Male postnatal increased mean corpuscular volume Haematology | Mean cell volume MRC Harwell | EuroPhenome 2.21E-5
Nipsnap1
Nipsnap1tm1a(EUCOMM)Wtsi
HOM Male postnatal increased mean corpuscular volume Haematology | Mean cell volume MRC Harwell | EuroPhenome 2.45E-5
Kcnk13
Kcnk13em1(IMPC)H
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 2.46E-5
Ccdc33
Ccdc33tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume UC Davis | IMPC 2.58E-5
Pak2
Pak2em1(IMPC)H
HET Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 2.63E-5
Cystm1
Cystm1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume HMGU | IMPC 2.7E-5
Eml1
Eml1em1(IMPC)Wtsi
HOM Male postnatal increased mean corpuscular volume Hematology | Mean cell volume WTSI | IMPC 2.91E-5
Epc1
Epc1tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased mean corpuscular volume Haematology | Mean cell volume WTSI | EuroPhenome 2.98E-5
Rps6kl1
Rps6kl1tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 3.39E-5
Clstn1
Clstn1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 3.41E-5
Iqce
Iqcetm1b(EUCOMM)Hmgu
HOM Female postnatal increased mean corpuscular volume Hematology | Mean cell volume ICS | IMPC 3.64E-5
Xbp1
Xbp1tm1b(EUCOMM)Wtsi
HET Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 3.84E-5
Pdcd5
Pdcd5tm1b(KOMP)Vlcg
HET Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume HMGU | IMPC 4.31E-5
Areg
Aregtm2b(EUCOMM)Hmgu
HOM Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 4.32E-5
Top2a
Top2aem2(IMPC)Tcp
HET Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume TCP | IMPC 4.55E-5
Alkbh8
Alkbh8tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume HMGU | IMPC 4.84E-5
BC055324
BC055324tm1a(EUCOMM)Hmgu
HET Female postnatal increased mean corpuscular volume Haematology | Mean cell volume MRC Harwell | EuroPhenome 4.98E-5
Abca13
Abca13tm1b(EUCOMM)Wtsi
HOM Female postnatal increased mean corpuscular volume Hematology | Mean cell volume BCM | IMPC 4.98E-5
Igsf6
Igsf6em1(IMPC)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume WTSI | IMPC 5.14E-5
Wsb2
Wsb2tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume HMGU | IMPC 5.32E-5
Rhobtb3
Rhobtb3tm1a(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Haematology test | Mean-cell-volume WTSI | EuroPhenome 5.42E-5
Kptn
Kptntm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Haematology test | Mean-cell-volume WTSI | EuroPhenome 5.43E-5
Gper1
Gper1tm1Dgen
HOM Female Male postnatal increased mean corpuscular volume Haematology | Mean cell volume HMGU | EuroPhenome 5.77E-5
Stard3
Stard3
HOM Female Male postnatal increased mean corpuscular volume Haematology | Mean cell volume ICS | EuroPhenome 5.92E-5
Htr1f
Htr1ftm1.1(KOMP)Vlcg
HOM Male postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 7.16E-5
Cbx7
Cbx7tm1a(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Haematology test | Mean-cell-volume WTSI | EuroPhenome 7.53E-5
Dcaf10
Dcaf10tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 7.53E-5
Ldlr
Ldlrtm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume HMGU | IMPC 7.75E-5
Rhou
Rhoutm1a(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Haematology test | Mean-cell-volume WTSI | EuroPhenome 7.87E-5
Rnpc3
Rnpc3em1(IMPC)H
HET Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 8.01E-5
Rpa1
Rpa1tm1b(KOMP)Wtsi
HET Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 8.03E-5
Mepce
Mepcetm1.1(KOMP)Vlcg
HOM Female postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 8.37E-5
Rai14
Rai14em1(IMPC)J
HET Male postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 8.45E-5
Trim25
Trim25tm2b(EUCOMM)Hmgu
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume WTSI | IMPC 8.57E-5
Sorcs2
Sorcs2em1(IMPC)Marc
HOM Female postnatal increased mean corpuscular volume Hematology | Mean cell volume MARC | IMPC 8.67E-5
Acbd3
Acbd3tm1b(EUCOMM)Hmgu
HET Female postnatal increased mean corpuscular volume Hematology | Mean cell volume HMGU | IMPC 9.24E-5
Tmem203
Tmem203em1(IMPC)H
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 9.9E-5

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