Phenotype: increased mean corpuscular volume

Definition greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices

Synonyms
  • increased MCV
  • increased MCV
  • high mean corpuscular volume
  • high mean corpuscular volume
  • high MCV
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Related
Synonyms
  • hyperchromic macrocytic anemia
  • hyperchromic macrocytic anemia
  • hypochromic macrocytic anemia
  • hypochromic macrocytic anemia
  • macrocytic anemia
  • macrocytic hypochromic anemia
Show more

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Phenotype associations stats

2.83% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased mean corpuscular volume (97/3428)

2.32% females (79/3399) 2.64% males (90/3410)

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Gene variants with increased mean corpuscular volume

Total number of significant genotype-phenotype associations: 177

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Fam53b
Fam53btm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume HMGU | IMPC 0.0
Foxo3
Foxo3tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 0.0
Knstrn
Knstrntm1b(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume ICS | IMPC 0.0
Mysm1
Mysm1tm1a(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Haematology | Mean cell volume WTSI | EuroPhenome 0.0
Ube2e1
Ube2e1em1Marc
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MARC | IMPC 1.67E-40
Osm
Osmtm1b(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 1.72E-39
Hnrnph1
Hnrnph1tm1b(KOMP)Wtsi
HET Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MARC | IMPC 1.31E-30
Btg2
Btg2tm1b(KOMP)Mbp
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 5.18E-29
Slc29a1
Slc29a1tm2b(NCOM)Mfgc
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume TCP | IMPC 1.73E-26
Pnpt1
Pnpt1tm1a(KOMP)Wtsi
HET Male postnatal increased mean corpuscular volume Haematology test | Mean-cell-volume WTSI | MGP 1.29E-20
Hfe2
Hfe2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 7.88E-19
Dkk3
Dkk3tm1Cni
HOM Male postnatal increased mean corpuscular volume Haematology (GMC) | Mean corpuscular volume HMGU | EuroPhenome 9.42E-18
Csnk1g2
Csnk1g2tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume HMGU | IMPC 3.91E-14
Ppp2r5e
Ppp2r5eem1Marc
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MARC | IMPC 7.19E-14
Fbxw13
Fbxw13em2Marc
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MARC | IMPC 9.48E-13
Mysm1
Mysm1tm1a(KOMP)Wtsi
HET Female Male postnatal increased mean corpuscular volume Haematology | Mean cell volume MRC Harwell | EuroPhenome 1.47E-12
Brcc3
Brcc3em1Marc
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MARC | IMPC 3.93E-12
Pola2
Pola2tm1b(KOMP)Mbp
HET Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 1.14E-11
Cpa1
Cpa1em1Marc
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MARC | IMPC 4.0E-11
Tbc1d4
Tbc1d4tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 2.26E-10
Hnrnpr
Hnrnprem1Marc
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MARC | IMPC 4.07E-10
Bbs5
Bbs5tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 4.67E-10
Irf8
Irf8tm1b(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 5.55E-10
Cdk5rap2
Cdk5rap2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Haematology test | Mean-cell-volume WTSI | MGP 5.82E-10
Arpc4
Arpc4tm1a(EUCOMM)Wtsi
HET Male postnatal increased mean corpuscular volume Haematology test | Mean-cell-volume WTSI | MGP 2.98E-9
Slc44a5
Slc44a5tm1a(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Haematology test | Mean-cell-volume WTSI | MGP 3.17E-9
Usmg5
Usmg5tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 9.18E-9
Ric1
Ric1tm1a(EUCOMM)Hmgu
HOM Female Male postnatal increased mean corpuscular volume Haematology | Mean cell volume MRC Harwell | EuroPhenome 1.6E-8
Rhobtb3
Rhobtb3tm1a(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Haematology test | Mean-cell-volume WTSI | MGP 2.29E-8
Pde6b
Pde6b
HOM Female Male postnatal increased mean corpuscular volume Haematology (GMC) | Mean corpuscular volume HMGU | EuroPhenome 4.37E-8
Fbxl20
Fbxl20tm1b(KOMP)Wtsi
HET Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 4.63E-8
Fbxl20
Fbxl20tm1b(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 4.63E-8
Itch
Itchtm1(NCOM)Cmhd
HET Female postnatal increased mean corpuscular volume Haematology | Mean cell volume CMHD | EuroPhenome 7.59E-8
Bmp7
Bmp7tm1a(EUCOMM)Hmgu
HET Female Male postnatal increased mean corpuscular volume Haematology | Mean cell volume MRC Harwell | EuroPhenome 1.05E-7
Gper1
Gper1tm1Dgen
HOM Female Male postnatal increased mean corpuscular volume Haematology | Mean cell volume HMGU | EuroPhenome 1.37E-7
Elmod1
Elmod1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 2.12E-7
Aspa
Aspatm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume HMGU | IMPC 3.35E-7
Phf5a
Phf5aem2Marc
HET Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MARC | IMPC 4.62E-7
Rab43
Rab43tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 7.3E-7
Nmnat1
Nmnat1tm1a(EUCOMM)Wtsi
HET Male postnatal increased mean corpuscular volume Haematology | Mean cell volume MRC Harwell | EuroPhenome 8.01E-7
Lepr
Leprtm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 9.34E-7
Rps6kl1
Rps6kl1tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 9.46E-7
Parl
Parltm1a(EUCOMM)Hmgu
HET Female Male postnatal increased mean corpuscular volume Haematology | Mean cell volume MRC Harwell | EuroPhenome 9.49E-7
Slc38a10
Slc38a10tm2a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Haematology | Mean cell volume MRC Harwell | EuroPhenome 1.03E-6
Nr1i2
Nr1i2
HOM Male postnatal increased mean corpuscular volume Haematology | Mean cell volume ICS | EuroPhenome 1.18E-6
Aldh3a2
Aldh3a2tm1a(EUCOMM)Wtsi
HOM Male postnatal increased mean corpuscular volume Haematology | Mean cell volume ICS | EuroPhenome 1.28E-6
Thsd1
Thsd1tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 1.49E-6
Trrap
Trraptm1a(EUCOMM)Wtsi
HET Female Male postnatal increased mean corpuscular volume Haematology test | Mean-cell-volume WTSI | MGP 1.5E-6
Bhlhe40
Bhlhe40tm1b(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 1.62E-6
Anapc13
Anapc13tm2b(EUCOMM)Wtsi
HET Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume BCM | IMPC 1.73E-6
Spns2
Spns2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume WTSI | IMPC 2.15E-6
Tmem189
Tmem189tm1a(KOMP)Wtsi
HOM Female postnatal increased mean corpuscular volume Hematology | Mean cell volume WTSI | IMPC 2.46E-6
Gpr182
Gpr182tm2b(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume UC Davis | IMPC 2.55E-6
Tlr2
Tlr2tm1.1(KOMP)Vlcg
HOM Female postnatal increased mean corpuscular volume Hematology | Mean cell volume UC Davis | IMPC 2.57E-6
Tmem165
Tmem165tm1e(EUCOMM)Wtsi
HOM Male postnatal increased mean corpuscular volume Haematology test | Mean-cell-volume WTSI | MGP 2.77E-6
Sox13
Sox13tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Haematology | Mean cell volume ICS | EuroPhenome 3.02E-6
Kif20a
Kif20atm1b(EUCOMM)Hmgu
HET Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume HMGU | IMPC 3.66E-6
Cyb5d1
Cyb5d1tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 3.69E-6
Abi2
Abi2tm1b(EUCOMM)Wtsi
HOM Male postnatal increased mean corpuscular volume Hematology | Mean cell volume TCP | IMPC 4.7E-6
Pkd1
Pkd1tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 4.81E-6
Kcnb1
Kcnb1tm1b(EUCOMM)Hmgu
HOM Female postnatal increased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 5.45E-6
Nt5c
Nt5ctm1.1(KOMP)Vlcg
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 6.88E-6
Fgf11
Fgf11tm1a(EUCOMM)Wtsi
HOM Female postnatal increased mean corpuscular volume Haematology | Mean cell volume MRC Harwell | EuroPhenome 7.32E-6
Nptn
Nptntm1b(EUCOMM)Hmgu
HOM Female postnatal increased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 8.0E-6
Esyt3
Esyt3tm1b(EUCOMM)Wtsi
HOM Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 9.24E-6
Dact2
Dact2tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume BCM | IMPC 9.65E-6
Btrc
Btrctm1b(KOMP)Wtsi
HET Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 1.2E-5
Btrc
Btrctm1b(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 1.2E-5
Kcng2
Kcng2em2Bay
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume BCM | IMPC 1.51E-5
Jmjd8
Jmjd8tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 1.56E-5
Epb41l5
Epb41l5tm1a(EUCOMM)Hmgu
HET Female Male postnatal increased mean corpuscular volume Haematology | Mean cell volume MRC Harwell | EuroPhenome 1.66E-5
Gatsl3
Gatsl3tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume UC Davis | IMPC 1.68E-5
Sorbs2
Sorbs2tm1.1(KOMP)Mbp
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 1.76E-5
Fam210a
Fam210atm1b(EUCOMM)Wtsi
HET Male postnatal increased mean corpuscular volume Hematology | Mean cell volume TCP | IMPC 1.97E-5
Pa2g4
Pa2g4tm1a(EUCOMM)Wtsi
HET Male postnatal increased mean corpuscular volume Haematology | Mean cell volume MRC Harwell | EuroPhenome 2.21E-5
Nipsnap1
Nipsnap1tm1a(EUCOMM)Wtsi
HOM Male postnatal increased mean corpuscular volume Haematology | Mean cell volume MRC Harwell | EuroPhenome 2.45E-5
Ldlr
Ldlrtm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume HMGU | IMPC 2.47E-5
Kcnk13
Kcnk13em2H
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 2.53E-5
Aak1
Aak1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume ICS | IMPC 2.59E-5
Epc1
Epc1tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased mean corpuscular volume Haematology | Mean cell volume WTSI | EuroPhenome 2.98E-5
Atg4b
Atg4bem1Marc
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MARC | IMPC 3.09E-5
Clstn1
Clstn1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 3.41E-5
Alkbh8
Alkbh8tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume HMGU | IMPC 4.14E-5
Trmt1
Trmt1tm1b(EUCOMM)Hmgu
HET Male postnatal increased mean corpuscular volume Hematology | Mean cell volume ICS | IMPC 4.16E-5
Areg
Aregtm2b(EUCOMM)Hmgu
HOM Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 4.32E-5
Suv39h2
Suv39h2em1Marc
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MARC | IMPC 4.55E-5
Htr1f
Htr1ftm1.1(KOMP)Vlcg
HOM Male postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 4.66E-5
BC055324
BC055324tm1a(EUCOMM)Hmgu
HET Female postnatal increased mean corpuscular volume Haematology | Mean cell volume MRC Harwell | EuroPhenome 4.98E-5
Rpa1
Rpa1tm1b(KOMP)Wtsi
HET Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 5.16E-5
Trip13
Trip13tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 5.55E-5
Syce1l
Syce1ltm1.1(KOMP)Vlcg
HET Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 5.61E-5
Syce1l
Syce1ltm1.1(KOMP)Vlcg
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 5.61E-5
Cystm1
Cystm1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume HMGU | IMPC 5.63E-5
Washc5
Washc5tm1a(EUCOMM)Hmgu
HET Male postnatal increased mean corpuscular volume Haematology | Mean cell volume HMGU | EuroPhenome 5.77E-5
Dcaf10
Dcaf10tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 5.78E-5
Mgst3
Mgst3tm1a(KOMP)Wtsi
HOM Male postnatal increased mean corpuscular volume Haematology test | Mean-cell-volume WTSI | MGP 5.94E-5
Aurka
Aurkatm1b(EUCOMM)Hmgu
HET Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume JAX | IMPC 6.63E-5
Xbp1
Xbp1tm1b(EUCOMM)Wtsi
HET Male postnatal increased mean corpuscular volume Hematology | Mean cell volume MRC Harwell | IMPC 6.78E-5
Rad18
Rad18tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Haematology test | Mean-cell-volume WTSI | MGP 7.93E-5
Dlg4
Dlg4tm1e(EUCOMM)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Hematology | Mean cell volume WTSI | IMPC 8.27E-5
Rhou
Rhoutm1a(KOMP)Wtsi
HOM Female Male postnatal increased mean corpuscular volume Haematology test | Mean-cell-volume WTSI | MGP 9.88E-5

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