Phenotype: increased circulating HDL cholesterol level

Definition higher amount in the blood of the small lipoprotein:cholesterol complex that transports cholesterol out of the arteries and to the liver for reprocessing or excretion

Synonyms
  • high HDL cholesterol level
  • high HDL cholesterol level
  • elevated circulating HDL cholesterol level
  • elevated circulating HDL cholesterol level
  • high HDL serum level
  • increased HDL cholesterol level
  • elevated HDL cholesterol level
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Phenotype associations stats

2.41% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased circulating HDL cholesterol level (84/3480)

1.95% females (67/3431) 2.15% males (74/3448)

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Gene variants with increased circulating HDL cholesterol level

Total number of significant genotype-phenotype associations: 141

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Duoxa2
Duoxa2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 0.0
Ldlr
Ldlrtm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 1.03E-20
Serf1
Serf1tm1a(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | MGP 1.62E-20
Nr1h4
Nr1h4
HOM Female Male postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol ICS | EuroPhenome 2.57E-18
Rxrg
Rxrg
HOM Female Male postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol ICS | EuroPhenome 1.64E-16
Eftud2
Eftud2tm1b(KOMP)Wtsi
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 1.92E-16
Cyp7a1
Cyp7a1tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 9.79E-14
Tchp
Tchptm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 7.94E-12
Ptpn23
Ptpn23tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 3.28E-10
Adipor1
Adipor1tm1b(EUCOMM)Hmgu
HOM Female postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 4.48E-10
Lepr
Leprtm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 1.37E-9
Lrrk1
Lrrk1tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 1.89E-9
Usp47
Usp47tm1b(EUCOMM)Wtsi
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MARC | IMPC 2.21E-9
Reg3g
Reg3gtm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 3.72E-9
Arrb2
Arrb2tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 5.15E-9
Hdac1
Hdac1tm1a(EUCOMM)Wtsi
HET Female postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol HMGU | MGP 8.79E-9
Fgf10
Fgf10tm1b(EUCOMM)Wtsi
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 9.04E-9
Rexo2
Rexo2tm1b(EUCOMM)Wtsi
HET Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 1.78E-8
Fam207a
Fam207atm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 2.71E-8
Pdzk1
Pdzk1tm2b(EUCOMM)Wtsi
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 3.06E-8
Dntt
Dntttm2b(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 3.1E-8
Cib2
Cib2tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 9.45E-8
Gm648
Gm648tm1e(KOMP)Wtsi
HEM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 1.16E-7
Otud6a
Otud6atm1(KOMP)Vlcg
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MARC | IMPC 1.55E-7
Ntf5
Ntf5tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 1.62E-7
Rfc1
Rfc1tm1b(KOMP)Mbp
HET Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 2.75E-7
Abcg2
Abcg2tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 3.38E-7
Slc5a5
Slc5a5tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 5.16E-7
Lrrc3
Lrrc3tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 6.56E-7
Ppil3
Ppil3tm1b(EUCOMM)Wtsi
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 9.07E-7
Hspa5
Hspa5tm1.1(KOMP)Vlcg
HET Female postnatal increased circulating HDL cholesterol level Plasma Chemistry | HDL cholesterol JAX | IMPC 1.19E-6
Kansl1
Kansl1tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 1.2E-6
H3f3b
H3f3btm1.1(KOMP)Mbp
HOM Female postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 1.29E-6
Tm9sf4
Tm9sf4tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 1.77E-6
Gm648
Gm648tm1e(KOMP)Wtsi
HOM Female postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 2.38E-6
Aspm
Aspmtm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 2.82E-6
Nat8f2
Nat8f2tm1.1(KOMP)Vlcg
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 3.51E-6
Elmod2
Elmod2tm1b(EUCOMM)Hmgu
HET Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 3.74E-6
Btbd9
Btbd9tm1b(EUCOMM)Wtsi
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 4.13E-6
BC055324
BC055324tm1a(EUCOMM)Hmgu
HET Female Male postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | MGP 5.44E-6
Rnf10
Rnf10tm1a(KOMP)Wtsi
HOM Female postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 5.62E-6
Mbd1
Mbd1em1(IMPC)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 6.79E-6
Slc24a4
Slc24a4tm1b(KOMP)Wtsi
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 7.24E-6
Hbs1l
Hbs1ltm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 8.8E-6
Celsr1
Celsr1Scy
HET Female postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 9.44E-6
Aqp1
Aqp1tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 1.02E-5
Fndc7
Fndc7tm1.1(KOMP)Vlcg
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 1.07E-5
Fam210b
Fam210btm1b(KOMP)Mbp
HOM Female postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 1.27E-5
Rars2
Rars2tm1a(EUCOMM)Wtsi
HET Male postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol WTSI | MGP 1.34E-5
Gimap6
Gimap6tm1b(KOMP)Wtsi
HOM Female postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 1.57E-5
Ankrd11
Ankrd11tm1b(EUCOMM)Wtsi
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 1.64E-5
Chrna7
Chrna7tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 1.7E-5
Taf2
Taf2tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 1.71E-5
Cdca8
Cdca8tm1a(KOMP)Wtsi
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 1.72E-5
Col4a5
Col4a5tm1b(EUCOMM)Wtsi
HOM Female postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 1.74E-5
Fbxo9
Fbxo9tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 1.81E-5
Cmpk2
Cmpk2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 1.82E-5
Slc22a8
Slc22a8tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 1.88E-5
Tnfaip1
Tnfaip1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 1.93E-5
Aqp3
Aqp3tm2b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 2.18E-5
Slc38a10
Slc38a10tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 2.18E-5
Ggps1
Ggps1tm1b(EUCOMM)Wtsi
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 2.34E-5
Smyd2
Smyd2tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol WTSI | MGP 2.48E-5
Map3k1
Map3k1Gt(YTC001)Byg
HET Female Male postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 2.51E-5
Map3k10
Map3k10tm1b(EUCOMM)Hmgu
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 2.99E-5
Dnmt3a
Dnmt3atm1b(KOMP)Wtsi
HET Female postnatal increased circulating HDL cholesterol level Plasma Chemistry | HDL cholesterol JAX | IMPC 3.22E-5
Pld5
Pld5tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 3.64E-5
Adal
Adaltm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 3.7E-5
Kcnh3
Kcnh3tm1.1(KOMP)Vlcg
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 3.97E-5
Ap2a2
Ap2a2em1(IMPC)Wtsi
HET Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 4.09E-5
Tmem51
Tmem51tm1b(EUCOMM)Hmgu
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 4.14E-5
Cul7
Cul7tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 4.45E-5
Bmp10
Bmp10tm3b(EUCOMM)Hmgu
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 4.67E-5
Brd9
Brd9em1(IMPC)Tcp
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 5.12E-5
Ska2
Ska2tm1b(KOMP)Wtsi
HET Female postnatal increased circulating HDL cholesterol level Plasma Chemistry | HDL cholesterol JAX | IMPC 5.2E-5
Entpd1
Entpd1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | MGP 5.97E-5
Eps15
Eps15tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 5.99E-5
Ccl9
Ccl9tm1(KOMP)Vlcg
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 6.26E-5
Rhpn1
Rhpn1tm1b(KOMP)Wtsi
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 6.54E-5
Hsf2bp
Hsf2bptm1a(EUCOMM)Hmgu
HOM Male postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol HMGU | EuroPhenome 6.96E-5
Cybrd1
Cybrd1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 8.21E-5
Pfkfb3
Pfkfb3tm1b(EUCOMM)Wtsi
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 8.28E-5
Cxcl9
Cxcl9tm1b(EUCOMM)Wtsi
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 9.01E-5
Cyp17a1
Cyp17a1tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MARC | IMPC 9.05E-5
Col4a5
Col4a5tm1b(EUCOMM)Wtsi
HEM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 9.53E-5
Kif18b
Kif18btm1a(EUCOMM)Wtsi
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 9.53E-5

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