Phenotype: increased circulating HDL cholesterol level

Definition higher amount in the blood of the small lipoprotein:cholesterol complex that transports cholesterol out of the arteries and to the liver for reprocessing or excretion

Synonyms
  • high HDL cholesterol level
  • high HDL cholesterol level
  • elevated circulating HDL cholesterol level
  • elevated circulating HDL cholesterol level
  • high HDL serum level
  • elevated HDL cholesterol level
  • increased HDL cholesterol level
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MP browserMP:0001556

Phenotype associations stats

2.19% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased circulating HDL cholesterol level (86/3935)

1.63% females (63/3871) 1.98% males (77/3884)

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Gene variants with increased circulating HDL cholesterol level

Total number of significant genotype-phenotype associations: 140

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Ldlr
Ldlrtm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 3.64E-24
Serf1
Serf1tm1a(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 1.62E-20
Nr1h4
Nr1h4
HOM Female Male postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol ICS | EuroPhenome 2.57E-18
Rxrg
Rxrg
HOM Female Male postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol ICS | EuroPhenome 1.64E-16
Cyp7a1
Cyp7a1tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 1.17E-13
Tchp
Tchptm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 2.59E-11
Ptpn23
Ptpn23tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 3.77E-10
Usp47
Usp47tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MARC | IMPC 4.04E-10
Lrrk1
Lrrk1tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 4.54E-10
Adipor1
Adipor1tm1b(EUCOMM)Hmgu
HOM Female postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 4.61E-10
Dntt
Dntttm2b(KOMP)Wtsi
HOM Female postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 4.54E-9
Fgf10
Fgf10tm1b(EUCOMM)Wtsi
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 6.29E-9
Arrb2
Arrb2tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 7.04E-9
Reg3g
Reg3gtm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 8.34E-9
Rexo2
Rexo2tm1b(EUCOMM)Wtsi
HET Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 1.38E-8
Pdzk1
Pdzk1tm2b(EUCOMM)Wtsi
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 5.92E-8
Cib2
Cib2tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 6.65E-8
Abcg2
Abcg2tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 9.78E-8
Otud6a
Otud6atm1(KOMP)Vlcg
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MARC | IMPC 1.08E-7
Eftud2
Eftud2tm1b(KOMP)Wtsi
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 1.87E-7
Ntf5
Ntf5tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 2.04E-7
Gm648
Gm648tm1e(KOMP)Wtsi
HEM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 2.18E-7
Rfc1
Rfc1tm1b(KOMP)Mbp
HET Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 2.58E-7
C4bp
C4bptm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 2.95E-7
Nodal
Nodaltm1b(EUCOMM)Wtsi
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 4.53E-7
Rnf10
Rnf10tm1a(KOMP)Wtsi
HOM Female postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 6.36E-7
H3f3b
H3f3btm1.1(KOMP)Mbp
HOM Female postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 1.01E-6
Kansl1
Kansl1tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 1.12E-6
Hspa5
Hspa5tm1.1(KOMP)Vlcg
HET Female postnatal increased circulating HDL cholesterol level Plasma Chemistry | HDL cholesterol JAX | IMPC 1.16E-6
Slc5a5
Slc5a5tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 1.27E-6
Ppil3
Ppil3tm1b(EUCOMM)Wtsi
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 1.34E-6
Gm648
Gm648tm1e(KOMP)Wtsi
HOM Female postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 1.45E-6
Fam207a
Fam207atm1b(EUCOMM)Hmgu
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 2.21E-6
Rnf144b
Rnf144btm1b(EUCOMM)Hmgu
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 2.96E-6
Elmod2
Elmod2tm1b(EUCOMM)Hmgu
HET Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 3.33E-6
Tm9sf4
Tm9sf4tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 3.7E-6
Lrba
Lrbaem1(IMPC)Wtsi
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 3.79E-6
Aspm
Aspmtm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 5.13E-6
BC055324
BC055324tm1a(EUCOMM)Hmgu
HET Female Male postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 5.44E-6
Btbd9
Btbd9tm1b(EUCOMM)Wtsi
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 5.63E-6
Slc24a4
Slc24a4tm1b(KOMP)Wtsi
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 5.91E-6
Aqp1
Aqp1tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 6.37E-6
Ehmt1
Ehmt1tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 6.75E-6
Nat8f2
Nat8f2tm1.1(KOMP)Vlcg
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 7.22E-6
Il13
Il13tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 7.33E-6
Kcnh3
Kcnh3tm1.1(KOMP)Vlcg
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 8.11E-6
Mbd1
Mbd1em1(IMPC)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 9.02E-6
Celsr1
Celsr1Scy
HET Female postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 9.44E-6
Matn4
Matn4em1(IMPC)Wtsi
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 1.03E-5
Fndc7
Fndc7tm1.1(KOMP)Vlcg
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 1.12E-5
Hbs1l
Hbs1ltm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 1.23E-5
Aqp3
Aqp3tm2b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 1.31E-5
Rars2
Rars2tm1a(EUCOMM)Wtsi
HET Male postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 1.34E-5
Chrna7
Chrna7tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 1.36E-5
Kdm8
Kdm8tm1b(EUCOMM)Wtsi
HET Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 1.44E-5
Rasal3
Rasal3tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 1.63E-5
Gimap6
Gimap6tm1b(KOMP)Wtsi
HOM Female postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 1.68E-5
Ankrd11
Ankrd11tm1b(EUCOMM)Wtsi
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 1.8E-5
Cmpk2
Cmpk2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 1.84E-5
Tnfaip1
Tnfaip1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 1.93E-5
Smyd2
Smyd2tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 2.48E-5
Map3k1
Map3k1Gt(YTC001)Byg
HET Female Male postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 2.51E-5
Map3k10
Map3k10tm1b(EUCOMM)Hmgu
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 2.87E-5
Dnmt3a
Dnmt3atm1b(KOMP)Wtsi
HET Female postnatal increased circulating HDL cholesterol level Plasma Chemistry | HDL cholesterol JAX | IMPC 3.22E-5
D6Wsu163e
D6Wsu163etm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 3.6E-5
Fbxo9
Fbxo9tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 3.71E-5
Slc38a10
Slc38a10tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 3.83E-5
Tmem51
Tmem51tm1b(EUCOMM)Hmgu
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 4.25E-5
Cul7
Cul7tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 4.45E-5
Adar
Adartm1b(EUCOMM)Wtsi
HET Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 4.49E-5
Dnajc5g
Dnajc5gtm1.1(KOMP)Vlcg
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 4.73E-5
Syt7
Syt7em2(IMPC)H
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 4.91E-5
Ap2a2
Ap2a2em1(IMPC)Wtsi
HET Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 4.97E-5
Ezh1
Ezh1tm1b(EUCOMM)Wtsi
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MARC | IMPC 5.04E-5
Ska2
Ska2tm1b(KOMP)Wtsi
HET Female postnatal increased circulating HDL cholesterol level Plasma Chemistry | HDL cholesterol JAX | IMPC 5.1E-5
Eps15
Eps15tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 5.24E-5
Entpd1
Entpd1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 5.97E-5
Ccl9
Ccl9tm1(KOMP)Vlcg
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 6.56E-5
Cybrd1
Cybrd1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 6.56E-5
Hsf2bp
Hsf2bptm1a(EUCOMM)Hmgu
HOM Male postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol HMGU | EuroPhenome 6.96E-5
Snx8
Snx8tm2a(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 7.17E-5
Cxcl9
Cxcl9tm1b(EUCOMM)Wtsi
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 7.56E-5
Pfkfb3
Pfkfb3tm1b(EUCOMM)Wtsi
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 7.65E-5
Cyp17a1
Cyp17a1tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MARC | IMPC 7.87E-5
Rhpn1
Rhpn1tm1b(KOMP)Wtsi
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 8.22E-5
Adal
Adaltm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 8.55E-5
Dnase1l2
Dnase1l2tm1.1(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 8.59E-5

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