Phenotype: increased circulating HDL cholesterol level

Definition higher amount in the blood of the small lipoprotein:cholesterol complex that transports cholesterol out of the arteries and to the liver for reprocessing or excretion

Synonyms
  • high HDL cholesterol level
  • high HDL cholesterol level
  • elevated circulating HDL cholesterol level
  • elevated circulating HDL cholesterol level
  • high HDL serum level
  • increased HDL cholesterol level
  • elevated HDL cholesterol level
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Phenotype associations stats

2.84% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased circulating HDL cholesterol level (88/3103)

2.34% females (72/3071) 2.59% males (80/3094)

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Gene variants with increased circulating HDL cholesterol level

Total number of significant genotype-phenotype associations: 156

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Duoxa2
Duoxa2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 0.0
Ldlr
Ldlrtm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 6.0E-24
Serf1
Serf1tm1a(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 1.62E-20
Nr1h4
Nr1h4
HOM Female Male postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol ICS | EuroPhenome 2.57E-18
Rxrg
Rxrg
HOM Female Male postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol ICS | EuroPhenome 1.64E-16
Eftud2
Eftud2tm1b(KOMP)Wtsi
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 2.74E-16
Tchp
Tchptm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 1.88E-12
Prdm13
Prdm13em2Tcp
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 1.47E-11
Notum
Notumem2Tcp
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 2.72E-11
Notum
Notumem2Tcp
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 2.72E-11
Cyp7a1
Cyp7a1tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 4.23E-11
Ptpn23
Ptpn23tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 7.72E-11
Mrgprb2
Mrgprb2em2Tcp
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 2.82E-10
Brd9
Brd9em1Tcp
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 3.69E-10
Adipor1
Adipor1tm1b(EUCOMM)Hmgu
HOM Female postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 4.41E-10
Cep55
Cep55em2Tcp
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 1.17E-9
Lepr
Leprtm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 1.37E-9
Reg3g
Reg3gtm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 1.73E-9
Lrrk1
Lrrk1tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 2.53E-9
Usp47
Usp47tm1b(EUCOMM)Wtsi
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MARC | IMPC 3.07E-9
Arrb2
Arrb2tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 4.44E-9
Hdac1
Hdac1tm1a(EUCOMM)Wtsi
HET Female postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol HMGU | EuroPhenome 8.79E-9
Spred3
Spred3em2Tcp
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 8.94E-9
Fgf10
Fgf10tm1b(EUCOMM)Wtsi
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 1.04E-8
Rexo2
Rexo2tm1b(EUCOMM)Wtsi
HET Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 2.02E-8
Dntt
Dntttm2b(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 4.02E-8
Fam207a
Fam207atm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 4.19E-8
Gm648
Gm648tm1e(KOMP)Wtsi
HEM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 9.63E-8
Cib2
Cib2tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 1.07E-7
Spred3
Spred3em2Tcp
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 1.36E-7
Ntf5
Ntf5tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 1.63E-7
Otud6a
Otud6atm1(KOMP)Vlcg
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MARC | IMPC 2.0E-7
Ccnb1ip1
Ccnb1ip1em1Tcp
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 3.66E-7
Rfc1
Rfc1tm1b(KOMP)Mbp
HET Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 4.17E-7
Tm9sf4
Tm9sf4tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 4.68E-7
Prdm5
Prdm5em2Tcp
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 5.25E-7
Abcg2
Abcg2tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 5.8E-7
Lrrc3
Lrrc3tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 7.37E-7
Ppil3
Ppil3tm1b(EUCOMM)Wtsi
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 7.75E-7
Btbd9
Btbd9tm1b(EUCOMM)Wtsi
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 7.9E-7
Hspa5
Hspa5tm1.1(KOMP)Vlcg
HET Female postnatal increased circulating HDL cholesterol level Plasma Chemistry | HDL cholesterol JAX | IMPC 1.19E-6
Gm648
Gm648tm1e(KOMP)Wtsi
HOM Female postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 1.25E-6
Kansl1
Kansl1tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 1.38E-6
Fbxo9
Fbxo9tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 1.45E-6
Aspm
Aspmtm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 1.73E-6
Ifi44
Ifi44tm1b(KOMP)Wtsi
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 3.59E-6
Elmod2
Elmod2tm1b(EUCOMM)Hmgu
HET Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 4.55E-6
Mllt6
Mllt6em1Tcp
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 4.72E-6
BC055324
BC055324tm1a(EUCOMM)Hmgu
HET Female Male postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 5.44E-6
Rnf10
Rnf10tm1a(KOMP)Wtsi
HOM Female postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 5.62E-6
Aqp1
Aqp1tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 5.91E-6
Hbs1l
Hbs1ltm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 6.1E-6
Nat8f2
Nat8f2tm1.1(KOMP)Vlcg
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 7.92E-6
Fndc7
Fndc7tm1.1(KOMP)Vlcg
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 8.09E-6
Slc24a4
Slc24a4tm1b(KOMP)Wtsi
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 8.33E-6
Celsr1
Celsr1Scy
HET Female postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 9.44E-6
Ggps1
Ggps1tm1b(EUCOMM)Wtsi
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 1.11E-5
Map3k10
Map3k10tm1b(EUCOMM)Hmgu
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 1.27E-5
Slc38a10
Slc38a10tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 1.3E-5
Rars2
Rars2tm1a(EUCOMM)Wtsi
HET Male postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 1.34E-5
Gimap6
Gimap6tm1b(KOMP)Wtsi
HOM Female postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 1.54E-5
Ankrd11
Ankrd11tm1b(EUCOMM)Wtsi
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 1.66E-5
Chrna7
Chrna7tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 1.69E-5
Cdca8
Cdca8tm1a(KOMP)Wtsi
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 1.72E-5
Slc22a8
Slc22a8tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 1.85E-5
Taf2
Taf2tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 1.86E-5
Tnfaip1
Tnfaip1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 1.93E-5
Cmpk2
Cmpk2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 1.97E-5
Aqp3
Aqp3tm2b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 2.22E-5
Col4a5
Col4a5tm1b(EUCOMM)Wtsi
HOM Female postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 2.29E-5
Smyd2
Smyd2tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 2.48E-5
Map3k1
Map3k1Gt(YTC001)Byg
HET Female Male postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 2.51E-5
Dnmt3a
Dnmt3atm1b(KOMP)Wtsi
HET Female postnatal increased circulating HDL cholesterol level Plasma Chemistry | HDL cholesterol JAX | IMPC 3.22E-5
Pld5
Pld5tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 3.64E-5
Tusc5
Tusc5em2Tcp
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 3.84E-5
Cul7
Cul7tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 4.45E-5
Bmp10
Bmp10tm3b(EUCOMM)Hmgu
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 4.99E-5
Ska2
Ska2tm1b(KOMP)Wtsi
HET Female postnatal increased circulating HDL cholesterol level Plasma Chemistry | HDL cholesterol JAX | IMPC 5.2E-5
Tmem51
Tmem51tm1b(EUCOMM)Hmgu
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 5.31E-5
Entpd1
Entpd1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 5.97E-5
Eps15
Eps15tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 5.99E-5
Pttg1
Pttg1tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 6.12E-5
Ccl9
Ccl9tm1(KOMP)Vlcg
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 6.49E-5
Hsf2bp
Hsf2bptm1a(EUCOMM)Hmgu
HOM Male postnatal increased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol HMGU | EuroPhenome 6.96E-5
Skida1
Skida1tm1.1(KOMP)Wtsi
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 7.05E-5
Usp12
Usp12tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 7.09E-5
Rhpn1
Rhpn1tm1b(KOMP)Wtsi
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 7.2E-5
Cybrd1
Cybrd1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 8.67E-5
Cyp17a1
Cyp17a1tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MARC | IMPC 9.23E-5
Yae1d1
Yae1d1tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 9.34E-5
Col4a5
Col4a5tm1b(EUCOMM)Wtsi
HEM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 9.63E-5
Cxcl9
Cxcl9tm1b(EUCOMM)Wtsi
HOM Male postnatal increased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 9.79E-5

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