Phenotype: increased circulating triglyceride level

Definition greater concentration of naturally occurring esters of three fatty acids and glycerol in the blood; triglycerides are widespread in adipose tissue, commonly circulate in the blood in the form of lipoproteins, and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liver

Synonyms
  • elevated plasma triacylglycerol level
  • elevated plasma triacylglycerol level
  • elevated serum triglyceride level
  • elevated serum triglyceride level
  • elevated plasma triglyceride level
  • hypertriglyceridemia
  • elevated serum triacylglycerol level
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Related
Synonyms
increased circulating VLDL triglyceride level

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Phenotype associations stats

1.35% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased circulating triglyceride level (44/3254)

0.68% females (22/3227) 1.11% males (36/3234)

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Gene variants with increased circulating triglyceride level

Total number of significant genotype-phenotype associations: 59

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Apoe
Apoetm1Unc
HOM Female Male postnatal increased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides WTSI | EuroPhenome 5.25E-12
Cacna1b
Cacna1btm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MRC Harwell | IMPC 8.91E-10
Mir28a
Mir28atm1(mirKO)Wtsi
HOM Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MARC | IMPC 9.14E-10
Setmar
Setmartm1a(EUCOMM)Wtsi
HOM Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglyceride WTSI | EuroPhenome 2.71E-9
Nr1h4
Nr1h4
HOM Female Male postnatal increased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides ICS | EuroPhenome 2.38E-8
Tmem63a
Tmem63atm1(KOMP)Vlcg
HOM Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MARC | IMPC 3.0E-8
Apoc4
Apoc4tm1.1(KOMP)Mbp
HOM Female Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides HMGU | IMPC 5.09E-8
Cog2
Cog2tm1a(KOMP)Wtsi
HET Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglyceride WTSI | EuroPhenome 1.47E-7
Phf11a
Phf11atm1b(NCOM)Mfgc
HET Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MARC | IMPC 2.62E-7
Sdc2
Sdc2tm1b(KOMP)Wtsi
HOM Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides HMGU | IMPC 2.9E-7
Elovl6
Elovl6tm1b(EUCOMM)Hmgu
HOM Female postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MRC Harwell | IMPC 4.2E-7
Pak1
Pak1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MRC Harwell | IMPC 4.23E-7
Lypd3
Lypd3tm1.1(KOMP)Vlcg
HOM Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides TCP | IMPC 7.36E-7
Lypd3
Lypd3tm1.1(KOMP)Vlcg
HET Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides TCP | IMPC 7.36E-7
Slc40a1
Slc40a1tm1b(EUCOMM)Hmgu
HET Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MRC Harwell | IMPC 9.89E-7
Ezh2
Ezh2tm1a(EUCOMM)Wtsi
HET Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglyceride WTSI | EuroPhenome 2.08E-6
Myo18b
Myo18bem2Ics
HET Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides ICS | IMPC 2.76E-6
Cyb561
Cyb561tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MRC Harwell | IMPC 4.03E-6
Rsbn1
Rsbn1tm1b(EUCOMM)Wtsi
HET Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MRC Harwell | IMPC 5.65E-6
Itga2
Itga2tm1b(EUCOMM)Hmgu
HOM Female postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MRC Harwell | IMPC 9.26E-6
Elmod1
Elmod1tm1b(EUCOMM)Hmgu
HOM Female postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MRC Harwell | IMPC 1.17E-5
Rwdd1
Rwdd1tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 1.21E-5
Mta1
Mta1tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglyceride WTSI | EuroPhenome 1.29E-5
Nr1d2
Nr1d2tm1Dgen
HOM Female Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglyceride ICS | EuroPhenome 1.42E-5
Nol8
Nol8tm1b(EUCOMM)Hmgu
HET Female postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides ICS | IMPC 1.45E-5
Tpcn2
Tpcn2tm1b(EUCOMM)Hmgu
HOM Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MRC Harwell | IMPC 1.83E-5
Boc
Boctm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MRC Harwell | IMPC 1.93E-5
Grm6
Grm6tm1b(EUCOMM)Wtsi
HOM Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MRC Harwell | IMPC 1.95E-5
Gnao1
Gnao1tm1b(EUCOMM)Hmgu
HET Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MRC Harwell | IMPC 1.95E-5
Usp46
Usp46em1Marc
HOM Female Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MARC | IMPC 2.31E-5
Pax5
Pax5tm1b(EUCOMM)Wtsi
HET Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides HMGU | IMPC 2.32E-5
Col4a5
Col4a5tm1b(EUCOMM)Wtsi
HEM Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MRC Harwell | IMPC 2.7E-5
Tnfaip1
Tnfaip1tm1a(EUCOMM)Wtsi
HOM Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglyceride ICS | EuroPhenome 2.71E-5
Vgf
Vgfem1H
HOM Female postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MRC Harwell | IMPC 2.79E-5
Sufu
Sufutm1b(KOMP)Wtsi
HET Female Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides TCP | IMPC 3.43E-5
Tmc1
Tmc1Bth
HET Female postnatal increased circulating triglyceride level Clinical chemistry (GMC) | Triglyceride HMGU | EuroPhenome 3.54E-5
Nfasc
Nfasctm1a(EUCOMM)Hmgu
HET Female Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglyceride ICS | EuroPhenome 3.62E-5
Cntn3
Cntn3em1Marc
HOM Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MARC | IMPC 3.75E-5
Magi2
Magi2tm1Grnt
HET Male postnatal increased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides WTSI | EuroPhenome 3.89E-5
Xbp1
Xbp1tm1b(EUCOMM)Wtsi
HET Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MRC Harwell | IMPC 4.91E-5
Grm3
Grm3tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MRC Harwell | IMPC 5.24E-5
Itga8
Itga8tm1b(KOMP)Wtsi
HET Female postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides JAX | IMPC 5.56E-5
Ube2b
Ube2btm1a(EUCOMM)Wtsi
HET Female postnatal increased circulating triglyceride level Clinical Chemistry | Triglyceride ICS | EuroPhenome 6.12E-5
Setd4
Setd4tm1a(KOMP)Wtsi
HOM Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 6.35E-5
Rnf10
Rnf10tm1a(KOMP)Wtsi
HOM Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglyceride WTSI | EuroPhenome 9.97E-5

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