Phenotype: increased circulating triglyceride level

Definition greater concentration of naturally occurring esters of three fatty acids and glycerol in the blood; triglycerides are widespread in adipose tissue, commonly circulate in the blood in the form of lipoproteins, and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liver

Synonyms
  • elevated plasma triacylglycerol level
  • elevated plasma triacylglycerol level
  • elevated serum triglyceride level
  • elevated serum triglyceride level
  • elevated plasma triglyceride level
  • hypertriglyceridemia
  • elevated serum triacylglycerol level
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Related
Synonyms
  • Lactescent serum
  • Lactescent serum
  • increased circulating VLDL triglyceride level
  • increased circulating VLDL triglyceride level

MP browserMP:0001552

Phenotype associations stats

1.07% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased circulating triglyceride level (43/4033)

0.60% females (24/3988) 0.85% males (34/4019)

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Gene variants with increased circulating triglyceride level

Total number of significant genotype-phenotype associations: 58

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Txnip
Txniptm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MRC Harwell | IMPC 1.68E-20
Apoe
Apoetm1Unc
HOM Female Male postnatal increased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides WTSI | EuroPhenome 5.25E-12
Cacna1b
Cacna1btm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MRC Harwell | IMPC 5.77E-10
Nr1h4
Nr1h4
HOM Female Male postnatal increased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides ICS | EuroPhenome 2.38E-8
Apoc4
Apoc4tm1.1(KOMP)Mbp
HOM Female Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides HMGU | IMPC 5.48E-8
Ufm1
Ufm1em1(IMPC)Marc
HET Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MARC | IMPC 2.18E-7
Ezh2
Ezh2tm1a(EUCOMM)Wtsi
HET Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglyceride WTSI | MGP 3.71E-7
Sdc2
Sdc2tm1b(KOMP)Wtsi
HOM Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides HMGU | IMPC 4.49E-7
Pak1
Pak1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MRC Harwell | IMPC 5.52E-7
Slc40a1
Slc40a1tm1b(EUCOMM)Hmgu
HET Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MRC Harwell | IMPC 8.26E-7
Elovl6
Elovl6tm1b(EUCOMM)Hmgu
HOM Female postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MRC Harwell | IMPC 8.61E-7
Epx
Epxtm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides ICS | IMPC 1.33E-6
Cyb561
Cyb561tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MRC Harwell | IMPC 1.37E-6
Ube2b
Ube2btm1a(EUCOMM)Wtsi
HET Female postnatal increased circulating triglyceride level Clinical Chemistry | Triglyceride ICS | MGP 1.94E-6
Cog2
Cog2tm1a(KOMP)Wtsi
HET Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglyceride WTSI | MGP 2.94E-6
Rsbn1
Rsbn1tm1b(EUCOMM)Wtsi
HET Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MRC Harwell | IMPC 3.58E-6
Phf11a
Phf11atm1b(NCOM)Mfgc
HET Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MARC | IMPC 3.61E-6
Alad
Aladem1(IMPC)Tcp
HET Female Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides TCP | IMPC 4.37E-6
Setd4
Setd4tm1a(KOMP)Wtsi
HOM Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 7.66E-6
Elmod1
Elmod1tm1b(EUCOMM)Hmgu
HOM Female postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MRC Harwell | IMPC 9.88E-6
Grm6
Grm6tm1b(EUCOMM)Wtsi
HOM Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MRC Harwell | IMPC 1.22E-5
Mta1
Mta1tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglyceride WTSI | EuroPhenome 1.29E-5
Pax5
Pax5tm1b(EUCOMM)Wtsi
HET Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides HMGU | IMPC 1.29E-5
Itga2
Itga2tm1b(EUCOMM)Hmgu
HOM Female postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MRC Harwell | IMPC 1.36E-5
Slc38a10
Slc38a10tm2a(EUCOMM)Wtsi
HOM Female postnatal increased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides ICS | MGP 1.42E-5
Nr1d2
Nr1d2tm1Dgen
HOM Female Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglyceride ICS | EuroPhenome 1.42E-5
Gnao1
Gnao1tm1b(EUCOMM)Hmgu
HET Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MRC Harwell | IMPC 1.66E-5
Itga8
Itga8tm1b(KOMP)Wtsi
HET Female postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides JAX | IMPC 1.68E-5
Usp46
Usp46em1(IMPC)Marc
HOM Female Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MARC | IMPC 2.33E-5
Tnfaip1
Tnfaip1tm1a(EUCOMM)Wtsi
HOM Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglyceride ICS | MGP 2.71E-5
Grm3
Grm3tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MRC Harwell | IMPC 3.18E-5
Tmc1
Tmc1Bth
HET Female postnatal increased circulating triglyceride level Clinical chemistry (GMC) | Triglyceride HMGU | EuroPhenome 3.54E-5
Nfasc
Nfasctm1a(EUCOMM)Hmgu
HET Female Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglyceride ICS | MGP 3.62E-5
Magi2
Magi2tm1Grnt
HET Male postnatal increased circulating triglyceride level Fasted Clinical Chemistry | Triglycerides WTSI | EuroPhenome 3.89E-5
Lypd3
Lypd3tm1.1(KOMP)Vlcg
HET Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides TCP | IMPC 4.51E-5
Cntn3
Cntn3em1(IMPC)Marc
HOM Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MARC | IMPC 4.89E-5
Hoxa2
Hoxa2tm1b(EUCOMM)Wtsi
HET Female Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides HMGU | IMPC 4.9E-5
Oas1g
Oas1gtm3e(KOMP)Wtsi
HOM Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 5.03E-5
Rnf10
Rnf10tm1a(KOMP)Wtsi
HOM Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglyceride WTSI | EuroPhenome 5.34E-5
Vgf
Vgfem1(IMPC)H
HOM Female postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides MRC Harwell | IMPC 5.67E-5
Smpdl3a
Smpdl3aem1(IMPC)Tcp
HOM Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides TCP | IMPC 8.37E-5
Pcsk9
Pcsk9tm2b(EUCOMM)Hmgu
HOM Female postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides HMGU | IMPC 9.14E-5
Ccdc18
Ccdc18tm1a(EUCOMM)Wtsi
HOM Male postnatal increased circulating triglyceride level Clinical Chemistry | Triglycerides WTSI | IMPC 9.27E-5

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