Phenotype: decreased startle reflex

Definition greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch

Synonyms reduced startle reflex

MP browserMP:0001489

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Phenotype associations stats

2.89% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased startle reflex (80/2766)

2.76% females (76/2754) 2.86% males (79/2765)



Gene variants with decreased startle reflex

Total number of significant genotype-phenotype associations: 166

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Myh1
Myh1tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S JAX | IMPC 1.38E-22
Marveld2
Marveld2tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S MRC Harwell | IMPC 6.55E-21
Elmod1
Elmod1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S MRC Harwell | IMPC 2.39E-17
Tmem51
Tmem51tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S MRC Harwell | IMPC 9.38E-17
Tmtc4
Tmtc4tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S UC Davis | IMPC 3.32E-16
Bicd1
Bicd1tm1.1(KOMP)Wtsi
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S UC Davis | IMPC 1.36E-15
Cib2
Cib2tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S MRC Harwell | IMPC 1.03E-14
Rnf10
Rnf10tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S BCM | IMPC 9.6E-14
Tprn
Tprntm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S JAX | IMPC 4.01E-13
Cast
Casttm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S JAX | IMPC 8.23E-13
Baiap2l2
Baiap2l2tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S ICS | IMPC 1.14E-12
Nin
Nintm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S RBRC | IMPC 5.27E-12
Nedd4l
Nedd4ltm1b(KOMP)Wtsi
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S MRC Harwell | IMPC 1.75E-11
Tox
Toxtm1b(KOMP)Wtsi
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S UC Davis | IMPC 6.07E-11
Gipc3
Gipc3tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S JAX | IMPC 8.56E-11
Aspa
Aspatm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S HMGU | IMPC 1.54E-10
Colca2
Colca2tm1b(NCOM)Mfgc
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S TCP | IMPC 2.01E-10
Slc9a4
Slc9a4tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S MRC Harwell | IMPC 2.02E-10
Aak1
Aak1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S ICS | IMPC 5.17E-10
Adgrv1
Adgrv1tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S UC Davis | IMPC 5.21E-10
Ankrd11
Ankrd11tm1b(EUCOMM)Wtsi
HET Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S ICS | IMPC 1.22E-9
Otogl
Otoglem1J
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S JAX | IMPC 1.76E-9
Mag
Magtm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S JAX | IMPC 2.24E-9
Rnf10
Rnf10em1J
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S JAX | IMPC 3.04E-9
Usp2
Usp2tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S MRC Harwell | IMPC 4.49E-9
Fbxo2
Fbxo2tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S MARC | IMPC 7.8E-9
Adra2a
Adra2atm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S UC Davis | IMPC 1.12E-8
Epha5
Epha5tm1b(NCOM)Mfgc
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S TCP | IMPC 2.35E-8
Mpdz
Mpdzem1J
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S JAX | IMPC 2.76E-8
Dixdc1
Dixdc1tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S JAX | IMPC 4.58E-8
Ttc28
Ttc28tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S TCP | IMPC 6.69E-8
Cpt1c
Cpt1ctm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S UC Davis | IMPC 1.02E-7
Iqsec3
Iqsec3tm3b(KOMP)Wtsi
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S BCM | IMPC 1.1E-7
Foxo3
Foxo3tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S JAX | IMPC 1.36E-7
Gatm
Gatmtm1b(KOMP)Wtsi
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S HMGU | IMPC 2.23E-7
Gramd1c
Gramd1ctm1b(KOMP)Wtsi
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S JAX | IMPC 2.41E-7
Kif3c
Kif3ctm1.1(KOMP)Vlcg
HET Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S JAX | IMPC 3.67E-7
Kansl1
Kansl1tm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S ICS | IMPC 6.22E-7
Prune1
Prune1tm1.1(KOMP)Vlcg
HET Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S UC Davis | IMPC 8.58E-7
Cdh4
Cdh4tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S JAX | IMPC 8.7E-7
Nmb
Nmbtm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S JAX | IMPC 8.84E-7
Gas6
Gas6tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S UC Davis | IMPC 1.05E-6
Dnase1l2
Dnase1l2tm1.1(KOMP)Wtsi
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S TCP | IMPC 1.24E-6
Crbn
Crbntm1b(KOMP)Wtsi
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S UC Davis | IMPC 1.54E-6
Arih2
Arih2tm1.1(KOMP)Vlcg
HET Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S UC Davis | IMPC 1.64E-6
2510002D24Rik
2510002D24Riktm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S UC Davis | IMPC 1.92E-6
Hectd3
Hectd3tm1(NCOM)Cmhd
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S MARC | IMPC 2.89E-6
Slc44a1
Slc44a1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S BCM | IMPC 4.14E-6
D17Wsu92e
D17Wsu92eGt(IST12471H5)Tigm
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S UC Davis | IMPC 4.8E-6
Cnnm2
Cnnm2tm1.1(KOMP)Vlcg
HET Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S UC Davis | IMPC 5.24E-6
Btg2
Btg2tm1b(KOMP)Mbp
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S JAX | IMPC 5.47E-6
Nptn
Nptntm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S MRC Harwell | IMPC 6.2E-6
Pla2g7
Pla2g7em1J
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S JAX | IMPC 7.64E-6
Trip13
Trip13tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S JAX | IMPC 7.8E-6
Rab11fip4
Rab11fip4em1J
HOM Female postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S JAX | IMPC 8.23E-6
Vax1
Vax1tm1b(KOMP)Mbp
HET Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S JAX | IMPC 9.81E-6
Ankrd1
Ankrd1tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S UC Davis | IMPC 1.35E-5
Ankrd1
Ankrd1tm1.1(KOMP)Vlcg
HET Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S UC Davis | IMPC 1.35E-5
Gpr142
Gpr142tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S JAX | IMPC 1.48E-5
Dyrk1b
Dyrk1btm1b(EUCOMM)Wtsi
HET Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S ICS | IMPC 1.49E-5
Tmem79
Tmem79tm1.1(KOMP)Wtsi
HOM Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S JAX | IMPC 1.53E-5
Slitrk1
Slitrk1tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S UC Davis | IMPC 1.57E-5
Wnt10b
Wnt10btm1e.1(KOMP)Wtsi
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S UC Davis | IMPC 2.38E-5
Smurf1
Smurf1tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S MRC Harwell | IMPC 2.92E-5
Fzd3
Fzd3tm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S MRC Harwell | IMPC 2.97E-5
Rnf10
Rnf10em2Bay
HOM Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S BCM | IMPC 3.09E-5
Arl6ip1
Arl6ip1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S MRC Harwell | IMPC 3.64E-5
Rfxank
Rfxanktm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S HMGU | IMPC 3.69E-5
Dpm3
Dpm3tm1.1(KOMP)Vlcg
HET Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S UC Davis | IMPC 3.88E-5
Gnao1
Gnao1tm1b(EUCOMM)Hmgu
HET Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S MRC Harwell | IMPC 3.96E-5
Btbd16
Btbd16tm2b(EUCOMM)Hmgu
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S BCM | IMPC 4.69E-5
Btbd16
Btbd16tm2b(EUCOMM)Hmgu
HET Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S BCM | IMPC 4.69E-5
Hnrnpc
Hnrnpctm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S JAX | IMPC 4.95E-5
Gstcd
Gstcdtm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S BCM | IMPC 5.33E-5
0610009B22Rik
0610009B22Riktm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S BCM | IMPC 5.68E-5
0610009B22Rik
0610009B22Riktm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S BCM | IMPC 5.68E-5
Acvr2b
Acvr2btm1.1(KOMP)Vlcg
HET Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S UC Davis | IMPC 5.87E-5
Evl
Evltm1b(KOMP)Wtsi
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S MRC Harwell | IMPC 5.88E-5
Dner
Dnertm3b(EUCOMM)Hmgu
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S HMGU | IMPC 6.11E-5
3110043O21Rik
3110043O21Riktm1b(KOMP)Mbp
HET Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S UC Davis | IMPC 6.31E-5
3110043O21Rik
3110043O21Riktm1b(KOMP)Mbp
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S UC Davis | IMPC 6.31E-5
Isca1
Isca1tm1b(KOMP)Wtsi
HET Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S JAX | IMPC 6.9E-5
D1Ertd622e
D1Ertd622etm1.1(KOMP)Vlcg
HET Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S JAX | IMPC 7.62E-5
Arrdc1
Arrdc1tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S JAX | IMPC 9.24E-5
Il10ra
Il10ratm1b(KOMP)Wtsi
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S ICS | IMPC 9.77E-5
Vgf
Vgfem1H
HOM Female Male postnatal decreased startle reflex Acoustic Startle and Pre-pulse Inhibition (PPI) | Response amplitude - S MRC Harwell | IMPC 9.84E-5

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