Phenotype: abnormal response to new environment

Definition altered behavioral reaction associated with placing an animal in a new location

Synonyms
  • transfer arousal
  • transfer arousal
  • abnormal transfer arousal
  • abnormal transfer arousal
Related
Synonyms
  • Agoraphobia
  • Agoraphobia
  • decreased exploration in new environment
  • decreased exploration in new environment
  • novel environmental response-related retropulsion
  • abnormal habituation to a new environment
  • abnormal exploration in a new environment
  • increased exploration in new environment
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Phenotype associations stats

1.58% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal response to new environment (32/2024)

1.15% females (23/2008) 1.35% males (27/2005)

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Gene variants with abnormal response to new environment

Total number of significant genotype-phenotype associations: 53

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Prkab1
Prkab1tm1a(KOMP)Wtsi
HEM Female Male postnatal abnormal response to new environment Modified SHIRPA | Transfer Arousal WTSI | EuroPhenome 0.0
Dlg4
Dlg4tm1Grnt
HOM Female Male postnatal decreased exploration in new environment Modified SHIRPA | Locomotor activity WTSI | EuroPhenome 2.41E-20
Shisa7
Shisa7em1(IMPC)J
HOM Female Male postnatal increased exploration in new environment Hole-board Exploration | Total holepokes JAX | IMPC 5.65E-10
Slc5a5
Slc5a5tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased exploration in new environment Hole-board Exploration | Total holepokes JAX | IMPC 2.29E-8
Pitx3
Pitx3eyl
HOM Female postnatal increased exploration in new environment Holeboard (GMC) | Latency familiar object exploration HMGU | EuroPhenome 8.78E-8
Gm5134
Gm5134tm1a(EUCOMM)Hmgu
HOM Female postnatal abnormal response to new environment Modified SHIRPA | Transfer arousal MRC Harwell | EuroPhenome 9.55E-8
Trim66
Trim66tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased exploration in new environment Modified SHIRPA | Locomotor activity WTSI | EuroPhenome 1.81E-7
Myh1
Myh1tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased exploration in new environment Hole-board Exploration | Total holepokes JAX | IMPC 2.51E-7
Fam161a
Fam161atm1b(KOMP)Wtsi
HOM Female Male postnatal decreased exploration in new environment Hole-board Exploration | Total holepokes JAX | IMPC 2.74E-7
Ppp1r9b
Ppp1r9btm1.1(KOMP)Vlcg
HOM Female Male postnatal increased exploration in new environment Hole-board Exploration | Total holepokes JAX | IMPC 3.07E-7
Abcd4
Abcd4tm1a(EUCOMM)Hmgu
HOM Female postnatal abnormal response to new environment Modified SHIRPA | Transfer arousal MRC Harwell | EuroPhenome 9.2E-7
Nars2
Nars2em1(IMPC)J
HET Male postnatal decreased exploration in new environment Hole-board Exploration | Total holepokes JAX | IMPC 1.19E-6
Pitx3
Pitx3tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased exploration in new environment Hole-board Exploration | Total holepokes JAX | IMPC 3.36E-6
Pitx3
Pitx3eyl
HOM Female Male postnatal decreased exploration in new environment Holeboard (GMC) | Familiar object exploration number HMGU | EuroPhenome 4.18E-6
Stx16
Stx16tm1b(KOMP)Wtsi
HOM Female postnatal increased exploration in new environment Hole-board Exploration | Total holepokes JAX | IMPC 9.03E-6
Isca1
Isca1tm1b(KOMP)Wtsi
HET Female Male postnatal decreased exploration in new environment Hole-board Exploration | Total holepokes JAX | IMPC 1.06E-5
Hsd17b1
Hsd17b1tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased exploration in new environment Hole-board Exploration | Total holepokes JAX | IMPC 1.53E-5
Cyb561
Cyb561tm1a(EUCOMM)Wtsi
HOM Male postnatal abnormal response to new environment Modified SHIRPA | Transfer arousal MRC Harwell | EuroPhenome 1.77E-5
Nespas
Gnas/Nespastm2.1Jop
HET Male postnatal abnormal response to new environment Modified SHIRPA | Transfer arousal MRC Harwell | EuroPhenome 3.17E-5
Zmiz2
Zmiz2tm1.1(KOMP)Vlcg
HET Female Male postnatal decreased exploration in new environment Hole-board Exploration | Total holepokes JAX | IMPC 3.26E-5
Lrp1
Lrp1tm1.1(KOMP)Wtsi
HET Female Male postnatal decreased exploration in new environment Hole-board Exploration | Total holepokes JAX | IMPC 4.87E-5
Dlg2
Dlg2tm1Dsb
HOM Female Male postnatal decreased exploration in new environment Modified SHIRPA | Locomotor activity WTSI | EuroPhenome 4.93E-5
Ptk7
Ptk7chz
HET Male postnatal abnormal response to new environment Modified SHIRPA | Transfer arousal MRC Harwell | EuroPhenome 4.95E-5
Ncam1
Ncam1tm1Cgn
HOM Female Male postnatal increased exploration in new environment Holeboard (GMC) | Holes explored HMGU | EuroPhenome 5.02E-5
Trpc3
Trpc3Mwk
HET Male postnatal abnormal response to new environment Modified SHIRPA | Transfer arousal MRC Harwell | EuroPhenome 5.87E-5
Gpc4
Gpc4tm2b(EUCOMM)Wtsi
HOM Female Male postnatal decreased exploration in new environment Hole-board Exploration | Total holepokes JAX | IMPC 5.91E-5
1700001O22Rik
1700001O22Rikem1(IMPC)J
HOM Female Male postnatal decreased exploration in new environment Hole-board Exploration | Total holepokes JAX | IMPC 6.03E-5
Mylip
Myliptm1.1(KOMP)Vlcg
HOM Female postnatal increased exploration in new environment Hole-board Exploration | Total holepokes JAX | IMPC 6.07E-5
Ankrd11
Ankrd11Yod
HET Male postnatal abnormal response to new environment Modified SHIRPA | Transfer arousal MRC Harwell | EuroPhenome 6.52E-5
Mybpc3
Mybpc3tm1a(EUCOMM)Hmgu
HOM Male postnatal abnormal response to new environment Modified SHIRPA | Transfer arousal MRC Harwell | EuroPhenome 6.9E-5
Stx8
Stx8tm2a(EUCOMM)Wtsi
HOM Male postnatal abnormal response to new environment Modified SHIRPA | Transfer arousal MRC Harwell | EuroPhenome 7.12E-5
Pbx3
Pbx3tm1a(EUCOMM)Wtsi
HET Female postnatal abnormal response to new environment Modified SHIRPA | Transfer arousal MRC Harwell | EuroPhenome 7.94E-5
Car7
Car7tm1b(KOMP)Wtsi
HET Female Male postnatal decreased exploration in new environment Hole-board Exploration | Total holepokes JAX | IMPC 8.69E-5
Yipf1
Yipf1tm1a(EUCOMM)Wtsi
HOM Male postnatal abnormal response to new environment Modified SHIRPA | Transfer Arousal WTSI | EuroPhenome 9.91E-5

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