Phenotype: abnormal lung morphology

Definition any structural anomaly of the paired lobed visceral organs of respiration in the pulmonary cavity of the thorax where aeration of the blood normally occurs

Synonyms
  • abnormal lung
  • abnormal lung
  • lung dysplasia
  • lung dysplasia
Related
Synonyms
  • Pulmonary fibrosis
  • Pulmonary fibrosis
  • abnormal wet-to-dry lung weight ratio
  • abnormal wet-to-dry lung weight ratio
  • impaired lung lobe morphogenesis
  • thick lung-associated mesenchyme
  • abnormal branching involved in bronchus morphogenesis
  • abnormal branching involved in alveolar duct morphogenesis
  • Pulmonary hypoplasia
  • abnormal right major bronchus morphology
  • multiple major aortopulmonary collateral arteries
  • Bronchomegaly
  • abnormal bronchioalveolar stem cell morphology
  • lung situs inversus
  • abnormal branching involved in trachea morphogenesis
  • increased lung weight
  • dilated terminal bronchiole tubes
  • abnormal right lung cranial lobe morphology
  • abnormal branching involved in alveolar sac morphogenesis
  • abnormal lung volume
  • Tracheo-oesophageal fistula
  • abnormal pulmonary alveolar sac morphology
  • trachea stenosis
  • abnormal pulmonary alveolar parenchyma morphology
  • abnormal trachea morphology
  • abnormal lung development
  • pulmonary necrosis
  • right pulmonary isomerism
  • trachea fibrosis
  • Bilateral basilar pulmonary fibrosis
  • abnormal right lung morphology
  • absent lungs
  • right pulmonary isomerism
  • abnormal functional residual capacity
  • absent right lung accessory lobe
  • abnormal pulmonary alveolar system morphology
  • abnormal right lung caudal lobe morphology
  • small lung saccule
  • fused right lung lobes
  • abnormal pulmonary interalveolar septum morphology
  • abnormal bronchoalveolar duct junction morphology
  • abnormal pulmonary alveolar duct morphology
  • abnormal respiratory bronchiole morphology
  • abnormal lung epithelium morphology
  • Pulmonary situs inversus
  • abnormal bronchus morphology
  • absent trachea
  • bronchial epithelial hyperplasia
  • pulmonary hypoplasia
  • pale lung
  • abnormal right lung accessory lobe morphology
  • absent lung buds
  • left pulmonary isomerism
  • increased number of pulmonary neuroendocrine bodies
  • abnormal residual volume
  • abnormal lung-associated mesenchyme development
  • decreased lung weight
  • increased pulmonary endothelial cell surface
  • abnormal lung saccule morphology
  • pulmonary interstitial fibrosis
  • decreased pulmonary endothelial cell surface
  • abnormal branching involved in alveolar sac morphogenesis
  • increased lung weight
  • abnormal pulmonary alveolar duct morphology
  • increased bronchioalveolar stem cell number
  • abnormal left major bronchus morphology
  • dilated pulmonary alveolar ducts
  • lung cysts
  • impaired lung alveolus development
  • abnormal pulmonary alveolus epithelial cell morphology
  • abnormal pulmonary collagen fibril morphology
  • bronchial situs inversus
  • pulmonary edema
  • Bilateral trilobed lungs
  • abnormal pulmonary elastic fiber morphology
  • abnormal lung interstitium morphology
  • abnormal terminal bronchiole morphology
  • abnormal lung position or orientation
  • abnormal pulmonary acinus morphology
  • abnormal branching involved in respiratory bronchiole morphogenesis
  • abnormal lung size
  • bronchial situs inversus
  • pulmonary alveolar edema
  • trachea occlusion
  • impaired lung lobe morphogenesis
  • emphysema
  • abnormal right lung middle lobe morphology
  • abnormal bronchus epithelium morphology
  • pulmonary alveolar edema
  • abnormal bronchiole epithelium morphology
  • small lung
  • pulmonary interstitial fibrosis
  • pulmonary epithelial necrosis
  • abnormal tracheal smooth muscle morphology
  • decreased bronchioalveolar stem cell number
  • Bilateral basilar pulmonary fibrosis
  • increased mesenchymal cell proliferation involved in lung development
  • abnormal vital capacity
  • Tracheal calcification
  • dilated respiratory conducting tubes
  • abnormal lung lobe morphology
  • thin lung-associated mesenchyme
  • abnormal branching involved in bronchus morphogenesis
  • abnormal bronchus epithelium morphology
  • left pulmonary isomerism
  • decreased number of pulmonary neuroendocrine bodies
  • aorta pulmonary collateral arteries
  • abnormal right lung caudal lobe morphology
  • abnormal inspiratory reserve volume
  • absent lung saccules
  • abnormal tracheal cartilage morphology
  • abnormal pulmonary neuroendocrine body morphology
  • abnormal lung vasculature morphology
  • Bronchial atresia
  • abnormal right lung cranial lobe morphology
  • abnormal bronchial cartilage morphology
  • abnormal tracheal ciliated epithelium morphology
  • abnormal lung bud morphology
  • absent right lung accessory lobe
  • abnormal pulmonary alveolus epithelial cell morphology
  • abnormal lung alveolus development
  • pulmonary epithelial necrosis
  • abnormal bronchiole epithelium morphology
  • pulmonary fibrosis
  • abnormal lung weight
  • tracheoesophageal fistula
  • small lung lobe
  • pulmonary hyperplasia
  • pulmonary interstitial fibrosis
  • small trachea
  • bronchiolar epithelial hyperplasia
  • abnormal alveolar macrophage morphology
  • Emphysema
  • abnormal right lung middle lobe morphology
  • abnormal pulmonary endothelial cell surface
  • abnormal tidal volume
  • abnormal branching involved in terminal bronchiole morphogenesis
  • abnormal branching involved in alveolar sac morphogenesis
  • abnormal whole-body plethysmography
  • abnormal trachea development
  • Abnormal lung lobation
  • abnormal pulmonary alveolus morphology
  • abnormal trachea submucosa morphology
  • abnormal branching involved in lung morphogenesis
  • Pulmonary edema
  • enlarged lung
  • abnormal branching involved in preterminal bronchiole morphogenesis
  • abnormal mesenchymal cell differentiation involved in lung development
  • Tracheal stenosis
  • Cartilaginous trachea
  • abnormal bronchiole morphology
  • abnormal total lung capacity
  • abnormal respiratory bronchiole morphology
  • abnormal inspiratory capacity
  • abnormal respiratory conducting tube morphology
  • decreased mesenchymal cell proliferation involved in lung development
  • enlarged trachea
  • abnormal pulmonary alveolar sac morphology
  • decreased lung weight
  • absent pulmonary neuroendocrine bodies
  • abnormal branching involved in alveolar duct morphogenesis
  • Pulmonary sequestration
  • abnormal mesenchymal cell proliferation involved in lung development
  • abnormal pulmonary alveolar sac morphology
  • pulmonary vascular congestion
  • lung epithelium hyperplasia
  • abnormal left lung morphology
  • abnormal pulmonary alveolus epithelium morphology
  • fused right lung lobes
  • abnormal right lung accessory lobe morphology
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MP browserMP:0001175

Phenotype associations stats

1.22% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal lung morphology (30/2469)

0.53% females (13/2447) 0.82% males (20/2443)

Gene variants with abnormal lung morphology

Total number of significant genotype-phenotype associations: 35

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Abcb11
Abcb11tm1b(EUCOMM)Hmgu
HET Male postnatal abnormal lung morphology Gross Pathology and Tissue Collection | Lung HMGU | IMPC 0.0
Adnp2
Adnp2em3(IMPC)Tcp
HOM Female postnatal abnormal lung morphology Gross Pathology and Tissue Collection | Lung TCP | IMPC 0.0
B3galt2
B3galt2tm1.1(KOMP)Vlcg
HET Male postnatal abnormal lung morphology Gross Pathology and Tissue Collection | Lung UC Davis | IMPC 0.0
B3galt2
B3galt2tm1.1(KOMP)Vlcg
HET Male postnatal enlarged lung Gross Pathology and Tissue Collection | Lung UC Davis | IMPC 0.0
Bcas1
Bcas1em1(IMPC)Tcp
HOM Male postnatal abnormal lung morphology Gross Pathology and Tissue Collection | Lung TCP | IMPC 0.0
Ccdc124
Ccdc124tm1b(KOMP)Wtsi
HOM Female Male postnatal small lung Gross Pathology and Tissue Collection | Lung MARC | IMPC 0.0
Cdkn1a
Cdkn1atm1.1(KOMP)Vlcg
HOM Male postnatal abnormal lung morphology Gross Pathology and Tissue Collection | Lung UC Davis | IMPC 0.0
Chchd7
Chchd7em3(IMPC)Tcp
HOM Male postnatal abnormal lung morphology Gross Pathology and Tissue Collection | Lung TCP | IMPC 0.0
Cox20
Cox20em1(IMPC)Tcp
HET Female postnatal abnormal lung morphology Gross Pathology and Tissue Collection | Lung TCP | IMPC 0.0
Dagla
Daglatm1a(EUCOMM)Wtsi
HOM Male postnatal small lung Gross Pathology and Tissue Collection | Lung MARC | IMPC 0.0
Dnal1
Dnal1tm1.1(KOMP)Vlcg
HET Male postnatal abnormal lung morphology Gross Pathology and Tissue Collection | Lung TCP | IMPC 0.0
Dync1li1
Dync1li1em1(IMPC)Tcp
HET Male postnatal abnormal lung morphology Gross Pathology and Tissue Collection | Lung TCP | IMPC 0.0
Eprs
Eprstm1b(EUCOMM)Hmgu
HET Male postnatal abnormal lung morphology Gross Pathology and Tissue Collection | Lung TCP | IMPC 0.0
Hectd3
Hectd3tm1(NCOM)Cmhd
HOM Female Male postnatal small lung Gross Pathology and Tissue Collection | Lung MARC | IMPC 0.0
Hgsnat
Hgsnatem4(IMPC)Tcp
HOM Male postnatal abnormal lung morphology Gross Pathology and Tissue Collection | Lung TCP | IMPC 0.0
Hook3
Hook3tm1b(NCOM)Mfgc
HOM Female postnatal abnormal lung morphology Gross Pathology and Tissue Collection | Lung TCP | IMPC 0.0
Ifng
Ifngtm1.1(KOMP)Vlcg
HET Male postnatal abnormal lung morphology Gross Pathology and Tissue Collection | Lung UC Davis | IMPC 0.0
Kdm1a
Kdm1atm1(NCOM)Mfgc
HET Female postnatal small lung Gross Pathology and Tissue Collection | Lung MARC | IMPC 0.0
Lhcgr
Lhcgrtm1(KOMP)Vlcg
HOM Male postnatal small lung Gross Pathology and Tissue Collection | Lung MARC | IMPC 0.0
Lrrc8a
Lrrc8atm1.1(KOMP)Vlcg
HET Female postnatal enlarged lung Gross Pathology and Tissue Collection | Lung UC Davis | IMPC 0.0
Lrrc8a
Lrrc8atm1.1(KOMP)Vlcg
HET Female postnatal abnormal lung morphology Gross Pathology and Tissue Collection | Lung UC Davis | IMPC 0.0
Mmachc
Mmachctm1.1(NCOM)Mfgc
HET Female Male postnatal abnormal lung morphology Gross Pathology and Tissue Collection | Lung TCP | IMPC 0.0
Mpz
Mpzem1(IMPC)Tcp
HOM Male postnatal abnormal lung morphology Gross Pathology and Tissue Collection | Lung TCP | IMPC 0.0
Nhsl1
Nhsl1tm1.1(KOMP)Vlcg
HOM Male postnatal abnormal lung morphology Gross Pathology and Tissue Collection | Lung UC Davis | IMPC 0.0
Pcsk1n
Pcsk1ntm1.1(KOMP)Vlcg
HOM Female postnatal abnormal lung morphology Gross Pathology and Tissue Collection | Lung UC Davis | IMPC 0.0
Raly
Ralyem2(IMPC)Tcp
HOM Female postnatal abnormal lung morphology Gross Pathology and Tissue Collection | Lung TCP | IMPC 0.0
Slc23a3
Slc23a3em1(IMPC)Tcp
HOM Male postnatal abnormal lung morphology Gross Pathology and Tissue Collection | Lung TCP | IMPC 0.0
Thbs1
Thbs1tm1.1(KOMP)Vlcg
HOM Male postnatal abnormal lung morphology Gross Pathology and Tissue Collection | Lung UC Davis | IMPC 0.0
Thoc6
Thoc6em5(IMPC)Tcp
HET Female postnatal abnormal lung morphology Gross Pathology and Tissue Collection | Lung TCP | IMPC 0.0
Tldc1
Tldc1em3(IMPC)Tcp
HOM Female postnatal abnormal lung morphology Gross Pathology and Tissue Collection | Lung TCP | IMPC 0.0
Tmem100
Tmem100tm1e.1(KOMP)Wtsi
HET Female postnatal abnormal lung morphology Gross Pathology and Tissue Collection | Lung TCP | IMPC 0.0
Zfp275
Zfp275tm1.1(NCOM)Mfgc
HEM Male postnatal abnormal lung morphology Gross Pathology and Tissue Collection | Lung TCP | IMPC 0.0

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