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Phenotype: decreased granulocyte number

Definition
fewer than expected number of leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils
Synonyms
agranulocytosis,  reduced granulocyte number,  granulocytopenia
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with decreased granulocyte number

Total number of significant genotype-phenotype associations: 84

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Tmem127
Tmem127tm1(KOMP)Wtsi 		HOM Early adult decreased neutrophil cell number Neutrophil percentage
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Wac
Wactm2b(EUCOMM)Wtsi 		HET Early adult decreased eosinophil cell number Eosinophil number
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Synj1
Synj1tm1b(EUCOMM)Wtsi 		HET Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MRC Harwell
IMPC		 1.19×10-15
Pkn1
Pkn1tm1b(KOMP)Wtsi 		HOM Early adult decreased neutrophil cell number Neutrophil cell count
Hematology		 MRC Harwell
IMPC		 1.21×10-13
C1ql3
C1ql3em1(IMPC)H 		HOM Early adult decreased eosinophil cell number Eosinophil cell count
Hematology		 MRC Harwell
IMPC		 2.95×10-12
Atl2
Atl2tm2b(EUCOMM)Hmgu 		HET Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MRC Harwell
IMPC		 2.42×10-10
Csf3
Csf3em1(IMPC)H 		HOM Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MRC Harwell
IMPC		 2.43×10-10
Has1
Has1tm1b(KOMP)Wtsi 		HOM Early adult decreased eosinophil cell number Eosinophil cell count
Hematology		 MRC Harwell
IMPC		 8.46×10-10
Gfi1b
Gfi1btm1b(EUCOMM)Hmgu 		HET Early adult decreased neutrophil cell number Neutrophil cell count
Hematology		 MRC Harwell
IMPC		 9.65×10-10
Atp5mg
Atp5mgtm1b(EUCOMM)Hmgu 		HET Early adult decreased eosinophil cell number Eosinophil cell count
Hematology		 MRC Harwell
IMPC		 8.22×10-09
Cxcl9
Cxcl9tm1b(EUCOMM)Wtsi 		HOM Early adult decreased neutrophil cell number Neutrophil cell count
Hematology		 MRC Harwell
IMPC		 1.45×10-08
Ccr2
Ccr2em1(IMPC)H 		HOM Late adult decreased neutrophil cell number Monocyte cell count
Hematology		 MRC Harwell
IMPC		 3.23×10-08
Ablim3
Ablim3em1(IMPC)Tcp 		HOM Early adult decreased basophil cell number Basophil differential count
Hematology		 TCP
IMPC		 4.54×10-08
Avp
Avptm1b(EUCOMM)Wtsi 		HET Early adult decreased neutrophil cell number Neutrophil cell count
Hematology		 MRC Harwell
IMPC		 1.39×10-07
Itgae
Itgaetm1b(EUCOMM)Wtsi 		HOM Early adult decreased neutrophil cell number Neutrophil cell count
Hematology		 MRC Harwell
IMPC		 1.98×10-07
Lypd2
Lypd2em1(IMPC)Marc 		HOM Early adult decreased neutrophil cell number Neutrophil cell count
Hematology		 MARC
IMPC		 2.05×10-07
Eif2b5
Eif2b5tm1a(EUCOMM)Wtsi 		HET Early adult decreased granulocyte number Granulocyte Gr1+ percentage
FACs Analysis		 ICS
EuroPhenome		 2.24×10-07
Cib1
Cib1tm1b(EUCOMM)Hmgu 		HOM Late adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MRC Harwell
IMPC		 4.55×10-07
Lrrk1
Lrrk1tm1b(KOMP)Wtsi 		HOM Early adult decreased eosinophil cell number Eosinophil cell count
Hematology		 MRC Harwell
IMPC		 4.74×10-07
Pcdhb13
Pcdhb13em1(IMPC)Tcp 		HOM Early adult decreased basophil cell number Basophil cell count
Hematology		 TCP
IMPC		 8.67×10-07
C5ar2
C5ar2em1(IMPC)H 		HOM Early adult decreased eosinophil cell number Eosinophil differential count
Hematology		 MRC Harwell
IMPC		 8.88×10-07
Flnb
Flnbtm1b(KOMP)Wtsi 		HET Early adult decreased neutrophil cell number Neutrophil cell count
Hematology		 MRC Harwell
IMPC		 9.28×10-07
Acvr2a
Acvr2atm1.1(KOMP)Vlcg 		HET Early adult decreased neutrophil cell number Neutrophil cell count
Hematology		 TCP
IMPC		 9.53×10-07
Clk1
Clk1tm1a(EUCOMM)Wtsi 		HOM Early adult decreased granulocyte number Granulocyte Gr1+ percentage
FACs Analysis		 MRC Harwell
EuroPhenome		 1.03×10-06
C1ql3
C1ql3em1(IMPC)H 		HOM Early adult decreased neutrophil cell number Neutrophil cell count
Hematology		 MRC Harwell
IMPC		 1.66×10-06
Bdkrb1
Bdkrb1em1(IMPC)H 		HOM Late adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MRC Harwell
IMPC		 1.70×10-06
Rhbdd1
Rhbdd1tm1.1Mfm 		HOM Early adult decreased granulocyte number Granulocyte Gr1+ percentage
FACs Analysis		 MRC Harwell
EuroPhenome		 2.46×10-06
Pfkfb2
Pfkfb2tm1b(KOMP)Wtsi 		HOM Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MARC
IMPC		 2.49×10-06
Pon2
Pon2tm1b(EUCOMM)Hmgu 		HOM Late adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MRC Harwell
IMPC		 4.59×10-06
Pard3
Pard3tm1b(KOMP)Wtsi 		HET Early adult decreased basophil cell number Basophil cell count
Hematology		 MRC Harwell
IMPC		 5.64×10-06
Hnrnph1
Hnrnph1tm1b(KOMP)Wtsi 		HET Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MARC
IMPC		 8.04×10-06
Ecm1
Ecm1tm1b(EUCOMM)Hmgu 		HET Early adult decreased neutrophil cell number Neutrophil cell count
Hematology		 MRC Harwell
IMPC		 1.10×10-05
Gprin1
Gprin1em1(IMPC)H 		HOM Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MRC Harwell
IMPC		 1.26×10-05
Cdc7
Cdc7tm1.1(KOMP)Vlcg 		HET Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 TCP
IMPC		 1.32×10-05
Gnao1
Gnao1tm1b(EUCOMM)Hmgu 		HET Early adult decreased eosinophil cell number Eosinophil differential count
Hematology		 MRC Harwell
IMPC		 1.35×10-05
Marchf8
Marchf8em2(IMPC)Ccpcz 		HOM Early adult decreased eosinophil cell number Eosinophils
Immunophenotyping		 CCP-IMG
IMPC		 1.44×10-05
Plac9
Plac9tm1b(EUCOMM)Hmgu 		HOM Early adult decreased neutrophil cell number Neutrophil cell count
Hematology		 MRC Harwell
IMPC		 1.64×10-05
Cps1
Cps1em1(IMPC)H 		HET Early adult decreased neutrophil cell number Neutrophil cell count
Hematology		 MRC Harwell
IMPC		 1.70×10-05
Blnk
Blnkem1(IMPC)H 		HOM Early adult decreased basophil cell number Basophil cell count
Hematology		 MRC Harwell
IMPC		 1.72×10-05
Glra2
Glra2tm1b(KOMP)Wtsi 		HEM Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MRC Harwell
IMPC		 1.73×10-05
Chmp4c
Chmp4ctm1b(EUCOMM)Wtsi 		HOM Early adult decreased basophil cell number Basophil cell count
Hematology		 MRC Harwell
IMPC		 1.82×10-05
Bdp1
Bdp1em1(IMPC)Tcp 		HET Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 TCP
IMPC		 2.14×10-05
Acvr2a
Acvr2atm1.1(KOMP)Vlcg 		HET Early adult decreased eosinophil cell number Eosinophil cell count
Hematology		 TCP
IMPC		 2.15×10-05
Aspscr1
Aspscr1em1(IMPC)Tcp 		HOM Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 TCP
IMPC		 2.22×10-05
Tnfrsf1a
Tnfrsf1atm2b(EUCOMM)Wtsi 		HOM Late adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MRC Harwell
IMPC		 2.30×10-05
Csf3
Csf3em1(IMPC)H 		HOM Early adult decreased eosinophil cell number Eosinophil differential count
Hematology		 MRC Harwell
IMPC		 2.37×10-05
Ube2b
Ube2btm1b(EUCOMM)Wtsi 		HET   Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MRC Harwell
IMPC		 2.68×10-05
Fbxo10
Fbxo10tm1b(KOMP)Wtsi 		HOM Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MARC
IMPC		 2.89×10-05
Fstl1
Fstl1tm1b(EUCOMM)Hmgu 		HOM Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MRC Harwell
IMPC		 3.16×10-05
Got1
Got1tm1b(EUCOMM)Hmgu 		HET Early adult decreased basophil cell number Basophil cell count
Hematology		 MRC Harwell
IMPC		 3.21×10-05
Spata24
Spata24tm1b(EUCOMM)Wtsi 		HOM Late adult decreased neutrophil cell number Monocyte cell count
Hematology		 MRC Harwell
IMPC		 4.03×10-05
Zfp595
Zfp595tm1b(KOMP)Wtsi 		HOM Early adult decreased eosinophil cell number Eosinophil cell count
Hematology		 MRC Harwell
IMPC		 4.04×10-05
Dnal1
Dnal1tm1.1(KOMP)Vlcg 		HET Early adult decreased eosinophil cell number Eosinophil cell count
Hematology		 TCP
IMPC		 4.27×10-05
Usp45
Usp45em1(IMPC)H 		HOM Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MRC Harwell
IMPC		 4.75×10-05
Abcc5
Abcc5em1(IMPC)H 		HOM Early adult decreased eosinophil cell number Eosinophil cell count
Hematology		 MRC Harwell
IMPC		 4.79×10-05
Usp32
Usp32em1(IMPC)Mhzh 		HET   Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MARC
IMPC		 4.81×10-05
Col4a3
Col4a3tm1b(EUCOMM)Wtsi 		HOM Early adult decreased basophil cell number Basophil differential count
Hematology		 MRC Harwell
IMPC		 4.98×10-05
Rexo2
Rexo2tm1b(EUCOMM)Wtsi 		HET Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MRC Harwell
IMPC		 5.15×10-05
Mat2a
Mat2atm1a(EUCOMM)Hmgu 		HET Early adult decreased granulocyte number Granulocyte Gr1+ percentage
FACs Analysis		 ICS
EuroPhenome		 5.18×10-05
Ampd1
Ampd1tm1b(KOMP)Wtsi 		HET Early adult decreased neutrophil cell number Neutrophil cell count
Hematology		 TCP
IMPC		 5.19×10-05
Sdhb
Sdhbtm1b(EUCOMM)Hmgu 		HET Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 HMGU
IMPC		 5.21×10-05
Neurl4
Neurl4em1(IMPC)Mbp 		HOM   Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 UC Davis
IMPC		 5.23×10-05
Ube2b
Ube2btm1b(EUCOMM)Wtsi 		HET Early adult decreased basophil cell number Basophil differential count
Hematology		 MRC Harwell
IMPC		 5.38×10-05
Cd300a
Cd300atm1b(EUCOMM)Hmgu 		HOM   Early adult decreased eosinophil cell number Eosinophil differential count
Hematology		 MRC Harwell
IMPC		 5.81×10-05
Pebp1
Pebp1em1(IMPC)Tcp 		HOM Late adult decreased eosinophil cell number Eosinophil cell count
Hematology		 TCP
IMPC		 5.94×10-05
Kcnj10
Kcnj10tm1b(KOMP)Wtsi 		HET Early adult decreased basophil cell number Basophil differential count
Hematology		 MRC Harwell
IMPC		 6.14×10-05
Susd6
Susd6tm1b(KOMP)Wtsi 		HOM Late adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MRC Harwell
IMPC		 6.30×10-05
Cib1
Cib1tm1b(EUCOMM)Hmgu 		HOM Late adult decreased eosinophil cell number Eosinophil differential count
Hematology		 MRC Harwell
IMPC		 6.75×10-05
Adss2
Adss2tm1b(EUCOMM)Wtsi 		HET Early adult decreased eosinophil cell number Eosinophil differential count
Hematology		 MRC Harwell
IMPC		 6.77×10-05
Ulk3
Ulk3em2(IMPC)Tcp 		HOM Late adult decreased neutrophil cell number Monocyte cell count
Hematology		 TCP
IMPC		 6.82×10-05
Rabggta
Rabggtatm1.1(KOMP)Vlcg 		HET Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MARC
IMPC		 6.86×10-05
Zftraf1
Zftraf1em1(IMPC)H 		HOM Early adult decreased eosinophil cell number Eosinophil differential count
Hematology		 MRC Harwell
IMPC		 6.97×10-05
Dicer1
Dicer1tm1b(EUCOMM)Wtsi 		HET Early adult decreased neutrophil cell number Neutrophil cell count
Hematology		 MRC Harwell
IMPC		 6.98×10-05
Lratd2
Lratd2em1(IMPC)Ccpcz 		HOM Early adult decreased eosinophil cell number Eosinophils
Immunophenotyping		 CCP-IMG
IMPC		 7.16×10-05
Gigyf2
Gigyf2tm1b(EUCOMM)Wtsi 		HOM Early adult decreased eosinophil cell number Eosinophil cell count
Hematology		 MRC Harwell
IMPC		 7.79×10-05
Msi2
Msi2em1(IMPC)Mbp 		HOM   Early adult decreased neutrophil cell number Neutrophil cell count
Hematology		 UC Davis
IMPC		 8.78×10-05
Tmem150b
Tmem150bem1(IMPC)Ccpcz 		HOM   Early adult decreased eosinophil cell number Eosinophils
Immunophenotyping		 CCP-IMG
IMPC		 8.81×10-05
Kdm4c
Kdm4ctm1a(KOMP)Wtsi 		HET Early adult decreased granulocyte number Granulocyte Gr1+ percentage
FACs Analysis		 HMGU
EuroPhenome		 9.65×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Immunophenotyping
Bone marrow immunophenotyping
Buffy coat peripheral blood leukocyte immunophenotyping
FACS
FACs Analysis
Haematology (GMC)
Hematology
Mesenteric Lymph Node Immunophenotyping
Spleen Immunophenotyping
Whole blood peripheral blood leukocyte immunophenotyping

 Phenotype associations stats

1.85% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased granulocyte number (73/3956)

0.59% females (21/3534) 1.49% males (53/3564)

Select a parameter    



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