Phenotype: increased granulocyte number

Definition greater than expected number of leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils

Synonyms granulocytosis
Related
Synonyms
  • Aseptic leukocyturia
  • Aseptic leukocyturia
  • Cutaneous mastocytosis
  • Cutaneous mastocytosis
  • Eosinophilia
  • Episodic eosinophilia
  • Hepatic mastocytosis
  • Hypereosinophilia
  • Increased basophil count
  • Mastocytosis
  • Pyuria
  • increased basophil cell number
  • increased eosinophil cell number
  • increased mast cell number
  • increased neutrophil cell number
  • pyuria
Show more

MP browserMP:0000322

Phenotype associations stats

1.90% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased granulocyte number (65/3413)

1.37% females (45/3276) 1.36% males (45/3320)

Select a parameter    



Gene variants with increased granulocyte number

Total number of significant genotype-phenotype associations: 119

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Bach2
Bach2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased eosinophil cell number Spleen Immunophenotyping | Eosinophils - % of CD45+ WTSI | 3i 0.0
Bach2
Bach2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased neutrophil cell number Whole blood peripheral blood leukocyte immunophenotyping | Neutrophil percentage WTSI | 3i 0.0
Cog6
Cog6tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased eosinophil cell number Mesenteric Lymph Node Immunophenotyping | Eosinophils - % of CD45+ WTSI | 3i 0.0
Cog6
Cog6tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased granulocyte number Mesenteric Lymph Node Immunophenotyping | Granulocytes - % of CD45+ WTSI | 3i 0.0
Cxcr2
Cxcr2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased granulocyte number Bone marrow immunophenotyping | Granulocytes - % of CD45+ WTSI | 3i 0.0
Cxcr2
Cxcr2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased eosinophil cell number Spleen Immunophenotyping | Eosinophils - % of CD45+ WTSI | 3i 0.0
Dph6
Dph6tm1a(KOMP)Wtsi
HOM Female Male postnatal increased granulocyte number Mesenteric Lymph Node Immunophenotyping | Granulocytes - % of CD45+ WTSI | 3i 0.0
Gmds
Gmdstm1a(KOMP)Wtsi
HOM Female Male postnatal increased granulocyte number Spleen Immunophenotyping | Granulocytes - % of CD45+ WTSI | 3i 0.0
Gmds
Gmdstm1a(KOMP)Wtsi
HOM Female Male postnatal increased neutrophil cell number Whole blood peripheral blood leukocyte immunophenotyping | Neutrophil percentage WTSI | 3i 0.0
Sik3
Sik3tm1a(EUCOMM)Hmgu
HOM Female Male postnatal increased eosinophil cell number Mesenteric Lymph Node Immunophenotyping | Eosinophils - % of CD45+ WTSI | 3i 0.0
Sik3
Sik3tm1a(EUCOMM)Hmgu
HOM Female Male postnatal increased granulocyte number Mesenteric Lymph Node Immunophenotyping | Granulocytes - % of CD45+ WTSI | 3i 0.0
Itch
Itchtm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 1.05E-24
Pou2af1
Pou2af1tm1b(KOMP)Wtsi
HOM Female Male postnatal increased neutrophil cell number Hematology | Neutrophil differential count UC Davis | IMPC 3.91E-24
Lrrk1
Lrrk1tm1b(KOMP)Wtsi
HOM Female Male postnatal increased neutrophil cell number Hematology | Neutrophil differential count MRC Harwell | IMPC 1.06E-22
Lta
Ltatm1.1(KOMP)Vlcg
HOM Female Male postnatal increased neutrophil cell number Hematology | Neutrophil cell count UC Davis | IMPC 2.26E-19
Fbxo15
Fbxo15em1(IMPC)Marc
HOM Male postnatal increased neutrophil cell number Hematology | Neutrophil differential count MARC | IMPC 1.53E-15
Emc10
Emc10tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 8.81E-13
Usp15
Usp15em1(IMPC)Marc
HOM Female postnatal increased eosinophil cell number Hematology | Eosinophil cell count MARC | IMPC 2.49E-11
Spns2
Spns2tm1a(KOMP)Wtsi
HOM Female postnatal increased granulocyte number Buffy coat peripheral blood leukocyte immunophenotyping | Granulocyte Gr1+ percentage WTSI | 3i 7.69E-11
Spns2
Spns2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased granulocyte number Buffy coat peripheral blood leukocyte immunophenotyping | Granulocyte Gr1+ percentage WTSI | 3i 5.76E-10
Hmgn2
Hmgn2tm1b(KOMP)Wtsi
HET Male postnatal increased neutrophil cell number Hematology | Neutrophil differential count UC Davis | IMPC 4.33E-9
Emc10
Emc10tm1b(EUCOMM)Wtsi
HOM Female postnatal increased eosinophil cell number Hematology | Eosinophil differential count MRC Harwell | IMPC 2.21E-8
Aars2
Aars2tm1(KOMP)Wtsi
HET Female Male postnatal increased basophil cell number Hematology | Basophil differential count MARC | IMPC 9.31E-8
Cxcr2
Cxcr2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased neutrophil cell number Whole blood peripheral blood leukocyte immunophenotyping | Neutrophil number WTSI | 3i 1.0E-7
Il10ra
Il10ratm1b(KOMP)Wtsi
HOM Female Male postnatal increased neutrophil cell number Hematology | Neutrophil differential count ICS | IMPC 1.2E-7
Cdc42
Cdc42tm1b(EUCOMM)Hmgu
HET Male postnatal increased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 1.45E-7
Tnfrsf1a
Tnfrsf1atm2b(EUCOMM)Wtsi
HOM Female Male postnatal increased eosinophil cell number Hematology | Eosinophil cell count MRC Harwell | IMPC 1.88E-7
Ikzf3
Ikzf3tm1(KOMP)Vlcg
HOM Female Male postnatal increased neutrophil cell number Hematology | Neutrophil differential count RBRC | IMPC 3.41E-7
Lyn
Lyntm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased neutrophil cell number Hematology | Neutrophil differential count MRC Harwell | IMPC 6.15E-7
Tnfrsf1a
Tnfrsf1atm2b(EUCOMM)Wtsi
HOM Female Male postnatal increased basophil cell number Hematology | Basophil cell count MRC Harwell | IMPC 9.76E-7
Sik3
Sik3tm1a(EUCOMM)Hmgu
HOM Female Male postnatal increased neutrophil cell number Whole blood peripheral blood leukocyte immunophenotyping | Neutrophil percentage WTSI | 3i 1.0E-6
Camsap3
Camsap3tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased neutrophil cell number Whole blood peripheral blood leukocyte immunophenotyping | Neutrophil number WTSI | 3i 2.3E-6
Zswim1
Zswim1tm1b(KOMP)Mbp
HOM Female postnatal increased eosinophil cell number Hematology | Eosinophil differential count MARC | IMPC 2.41E-6
Atn1
Atn1tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased neutrophil cell number Hematology | Neutrophil differential count MRC Harwell | IMPC 5.05E-6
Herc1
Herc1em3(IMPC)Wtsi
HOM Female Male postnatal increased eosinophil cell number Whole blood peripheral blood leukocyte immunophenotyping | Eosinophil number WTSI | 3i 5.4E-6
Edc4
Edc4tm1a(EUCOMM)Wtsi
HET Male postnatal increased granulocyte number Buffy coat peripheral blood leukocyte immunophenotyping | Granulocyte Gr1+ percentage WTSI | 3i 5.73E-6
Setx
Setxtm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased neutrophil cell number Hematology | Neutrophil differential count ICS | IMPC 5.76E-6
Cd19
Cd19em2(IMPC)Ics
HOM Female Male postnatal increased neutrophil cell number Hematology | Neutrophil differential count ICS | IMPC 6.06E-6
Hmgb1
Hmgb1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased granulocyte number Buffy coat peripheral blood leukocyte immunophenotyping | Granulocyte Gr1+ percentage WTSI | 3i 6.78E-6
Itprid1
Itprid1em1(IMPC)Marc
HOM Male postnatal increased neutrophil cell number Hematology | Neutrophil differential count MARC | IMPC 7.34E-6
Bud23
Bud23em2(IMPC)H
HET Female postnatal increased neutrophil cell number Hematology | Neutrophil differential count MRC Harwell | IMPC 1.16E-5
Fbxl19
Fbxl19tm1b(EUCOMM)Wtsi
HET Male postnatal increased basophil cell number Hematology | Basophil cell count MARC | IMPC 1.26E-5
Gpr65
Gpr65tm1b(KOMP)Wtsi
HOM Female Male postnatal increased neutrophil cell number Hematology | Neutrophil differential count UC Davis | IMPC 1.3E-5
Stambp
Stambptm1b(EUCOMM)Hmgu
HET Male postnatal increased basophil cell number Hematology | Basophil cell count MRC Harwell | IMPC 1.34E-5
Mfrp
Mfrptm2a(KOMP)Wtsi
HOM Female postnatal increased granulocyte number Buffy coat peripheral blood leukocyte immunophenotyping | Granulocyte Gr1+ percentage WTSI | 3i 1.45E-5
Stat1
Stat1tm2b(EUCOMM)Wtsi
HOM Female Male postnatal increased basophil cell number Hematology | Basophil differential count ICS | IMPC 1.45E-5
Slc16a3
Slc16a3tm1b(EUCOMM)Wtsi
HOM Female postnatal increased eosinophil cell number Hematology | Eosinophil cell count MRC Harwell | IMPC 1.59E-5
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased eosinophil cell number Whole blood peripheral blood leukocyte immunophenotyping | Eosinophil number WTSI | 3i 2.26E-5
Mkrn2
Mkrn2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased eosinophil cell number Whole blood peripheral blood leukocyte immunophenotyping | Eosinophil number WTSI | 3i 2.26E-5
Bcl3
Bcl3tm1b(EUCOMM)Wtsi
HOM Female postnatal increased neutrophil cell number Hematology | Neutrophil differential count MRC Harwell | IMPC 2.28E-5
Lepr
Leprtm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased neutrophil cell number Hematology | Neutrophil differential count MRC Harwell | IMPC 2.28E-5
Lrrc3
Lrrc3tm1b(EUCOMM)Hmgu
HOM Female postnatal increased neutrophil cell number Hematology | Neutrophil differential count ICS | IMPC 2.4E-5
Duoxa2
Duoxa2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased neutrophil cell number Whole blood peripheral blood leukocyte immunophenotyping | Neutrophil percentage WTSI | 3i 2.42E-5
Irgm1
Irgm1em1(IMPC)Wtsi
HOM Female Male postnatal increased neutrophil cell number Whole blood peripheral blood leukocyte immunophenotyping | Neutrophil percentage WTSI | 3i 2.42E-5
Itch
Itchtm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased eosinophil cell number Hematology | Eosinophil differential count MRC Harwell | IMPC 2.79E-5
Zswim1
Zswim1tm1b(KOMP)Mbp
HOM Female postnatal increased basophil cell number Hematology | Basophil differential count MARC | IMPC 2.93E-5
Ankrd27
Ankrd27tm1b(EUCOMM)Hmgu
HOM Female postnatal increased neutrophil cell number Hematology | Neutrophil differential count ICS | IMPC 3.06E-5
Lpcat1
Lpcat1tm1b(EUCOMM)Hmgu
HOM Female postnatal increased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 3.26E-5
Stat1
Stat1tm2b(EUCOMM)Wtsi
HOM Female Male postnatal increased neutrophil cell number Hematology | Neutrophil differential count ICS | IMPC 3.6E-5
Slc7a8
Slc7a8tm2b(EUCOMM)Hmgu
HET Female postnatal increased neutrophil cell number Hematology | Neutrophil differential count MRC Harwell | IMPC 3.67E-5
Dyrk1b
Dyrk1btm1b(EUCOMM)Wtsi
HET Female Male postnatal increased neutrophil cell number Hematology | Neutrophil differential count ICS | IMPC 3.99E-5
Vim
Vimtm2Cba
HOM Male postnatal increased granulocyte number Haematology (GMC) | Absolute number of granulocytes HMGU | EuroPhenome 4.04E-5
Vrk1
Vrk1em1(IMPC)Mbp
HET Male postnatal increased basophil cell number Hematology | Basophil differential count UC Davis | IMPC 4.16E-5
H2-Eb1
H2-Eb1tm1a(KOMP)Wtsi
HOM Male postnatal increased granulocyte number Buffy coat peripheral blood leukocyte immunophenotyping | Granulocyte Gr1+ percentage WTSI | 3i 4.34E-5
Dlgap2
Dlgap2em1(IMPC)Mhzh
HOM Male postnatal increased neutrophil cell number Hematology | Neutrophil differential count MARC | IMPC 4.72E-5
Arhgef18
Arhgef18tm1b(KOMP)Mbp
HET Female Male postnatal increased basophil cell number Hematology | Basophil cell count MRC Harwell | IMPC 4.83E-5
Mxra7
Mxra7tm1b(EUCOMM)Wtsi
HOM Female postnatal increased neutrophil cell number Hematology | Neutrophil differential count MRC Harwell | IMPC 6.23E-5
Boc
Boctm1b(KOMP)Wtsi
HOM Female Male postnatal increased basophil cell number Hematology | Basophil cell count MRC Harwell | IMPC 6.8E-5
Fbxo28
Fbxo28em1(IMPC)Mhzh
HET Male postnatal increased eosinophil cell number Hematology | Eosinophil cell count MARC | IMPC 6.9E-5
Boc
Boctm1b(KOMP)Wtsi
HOM Female Male postnatal increased eosinophil cell number Hematology | Eosinophil cell count MRC Harwell | IMPC 7.13E-5
Nrbp2
Nrbp2tm2b(EUCOMM)Wtsi
HOM Male postnatal increased eosinophil cell number Hematology | Eosinophil differential count MRC Harwell | IMPC 7.47E-5
Gcsh
Gcshem1(IMPC)H
HET Female Male postnatal increased basophil cell number Hematology | Basophil differential count MRC Harwell | IMPC 7.52E-5
Rtraf
Rtraftm1b(EUCOMM)Hmgu
HET Female Male postnatal increased eosinophil cell number Hematology | Eosinophil cell count MRC Harwell | IMPC 7.76E-5
Nfix
Nfixem3(IMPC)H
HET Female postnatal increased neutrophil cell number Hematology | Neutrophil differential count MRC Harwell | IMPC 8.0E-5
Fbxo36
Fbxo36tm1b(KOMP)Wtsi
HOM Female Male postnatal increased neutrophil cell number Hematology | Neutrophil differential count MARC | IMPC 8.87E-5
Ncf2
Ncf2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased neutrophil cell number Whole blood peripheral blood leukocyte immunophenotyping | Neutrophil percentage WTSI | 3i 9.41E-5
Mysm1
Mysm1tm1a(KOMP)Wtsi
HOM Female postnatal increased granulocyte number FACs Analysis | Granulocyte Gr1+ percentage HMGU | MGP 9.7E-5
Fbxo43
Fbxo43em1(IMPC)Marc
HOM Female Male postnatal increased basophil cell number Hematology | Basophil differential count MARC | IMPC 9.87E-5
5330417C22Rik
5330417C22Riktm1b(EUCOMM)Hmgu
HET Female Male postnatal increased neutrophil cell number Hematology | Neutrophil differential count ICS | IMPC 9.98E-5

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Images

  • Spns2tm1b(KOMP)Wtsi
    increased monocyte cell number, increased granulocyte number, HOM, Female, WTSI
  • Spns2tm1b(KOMP)Wtsi
    increased monocyte cell number, increased granulocyte number, HOM, Female, WTSI