Phenotype: decreased neutrophil cell number

Definition reduced count of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes

Synonyms
  • reduced neutrophil count
  • reduced neutrophil count
  • decreased neutrophil number
  • decreased neutrophil number
  • reduced neutrophil cell number
  • neutropenia
  • decreased neutrophil count
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Related
Synonyms
  • Chronic neutropenia
  • Chronic neutropenia
  • Chronic neutropenia in myeloid maturation arrest in bone marrow
  • Chronic neutropenia in myeloid maturation arrest in bone marrow
  • Cyclic neutropenia
  • Cyclic neutropenia in myeloid maturation arrest in bone marrow
  • Infection associated neutropenia
  • Neutropenia in presence of anti-neutropil antibodies
  • Transient neutropenia
  • absent neutrophils
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MP browserMP:0000222

Phenotype associations stats

1.99% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased neutrophil cell number (52/2616)

0.87% females (22/2521) 1.90% males (48/2526)

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Gene variants with decreased neutrophil cell number

Total number of significant genotype-phenotype associations: 74

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Dlg4
Dlg4tm1e(EUCOMM)Wtsi
HOM Female Male postnatal decreased neutrophil cell number Whole blood peripheral blood leukocyte immunophenotyping | Neutrophil percentage WTSI | 3i 0.0
Tmem127
Tmem127tm1(KOMP)Wtsi
HOM Female Male postnatal decreased neutrophil cell number Whole blood peripheral blood leukocyte immunophenotyping | Neutrophil percentage WTSI | 3i 0.0
Synj1
Synj1tm1b(EUCOMM)Wtsi
HET Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MRC Harwell | IMPC 3.27E-12
Hnrnph1
Hnrnph1tm1b(KOMP)Wtsi
HET Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MARC | IMPC 2.19E-10
Lypd2
Lypd2em1(IMPC)Marc
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MARC | IMPC 6.99E-9
Gfi1b
Gfi1btm1b(EUCOMM)Hmgu
HET Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 8.22E-9
Pkn1
Pkn1tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 1.12E-8
Itgae
Itgaetm1b(EUCOMM)Wtsi
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 1.78E-8
Pfkfb2
Pfkfb2tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MARC | IMPC 1.86E-8
Bbof1
Bbof1em1(IMPC)Marc
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MARC | IMPC 3.14E-8
Atl2
Atl2tm2b(EUCOMM)Hmgu
HET Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MRC Harwell | IMPC 3.62E-8
Hapln4
Hapln4em1(IMPC)Wtsi
HOM Female Male postnatal decreased neutrophil cell number Whole blood peripheral blood leukocyte immunophenotyping | Neutrophil percentage WTSI | 3i 1.0E-7
Fntb
Fntbtm1b(EUCOMM)Hmgu
HET Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MARC | IMPC 1.03E-7
Usp47
Usp47tm1b(EUCOMM)Wtsi
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MARC | IMPC 2.47E-7
Cpa1
Cpa1em1(IMPC)Marc
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MARC | IMPC 3.37E-7
Ppm1j
Ppm1jtm1b(KOMP)Wtsi
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MARC | IMPC 5.27E-7
Fbxw13
Fbxw13em2(IMPC)Marc
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MARC | IMPC 6.98E-7
Dicer1
Dicer1tm1b(EUCOMM)Wtsi
HET Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 1.11E-6
Cxcl9
Cxcl9tm1b(EUCOMM)Wtsi
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 1.12E-6
Micu1
Micu1tm1bNarl
HET Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 1.49E-6
Gprin1
Gprin1em1(IMPC)H
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MRC Harwell | IMPC 1.85E-6
Ampd1
Ampd1tm1b(KOMP)Wtsi
HET Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count TCP | IMPC 2.08E-6
Clec4a4
Clec4a4tm1(KOMP)Vlcg
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count UC Davis | IMPC 2.45E-6
Flnb
Flnbtm1b(KOMP)Wtsi
HET Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 2.71E-6
Avp
Avptm1b(EUCOMM)Wtsi
HET Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 2.88E-6
Plac9a
Plac9atm1b(EUCOMM)Hmgu
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 3.76E-6
Carm1
Carm1tm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MARC | IMPC 3.86E-6
Usp45
Usp45em1(IMPC)H
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MRC Harwell | IMPC 5.42E-6
Cps1
Cps1em1(IMPC)H
HET Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MRC Harwell | IMPC 6.75E-6
Tardbp
Tardbptm1b(EUCOMM)Wtsi
HET Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MRC Harwell | IMPC 1.09E-5
Zfp420
Zfp420tm1b(EUCOMM)Hmgu
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 1.18E-5
Nfix
Nfixem3(IMPC)H
HET Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 1.25E-5
Speg
Spegtm1b(KOMP)Wtsi
HET Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MARC | IMPC 1.54E-5
Ube2d3
Ube2d3tm1b(EUCOMM)Hmgu
HET Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MARC | IMPC 1.91E-5
Hpf1
Hpf1em1(IMPC)Wtsi
HOM Female Male postnatal decreased neutrophil cell number Whole blood peripheral blood leukocyte immunophenotyping | Neutrophil percentage WTSI | 3i 2.12E-5
Cntf
Cntftm1b(KOMP)Wtsi
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count UC Davis | IMPC 2.5E-5
Ube2z
Ube2zem1(IMPC)Marc
HET Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MARC | IMPC 2.62E-5
Adamts16
Adamts16em1(IMPC)H
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 2.69E-5
Usp32
Usp32em1(IMPC)Mhzh
HET Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MARC | IMPC 2.73E-5
Sacs
Sacsem1(IMPC)Tcp
HET Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count TCP | IMPC 3.06E-5
C2cd4a
C2cd4aem1(IMPC)H
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 3.16E-5
Lpcat1
Lpcat1tm1b(EUCOMM)Hmgu
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 3.26E-5
Fbxo10
Fbxo10tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MARC | IMPC 3.39E-5
Glra2
Glra2tm1b(KOMP)Wtsi
HEM Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 3.91E-5
Efemp1
Efemp1tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count UC Davis | IMPC 4.92E-5
Frrs1l
Frrs1ltm1b(EUCOMM)Hmgu
HET Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 5.25E-5
Mxra7
Mxra7tm1b(EUCOMM)Wtsi
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MRC Harwell | IMPC 6.23E-5
Mc1r
Mc1rtm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count UC Davis | IMPC 7.89E-5
Aldh3a1
Aldh3a1tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 8.04E-5
Cacna1b
Cacna1btm1b(KOMP)Wtsi
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MRC Harwell | IMPC 8.73E-5
Angptl4
Angptl4tm1b(EUCOMM)Hmgu
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 9.68E-5
Pak1
Pak1tm1b(EUCOMM)Hmgu
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 9.73E-5

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