Phenotype: decreased neutrophil cell number

Definition reduced count of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes

Synonyms
  • reduced neutrophil count
  • reduced neutrophil count
  • decreased neutrophil number
  • decreased neutrophil number
  • reduced neutrophil cell number
  • neutropenia
  • decreased neutrophil count
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Related
Synonyms
absent neutrophils

MP browserMP:0000222

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Phenotype associations stats

3.03% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased neutrophil cell number (46/1519)

1.58% females (24/1515) 3.05% males (46/1508)

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Gene variants with decreased neutrophil cell number

Total number of significant genotype-phenotype associations: 72

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Synj1
Synj1tm1b(EUCOMM)Wtsi
HET Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 1.39E-17
Gfi1b
Gfi1btm1b(EUCOMM)Hmgu
HET Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 8.22E-9
Hnrnph1
Hnrnph1tm1b(KOMP)Wtsi
HET Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MARC | IMPC 8.39E-9
Esr2
Esr2em1Marc
HOM Female Male postnatal decreased neutrophil cell number Hematology | Monocyte cell count MARC | IMPC 9.48E-9
Pkn1
Pkn1tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 1.12E-8
Itgae
Itgaetm1b(EUCOMM)Wtsi
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 1.15E-8
Pfkfb2
Pfkfb2tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MARC | IMPC 2.02E-8
Atl2
Atl2tm2b(EUCOMM)Hmgu
HET Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MRC Harwell | IMPC 4.02E-8
Bbof1
Bbof1em1Marc
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MARC | IMPC 5.37E-8
Ccdc83
Ccdc83em1Marc
HOM Female Male postnatal decreased neutrophil cell number Hematology | Monocyte cell count MARC | IMPC 6.96E-8
Lypd2
Lypd2em1Marc
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MARC | IMPC 7.3E-8
Micu1
Micu1tm1bNarl
HET Female Male postnatal decreased neutrophil cell number Hematology | Monocyte cell count MRC Harwell | IMPC 8.66E-8
Micu1
Micu1tm1bNarl
HOM Female Male postnatal decreased neutrophil cell number Hematology | Monocyte cell count MRC Harwell | IMPC 8.66E-8
Fntb
Fntbtm1b(EUCOMM)Hmgu
HET Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MARC | IMPC 2.56E-7
Cpa1
Cpa1em1Marc
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MARC | IMPC 2.82E-7
Usp47
Usp47tm1b(EUCOMM)Wtsi
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MARC | IMPC 3.36E-7
Elmod1
Elmod1tm1b(EUCOMM)Hmgu
HOM Male postnatal decreased neutrophil cell number Hematology | Monocyte cell count MRC Harwell | IMPC 4.29E-7
Fbxw13
Fbxw13em2Marc
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MARC | IMPC 5.49E-7
Dicer1
Dicer1tm1b(EUCOMM)Wtsi
HET Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 5.65E-7
Clec4a4
Clec4a4tm1(KOMP)Vlcg
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count UC Davis | IMPC 1.03E-6
Cxcl9
Cxcl9tm1b(EUCOMM)Wtsi
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 1.12E-6
Ppm1j
Ppm1jtm1b(KOMP)Wtsi
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MARC | IMPC 1.19E-6
Flnb
Flnbtm1b(KOMP)Wtsi
HET Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 2.69E-6
Avp
Avptm1b(EUCOMM)Wtsi
HET Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 2.88E-6
Plac9a
Plac9atm1b(EUCOMM)Hmgu
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 3.74E-6
Usp45
Usp45em2H
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MRC Harwell | IMPC 5.96E-6
Speg
Spegtm1b(KOMP)Wtsi
HET Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MARC | IMPC 8.69E-6
Ampd1
Ampd1tm1b(KOMP)Wtsi
HET Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count TCP | IMPC 1.7E-5
Usp32
Usp32em1Mhzh
HET Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MARC | IMPC 2.04E-5
Glra2
Glra2tm1b(KOMP)Wtsi
HEM Male postnatal decreased neutrophil cell number Hematology | Monocyte cell count MRC Harwell | IMPC 2.08E-5
Mc1r
Mc1rtm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count UC Davis | IMPC 2.54E-5
Tardbp
Tardbptm1b(EUCOMM)Wtsi
HET Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MRC Harwell | IMPC 2.78E-5
Ube2d3
Ube2d3tm1b(EUCOMM)Hmgu
HET Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MARC | IMPC 3.24E-5
Fbxo10
Fbxo10tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MARC | IMPC 3.28E-5
Efemp1
Efemp1tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count UC Davis | IMPC 4.49E-5
Carm1
Carm1tm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MARC | IMPC 5.01E-5
Frrs1l
Frrs1ltm1b(EUCOMM)Hmgu
HET Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 5.25E-5
Ppp2r1b
Ppp2r1btm1b(EUCOMM)Wtsi
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MARC | IMPC 5.37E-5
Hnrnpd
Hnrnpdtm1b(KOMP)Wtsi
HET Female Male postnatal decreased neutrophil cell number Hematology | Monocyte cell count MARC | IMPC 5.56E-5
Mxra7
Mxra7tm1b(EUCOMM)Wtsi
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MRC Harwell | IMPC 6.23E-5
Ifi204
Ifi204tm1b(KOMP)Wtsi
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count UC Davis | IMPC 6.79E-5
Trim37
Trim37em1Marc
HOM Female Male postnatal decreased neutrophil cell number Hematology | Monocyte cell count MARC | IMPC 7.5E-5
Aldh3a1
Aldh3a1tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 8.04E-5
Eftud2
Eftud2tm1b(KOMP)Wtsi
HET Female Male postnatal decreased neutrophil cell number Hematology | Monocyte cell count ICS | IMPC 8.45E-5
Cacna1b
Cacna1btm1b(KOMP)Wtsi
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MRC Harwell | IMPC 8.73E-5
Angptl4
Angptl4tm1b(EUCOMM)Hmgu
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 9.68E-5
Pak1
Pak1tm1b(EUCOMM)Hmgu
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 9.73E-5

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