Phenotype: decreased neutrophil cell number

Definition reduced count of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes

Synonyms
  • reduced neutrophil count
  • reduced neutrophil count
  • decreased neutrophil number
  • decreased neutrophil number
  • reduced neutrophil cell number
  • neutropenia
  • decreased neutrophil count
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Related
Synonyms
  • Cyclic neutropenia
  • Cyclic neutropenia
  • absent neutrophils
  • absent neutrophils
  • Congenital neutropenia
  • Autoimmune neutropenia
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Phenotype associations stats

3.20% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased neutrophil cell number (59/1843)

1.80% females (32/1782) 3.31% males (59/1782)

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Gene variants with decreased neutrophil cell number

Total number of significant genotype-phenotype associations: 91

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Synj1
Synj1tm1b(EUCOMM)Wtsi
HET Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MRC Harwell | IMPC 3.47E-12
Gfi1b
Gfi1btm1b(EUCOMM)Hmgu
HET Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 8.22E-9
Hnrnph1
Hnrnph1tm1b(KOMP)Wtsi
HET Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MARC | IMPC 8.39E-9
Esr2
Esr2em1(IMPC)Marc
HOM Female Male postnatal decreased neutrophil cell number Hematology | Monocyte cell count MARC | IMPC 9.61E-9
Pkn1
Pkn1tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 1.12E-8
Itgae
Itgaetm1b(EUCOMM)Wtsi
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 1.78E-8
Pfkfb2
Pfkfb2tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MARC | IMPC 2.02E-8
Atl2
Atl2tm2b(EUCOMM)Hmgu
HET Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MRC Harwell | IMPC 3.97E-8
Bbof1
Bbof1em1(IMPC)Marc
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MARC | IMPC 5.37E-8
Ccdc83
Ccdc83em1(IMPC)Marc
HOM Female Male postnatal decreased neutrophil cell number Hematology | Monocyte cell count MARC | IMPC 5.96E-8
Lypd2
Lypd2em1(IMPC)Marc
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MARC | IMPC 7.3E-8
Micu1
Micu1tm1bNarl
HET Female Male postnatal decreased neutrophil cell number Hematology | Monocyte cell count MRC Harwell | IMPC 8.66E-8
Fntb
Fntbtm1b(EUCOMM)Hmgu
HET Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MARC | IMPC 2.56E-7
Cpa1
Cpa1em1(IMPC)Marc
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MARC | IMPC 2.82E-7
Usp47
Usp47tm1b(EUCOMM)Wtsi
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MARC | IMPC 3.36E-7
Elmod1
Elmod1tm1b(EUCOMM)Hmgu
HOM Male postnatal decreased neutrophil cell number Hematology | Monocyte cell count MRC Harwell | IMPC 4.29E-7
Fbxw13
Fbxw13em2(IMPC)Marc
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MARC | IMPC 5.49E-7
Clec4a4
Clec4a4tm1(KOMP)Vlcg
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count UC Davis | IMPC 5.7E-7
Cps1
Cps1em1(IMPC)H
HET Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MRC Harwell | IMPC 5.96E-7
Gja10
Gja10em2(IMPC)Mbp
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count UC Davis | IMPC 9.09E-7
Ckb
Ckbtm1.1(KOMP)Wtsi
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count UC Davis | IMPC 9.18E-7
Dicer1
Dicer1tm1b(EUCOMM)Wtsi
HET Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 1.11E-6
Cxcl9
Cxcl9tm1b(EUCOMM)Wtsi
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 1.12E-6
Ppm1j
Ppm1jtm1b(KOMP)Wtsi
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MARC | IMPC 1.19E-6
Rbm22
Rbm22em1(IMPC)Mbp
HET Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count UC Davis | IMPC 1.45E-6
Flnb
Flnbtm1b(KOMP)Wtsi
HET Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 2.71E-6
Avp
Avptm1b(EUCOMM)Wtsi
HET Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 2.88E-6
Plac9a
Plac9atm1b(EUCOMM)Hmgu
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 3.74E-6
Zfp420
Zfp420tm1b(EUCOMM)Hmgu
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 5.03E-6
Usp45
Usp45em2(IMPC)H
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MRC Harwell | IMPC 5.87E-6
Prkab1
Prkab1em2(IMPC)Mbp
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count UC Davis | IMPC 6.6E-6
Carm1
Carm1tm1b(EUCOMM)Hmgu
HET Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MARC | IMPC 7.16E-6
Speg
Spegtm1b(KOMP)Wtsi
HET Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MARC | IMPC 8.69E-6
Mc1r
Mc1rtm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count UC Davis | IMPC 1.02E-5
Ampd1
Ampd1tm1b(KOMP)Wtsi
HET Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count TCP | IMPC 1.7E-5
Usp32
Usp32em1(IMPC)Mhzh
HET Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MARC | IMPC 2.04E-5
Glra2
Glra2tm1b(KOMP)Wtsi
HEM Male postnatal decreased neutrophil cell number Hematology | Monocyte cell count MRC Harwell | IMPC 2.08E-5
Efemp1
Efemp1tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count UC Davis | IMPC 2.21E-5
Ptgdr
Ptgdrtm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count UC Davis | IMPC 2.48E-5
Adamts16
Adamts16em1(IMPC)H
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 2.75E-5
Tardbp
Tardbptm1b(EUCOMM)Wtsi
HET Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MRC Harwell | IMPC 2.85E-5
Nr1d2
Nr1d2em1(IMPC)Mbp
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count UC Davis | IMPC 2.86E-5
Srpk3
Srpk3tm1b(KOMP)Wtsi
HEM Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count UC Davis | IMPC 2.87E-5
Ube2d3
Ube2d3tm1b(EUCOMM)Hmgu
HET Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MARC | IMPC 3.24E-5
Fbxo10
Fbxo10tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MARC | IMPC 3.28E-5
C2cd4a
C2cd4aem1(IMPC)H
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 3.32E-5
Frrs1l
Frrs1ltm1b(EUCOMM)Hmgu
HET Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 5.25E-5
Ppp2r1b
Ppp2r1btm1b(EUCOMM)Wtsi
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MARC | IMPC 5.37E-5
Hnrnpd
Hnrnpdtm1b(KOMP)Wtsi
HET Female Male postnatal decreased neutrophil cell number Hematology | Monocyte cell count MARC | IMPC 5.56E-5
Mxra7
Mxra7tm1b(EUCOMM)Wtsi
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MRC Harwell | IMPC 6.23E-5
Trim37
Trim37em1(IMPC)Marc
HOM Female Male postnatal decreased neutrophil cell number Hematology | Monocyte cell count MARC | IMPC 6.65E-5
Aldh3a1
Aldh3a1tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 8.04E-5
Cacna1b
Cacna1btm1b(KOMP)Wtsi
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MRC Harwell | IMPC 8.73E-5
Rab4a
Rab4atm1b(EUCOMM)Hmgu
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil differential count MRC Harwell | IMPC 8.95E-5
Endou
Endoutm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count UC Davis | IMPC 9.03E-5
Cntf
Cntftm1b(KOMP)Wtsi
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count UC Davis | IMPC 9.26E-5
Eftud2
Eftud2tm1b(KOMP)Wtsi
HET Female Male postnatal decreased neutrophil cell number Hematology | Monocyte cell count ICS | IMPC 9.47E-5
Angptl4
Angptl4tm1b(EUCOMM)Hmgu
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 9.68E-5
Pak1
Pak1tm1b(EUCOMM)Hmgu
HOM Male postnatal decreased neutrophil cell number Hematology | Neutrophil cell count MRC Harwell | IMPC 9.73E-5

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