Phenotype: increased circulating calcium level

Definition abnormally high concentration of calcium ions in the circulating blood

Synonyms
  • hypercalcemia
  • hypercalcemia
  • increased circulating calcium
  • increased circulating calcium
  • hypercalcaemia
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Related
Synonyms
Infantile hypercalcemia

MP browserMP:0000194

Phenotype associations stats

1.02% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased circulating calcium level (43/4220)

0.91% females (38/4186) 0.86% males (36/4196)

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Gene variants with increased circulating calcium level

Total number of significant genotype-phenotype associations: 74

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Slc25a4
Slc25a4tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium WTSI | IMPC 8.69E-44
Gna11
Gna11tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium MRC Harwell | MGP 9.78E-33
Slc12a1
Slc12a1urehr3
HOM Female Male postnatal increased circulating calcium level Clinical chemistry (GMC) | Calcium HMGU | EuroPhenome 2.41E-9
Txnip
Txniptm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium MRC Harwell | IMPC 2.42E-9
Tmem203
Tmem203em1(IMPC)H
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium MRC Harwell | IMPC 1.2E-8
Gys2
Gys2tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium WTSI | EuroPhenome 1.82E-8
Kdm4c
Kdm4ctm1a(KOMP)Wtsi
HET Male postnatal increased circulating calcium level Clinical Chemistry | Calcium HMGU | EuroPhenome 2.92E-8
Wdr37
Wdr37tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium WTSI | IMPC 7.51E-8
Tm9sf4
Tm9sf4tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium WTSI | IMPC 1.81E-7
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium WTSI | IMPC 1.89E-7
Grhl3
Grhl3tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium ICS | MGP 2.84E-7
Gpr101
Gpr101tm1b(KOMP)Mbp
HEM Male postnatal increased circulating calcium level Clinical Chemistry | Calcium ICS | IMPC 3.37E-7
Cxcr2
Cxcr2tm1a(EUCOMM)Wtsi
HOM Female postnatal increased circulating calcium level Clinical Chemistry | Calcium WTSI | IMPC 4.95E-7
Slitrk4
Slitrk4tm1b(KOMP)Wtsi
HEM Male postnatal increased circulating calcium level Clinical Chemistry | Calcium WTSI | IMPC 1.23E-6
Itch
Itchtm1b(EUCOMM)Hmgu
HOM Female postnatal increased circulating calcium level Clinical Chemistry | Calcium MRC Harwell | IMPC 1.98E-6
Eftud2
Eftud2tm1b(KOMP)Wtsi
HET Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium ICS | IMPC 2.54E-6
Mrap2
Mrap2tm1a(EUCOMM)Wtsi
HOM Male postnatal increased circulating calcium level Clinical Chemistry | Calcium WTSI | IMPC 4.16E-6
Ucn3
Ucn3tm1.1(KOMP)Vlcg
HOM Female postnatal increased circulating calcium level Clinical Chemistry | Calcium UC Davis | IMPC 5.57E-6
Dsg1c
Dsg1cem1(IMPC)Mbp
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium UC Davis | IMPC 6.57E-6
Ttc39a
Ttc39atm1b(KOMP)Mbp
HOM Female postnatal increased circulating calcium level Clinical Chemistry | Calcium ICS | IMPC 7.91E-6
Rxfp2
Rxfp2tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium HMGU | IMPC 1.27E-5
Ndfip2
Ndfip2tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium HMGU | IMPC 1.38E-5
1500011B03Rik
1500011B03Riktm2(KOMP)Wtsi
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium WTSI | IMPC 2.26E-5
Prss52
Prss52tm2a(KOMP)Wtsi
HOM Female postnatal increased circulating calcium level Clinical Chemistry | Calcium WTSI | IMPC 2.31E-5
Arhgef7
Arhgef7tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium WTSI | IMPC 2.61E-5
Ptdss1
Ptdss1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium ICS | IMPC 2.63E-5
Aldh16a1
Aldh16a1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium WTSI | IMPC 2.95E-5
Itga8
Itga8tm1b(KOMP)Wtsi
HET Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium JAX | IMPC 3.2E-5
Tedc1
Tedc1em1(IMPC)Tcp
HET Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium TCP | IMPC 3.81E-5
Suv39h2
Suv39h2em1(IMPC)Marc
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium MARC | IMPC 4.61E-5
Lonrf3
Lonrf3tm1a(KOMP)Wtsi
HOM Female postnatal increased circulating calcium level Clinical Chemistry | Calcium WTSI | IMPC 4.72E-5
Syt1
Syt1tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium WTSI | IMPC 4.76E-5
Fyn
Fyntm1a(EUCOMM)Wtsi
HET Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium WTSI | IMPC 4.81E-5
Rnf144b
Rnf144btm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium ICS | IMPC 4.89E-5
Pdpn
Pdpntm1b(EUCOMM)Wtsi
HET Female postnatal increased circulating calcium level Clinical Chemistry | Calcium MRC Harwell | IMPC 5.52E-5
Fam234b
Fam234btm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium HMGU | EuroPhenome 6.4E-5
Lrrk1
Lrrk1tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium MRC Harwell | IMPC 6.51E-5
Ninj2
Ninj2tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium WTSI | IMPC 6.72E-5
Myo7a
Myo7atm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium WTSI | IMPC 7.46E-5
Tmem68
Tmem68tm1a(EUCOMM)Wtsi
HOM Male postnatal increased circulating calcium level Clinical Chemistry | Calcium ICS | MGP 7.51E-5
Smdt1
Smdt1tm1b(EUCOMM)Wtsi
HET Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium BCM | IMPC 7.87E-5
Mta1
Mta1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium WTSI | EuroPhenome 9.38E-5
Aqp3
Aqp3tm2b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium MRC Harwell | IMPC 9.4E-5

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