Phenotype: increased circulating calcium level

Definition abnormally high concentration of calcium ions in the circulating blood

Synonyms
  • hypercalcemia
  • hypercalcemia
  • increased circulating calcium
  • increased circulating calcium

MP browserMP:0000194

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Phenotype associations stats

1.11% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased circulating calcium level (36/3230)

0.93% females (30/3219) 0.94% males (30/3206)

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Gene variants with increased circulating calcium level

Total number of significant genotype-phenotype associations: 61

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Slc25a4
Slc25a4tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium WTSI | IMPC 1.6E-41
Gna11
Gna11tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium MRC Harwell | MGP 9.78E-33
Lepr
Leprtm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium MRC Harwell | IMPC 2.31E-27
Eftud2
Eftud2tm1b(KOMP)Wtsi
HET Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium ICS | IMPC 2.69E-12
Duoxa2
Duoxa2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium WTSI | IMPC 1.1E-11
Ptdss1
Ptdss1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium ICS | IMPC 2.52E-11
Slc12a1
Slc12a1urehr3
HOM Female Male postnatal increased circulating calcium level Clinical chemistry (GMC) | Calcium HMGU | EuroPhenome 2.41E-9
Fam234b
Fam234btm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium HMGU | EuroPhenome 3.71E-8
Ndfip2
Ndfip2tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium HMGU | IMPC 4.59E-8
Grhl3
Grhl3tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium ICS | EuroPhenome 2.84E-7
Wdr37
Wdr37tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium WTSI | IMPC 3.19E-7
Gys2
Gys2tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium WTSI | MGP 3.74E-7
Gimap6
Gimap6tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium JAX | IMPC 5.11E-7
Cxcr2
Cxcr2tm1a(EUCOMM)Wtsi
HOM Female postnatal increased circulating calcium level Clinical Chemistry | Calcium WTSI | IMPC 8.92E-7
Tm9sf4
Tm9sf4tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium WTSI | IMPC 1.91E-6
Slitrk4
Slitrk4tm1b(KOMP)Wtsi
HEM Male postnatal increased circulating calcium level Clinical Chemistry | Calcium WTSI | IMPC 2.01E-6
Itch
Itchtm1b(EUCOMM)Hmgu
HOM Female postnatal increased circulating calcium level Clinical Chemistry | Calcium MRC Harwell | IMPC 2.11E-6
Ucn3
Ucn3tm1.1(KOMP)Vlcg
HOM Female postnatal increased circulating calcium level Clinical Chemistry | Calcium UC Davis | IMPC 3.52E-6
Txnip
Txniptm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium MRC Harwell | IMPC 5.27E-6
Kptn
Kptntm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium WTSI | EuroPhenome 1.01E-5
Rnf144b
Rnf144btm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium ICS | IMPC 1.13E-5
Zfp760
Zfp760tm1a(EUCOMM)Hmgu
HET Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium HMGU | EuroPhenome 1.25E-5
Zfp106
Zfp106tm1a(KOMP)Wtsi
HET Male postnatal increased circulating calcium level Clinical Chemistry | Calcium WTSI | EuroPhenome 1.57E-5
Mrap2
Mrap2tm1a(EUCOMM)Wtsi
HOM Male postnatal increased circulating calcium level Clinical Chemistry | Calcium WTSI | IMPC 1.9E-5
Pdpn
Pdpntm1b(EUCOMM)Wtsi
HOM Female postnatal increased circulating calcium level Clinical Chemistry | Calcium MRC Harwell | IMPC 4.19E-5
Pdpn
Pdpntm1b(EUCOMM)Wtsi
HET Female postnatal increased circulating calcium level Clinical Chemistry | Calcium MRC Harwell | IMPC 4.19E-5
Rxfp2
Rxfp2tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium HMGU | IMPC 4.69E-5
Suv39h2
Suv39h2em1Marc
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium MARC | IMPC 4.72E-5
Arhgef7
Arhgef7tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium WTSI | IMPC 5.24E-5
Col4a5
Col4a5tm1b(EUCOMM)Wtsi
HOM Female postnatal increased circulating calcium level Clinical Chemistry | Calcium MRC Harwell | IMPC 6.26E-5
Tmem68
Tmem68tm1a(EUCOMM)Wtsi
HOM Male postnatal increased circulating calcium level Clinical Chemistry | Calcium ICS | EuroPhenome 7.51E-5
Ndufs3
Ndufs3tm1a(EUCOMM)Wtsi
HET Male postnatal increased circulating calcium level Clinical Chemistry | Calcium ICS | EuroPhenome 8.24E-5
Arhgap18
Arhgap18tm1a(KOMP)Wtsi
HOM Male postnatal increased circulating calcium level Clinical Chemistry | Calcium WTSI | EuroPhenome 9.02E-5
Lonrf3
Lonrf3tm1a(KOMP)Wtsi
HOM Female postnatal increased circulating calcium level Clinical Chemistry | Calcium WTSI | IMPC 9.03E-5
Ninj2
Ninj2tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium WTSI | IMPC 9.1E-5
Mta1
Mta1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium WTSI | EuroPhenome 9.38E-5
Lrrk1
Lrrk1tm1b(KOMP)Wtsi
HOM Female Male postnatal increased circulating calcium level Clinical Chemistry | Calcium MRC Harwell | IMPC 9.92E-5

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