Phenotype: decreased circulating HDL cholesterol level

Definition reduced amount in the blood of the small lipoprotein:cholesterol complex that transports cholesterol out of the arteries and to the liver for reprocessing or excretion

Synonyms
  • low serum HDL level
  • low serum HDL level
  • reduced circulating HDL level
  • reduced circulating HDL level
  • low HDL cholesterol level
  • low circulating HDL cholesterol level
  • decreased HDL cholesterol level
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Phenotype associations stats

2.29% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased circulating HDL cholesterol level (71/3103)

1.47% females (45/3071) 2.17% males (67/3094)

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Gene variants with decreased circulating HDL cholesterol level

Total number of significant genotype-phenotype associations: 116

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Apoc4
Apoc4tm1.1(KOMP)Mbp
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 7.93E-26
Pcsk9
Pcsk9tm2b(EUCOMM)Hmgu
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 3.19E-25
Mir141
Mir141tm1(mirKO)Wtsi
HET Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MARC | IMPC 2.53E-21
Dbn1
Dbn1tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 2.01E-16
Akap9
Akap9tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 3.32E-16
Akap9
Akap9tm1a(KOMP)Wtsi
HET Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 3.32E-16
Pex3
Pex3tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 1.0E-11
Sec16b
Sec16btm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 1.73E-11
Dlg4
Dlg4tm1e(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 6.26E-11
Sec24a
Sec24atm1a(KOMP)Wtsi
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 1.18E-10
Cyp27b1
Cyp27b1tm1b(EUCOMM)Hmgu
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 1.98E-10
Acsl5
Acsl5tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 7.66E-10
Prkab1
Prkab1tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 8.57E-10
Arhgef4
Arhgef4tm1a(KOMP)Wtsi
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 1.03E-9
Krtap17-1
Krtap17-1tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 2.35E-9
BC048403
BC048403tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MARC | IMPC 3.54E-9
Setd1a
Setd1atm1a(EUCOMM)Wtsi
HET Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 3.82E-9
Adgrf5
Adgrf5tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 1.86E-8
Ahrr
Ahrrtm1b(KOMP)Wtsi
HET Female Male postnatal decreased circulating HDL cholesterol level Plasma Chemistry | HDL cholesterol JAX | IMPC 2.68E-8
Stx8
Stx8tm2a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 3.48E-8
Zfp84
Zfp84tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 3.71E-8
Far2
Far2tm2b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Plasma Chemistry | HDL cholesterol JAX | IMPC 3.72E-8
Nab2
Nab2tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 4.28E-8
Cbx6
Cbx6tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 4.69E-8
Nrxn1
Nrxn1tm1b(KOMP)Wtsi
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 5.76E-8
Eif4e3
Eif4e3tm1a(KOMP)Wtsi
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 1.34E-7
Dusp7
Dusp7tm1(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MARC | IMPC 1.4E-7
Elk4
Elk4tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol HMGU | EuroPhenome 2.08E-7
Sptbn1
Sptbn1tm1a(EUCOMM)Wtsi
HET Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 3.11E-7
Dlg2
Dlg2tm1Dsb
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 3.47E-7
Sar1b
Sar1btm1a(EUCOMM)Wtsi
HET Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 3.79E-7
Optn
Optntm1a(EUCOMM)Wtsi
HOM Female postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 6.43E-7
Ppil3
Ppil3tm1b(EUCOMM)Wtsi
HOM Female postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 7.75E-7
Trmt10a
Trmt10atm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 9.89E-7
Fam117b
Fam117btm1a(EUCOMM)Wtsi
HOM Female postnatal decreased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 1.18E-6
Hspa5
Hspa5tm1.1(KOMP)Vlcg
HET Male postnatal decreased circulating HDL cholesterol level Plasma Chemistry | HDL cholesterol JAX | IMPC 1.19E-6
Dnase1l2
Dnase1l2tm1(KOMP)Wtsi
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol RBRC | IMPC 1.38E-6
Ltbp1
Ltbp1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 1.88E-6
Gc
Gctm1.1(KOMP)Vlcg
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 1.99E-6
Nfil3
Nfil3tm1.1(KOMP)Vlcg
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 2.72E-6
Igfbp3
Igfbp3tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 2.86E-6
Krt7
Krt7tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 4.15E-6
Rnf10
Rnf10tm1a(KOMP)Wtsi
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 5.62E-6
Tmprss15
Tmprss15tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 6.17E-6
Cyld
Cyldem2Marc
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MARC | IMPC 6.24E-6
Slc16a2
Slc16a2tm1a(KOMP)Wtsi
HEM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 7.14E-6
Lactb
Lactbtm1.1(KOMP)Mbp
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 7.64E-6
Pabpc4
Pabpc4tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 8.11E-6
Smc5
Smc5tm1b(KOMP)Wtsi
HET Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 8.9E-6
Miga2
Miga2tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 1.49E-5
Ttc28
Ttc28tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 1.76E-5
Sorbs2
Sorbs2tm1.1(KOMP)Mbp
HOM Female Male postnatal decreased circulating HDL cholesterol level Plasma Chemistry | HDL cholesterol JAX | IMPC 1.98E-5
Rhd
Rhdtm1e(EUCOMM)Wtsi
HOM Male postnatal decreased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 2.1E-5
Slc16a2
Slc16a2tm1a(KOMP)Wtsi
HOM Female postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 2.16E-5
Aldh2
Aldh2tm1a(EUCOMM)Wtsi
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 2.47E-5
Chd7
Chd7Whi
HET Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 2.6E-5
Dnmt3a
Dnmt3atm1b(KOMP)Wtsi
HET Male postnatal decreased circulating HDL cholesterol level Plasma Chemistry | HDL cholesterol JAX | IMPC 3.22E-5
Rnf10
Rnf10tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 3.27E-5
Tmc6
Tmc6tm1a(EUCOMM)Wtsi
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 3.49E-5
Vangl2
Vangl2Lp
HET Female Male postnatal decreased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 3.65E-5
Ldha
Ldhatm1a(EUCOMM)Wtsi
HET Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 4.1E-5
Polr3a
Polr3aem3Tcp
HET Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 4.5E-5
4930402H24Rik
4930402H24Riktm1b(EUCOMM)Hmgu
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 4.89E-5
Txndc5
Txndc5tm1.1(KOMP)Vlcg
HET Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 4.97E-5
Pigh
Pightm1.1(KOMP)Vlcg
HET Male postnatal decreased circulating HDL cholesterol level Plasma Chemistry | HDL cholesterol JAX | IMPC 5.56E-5
Snx5
Snx5tm1a(KOMP)Wtsi
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 5.63E-5
Baz1b
Baz1btm2a(KOMP)Wtsi
HET Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 6.47E-5
Psph
Psphtm1.1(KOMP)Vlcg
HET Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 6.56E-5
Pcsk5
Pcsk5tm1b(KOMP)Mbp
HET Male postnatal decreased circulating HDL cholesterol level Plasma Chemistry | HDL cholesterol JAX | IMPC 6.68E-5
Aak1
Aak1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 7.16E-5
March9
March9tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 8.78E-5
Nipa1
Nipa1tm1a(KOMP)Wtsi
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 8.97E-5
Rundc1
Rundc1tm1a(EUCOMM)Wtsi
HET Female postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 9.16E-5
Mro
Mrotm1H
HOM Female Male postnatal decreased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 9.85E-5

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