Phenotype: decreased circulating HDL cholesterol level

Definition reduced amount in the blood of the small lipoprotein:cholesterol complex that transports cholesterol out of the arteries and to the liver for reprocessing or excretion

Synonyms
  • low serum HDL level
  • low serum HDL level
  • reduced circulating HDL level
  • reduced circulating HDL level
  • low HDL cholesterol level
  • low circulating HDL cholesterol level
  • decreased HDL cholesterol level
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Phenotype associations stats

2.29% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased circulating HDL cholesterol level (85/3705)

1.59% females (58/3642) 2.18% males (80/3662)

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Gene variants with decreased circulating HDL cholesterol level

Total number of significant genotype-phenotype associations: 139

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Pcsk9
Pcsk9tm2b(EUCOMM)Hmgu
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 2.03E-25
Akap9
Akap9tm1a(KOMP)Wtsi
HET Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 1.31E-16
Dbn1
Dbn1tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 4.84E-16
Ttc28
Ttc28tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 6.59E-16
Il2ra
Il2ratm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 2.53E-13
Apoc4
Apoc4tm1.1(KOMP)Mbp
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 2.89E-13
Pex3
Pex3tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 1.6E-11
Sec24a
Sec24atm1a(KOMP)Wtsi
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 6.9E-11
Arhgef4
Arhgef4tm1a(KOMP)Wtsi
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 1.39E-10
Prkab1
Prkab1tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 1.79E-10
Dlg4
Dlg4tm1e(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 2.24E-10
Acsl5
Acsl5tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 8.82E-10
Sec16b
Sec16btm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 9.24E-10
2410015M20Rik
2410015M20Riktm1.1(KOMP)Vlcg
HET Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 2.6E-9
Krtap17-1
Krtap17-1tm1.1(KOMP)Vlcg
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 3.11E-9
BC048403
BC048403tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MARC | IMPC 3.63E-9
Rnf10
Rnf10tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 3.69E-9
Nab2
Nab2tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 4.95E-9
Cyp27b1
Cyp27b1tm1b(EUCOMM)Hmgu
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 1.05E-8
Setd1a
Setd1atm1a(EUCOMM)Wtsi
HET Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 1.69E-8
Zfp84
Zfp84tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 1.88E-8
Adgrf5
Adgrf5tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 2.42E-8
Ahrr
Ahrrtm1b(KOMP)Wtsi
HET Female Male postnatal decreased circulating HDL cholesterol level Plasma Chemistry | HDL cholesterol JAX | IMPC 2.68E-8
Stx8
Stx8tm2a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 3.48E-8
Cbx6
Cbx6tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 3.56E-8
Far2
Far2tm2b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Plasma Chemistry | HDL cholesterol JAX | IMPC 3.72E-8
Nrxn1
Nrxn1tm1b(KOMP)Wtsi
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 6.37E-8
Eif4e3
Eif4e3tm1a(KOMP)Wtsi
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 8.59E-8
Dusp7
Dusp7tm1(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MARC | IMPC 1.63E-7
Sptbn1
Sptbn1tm1a(EUCOMM)Wtsi
HET Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 1.94E-7
Elk4
Elk4tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol HMGU | EuroPhenome 2.08E-7
Dlg2
Dlg2tm1Dsb
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 3.47E-7
Rnf10
Rnf10tm1a(KOMP)Wtsi
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 5.39E-7
Setbp1
Setbp1tm1b(EUCOMM)Wtsi
HET Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 5.98E-7
Dync1i2
Dync1i2tm1a(EUCOMM)Wtsi
HET Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 8.38E-7
Trim8
Trim8em1(IMPC)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 1.07E-6
Baz1b
Baz1btm2a(KOMP)Wtsi
HET Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 1.15E-6
Fam117b
Fam117btm1a(EUCOMM)Wtsi
HOM Female postnatal decreased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 1.18E-6
Hspa5
Hspa5tm1.1(KOMP)Vlcg
HET Male postnatal decreased circulating HDL cholesterol level Plasma Chemistry | HDL cholesterol JAX | IMPC 1.19E-6
Sar1b
Sar1btm1a(EUCOMM)Wtsi
HET Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 1.28E-6
Dnase1l2
Dnase1l2tm1(KOMP)Wtsi
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol RBRC | IMPC 1.38E-6
H3f3b
H3f3btm1.1(KOMP)Mbp
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 1.47E-6
Ppil3
Ppil3tm1b(EUCOMM)Wtsi
HOM Female postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 1.51E-6
Krt7
Krt7tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 1.82E-6
Igfbp3
Igfbp3tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 2.68E-6
Lactb
Lactbtm1.1(KOMP)Mbp
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 2.79E-6
Pabpc4
Pabpc4tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 2.8E-6
Gc
Gctm1.1(KOMP)Vlcg
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 3.03E-6
Optn
Optntm1a(EUCOMM)Wtsi
HOM Female postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 3.07E-6
Tial1
Tial1tm1b(EUCOMM)Wtsi
HET Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 3.07E-6
Nfil3
Nfil3tm1.1(KOMP)Vlcg
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 3.35E-6
Tmem203
Tmem203em1(IMPC)H
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MRC Harwell | IMPC 5.24E-6
Slc16a2
Slc16a2tm1a(KOMP)Wtsi
HEM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 6.5E-6
Rbpj
Rbpjtm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 8.54E-6
Nucks1
Nucks1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 8.93E-6
Cyld
Cyldem2(IMPC)Marc
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol MARC | IMPC 1.28E-5
Miga2
Miga2tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 1.36E-5
4933434E20Rik
4933434E20Riktm1a(EUCOMM)Wtsi
HET Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 1.38E-5
Trmt10a
Trmt10atm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 1.58E-5
Sorbs2
Sorbs2tm1.1(KOMP)Mbp
HOM Female Male postnatal decreased circulating HDL cholesterol level Plasma Chemistry | HDL cholesterol JAX | IMPC 1.98E-5
Rhd
Rhdtm1e(EUCOMM)Wtsi
HOM Male postnatal decreased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 2.1E-5
Slc16a2
Slc16a2tm1a(KOMP)Wtsi
HOM Female postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 2.31E-5
Dmxl2
Dmxl2tm1a(EUCOMM)Wtsi
HET Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 2.47E-5
Chd7
Chd7Whi
HET Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 2.6E-5
Ldha
Ldhatm1a(EUCOMM)Wtsi
HET Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 2.9E-5
Dnmt3a
Dnmt3atm1b(KOMP)Wtsi
HET Male postnatal decreased circulating HDL cholesterol level Plasma Chemistry | HDL cholesterol JAX | IMPC 3.22E-5
Rundc1
Rundc1tm1a(EUCOMM)Wtsi
HET Female postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 3.22E-5
Kcnh3
Kcnh3tm1.1(KOMP)Vlcg
HOM Female postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol JAX | IMPC 3.41E-5
Vangl2
Vangl2Lp
HET Female Male postnatal decreased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 3.65E-5
Cpgi5563
Cpgi5563tm1.1(NCC)WCS
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 3.89E-5
Snx5
Snx5tm1a(KOMP)Wtsi
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 3.92E-5
Dcaf11
Dcaf11tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 4.69E-5
Atp6v0d1
Atp6v0d1tm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol TCP | IMPC 4.97E-5
Gatm
Gatmtm1b(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol HMGU | IMPC 5.32E-5
Txndc5
Txndc5tm1.1(KOMP)Vlcg
HET Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol UC Davis | IMPC 5.37E-5
Acer1
Acer1tm1a(EUCOMM)Wtsi
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 5.53E-5
Pigh
Pightm1.1(KOMP)Vlcg
HET Male postnatal decreased circulating HDL cholesterol level Plasma Chemistry | HDL cholesterol JAX | IMPC 5.56E-5
Tuft1
Tuft1tm1a(KOMP)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 5.83E-5
Nipa1
Nipa1tm1a(KOMP)Wtsi
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 6.43E-5
Pcsk5
Pcsk5tm1b(KOMP)Mbp
HET Male postnatal decreased circulating HDL cholesterol level Plasma Chemistry | HDL cholesterol JAX | IMPC 6.68E-5
Vps51
Vps51tm1a(KOMP)Wtsi
HET Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 6.99E-5
Kat2b
Kat2bem1(IMPC)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 7.11E-5
Ltbp1
Ltbp1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | EuroPhenome 8.02E-5
Atad2b
Atad2btm1b(EUCOMM)Hmgu
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol ICS | IMPC 8.16E-5
Enc1
Enc1tm1a(EUCOMM)Wtsi
HOM Male postnatal decreased circulating HDL cholesterol level Clinical Chemistry | HDL-cholesterol WTSI | IMPC 8.43E-5
March9
March9tm1a(EUCOMM)Wtsi
HOM Female Male postnatal decreased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 8.78E-5
Mro
Mrotm1H
HOM Female Male postnatal decreased circulating HDL cholesterol level Fasted Clinical Chemistry | HDL-cholesterol MRC Harwell | EuroPhenome 9.85E-5

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