Phenotype: increased bone mineral density

Definition increase in the quatitative measurment value of mineral content of bone; BMD is used as an indicator of bone strength used as a measure of structural strength and screen for osteoporosis; bone mineral density is the ratio of bone mineral content to bone size

Synonyms
  • increased bone density
  • increased bone density
  • elevated BMD
  • elevated BMD
  • increased BMD
  • elevated bone mineral density
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MP browserMP:0000062

Phenotype associations stats

1.79% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased bone mineral density (91/5086)

1.10% females (55/5021) 1.49% males (75/5036)

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Gene variants with increased bone mineral density

Total number of significant genotype-phenotype associations: 130

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Lrrk1
Lrrk1tm1b(KOMP)Wtsi
HOM Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) MRC Harwell | IMPC 0.0
Ctnnb1
Ctnnb1Bfc
HET Female Male postnatal increased bone mineral density DEXA | Bone Mineral Density (excluding skull) MRC Harwell | EuroPhenome 2.11E-16
Tnfrsf9
Tnfrsf9tm1b(EUCOMM)Wtsi
HET Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) ICS | IMPC 1.64E-10
Hgsnat
Hgsnatem4(IMPC)Tcp
HOM Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) TCP | IMPC 5.94E-10
Tnfaip1
Tnfaip1tm1a(EUCOMM)Wtsi
HOM Male postnatal increased bone mineral density DEXA | Bone Mineral Density (excluding skull) MRC Harwell | EuroPhenome 1.12E-9
Babam2
Babam2tm1a(EUCOMM)Wtsi
HOM Male postnatal increased bone mineral density DEXA | Bone Mineral Density (excluding skull) MRC Harwell | EuroPhenome 1.5E-9
Plekha3
Plekha3tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) JAX | IMPC 3.42E-9
Bzw2
Bzw2tm1b(KOMP)Mbp
HOM Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) JAX | IMPC 1.18E-8
Setd1a
Setd1atm1a(EUCOMM)Wtsi
HET Female Male postnatal increased bone mineral density Dexa-scan analysis | Bone Mineral Density (excluding skull) WTSI | MGP 1.42E-8
Parvb
Parvbtm1a(EUCOMM)Wtsi
HOM Male postnatal increased bone mineral density DEXA | Bone Mineral Density (excluding skull) MRC Harwell | MGP 1.68E-8
Zhx3
Zhx3tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) UC Davis | IMPC 2.71E-8
Sgsh
Sgshem3(IMPC)Tcp
HOM Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) TCP | IMPC 7.07E-8
Xylb
Xylbtm1a(EUCOMM)Hmgu
HOM Male postnatal increased bone mineral density DEXA | Bone Mineral Density (excluding skull) MRC Harwell | EuroPhenome 7.69E-8
Txlna
Txlnatm1b(EUCOMM)Hmgu
HET Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) MRC Harwell | IMPC 1.49E-7
Actr5
Actr5tm2b(EUCOMM)Wtsi
HET Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) BCM | IMPC 2.77E-7
Entpd6
Entpd6tm1a(KOMP)Wtsi
HOM Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) WTSI | IMPC 4.96E-7
Dppa1
Dppa1tm1a(KOMP)Wtsi
HOM Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) WTSI | IMPC 6.24E-7
Il33
Il33em2(IMPC)Bay
HOM Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) BCM | IMPC 6.9E-7
Hspb6
Hspb6em1(IMPC)J
HOM Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) JAX | IMPC 7.67E-7
Stard5
Stard5tm1a(KOMP)Wtsi
HOM Male postnatal increased bone mineral density Dexa-scan analysis | Bone Mineral Density (excluding skull) WTSI | EuroPhenome 8.2E-7
Pank3
Pank3tm1b(KOMP)Mbp
HOM Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) MRC Harwell | IMPC 1.39E-6
Cast
Casttm1.1(KOMP)Vlcg
HOM Female postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) JAX | IMPC 1.75E-6
Tssk5
Tssk5tm1.1(KOMP)Vlcg
HOM Female postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) JAX | IMPC 2.49E-6
Dnajb3
Dnajb3tm1.1(KOMP)Vlcg
HOM Female postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) JAX | IMPC 2.99E-6
Mlec
Mlectm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) WTSI | IMPC 4.15E-6
Dock9
Dock9em1(IMPC)J
HOM Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) JAX | IMPC 4.25E-6
Tbc1d16
Tbc1d16em1(IMPC)J
HOM Female postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) JAX | IMPC 4.57E-6
Pbx3
Pbx3tm1a(EUCOMM)Wtsi
HOM Male postnatal increased bone mineral density DEXA | Bone Mineral Density (excluding skull) MRC Harwell | EuroPhenome 4.61E-6
4930591A17Rik
4930591A17Riktm1a(KOMP)Wtsi
HOM Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) WTSI | IMPC 4.84E-6
Nos1ap
Nos1aptm1b(KOMP)Wtsi
HOM Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) BCM | IMPC 7.49E-6
Phf19
Phf19tm1.1(KOMP)Vlcg
HOM Female postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) UC Davis | IMPC 8.04E-6
Fuca1
Fuca1em1(IMPC)J
HOM Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) JAX | IMPC 8.14E-6
Gpr135
Gpr135em1(IMPC)J
HOM Female postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) JAX | IMPC 9.11E-6
Dop1b
Dop1btm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) WTSI | IMPC 1.13E-5
Ctsh
Ctshtm1b(KOMP)Wtsi
HOM Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) BCM | IMPC 1.17E-5
Ddhd1
Ddhd1tm1a(KOMP)Wtsi
HOM Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) WTSI | IMPC 1.23E-5
Thg1l
Thg1ltm1b(EUCOMM)Wtsi
HET Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) HMGU | IMPC 1.23E-5
Trim39
Trim39tm1b(EUCOMM)Hmgu
HOM Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) MRC Harwell | IMPC 1.42E-5
Prim1
Prim1em1(IMPC)J
HET Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) JAX | IMPC 1.44E-5
Cdh4
Cdh4tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) JAX | IMPC 1.56E-5
Acmsd
Acmsdtm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) HMGU | IMPC 1.62E-5
Lingo2
Lingo2em1(IMPC)KMPC
HOM Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) KMPC | IMPC 1.67E-5
Stag3
Stag3tm1e.1(KOMP)Wtsi
HOM Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) JAX | IMPC 1.69E-5
Csmd1
Csmd1em1(IMPC)Wtsi
HOM Female postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) WTSI | IMPC 1.87E-5
Atf7
Atf7tm2b(EUCOMM)Hmgu
HOM Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) BCM | IMPC 2.09E-5
Prkab1
Prkab1tm1b(KOMP)Wtsi
HET Female postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) JAX | IMPC 2.48E-5
Col1a2
Col1a2tm1b(EUCOMM)Wtsi
HOM Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) BCM | IMPC 2.53E-5
Zfp14
Zfp14tm1b(KOMP)Wtsi
HOM Female postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) JAX | IMPC 2.79E-5
Slc35f6
Slc35f6tm1a(EUCOMM)Wtsi
HOM Male postnatal increased bone mineral density Dexa-scan analysis | Bone Mineral Density (excluding skull) WTSI | EuroPhenome 2.79E-5
Clcf1
Clcf1tm1.1(KOMP)Vlcg
HET Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) TCP | IMPC 2.81E-5
Zfp706
Zfp706em1(IMPC)J
HET Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) JAX | IMPC 2.94E-5
Tmem42
Tmem42tm1b(KOMP)Wtsi
HOM Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) WTSI | IMPC 3.12E-5
Ckap5
Ckap5tm2b(EUCOMM)Hmgu
HET Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) BCM | IMPC 3.16E-5
Dcun1d3
Dcun1d3em1(IMPC)Wtsi
HOM Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) WTSI | IMPC 3.25E-5
Map3k1
Map3k1tm1a(KOMP)Wtsi
HET Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) WTSI | IMPC 3.88E-5
Slx4
Slx4tm1a(EUCOMM)Wtsi
HET Male postnatal increased bone mineral density Dexa-scan analysis | Bone Mineral Density (excluding skull) WTSI | EuroPhenome 4.11E-5
Wdhd1
Wdhd1em1(IMPC)Bay
HET Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) BCM | IMPC 4.33E-5
C3ar1
C3ar1tm1.1(KOMP)Vlcg
HOM Female postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) UC Davis | IMPC 4.51E-5
Usp15
Usp15tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) WTSI | IMPC 4.56E-5
Nek7
Nek7tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) JAX | IMPC 4.74E-5
Rxrg
Rxrg
HOM Female Male postnatal increased bone mineral density DEXA | Bone Mineral Density (excluding skull) ICS | EuroPhenome 4.88E-5
Cacng6
Cacng6em1(IMPC)J
HOM Female postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) JAX | IMPC 5.16E-5
Pclaf
Pclaftm1a(EUCOMM)Wtsi
HOM Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) WTSI | IMPC 5.4E-5
Ap1g1
Ap1g1tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) JAX | IMPC 5.54E-5
Svop
Svopem1(IMPC)H
HOM Female postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) MRC Harwell | IMPC 5.67E-5
Sirt2
Sirt2tm1a(EUCOMM)Wtsi
HOM Male postnatal increased bone mineral density DEXA | Bone Mineral Density (excluding skull) MRC Harwell | MGP 5.77E-5
Defb14
Defb14tm1b(KOMP)Wtsi
HOM Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) WTSI | IMPC 5.82E-5
Pla2g7
Pla2g7em1(IMPC)J
HOM Female postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) JAX | IMPC 5.85E-5
Reg3d
Reg3dtm1b(EUCOMM)Wtsi
HOM Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) WTSI | IMPC 6.1E-5
Zfyve28
Zfyve28tm1b(EUCOMM)Wtsi
HOM Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) WTSI | IMPC 6.18E-5
Htr3b
Htr3btm1.1(KOMP)Vlcg
HET Female postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) JAX | IMPC 6.3E-5
Prss45
Prss45em1(IMPC)Bay
HET Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) BCM | IMPC 6.32E-5
Iqcb1
Iqcb1em1(IMPC)Bay
HET Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) BCM | IMPC 6.33E-5
Dok7
Dok7tm1.1(KOMP)Vlcg
HET Female postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) UC Davis | IMPC 6.34E-5
Ehd1
Ehd1tm1a(EUCOMM)Wtsi
HET Male postnatal increased bone mineral density Dexa-scan analysis | Bone Mineral Density (excluding skull) WTSI | EuroPhenome 6.42E-5
Trim8
Trim8em1(IMPC)Wtsi
HOM Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) WTSI | IMPC 6.71E-5
Osbpl3
Osbpl3tm1a(EUCOMM)Wtsi
HOM Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) WTSI | IMPC 6.71E-5
AU040320
AU040320em1(IMPC)J
HOM Female postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) JAX | IMPC 6.82E-5
Tial1
Tial1tm1b(EUCOMM)Wtsi
HET Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) WTSI | IMPC 7.04E-5
Cdc26
Cdc26tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) ICS | IMPC 7.35E-5
Ankle2
Ankle2em1(IMPC)Bay
HET Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) BCM | IMPC 7.35E-5
Adprhl2
Adprhl2em1(IMPC)Wtsi
HOM Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) WTSI | IMPC 7.78E-5
Atp11a
Atp11atm1a(KOMP)Wtsi
HET Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) WTSI | IMPC 8.02E-5
Bhlhe40
Bhlhe40tm1b(KOMP)Wtsi
HOM Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) JAX | IMPC 8.46E-5
Lipe
Lipetm1b(KOMP)Wtsi
HOM Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) UC Davis | IMPC 8.67E-5
Trmt10a
Trmt10atm1a(EUCOMM)Wtsi
HOM Male postnatal increased bone mineral density Dexa-scan analysis | Bone Mineral Density (excluding skull) WTSI | EuroPhenome 8.88E-5
Iars2
Iars2em1(IMPC)Tcp
HET Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) TCP | IMPC 8.99E-5
Kcnab3
Kcnab3tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) UC Davis | IMPC 9.04E-5
Akap9
Akap9tm1a(KOMP)Wtsi
HET Male postnatal increased bone mineral density Dexa-scan analysis | Bone Mineral Density (excluding skull) WTSI | EuroPhenome 9.18E-5
Tmem181a
Tmem181atm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) JAX | IMPC 9.83E-5
Slitrk2
Slitrk2em1(IMPC)Mbp
HOM Female Male postnatal increased bone mineral density Body Composition (DEXA lean/fat) | Bone Mineral Density (excluding skull) UC Davis | IMPC 9.85E-5

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