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Gene: Zfp61 MGI:99663

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Gene Summary

Name:
zinc finger protein 61
Synonyms:
N/A

Order Alleles

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased circulating creatinine level Zfp61tm1b(EUCOMM)Hmgu HOM Early adult 5.89×10-05
enlarged cecum Zfp61tm1b(EUCOMM)Hmgu HOM Early adult 0.00
increased circulating calcium level Zfp61tm1b(EUCOMM)Hmgu HOM   Early adult 8.61×10-05

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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Human diseases caused by Zfp61 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Zfp61 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Adamantinoma
Hypercalcemia ORPHA:55881
Ulna Metaphyseal Dysplasia Syndrome
Hypercalcemia OMIM:191420
Blue Diaper Syndrome
Abnormal circulating tryptophan concentration, Hypercalcemia OMIM:211000
Hyperparathyroidism 1
Hypercalcemia OMIM:145000
Hypoparathyroidism, Familial Isolated, 2
Hyperphosphatemia, Hypocalcemia, Hypocalcemic seizures OMIM:618883
Appendicitis, Proneness To
Abnormal large intestine morphology OMIM:107700
Hypocalcemia, Autosomal Dominant 2
Abnormal blood phosphate concentration, Hypocalcemia OMIM:615361
Hypomagnesemia 1, Intestinal
Hypocalcemia, Hypomagnesemia OMIM:602014
Parathyroid Carcinoma
Hypercalcemia OMIM:608266
22q11 deletion syndrome (Velocardiofacial / DiGeorge syndrome)
Hypocalcemia DECIPHER:16
Hyperparathyroidism 4
Hypercalcemia OMIM:617343
Pseudohypoparathyroidism, Type Ii
Hyperphosphatemia, Hypocalcemia OMIM:203330
Hypercalcemia, Infantile, 2
Hypercalcemia, Hypophosphatemia OMIM:616963
Granulomatous Slack Skin
Hypercalcemia ORPHA:33111
Small Cell Carcinoma Of The Bladder
Hypercalcemia ORPHA:284400
Renal Failure, Progressive, With Hypertension
Elevated circulating creatinine concentration OMIM:161900
Alpha-Heavy Chain Disease
Abnormal small intestine morphology, Hypocalcemia, Malabsorption ORPHA:100025
Hypocalciuric Hypercalcemia, Familial, Type Ii
Hypercalcemia, Hypermagnesemia, Peptic ulcer OMIM:145981
Nephropathy-Deafness-Hyperparathyroidism Syndrome
Hypercalcemia ORPHA:2668
Familial Isolated Hypoparathyroidism Due To Agenesis Of Parathyroid Gland
Hyperphosphatemia, Hypocalcemia, Hypocalcemic seizures, Hypomagnesemia ORPHA:2239
Hyperparathyroidism, Neonatal Self-Limited Primary, With Hypercalciuria
Hypercalcemia OMIM:239199
Infantile Myofibromatosis
Hypercalcemia, Intestinal obstruction, Abnormal intestine morphology, Tracheoesophageal fistula ORPHA:2591
Blue Diaper Syndrome
Hyperphosphatemia, Hypercalcemia ORPHA:94086
Progressive Familial Intrahepatic Cholestasis
Hypocalcemia, Malabsorption ORPHA:172
Renal Tubular Acidosis, Distal, 1
Hypokalemia, Elevated circulating creatinine concentration, Hypocalcemia OMIM:179800
Ichthyosis, Mental Retardation, Dwarfism, And Renal Impairment
Elevated circulating creatinine concentration OMIM:242530
Diffuse Neonatal Hemangiomatosis
Hypercalcemia ORPHA:2123
Rhabdoid Tumor
Neoplasm of the liver, Hypercalcemia ORPHA:69077
Myopathy, Tubular Aggregate, 2
Hypocalcemia, Elevated circulating creatine kinase concentration OMIM:615883
Uremic Pruritus
Hypermagnesemia, Renal hypophosphatemia, Hypercalcemia, Increased blood urea nitrogen ORPHA:94059
Hypercalcemia, Infantile, 1
Hypercalcemia OMIM:143880
Hypomagnesemia 7, Renal, With Or Without Dilated Cardiomyopathy
Hyponatremia, Hypokalemia, Hypocalcemia, Hypomagnesemia OMIM:620152
Familial Isolated Hyperparathyroidism
Hypercalcemia, Hypophosphatemia ORPHA:99879
Hypocalciuric Hypercalcemia, Familial, Type I
Hypermagnesemia, Hypercalcemia OMIM:145980
Hypoparathyroidism, Familial Isolated, 1
Hyperphosphatemia, Hypocalcemia, Hypocalcemic seizures OMIM:146200
Nephrogenic Syndrome Of Inappropriate Antidiuresis
Hyponatremia, Decreased circulating renin level, Reduced blood urea nitrogen, Decreased serum cre... OMIM:300539
Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies
Hypercalcemia OMIM:614732
Hypophosphatasia
Hypercalcemia ORPHA:436
Polyposis, Skin Pigmentation, Alopecia, And Fingernail Changes
Malabsorption, Xerostomia, Hamartomatous polyposis, Hematochezia, Hypokalemia, Protein-losing ent... OMIM:175500
Hypocalciuric Hypercalcemia, Familial, Type Iii
Hypercalcemia, Hypermagnesemia, Peptic ulcer, Hypophosphatemia OMIM:600740
Vitamin D-Dependent Rickets, Type 3
Hypocalcemia, Hypophosphatemia OMIM:619073
Pseudohypoparathyroidism, Type Ib
Hyperphosphatemia, Hypocalcemia OMIM:603233
Hyperparathyroidism 2 With Jaw Tumors
Hypercalcemia OMIM:145001
Oculoskeletodental Syndrome
Hypercalcemia, Hypocalcemia ORPHA:557003
Pseudohypoparathyroidism Type 2
Calcinosis, Hyperphosphatemia, Hypocalcemia, Hypocalcemic tetany, Hypocalcemic seizures ORPHA:94090
Tumoral Calcinosis, Hyperphosphatemic, Familial, 3
Hyperphosphatemia, Hypercalcemia OMIM:617994
Refractory Celiac Disease
Villous atrophy, Malabsorption, Hypophosphatemia, Protein-losing enteropathy, Hypocalcemia, Hypoa... ORPHA:398063
Cystinosis, Adult Nonnephropathic
Elevated circulating creatinine concentration OMIM:219750
Hypophosphatemic Rickets And Hyperparathyroidism
Hypophosphatemic rickets, Hypercalcemia, Hypophosphatemia OMIM:612089
Oculoskeletodental Syndrome
Macroglossia, Hypercalcemia, Protein-losing enteropathy, Hypocalcemia OMIM:618440
Combined Oxidative Phosphorylation Deficiency 34
Elevated circulating creatinine concentration, Increased blood urea nitrogen OMIM:617872
Glycogen Storage Disease Due To Lactate Dehydrogenase M-Subunit Deficiency
Elevated creatine kinase after exercise, Hypercalcemia ORPHA:284426
Glucose-Galactose Malabsorption
Hypernatremia, Hypercalcemia ORPHA:35710
Cholestasis, Progressive Familial Intrahepatic, 7, With Or Without Hearing Loss
Hypocalcemia, Elevated circulating gamma-aminobutyric acid concentration OMIM:619658
Hypocalcemia, Autosomal Dominant 1
Hypokalemia, Hyperphosphatemia, Increased circulating renin level, Hypocalcemia, Hypomagnesemia OMIM:601198
Non-Functioning Paraganglioma
Hypercalcemia ORPHA:94080
2P21 Microdeletion Syndrome
Hypocalcemia, Cystinuria ORPHA:163693
Interstitial Nephritis, Karyomegalic
Elevated circulating creatinine concentration, Increased blood urea nitrogen OMIM:614817
Preeclampsia
Helicobacter pylori infection, Elevated circulating creatinine concentration ORPHA:275555
Pheochromocytoma--Islet Cell Tumor Syndrome
Hypercalcemia OMIM:171420
Hyperparathyroidism, Neonatal Severe
Calcinosis, Aminoaciduria, Hypercalcemia, Hypophosphatemia OMIM:239200
Tubulointerstitial Kidney Disease, Autosomal Dominant, 5
Elevated circulating creatinine concentration, Hyperuricemia OMIM:617056
Familial Hypocalciuric Hypercalcemia
Renal hypophosphatemia, Hypercalcemia, Peptic ulcer, Hypermagnesemia, Hypocalcemic seizures ORPHA:405
Immunodeficiency, Developmental Delay, And Hypohomocysteinemia
Decreased serum creatinine, Hypohomocysteinemia, Hypocystinemia OMIM:617744
Nephronophthisis-Like Nephropathy 2
Elevated circulating creatinine concentration OMIM:619468
Hypophosphatasia, Infantile
Elevated plasma pyrophosphate, Hypercalcemia OMIM:241500
Paget Disease Of Bone 2, Early-Onset
Hydroxyprolinuria, Hypercalcemia OMIM:602080
Late-Onset Isolated Acth Deficiency
Hyponatremia, Hypercalcemia, Celiac disease, Hyperkalemia, Hyperuricemia ORPHA:199299
Lipodystrophy, Congenital Generalized, Type 3
Hypercholesterolemia, Hypertriglyceridemia, Hypocalcemia OMIM:612526
Fanconi Renotubular Syndrome 3
Aminoaciduria, Elevated circulating creatinine concentration OMIM:615605
Paternal Uniparental Disomy Of Chromosome 1
Hypercalcemia, Increased blood urea nitrogen ORPHA:251004
Osteopetrosis, Autosomal Recessive 9
Elevated circulating creatinine concentration, Hyperkalemia OMIM:620366
Multiple Myeloma
Hyperproteinemia, Elevated circulating creatinine concentration, Hypercalcemia, Functional abnorm... ORPHA:29073
Idiopathic Non-Lupus Full-House Nephropathy
Elevated circulating creatinine concentration ORPHA:567544
Hereditary Arterial And Articular Multiple Calcification Syndrome
Decreased serum creatinine ORPHA:289601
Multiple Endocrine Neoplasia, Type I
Hypercalcemia, Zollinger-Ellison syndrome, Peptic ulcer, Esophagitis OMIM:131100
Coenzyme Q10 Deficiency, Primary, 8
Elevated circulating creatinine concentration OMIM:616733
Metaphyseal Chondrodysplasia, Jansen Type
Hypercalcemia, Hypophosphatemia OMIM:156400
Visceral Myopathy 2
Intestinal obstruction, Necrotizing enterocolitis, Intestinal pseudo-obstruction, Intestinal malr... OMIM:619350
Cerebral Creatine Deficiency Syndrome 2
Decreased serum creatinine, Elevated circulating guanidinoacetic acid concentration OMIM:612736
Ring Chromosome 10 Syndrome
Aganglionic megacolon, Hypocalcemia ORPHA:1438
Coach Syndrome 2
Elevated circulating creatinine concentration OMIM:619111
Thymic Neuroendocrine Tumor
Hypercalcemia ORPHA:97289
Adenine Phosphoribosyltransferase Deficiency
Elevated circulating creatinine concentration OMIM:614723
Shiga Toxin-Associated Hemolytic Uremic Syndrome
Hyponatremia, Intestinal perforation, Rectal prolapse, Colonic stenosis, Elevated circulating cre... ORPHA:90038
Monosomy 13Q34
Hematochezia, Hypercalcemia ORPHA:96168
Autosomal Recessive Kenny-Caffey Syndrome
Hypocalcemic tetany, Hypocalcemia, Hypocalcemic seizures ORPHA:93324
Zollinger-Ellison Syndrome
Gastrointestinal hemorrhage, Intestinal obstruction, Duodenal ulcer, Peptic ulcer, Hypercalcemia,... ORPHA:913
Autoimmune Hypoparathyroidism
Hypocalcemic tetany, Hyperphosphatemia, Hypocalcemia, Hypocalcemic seizures ORPHA:36913
Congenital Disorder Of Glycosylation, Type Ih
Elevated circulating creatinine concentration, Protein-losing enteropathy, Hypoalbuminemia OMIM:608104
Primary Intestinal Lymphangiectasia
Increased stool alpha1-antitrypsin concentration, Functional abnormality of the gastrointestinal ... ORPHA:90362
Nephronophthisis 2
Elevated circulating creatinine concentration, Hyperkalemia OMIM:602088
Micrognathia-Recurrent Infections-Behavioral Abnormalities-Mild Intellectual Disability Syndrome
High palate, Hypercalcemia ORPHA:476126
Hypouricemia, Renal, 1
Elevated circulating creatinine concentration, Hypouricemia OMIM:220150
Acute Adrenal Insufficiency
Hyponatremia, Hypercalcemia, Hyperkalemia, Increased circulating renin level, Hyperuricemia ORPHA:95409
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 4
Elevated circulating creatinine concentration, Increased blood urea nitrogen OMIM:612924
Pseudopseudohypoparathyroidism
Hyperphosphatemia, Hypocalcemia ORPHA:79445
Sporadic Pheochromocytoma/Secreting Paraganglioma
Hypercalcemia ORPHA:276621
C3 Glomerulopathy
Elevated circulating creatinine concentration ORPHA:329918
Intellectual Disability-Seizures-Hypophosphatasia-Ophthalmic-Skeletal Anomalies Syndrome
Hypertriglyceridemia, Hypercalcemia, High, narrow palate, Gastroesophageal reflux, Abnormal gastr... ORPHA:369837
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 3
Elevated circulating creatinine concentration, Increased blood urea nitrogen OMIM:612923
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 2
Elevated circulating creatinine concentration, Increased blood urea nitrogen OMIM:612922
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 6
Elevated circulating creatinine concentration, Increased blood urea nitrogen OMIM:612926
Vipoma
Hypercalcemia, Malabsorption, Hematochezia, Neoplasm of the liver, Hypokalemia, Abnormal gastroin... ORPHA:97282
Addison Disease
Hyponatremia, Hypercalcemia, Celiac disease, Hyperkalemia, Increased circulating renin level, Hyp... ORPHA:85138
Cryoglobulinemia, Familial Mixed
Elevated circulating creatinine concentration OMIM:123550
Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease
Hypokalemia, Elevated circulating creatinine concentration, Elevated circulating alpha-fetoprotei... OMIM:613095
Thrombotic Thrombocytopenic Purpura
Decreased serum creatinine ORPHA:54057
Autosomal Dominant Hypophosphatemic Rickets
Hypocalcemia, Hypophosphatemia ORPHA:89937
Pheochromocytoma
Hypercalcemia OMIM:171300
Myopathy With Myalgia, Increased Serum Creatine Kinase, And With Or Without Episodic Rhabdomyolysis
Elevated circulating creatinine concentration, Elevated circulating creatine kinase concentration OMIM:620138
46,Xy Sex Reversal 4
Elevated circulating creatinine concentration, Cleft palate, High palate, Increased blood urea ni... OMIM:154230
Ppoma
Gastrointestinal hemorrhage, Intestinal obstruction, Hypercalcemia, Intestinal carcinoid, Neoplas... ORPHA:97278
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 5
Elevated circulating creatinine concentration, Increased blood urea nitrogen OMIM:612925
Hypotonia-Cystinuria Syndrome
Hypocalcemia, Cystinuria OMIM:606407
Somatostatinoma
Gastrointestinal hemorrhage, Intestinal obstruction, Hypercalcemia, Steatorrhea, Neoplasm of the ... ORPHA:97283
Diarrhea 10, Protein-Losing Enteropathy Type
Hyponatremia, Hypertriglyceridemia, Hematochezia, Hypoalbuminemia, Protein-losing enteropathy, Hy... OMIM:618183
Familial Isolated Hypoparathyroidism
Hypocalcemia ORPHA:2238
Hereditary Amyloidosis With Primary Renal Involvement
Abnormality of the gastrointestinal tract, Gastrointestinal hemorrhage, Intestinal obstruction, D... ORPHA:85450
Hypouricemia, Familial Renal, Due To Tubular Hypersecretion
Hypouricemia OMIM:307830
Grfoma
Gastrointestinal hemorrhage, Intestinal obstruction, Hypercalcemia, Zollinger-Ellison syndrome, I... ORPHA:97261
X-Linked Agammaglobulinemia
Glossoptosis, Hypocalcemia, Malabsorption ORPHA:47
Hyperparathyroidism-Jaw Tumor Syndrome
Hypercalcemia, Hypophosphatemia, Peptic ulcer, Dysphagia ORPHA:99880
Pseudohypoparathyroidism, Type Ic
Hypocalcemic tetany, Hyperphosphatemia, Hypocalcemia OMIM:612462
Parathyroid Carcinoma
Hypercalcemia, Hypophosphatemia, Peptic ulcer, Dysphagia ORPHA:143
Glucagonoma
Gastrointestinal hemorrhage, Intestinal obstruction, Hypercalcemia, Abnormal gastrointestinal mot... ORPHA:97280
Bartter Syndrome, Type 1, Antenatal
Hyperchloriduria, Increased serum prostaglandin E2, Hypercalcemia, Hypochloremia, Hypokalemia, In... OMIM:601678
Hereditary Pheochromocytoma-Paraganglioma
Hypercalcemia ORPHA:29072
Juvenile Nephropathic Cystinosis
Hyponatremia, Hypouricemia, Elevated circulating creatinine concentration, Hypokalemia, Aminoacid... ORPHA:411634
Fibrous Dysplasia Of Bone
Hypercalcemia, Hypophosphatemia ORPHA:249
Hypoxanthine Guanine Phosphoribosyltransferase Partial Deficiency
Elevated circulating creatinine concentration, Hyperuricemia ORPHA:79233
Hypoparathyroidism-Retardation-Dysmorphism Syndrome
Hypocalcemia, Hyperphosphatemia, Bifid uvula, Hypocalcemic seizures OMIM:241410
Intermediate Osteopetrosis
Hypocalcemia ORPHA:210110
Relapsing Fever
Elevated circulating creatinine concentration, Elevated circulating C-reactive protein concentrat... ORPHA:91547
Colchicine Poisoning
Hyponatremia, Abnormal blood ion concentration, Hypophosphatemia, Hypokalemia, Hypocalcemia, Hypo... ORPHA:31824
Very Long Chain Acyl-Coa Dehydrogenase Deficiency
Elevated circulating creatine kinase concentration, Increased circulating free fatty acid level, ... ORPHA:26793
Multiple Endocrine Neoplasia Type 2
Aganglionic megacolon, Hypercalcemia, Abnormal tongue morphology, Neoplasm of the liver, Ganglion... ORPHA:653
Carnitine Palmitoyltransferase Ii Deficiency, Lethal Neonatal
Elevated circulating creatine kinase concentration, Elevated circulating long chain fatty acid co... OMIM:608836
Vitamin D Hydroxylation-Deficient Rickets, Type 1A
Generalized aminoaciduria, Hypocalcemia, Hypocalcemic seizures, Hypophosphatemia OMIM:264700
Kenny-Caffey Syndrome, Type 1
Hypocalcemia, Hypomagnesemia OMIM:244460
Genetic Recurrent Myoglobinuria
Highly elevated creatine kinase, Hyperphosphatemia, Hyperkalemia, Hypocalcemia ORPHA:99845
Sickle Cell Anemia
Elevated circulating creatinine concentration, Unconjugated hyperbilirubinemia ORPHA:232
Generalized Pustular Psoriasis
Hyponatremia, Elevated circulating C-reactive protein concentration, Hypoalbuminemia, Hypocalcemi... ORPHA:247353
Double Outlet Right Ventricle
Hypocalcemia, Submucous cleft hard palate, Intestinal malrotation, Cleft palate ORPHA:3426
Multiple Endocrine Neoplasia Type 4
Hypercalcemia, Zollinger-Ellison syndrome, Peptic ulcer, Esophagitis ORPHA:276152
Neurodevelopmental Disorder With Microcephaly, Cataracts, And Renal Abnormalities
Hyponatremia, Calcinosis, Hypokalemia, Aminoaciduria, Gastroesophageal reflux, High palate, Hypoc... OMIM:617913
Short-Rib Thoracic Dysplasia 5 With Or Without Polydactyly
Elevated circulating creatinine concentration OMIM:614376
Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome
Gastritis, Malabsorption, Hypomagnesemia, Ileus, Abnormal blood ion concentration, Colitis, Abnor... ORPHA:37042
Vitamin D Hydroxylation-Deficient Rickets, Type 1B
Hypocalcemia, Hypophosphatemia OMIM:600081
Albers-Schönberg Osteopetrosis
Hypocalcemia ORPHA:53
Cholera
Hyponatremia, Achlorhydria, Abnormal blood ion concentration, Hypokalemia, Hypocalcemia ORPHA:173
Sanjad-Sakati Syndrome
Intestinal obstruction, Hyperphosphatemia, Hypocalcemia ORPHA:2323
Aapoaiv Amyloidosis
Abnormality of the gastrointestinal tract, Hyperlipidemia, Elevated circulating creatinine concen... ORPHA:439232
Mullerian Derivatives, Persistence Of, With Lymphangiectasia And Postaxial Polydactyly
Cleft palate, High palate, Hypocalcemia, Protein-losing enteropathy, Hypoproteinemia OMIM:235255
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1
Hyperlipidemia, Elevated circulating creatinine concentration, Increased blood urea nitrogen OMIM:235400
Pseudohypoparathyroidism Type 1B
Calcinosis, Hyperphosphatemia, Hypocalcemia, Hypocalcemic tetany, Hypocalcemic seizures ORPHA:94089
Gracile Bone Dysplasia
Ankyloglossia, Hypocalcemia OMIM:602361
Car T Cell Therapy-Associated Cytokine Release Syndrome
Elevated circulating creatinine concentration, Hyperbilirubinemia ORPHA:542323
Neuroleptic Malignant Syndrome
Hyponatremia, Elevated circulating creatine kinase concentration, Hypomagnesemia, Hyperkalemia, H... ORPHA:94093
Timothy Syndrome
Hypocalcemia OMIM:601005
Acute Interstitial Pneumonia
Elevated circulating creatinine concentration, Elevated circulating C-reactive protein concentration ORPHA:79126
Diffuse Alveolar Hemorrhage
Elevated circulating creatinine concentration ORPHA:90060
Dahlberg-Borer-Newcomer Syndrome
Hypocalcemia ORPHA:1563
Neuropathy, Hereditary Sensory And Autonomic, Type Iii
Elevated circulating creatinine concentration, Gastroesophageal reflux, Increased blood urea nitr... OMIM:223900
Multiple Endocrine Neoplasia Type 1
Duodenal ulcer, Peptic ulcer, Hypercalcemia, Hematemesis, Melena, Zollinger-Ellison syndrome, Gas... ORPHA:652
Thrombotic Thrombocytopenic Purpura, Hereditary
Elevated circulating creatinine concentration, Increased blood urea nitrogen OMIM:274150
Hypocalcemic Vitamin D-Dependent Rickets
Generalized aminoaciduria, Hypocalcemia, Hypocalcemic seizures, Hypophosphatemia ORPHA:289157
Hypocalcemic Vitamin D-Resistant Rickets
Hypocalcemia, Hypophosphatemia ORPHA:93160
Congenital Disorder Of Glycosylation, Type Iit
Decreased serum creatinine, Decreased HDL cholesterol concentration, Hypotriglyceridemia OMIM:618885
Bacterial Toxic-Shock Syndrome
Hypocalcemia, Elevated circulating creatinine concentration, Hypoalbuminemia, Elevated circulatin... ORPHA:36234
Müllerian Derivatives-Lymphangiectasia-Polydactyly Syndrome
Hypoproteinemia, Hypocalcemia, High palate, Protein-losing enteropathy ORPHA:1655
Celiac Disease, Susceptibility To, 1
Celiac disease, Hypocalcemia, Steatorrhea OMIM:212750
Oncogenic Osteomalacia
Hypocalcemia, Hypophosphatemia ORPHA:352540
Williams Syndrome
Colonic diverticula, Peptic ulcer, Hypercalcemia, Malabsorption, Elevated circulating creatine ki... ORPHA:904
Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations
Gastrointestinal hemorrhage, Elevated circulating creatinine concentration ORPHA:247691
Dopamine Beta-Hydroxylase Deficiency
Elevated circulating creatinine concentration, Increased blood urea nitrogen ORPHA:230
Senior-Loken Syndrome 1
Elevated circulating creatinine concentration OMIM:266900
Tubulointerstitial Kidney Disease, Autosomal Dominant, 2
Elevated circulating creatinine concentration, Hyperuricemia OMIM:174000
Osteopetrosis, Autosomal Recessive 1
Hypocalcemia OMIM:259700
Congenital Disorder Of Glycosylation, Type Ig
Hypocalcemia OMIM:607143
Kenny-Caffey Syndrome, Type 2
Transient hypophosphatemia, Hyperphosphatemia, Hypocalcemia OMIM:127000
Autosomal Dominant Hypocalcemia
Hyperphosphatemia, Hypocalcemia, Hypomagnesemia ORPHA:428
Pseudohypoparathyroidism Type 1C
Calcinosis, Hyperphosphatemia, Hypocalcemia, Hypocalcemic tetany, Hypocalcemic seizures ORPHA:79444
Brain Abnormalities, Neurodegeneration, And Dysosteosclerosis
Hypocalcemia OMIM:618476
Williams-Beuren Syndrome
Colonic diverticula, Hypercalcemia, Celiac disease, Rectal prolapse, Gastroesophageal reflux OMIM:194050
Kidney Tubulopathy-Dilated Cardiomyopathy Syndrome
Hypocalcemic tetany, Hypocalcemia, Hypomagnesemia ORPHA:73224
Igg4-Related Thyroid Disease
Sialadenitis, Hypocalcemia, Dysphagia ORPHA:64744
Infection-Related Hemolytic Uremic Syndrome
Hyponatremia, Intestinal perforation, Hyperkalemia, Gastrointestinal infarctions, Hypocalcemia, I... ORPHA:544482
Ethylene Glycol Poisoning
Hyperkalemia, Gastritis, Hypocalcemia ORPHA:31826
Isotretinoin-Like Syndrome
Gastroesophageal reflux, Hypocalcemia, Cleft palate ORPHA:2306
Igg4-Related Retroperitoneal Fibrosis
Elevated circulating creatinine concentration, Elevated circulating C-reactive protein concentrat... ORPHA:49041
Mitochondrial Trifunctional Protein Deficiency
Hypocalcemia ORPHA:746
Papillorenal Syndrome
Elevated circulating creatinine concentration OMIM:120330
Sarcoidosis
Enlargement of parotid gland, Abnormality of the gastrointestinal tract, Hypercalcemia, Parotitis ORPHA:797
Velocardiofacial Syndrome
Velopharyngeal insufficiency, Submucous cleft hard palate, Hypocalcemia, Cleft palate OMIM:192430
Pseudohypoparathyroidism Type 1A
Calcinosis, Hyperphosphatemia, Hypocalcemia, Hypocalcemic tetany, Hypocalcemic seizures ORPHA:79443
Oligomeganephronia
Elevated circulating creatinine concentration ORPHA:2260
Autosomal Dominant Polycystic Kidney Disease
Elevated circulating creatinine concentration ORPHA:730
Cartilage-Hair Hypoplasia
Aganglionic megacolon, Hypocalcemia, Malabsorption ORPHA:175
Hemorrhagic Fever-Renal Syndrome
Hematemesis, Hyperkalemia, Elevated circulating creatinine concentration, Melena, Hyperphosphatemia ORPHA:340
Hypoparathyroidism-Sensorineural Deafness-Renal Disease Syndrome
Hypocalcemic seizures, Hypocalcemia, Cleft palate ORPHA:2237
Pseudohypoparathyroidism, Type Ia
Hypocalcemic tetany, Hyperphosphatemia OMIM:103580
Pearson Syndrome
Hypomagnesemia, Dysphagia, Hypophosphatemia, Hypokalemia, Hypocalcemia, Steatorrhea, Hyperalanine... ORPHA:699
Rajab Interstitial Lung Disease With Brain Calcifications 1
Intestinal malrotation, Esophageal varix, Gastroesophageal reflux, Hypocalcemia, High palate, Hyp... OMIM:613658
Cardiogenic Shock
Elevated circulating creatinine concentration ORPHA:97292
Osteopetrosis, Autosomal Recessive 5
Hypocalcemia, Hyperbilirubinemia OMIM:259720
Structural Heart Defects And Renal Anomalies Syndrome
Elevated circulating creatinine concentration OMIM:617478
Marburg Hemorrhagic Fever
Abnormality of the gastrointestinal tract, Elevated circulating creatine kinase concentration, Hy... ORPHA:99826
Hennekam Syndrome
Pyloric stenosis, Hypocalcemia, Malabsorption ORPHA:2136
Sotos Syndrome
Gastroesophageal reflux, Aganglionic megacolon, Hypercalcemia ORPHA:821
Pauci-Immune Glomerulonephritis
Abnormality of the gastrointestinal tract, Elevated circulating creatinine concentration ORPHA:93126
Craniofacioskeletal Syndrome
Hypocalcemia, Cleft palate OMIM:300712
X-Linked Intellectual Disability-Craniofacioskeletal Syndrome
Hyperbilirubinemia, Hypocalcemia, Cleft palate ORPHA:163979
22Q11.2 Deletion Syndrome
Gastrointestinal hemorrhage, Aganglionic megacolon, Intestinal malrotation, Anorectal anomaly, Cl... ORPHA:567
Liver Disease, Severe Congenital
Hyponatremia, Chronic gastritis, Elevated circulating alpha-fetoprotein concentration, Increased ... OMIM:619991
Renal Cysts And Diabetes Syndrome
Elevated circulating creatinine concentration, Hyperuricemia OMIM:137920
T-Cell Immunodeficiency With Thymic Aplasia
Hypocalcemic tetany, Recurrent infection of the gastrointestinal tract, Malabsorption ORPHA:83471
Exercise-Induced Malignant Hyperthermia
Hypocalcemia, Hyperphosphatemia, Hyperkalemia, Elevated circulating creatine kinase concentration ORPHA:466650
Gitelman Syndrome
Hypokalemia, Hypermagnesemia, Hypocalcemia, Hypomagnesemia ORPHA:358
Cranioectodermal Dysplasia 1
High, narrow palate, High palate, Hypocalcemia OMIM:218330
Osteopetrosis With Renal Tubular Acidosis
Hypocalcemia, High palate, Elevated circulating creatine kinase concentration ORPHA:2785
Yellow Fever
Hematemesis, Elevated circulating creatinine concentration, Elevated circulating creatine kinase ... ORPHA:99829
Autosomal Recessive Hypophosphatemic Rickets
Hypocalcemic tetany, Hypophosphatemic rickets, Renal hypophosphatemia, Malabsorption ORPHA:289176
Igg4-Related Kidney Disease
Sialadenitis, Elevated circulating creatinine concentration, Decreased retinol-binding protein le... ORPHA:449395
Autosomal Recessive Malignant Osteopetrosis
Hypocalcemia, Hypophosphatemia ORPHA:667
Autosomal Dominant Kenny-Caffey Syndrome
Hypocalcemic tetany, Hyperphosphatemia, Hypocalcemic seizures ORPHA:93325
Biliary, Renal, Neurologic, And Skeletal Syndrome
Conjugated hyperbilirubinemia, Increased circulating ferritin concentration, Elevated circulating... OMIM:619534
Neurodevelopmental Disorder With Hypotonia And Dysmorphic Facies
Cleft soft palate, Esophageal varix, Dysphagia, High palate, Hypocalcemia, Hypomagnesemia OMIM:619503
Charge Syndrome
Anal stenosis, Esophageal atresia, Tracheoesophageal fistula, Cleft palate, Hypocalcemia, Dysphag... OMIM:214800
Johanson-Blizzard Syndrome
Colonic diverticula, Increased VLDL cholesterol concentration, Malabsorption, Conjugated hyperbil... OMIM:243800
Tubulointerstitial Nephritis And Uveitis Syndrome
Aminoaciduria, Elevated circulating creatinine concentration, Elevated circulating C-reactive pro... ORPHA:91500
Intellectual Developmental Disorder, Autosomal Dominant 71, With Behavioral Abnormalities
Hypocalcemia, High palate, Bifid uvula OMIM:620330
Digeorge Syndrome
High, narrow palate, Cleft palate, High palate, Gastroesophageal reflux, Hypocalcemia, Bifid uvula OMIM:188400

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Zfp61

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Zfp61.

There are 5 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Zfp616tm1b(KOMP)Wtsi PMC7263671
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation. Nature immunology (December 2019) Zfp616tm1b(KOMP)Wtsi PMC7338221
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Zfp616tm1b(KOMP)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Zfp616tm1b(KOMP)Wtsi PMC6459510
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Zfp616tm1b(KOMP)Wtsi PMC5827107

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Zfp61tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (with selection cassette) Mice
Zfp61tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Zfp61tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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