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Gene: Cd63 MGI:99529

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
CD63 antigen
Synonyms:
Tspan30,  ME491

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Cd63 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Cd63 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Renal Glucosuria
Polyuria, Enuresis nocturna, Glycosuria, Polydipsia, Polyphagia OMIM:233100
Senior-Loken Syndrome 4
Polydipsia, Stage 5 chronic kidney disease, Polyuria, Nephronophthisis OMIM:606996
Pentosuria
Abnormality of urine homeostasis OMIM:260800
Nephronophthisis-Like Nephropathy 2
Renal insufficiency, Polyuria, Periglomerular fibrosis, Stage 5 chronic kidney disease, Tubular l... OMIM:619468
Type 1 Diabetes Mellitus
Polydipsia, Polyphagia, Polyuria OMIM:222100
Renal Hypoplasia
Renal insufficiency, Urethral valve, Proteinuria, Recurrent urinary tract infections, Unilateral ... ORPHA:93101
Ochoa Syndrome
Renal insufficiency, Recurrent urinary tract infections, Urinary incontinence, Bowel incontinence... ORPHA:2704
Nephronophthisis 1
Tubular basement membrane disintegration, Polyuria, Stage 5 chronic kidney disease, Renal cortico... OMIM:256100
Hypercalcemia, Infantile, 1
Polyuria, Nephrolithiasis, Hypercalciuria, Dehydration, Nephrocalcinosis, Vomiting, Medullary nep... OMIM:143880
Nephronophthisis 3
Renal insufficiency, Polyuria, Stage 5 chronic kidney disease, Enuresis, Renal corticomedullary c... OMIM:604387
Nephronophthisis 4
Polyuria, Stage 5 chronic kidney disease, Renal corticomedullary cysts, Nephronophthisis, Renal t... OMIM:606966
Central Diabetes Insipidus
Anorexia, Diarrhea, Dehydration, Polydipsia, Nocturia ORPHA:178029
Diabetes Insipidus, Nephrogenic, 2, Autosomal
Polyuria, Megacystis, Hypertonic dehydration, Vomiting, Constipation, Polydipsia OMIM:125800
Diabetes Insipidus, Nephrogenic, 1, X-Linked
Polyuria, Megacystis, Hypertonic dehydration, Vomiting, Constipation, Polydipsia OMIM:304800
Nephrogenic Diabetes Insipidus
Hypernatremic dehydration, Renal insufficiency, Hydroureter, Polyhydramnios, Anorexia, Functional... ORPHA:223
Hypercalcemia, Infantile, 2
Polyuria, Hypercalciuria, Renal phosphate wasting, Nephrocalcinosis, Medullary nephrocalcinosis OMIM:616963
Senior-Loken Syndrome 3
Polyuria, Stage 5 chronic kidney disease, Enuresis, Renal corticomedullary cysts, Nephronophthisi... OMIM:606995
Senior-Loken Syndrome 1
Renal insufficiency, Polyuria, Thickening of the tubular basement membrane, Impaired renal concen... OMIM:266900
Hypomagnesemia, Seizures, And Impaired Intellectual Development 2
Hyperactivity, Polyuria, Renal magnesium wasting, Self-biting, Nephrocalcinosis, Renal potassium ... OMIM:618314
Acquired Central Diabetes Insipidus
Pollakisuria, Polydipsia ORPHA:95626
Teratoma, Pineal
Polydipsia, Polyuria OMIM:273120
Hypomagnesemia 3, Renal
Recurrent urinary tract infections, Polyuria, Hypocitraturia, Renal magnesium wasting, Chronic ki... OMIM:248250
Cystinosis
Renal insufficiency, Proteinuria, Dehydration, Renal tubular dysfunction, Aminoaciduria, Vomiting... ORPHA:213
Nephronophthisis 11
Tubular basement membrane disintegration, Polyuria, Stage 5 chronic kidney disease, Renal cortico... OMIM:613550
Bartter Syndrome, Type 4A, Neonatal, With Sensorineural Deafness
Hyperchloriduria, Global glomerulosclerosis, Renal insufficiency, Polyuria, Edema, Renal salt was... OMIM:602522
Hyperaldosteronism, Familial, Type Iii
Hypercalciuria, Polydipsia, Polyuria OMIM:613677
Oligomeganephronia
Renal insufficiency, Proteinuria, Unilateral renal agenesis, Abnormal renal cortex morphology, Gl... ORPHA:2260
Helix Syndrome
Renal insufficiency, Polyuria, Xerostomia, Nephrolithiasis, Hypocalciuria, Polydipsia OMIM:617671
Hereditary Central Diabetes Insipidus
Polydipsia, Vomiting, Diarrhea ORPHA:30925
East Syndrome
Salt craving, Renal salt wasting, Renal magnesium wasting, Enuresis, Abnormal urinary electrolyte... ORPHA:199343
Distal Renal Tubular Acidosis
Hyperphosphaturia, Hypocitraturia, Diarrhea, Nephrolithiasis, Renal cyst, Hypercalciuria, Nephroc... ORPHA:18
Bartter Syndrome, Type 4B, Neonatal, With Sensorineural Deafness
Hyperchloriduria, Renal insufficiency, Polyuria, Edema, Increased urinary potassium, Renal salt w... OMIM:613090
Bartter Syndrome, Type 3
Hyperchloriduria, Impaired renal ltubular reabsorption of chloride, Polyuria, Renal salt wasting,... OMIM:607364
Kleine-Levin Syndrome
Abnormal eating behavior, Repetitive compulsive behavior, Sweet craving, Hypersexuality, Agitatio... ORPHA:33543
Senior-Boichis Syndrome
Polydipsia, Thickening of the tubular basement membrane, Aggressive behavior, Chronic kidney dise... ORPHA:84081
Adenine Phosphoribosyltransferase Deficiency
2,8-dihydroxyadenine crystalluria, Renal insufficiency, Urolithiasis, Nephrolithiasis, Oliguria, ... OMIM:614723
Idiopathic Steroid-Resistant Nephrotic Syndrome
Diffuse mesangial sclerosis, Foamy urine, Proteinuria, Edema, Minimal change glomerulonephritis, ... ORPHA:567548
Adenine Phosphoribosyltransferase Deficiency
Renal insufficiency, Recurrent urinary tract infections, Proteinuria, Dysuria, Chronic kidney dis... ORPHA:976
Proximal Renal Tubular Acidosis
Hyperphosphaturia, Diarrhea, Bicarbonaturia, Bicarbonate-wasting renal tubular acidosis, Nephroli... ORPHA:47159
Apparent Mineralocorticoid Excess
Renal insufficiency, Abnormal urine sodium concentration, Nephrocalcinosis, Renal sodium wasting,... ORPHA:320
Bartter Syndrome, Type 5, Antenatal, Transient
Hypercalciuria, Medullary nephrocalcinosis, Polyuria, Polyhydramnios OMIM:300971
Bardet-Biedl Syndrome 9
Renal insufficiency, Polydipsia, Polyphagia OMIM:615986
Hyperparathyroidism, Neonatal Severe
Hyperphosphaturia, Polyuria, Hypercalciuria, Aminoaciduria, Constipation, Polydipsia OMIM:239200
Seizures, Sensorineural Deafness, Ataxia, Impaired Intellectual Development, And Electrolyte Imbalance
Salt craving, Polyuria, Renal salt wasting, Enuresis, Hypocalciuria, Renal sodium wasting, Polydi... OMIM:612780
Juvenile Nephropathic Cystinosis
Renal insufficiency, Proteinuria, Chronic kidney disease, Abnormal urine potassium concentration,... ORPHA:411634
Renal Tubulopathy, Diabetes Mellitus, And Cerebellar Ataxia
Polyuria, Diarrhea, Dehydration, Proximal tubulopathy, Vomiting OMIM:560000
Infantile Nephropathic Cystinosis
Hyperphosphaturia, Abnormal tubulointerstitial morphology, Dehydration, Renal tubular dysfunction... ORPHA:411629
Bardet-Biedl Syndrome 17
Polydipsia, Polyuria, Stage 5 chronic kidney disease, Renal cyst, Micropenis OMIM:615994
Gitelman Syndrome
Salt craving, Polyuria, Renal magnesium wasting, Enuresis, Hypocalciuria, Vomiting, Constipation,... OMIM:263800
Familial Cold Urticaria
Polydipsia, Dehydration ORPHA:47045
Familial Hyperaldosteronism Type Iii
Polydipsia, Hypercalciuria, Nausea ORPHA:251274
Primary Unilateral Adrenal Hyperplasia
Polydipsia, Nausea, Increased urinary potassium ORPHA:231580
Bartter Syndrome, Type 2, Antenatal
Hyperchloriduria, Polyuria, Polyhydramnios, Renal salt wasting, Increased urinary potassium, Diar... OMIM:241200
Hypouricemia, Renal, 1
Proteinuria, Urolithiasis, Oliguria, Renal tubular epithelial necrosis, Hyperuricosuria, Renal co... OMIM:220150
Amelogenesis Imperfecta, Type Ig
Renal insufficiency, Polyuria, Impaired renal concentrating ability, Nephrocalcinosis, Enuresis OMIM:204690
Hypomagnesemia 7, Renal, With Or Without Dilated Cardiomyopathy
Nephrocalcinosis, Polyuria OMIM:620152
Hyperuricemia, Pulmonary Hypertension, Renal Failure, And Alkalosis Syndrome
Proteinuria, Polyuria, Renal salt wasting, Chronic kidney disease, Hyperechogenic kidneys OMIM:613845
Proteinuria, Low Molecular Weight, With Hypercalciuria And Nephrocalcinosis
Renal insufficiency, Hypercalciuria, Nephrocalcinosis, Focal segmental glomerulosclerosis, Aminoa... OMIM:308990
Cystinosis, Nephropathic
Renal insufficiency, Hyperphosphaturia, Proteinuria, Polyuria, Oral-pharyngeal dysphagia, Exocrin... OMIM:219800
Bartter Syndrome, Type 1, Antenatal
Hyperchloriduria, Polyuria, Polyhydramnios, Renal salt wasting, Increased urinary potassium, Diar... OMIM:601678
Hnf1B-Related Autosomal Dominant Tubulointerstitial Kidney Disease
Glomerulopathy, Multicystic kidney dysplasia, Renal insufficiency, Hypospadias, Renal agenesis, H... ORPHA:93111
Diarrhea 10, Protein-Losing Enteropathy Type
Polyuria, Polyhydramnios, Pericardial effusion, Secretory diarrhea, Hematochezia, Anasarca, Pleur... OMIM:618183
Primary Hyperaldosteronism-Seizures-Neurological Abnormalities Syndrome
Polydipsia, Nephrolithiasis, Nausea ORPHA:369929
Arima Syndrome
Proteinuria, Polyuria, Stage 5 chronic kidney disease, Hematuria, Renal corticomedullary cysts, R... OMIM:243910
Renal Hypoplasia, Bilateral
Proteinuria, Edema, Chronic kidney disease, Oliguria, Renal hypoplasia, Renal cyst, Beta 2-microg... ORPHA:97362
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 5
Anuria, Proteinuria, Hemolytic-uremic syndrome, Stage 5 chronic kidney disease, Hematuria, Acute ... OMIM:612925
Hyperparathyroidism-Jaw Tumor Syndrome
Renal insufficiency, Polydipsia, Renal hamartoma, Nephrolithiasis, Renal cyst, Hypercalciuria, Ne... ORPHA:99880
Familial Hyperaldosteronism Type I
Polydipsia, Nausea ORPHA:403
Parathyroid Carcinoma
Renal insufficiency, Polydipsia, Renal hamartoma, Nephrolithiasis, Renal cyst, Hypercalciuria, Ne... ORPHA:143
Pediatric-Onset Graves Disease
Hyperactivity, Diarrhea, Polydipsia, Polyphagia, Oligohydramnios ORPHA:525731
Primary Hyperoxaluria Type 3
Hyperoxaluria, Dysuria, Calcium oxalate nephrolithiasis, Nephrocalcinosis, Hematuria, Pollakisuri... ORPHA:93600
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 4
Anuria, Proteinuria, Hemolytic-uremic syndrome, Hematuria, Acute kidney injury OMIM:612924
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 3
Anuria, Proteinuria, Hemolytic-uremic syndrome, Hematuria, Acute kidney injury OMIM:612923
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 2
Anuria, Proteinuria, Hemolytic-uremic syndrome, Hematuria, Acute kidney injury OMIM:612922
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 6
Anuria, Proteinuria, Hemolytic-uremic syndrome, Hematuria, Acute kidney injury OMIM:612926
Renal Tubular Dysgenesis
Renotubular dysgenesis, Abnormality of the urinary system, Anuria, Oligohydramnios OMIM:267430
Wolfram Syndrome
Gastrointestinal hemorrhage, Recurrent urinary tract infections, Dysuria, Abnormality of the urin... ORPHA:3463
Septo-Optic Dysplasia Spectrum
Hypoplasia of penis, Polydipsia, Constipation ORPHA:3157
Erdheim-Chester Disease
Renal insufficiency, Polydipsia, Dysuria, Joint swelling, Pleural effusion, Hydronephrosis ORPHA:35687
Panhypophysitis
Polydipsia, Hyposthenuria, Nausea ORPHA:95513
Whipple Disease
Gastrointestinal hemorrhage, Anorexia, Diarrhea, Pedal edema, Polydipsia ORPHA:3452
Gitelman Syndrome
Salt craving, Proteinuria, Urinary incontinence, Decreased urinary potassium, Pericardial effusio... ORPHA:358
Systemic Capillary Leak Syndrome
Renal insufficiency, Pulmonary edema, Diarrhea, Oliguria, Pedal edema, Pleural effusion, Abnormal... ORPHA:188
Autosomal Recessive Polycystic Kidney Disease
Gastrointestinal hemorrhage, Recurrent urinary tract infections, Renal insufficiency, Oliguria, S... ORPHA:731
Toxic Epidermal Necrolysis
Gastrointestinal hemorrhage, Renal insufficiency, Dysuria, Abnormality of the urethra, Dysphagia,... ORPHA:537
Tubulointerstitial Kidney Disease, Autosomal Dominant, 2
Renal cortical atrophy, Impaired renal uric acid clearance, Tubular basement membrane disintegrat... OMIM:174000
Car T Cell Therapy-Associated Cytokine Release Syndrome
Nausea, Diarrhea, Vomiting, Pleural effusion, Acute kidney injury, Decreased urine output, Pulmon... ORPHA:542323
Lassa Fever
Facial edema, Diarrhea, Oliguria, Dysphagia ORPHA:99824
Ethylene Glycol Poisoning
Renal insufficiency, Gastritis, Nausea, Renal tubular epithelial necrosis, Renal tubular dysfunct... ORPHA:31826
Genetic Recurrent Myoglobinuria
Dark urine, Renal insufficiency, Recurrent myoglobinuria, Exercise-induced myoglobinuria, Oliguri... ORPHA:99845
Hemorrhagic Fever-Renal Syndrome
Anuria, Proteinuria, Glomerulonephritis, Nausea, Hematemesis, Diarrhea, Chronic kidney disease, O... ORPHA:340
Rabson-Mendenhall Syndrome
Nephrocalcinosis, Polydipsia, Long penis ORPHA:769
Acute Monoblastic/Monocytic Leukemia
Periorbital edema, Oliguria, Anorexia ORPHA:514
Diffuse Cutaneous Systemic Sclerosis
Renal insufficiency, Xerostomia, Oliguria, Gastroesophageal reflux, Dysphagia ORPHA:220393
Cholera
Abnormality of renal excretion, Diarrhea, Dehydration, Vomiting, Acute kidney injury, Decreased u... ORPHA:173
Duplication Of Urethra
Urethral stricture, Recurrent urinary tract infections, Anuria, Hypospadias, Urinary incontinence... ORPHA:237
Pituitary Dermoid And Epidermoid Cysts
Polydipsia ORPHA:91351
Lujo Hemorrhagic Fever
Renal insufficiency, Facial edema, Periorbital edema, Diarrhea, Oliguria, Vomiting, Dysphagia, Mi... ORPHA:319213
Infection-Related Hemolytic Uremic Syndrome
Anuria, Edema, Nausea, Diarrhea, Secretory diarrhea, Oliguria, Bloody diarrhea, Pleural empyema, ... ORPHA:544482
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Aggressive behavior, Enuresis, Self-injurious behavior, Compulsive behaviors, Polydipsia, Polyphagia ORPHA:293987
Microscopic Polyangiitis
Gastrointestinal hemorrhage, Glomerulopathy, Renal insufficiency, Diarrhea, Peritonitis, Oliguria... ORPHA:727
Aneurysm Of Sinus Of Valsalva
Oliguria, Edema ORPHA:1054
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 2
Anuria, Peritonitis, Megacystis, Pyelonephritis, Fetal megacystis, Renal cortical hyperechogenici... OMIM:619351
Shiga Toxin-Associated Hemolytic Uremic Syndrome
Anuria, Diarrhea, Peritonitis, Dehydration, Bloody diarrhea, Hemoglobinuria, Vomiting, Acute kidn... ORPHA:90038
Colchicine Poisoning
Renal insufficiency, Diarrhea, Oliguria, Dehydration, Vomiting, Nausea ORPHA:31824
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1
Hemolytic-uremic syndrome, Diarrhea, Anuria, Acute kidney injury OMIM:235400
Zttk Syndrome
Chronic diarrhea, Polyuria, Unilateral renal agenesis, Horseshoe kidney OMIM:617140
Lipodystrophy, Familial Partial, Type 7
Polyuria, Diarrhea, Vomiting, Dysphagia, Pleural effusion OMIM:606721
Tumoral Calcinosis, Hyperphosphatemic, Familial, 1
Decreased renal tubular phosphate excretion, Nephrocalcinosis, Increased renal tubular phosphate ... OMIM:211900
Sepsis In Premature Infants
Edema, Diarrhea, Enterocolitis, Oliguria, Vomiting, Reversible renal failure ORPHA:90051
Carnitine-Acylcarnitine Translocase Deficiency
Dicarboxylic aciduria, Oliguria ORPHA:159
Brain-Lung-Thyroid Syndrome
Hyperactivity, Hypospadias, Abnormal eating behavior, Megacystis, Abnormal drinking behavior, Com... ORPHA:209905
Autosomal Recessive Hypophosphatemic Rickets
Renal phosphate wasting, Hyperphosphaturia, Abnormality of renal excretion ORPHA:289176
Cardiogenic Shock
Oliguria ORPHA:97292
Yellow Fever
Renal insufficiency, Anuria, Hematemesis, Diarrhea, Vomiting, Acute kidney injury, Nausea ORPHA:99829
Exercise-Induced Malignant Hyperthermia
Acute kidney injury, Vomiting, Oliguria, Nausea ORPHA:466650

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cd63

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cd63.

No publications found that use IMPC mice or data for Cd63.

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MGI Allele Allele Type Produced
Cd63tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Cd63tm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Cd63tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Cd63tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

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