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Gene: Pgm1 MGI:97565

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Gene Summary

Name:
phosphoglucomutase 1
Synonyms:
2610020G18Rik,  Pgm2,  Pgm-2,  Pgm1a

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IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
embryonic lethality prior to tooth bud stage Pgm1em1(IMPC)Bay HOM   E12.5 0.00
abnormal vocalization Pgm1em1(IMPC)J HET Early adult 2.42×10-10
abnormal coat/ hair morphology Pgm1em1(IMPC)J HET Early adult 3.06×10-07
preweaning lethality, incomplete penetrance Pgm1em1(IMPC)Bay HOM   Early adult 0.00
embryonic lethality prior to tooth bud stage Pgm1em1(IMPC)J HOM   E12.5 0.00
abnormal forebrain development Pgm1em1(IMPC)Bay HOM E9.5 0.00
abnormal coat appearance Pgm1em1(IMPC)J HET Early adult 2.22×10-06
abnormal embryo size Pgm1em1(IMPC)J HOM E12.5 0.00
preweaning lethality, complete penetrance Pgm1em1(IMPC)J HOM   Early adult 0.00
preweaning lethality, complete penetrance Pgm1em1(IMPC)Bay HOM Early adult 0.00
decreased locomotor activity Pgm1em1(IMPC)Bay HET Early adult 5.23×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Eye Morphology

VIP of right eye

16 Images

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Eye Morphology

VIP of right fundus

16 Images

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Eye Morphology

VIP of left fundus

16 Images

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Eye Morphology

VIP of left eye

16 Images

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MicroCT E9.5

Embryo reconstruction

6 Images

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PDF thumbnail PDF
Auditory Brain Stem Response

Click-evoked + 6 to 30kHz tone waveforms (pdf format)

7 Images

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Human diseases caused by Pgm1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Pgm1 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Congenital Disorder Of Glycosylation, Type It
OMIM:614921

The table below shows human diseases predicted to be associated to Pgm1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Intellectual Developmental Disorder, X-Linked 110
Bradykinesia OMIM:301095
Aprosencephaly Syndrome
Aprosencephaly, Anencephaly OMIM:207770
Aprosencephaly And Cerebellar Dysgenesis
Aprosencephaly OMIM:601374
Congenital Disorder Of Glycosylation, Type It
OMIM:614921

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Pgm1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Pgm1.

No publications found that use IMPC mice or data for Pgm1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Pgm1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Pgm1em1(IMPC)Bay Exon Deletion Mice
Pgm1tm41296(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Pgm1em1(IMPC)J Exon Deletion Mice

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