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Gene: Oprk1 MGI:97439

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
opioid receptor, kappa 1
Synonyms:
Oprk2,  R21,  KOR-1

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Oprk1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Oprk1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Specific Language Impairment 2
Deficit in phonologic short-term memory OMIM:606712
Specific Language Impairment 1
Deficit in phonologic short-term memory OMIM:606711
7q11.23 duplication syndrome
Short attention span DECIPHER:43
Presenile Dementia, Kraepelin Type
Dementia OMIM:176600
Monoamine Oxidase A Deficiency
Cognitive impairment ORPHA:3057
Spinocerebellar Ataxia Type 27
Akinesia, Limb ataxia, Gait ataxia, Gait disturbance, Difficulty walking, Truncal ataxia ORPHA:98764
Progressive Supranuclear Palsy-Pure Akinesia With Gait Freezing Syndrome
Freezing of gait, Akinesia, Unsteady gait, Falls, Gait imbalance, Loss of ambulation, Short stepp... ORPHA:240094
Spinocerebellar Ataxia Type 21
Progressive cerebellar ataxia, Akinesia, Gait ataxia ORPHA:98773
Parkinson Disease 17
Akinesia OMIM:614203
Atypical Juvenile Parkinsonism
Akinesia, Inability to walk, Gait ataxia, Shuffling gait, Short stepped shuffling gait ORPHA:391411
Spinocerebellar Ataxia 21
Ataxia, Akinesia, Limb ataxia, Gait ataxia, Progressive cerebellar ataxia OMIM:607454
Congenital Myopathy 9A
Akinesia OMIM:618822
Sporadic Adult-Onset Ataxia Of Unknown Etiology
Ataxia, Akinesia, Gait ataxia, Dysdiadochokinesis, Shuffling gait, Abnormal vestibulo-ocular reflex ORPHA:247234
Intellectual Developmental Disorder With Language Impairment And Early-Onset Dopa-Responsive Dystonia-Parkinsonism
Freezing of gait, Akinesia OMIM:619911
Corticobasal Syndrome
Gait disturbance, Akinesia ORPHA:454887
Arthrogryposis Multiplex Congenita 6
Akinesia OMIM:619334
Complex Regional Pain Syndrome
Edema of the upper limbs, Allodynia, Pedal edema ORPHA:83452
Lethal Congenital Contracture Syndrome 2
Akinesia OMIM:607598
Perry Syndrome
Short stepped shuffling gait, Akinesia OMIM:168605
Kufor-Rakeb Syndrome
Akinesia, Ataxia, Gait disturbance OMIM:606693
Neurodegeneration With Brain Iron Accumulation 5
Akinesia OMIM:300894
Manganese Poisoning
Gait disturbance, Akinesia ORPHA:306682
Mitochondrial Complex I Deficiency, Nuclear Type 28
Choreoathetosis, Akinesia, Truncal ataxia OMIM:618249
Classic Progressive Supranuclear Palsy Syndrome
Falls, Gait imbalance, Akinesia ORPHA:240071
Congenital Myopathy 12
Akinesia OMIM:612540
Fetal Akinesia Deformation Sequence
Akinesia ORPHA:994
Erythermalgia, Primary
Diarrhea, Constipation, Xerostomia, Hyperhidrosis OMIM:133020
Multiple Pterygium Syndrome, Lethal Type
Akinesia OMIM:253290
Parkinson Disease 23, Autosomal Recessive Early-Onset
Akinesia OMIM:616840
Anterior Cutaneous Nerve Entrapment Syndrome
Allodynia, Nausea, Hyperhidrosis ORPHA:51890
Aceruloplasminemia
Akinesia, Ataxia, Limb ataxia, Gait ataxia ORPHA:48818
Proliferative Vasculopathy And Hydranencephaly-Hydrocephaly Syndrome
Akinesia OMIM:225790
Postencephalitic Parkinsonism
Akinesia ORPHA:97349
Leukoencephalopathy, Progressive, Infantile-Onset, With Or Without Deafness
Akinesia OMIM:619147
Achalasia, Familial Esophageal
Achalasia, Xerostomia OMIM:200400
Intestinal Botulism
Diarrhea, Xerostomia, Dysphagia ORPHA:178481
Prune Belly Syndrome
Cryptorchidism, Xerostomia, Oligohydramnios OMIM:100100
Gaucher Disease, Perinatal Lethal
Akinesia OMIM:608013
Postorgasmic Illness Syndrome
Xerostomia, Hyperhidrosis ORPHA:279947
Hereditary Late-Onset Parkinson Disease
Shuffling gait, Akinesia ORPHA:411602
Neurotrophic Keratopathy
Corneal stromal edema, Allodynia ORPHA:137596
Iatrogenic Botulism
Constipation, Xerostomia, Dysphagia ORPHA:254509
Ichthyotic Keratoderma, Spasticity, Hypomyelination, And Dysmorphic Facial Features
Ataxia, Xerostomia, Dysmetria OMIM:618527
Inhalational Botulism
Diarrhea, Xerostomia, Constipation ORPHA:254504
Sjogren Syndrome
Xerostomia OMIM:270150
Botulism
Diarrhea, Xerostomia, Dysphagia, Constipation ORPHA:1267
Supranuclear Palsy, Progressive, 2
Falls, Gait imbalance, Akinesia OMIM:609454
Foodborne Botulism
Diarrhea, Xerostomia, Dysphagia, Constipation ORPHA:228371
Trigeminal Neuralgia
Allodynia ORPHA:221091
Mitochondrial Dna Depletion Syndrome 1 (Mngie Type)
Gastroparesis, Diarrhea, Constipation, Vomiting, Dysphagia, Intermittent diarrhea, Allodynia OMIM:603041
Arthrogryposis Multiplex Congenita 5
Akinesia OMIM:618947
Supranuclear Palsy, Progressive, 1
Falls, Gait imbalance, Akinesia OMIM:601104
Lambert-Eaton Myasthenic Syndrome
Constipation, Xerostomia, Impotence, Hypohidrosis ORPHA:43393
Neurodegeneration With Brain Iron Accumulation 1
Choreoathetosis, Akinesia, Ataxia, Gait disturbance OMIM:234200
Dpagt1-Cdg
Inability to walk, Ataxia, Akinesia ORPHA:86309
Helix Syndrome
Anhidrosis, Hyperparathyroidism, Xerostomia, Hypohidrosis OMIM:617671
Autoimmune Polyendocrinopathy Type 3
Atrophic gastritis, Hypergonadotropic hypogonadism, Autoimmune hypoparathyroidism, Primary adrena... ORPHA:227982
Aplasia Of Lacrimal And Salivary Glands
Xerostomia OMIM:180920
African Trypanosomiasis
Choreoathetosis, Difficulty walking, Gait disturbance, Akinesia ORPHA:3385
Benign Schwannoma
Allodynia ORPHA:252164

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Oprk1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Oprk1.

No publications found that use IMPC mice or data for Oprk1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Oprk1tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Oprk1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Oprk1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Oprk1em1(IMPC)Ccpcz Exon Deletion Mice

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