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Gene: Lgals1 MGI:96777

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
lectin, galactose binding, soluble 1
Synonyms:
Galbp,  Gal-1,  L14,  Lect14,  galectin-1

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Lgals1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Lgals1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Intellectual Disability-Expressive Aphasia-Facial Dysmorphism Syndrome
Hyperactivity, Abnormal social behavior ORPHA:436151
Hereditary Geniospasm
Abnormality of mentalis muscle, Abnormal social behavior ORPHA:53372
Hsd10 Disease
Abnormal social behavior, Optic atrophy, Dysphagia ORPHA:391417
Pandas
Anorexia, Impulsivity, Abnormal fear-induced behavior, Depression, Irritability, Tics, Attention ... ORPHA:66624
11Q22.2Q22.3 Microdeletion Syndrome
Attention deficit hyperactivity disorder, Abnormal social behavior, Depressed nasal bridge, Compu... ORPHA:444002
Lamb-Shaffer Syndrome
Hyperactivity, Broad nasal tip, Optic atrophy, Abnormal temper tantrums, Abnormal social behavior... ORPHA:530983
Female Restricted Epilepsy With Intellectual Disability
Hyperactivity, Impulsivity, Aggressive behavior, Abnormal eating behavior, Compulsive behaviors, ... ORPHA:101039
Bilateral Parasagittal Parieto-Occipital Polymicrogyria
Abnormal fear-induced behavior, Pseudobulbar paralysis, Aggressive behavior ORPHA:208441
Trigeminal Neuralgia
Cranial nerve compression, Allodynia, Depression ORPHA:221091
Symptomatic Form Of Fragile X Syndrome In Female Carriers
Hyperactivity, Autoimmunity, Shyness, Aggressive behavior, Depression, Irritability, Self-injurio... ORPHA:449291
X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome
Hyperactivity, Anorexia, Aggressive behavior, Abnormal fear-induced behavior, Irritability, Abnor... ORPHA:3077
Young-Onset Parkinson Disease
Restless legs, Impulsivity, Depression, Agitation, Abnormal autonomic nervous system physiology, ... ORPHA:2828
Metachromatic Leukodystrophy, Late Infantile Form
Decreased nerve conduction velocity, Emotional lability, Abnormal social behavior, Optic atrophy ORPHA:309256
Myasthenia Gravis
Limb muscle weakness, Autoimmunity, Facial palsy, Dysphagia OMIM:254200
Metachromatic Leukodystrophy, Juvenile Form
Decreased nerve conduction velocity, Emotional lability, Abnormal social behavior, Optic atrophy ORPHA:309263
Fg Syndrome Type 1
Progressive flexion contractures, Optic nerve hypoplasia, Choanal atresia, Prominent nose, Attent... ORPHA:93932
Metachromatic Leukodystrophy, Adult Form
Decreased nerve conduction velocity, Optic atrophy, Depression, Emotional lability, Abnormal soci... ORPHA:309271
Gm2 Gangliosidosis, Ab Variant
Abnormal fear-induced behavior, Exaggerated startle response, Inappropriate behavior ORPHA:309246
Adult Acute Respiratory Distress Syndrome
Abnormal circulating interleukin concentration, Increased circulating interleukin 6 concentration... ORPHA:70578
Early-Onset Autosomal Dominant Alzheimer Disease
Abnormal social behavior, Agitation, Deposits immunoreactive to beta-amyloid protein, Disinhibition ORPHA:1020
Benign Schwannoma
Nasal polyposis, Facial palsy, Abnormality of the twelfth cranial nerve, Vestibular schwannoma, A... ORPHA:252164
48,Xxxy Syndrome
Depressed nasal ridge, Irritability, Attention deficit hyperactivity disorder, Abnormal social be... ORPHA:96263
Porphyria Due To Ala Dehydratase Deficiency
Restlessness, Ankle flexion contracture, Abnormal fear-induced behavior, Depression, Agitation, L... ORPHA:100924
Childhood Absence Epilepsy
Abnormal social behavior, Punding, Attention deficit hyperactivity disorder, Depression ORPHA:64280
Prader-Willi Syndrome Due To Translocation
Narrow nasal bridge, Anteverted nares, Prominent nose, Broad nasal tip, Head-banging, Compulsive ... ORPHA:177907
Acute Lung Injury
Increased circulating interleukin 6 concentration, Abnormality of serum cytokine level, Abnormali... ORPHA:178320
Mend Syndrome
Hyperactivity, Prominent nasal bridge, Abnormal auditory evoked potentials, Aggressive behavior, ... ORPHA:401973
Koolen-De Vries Syndrome Due To A Point Mutation
Hand muscle atrophy, Thick nasal alae, Prominent nasal bridge, Underdeveloped nasal alae, Bulbous... ORPHA:363965
17Q21.31 Microdeletion Syndrome
Hand muscle atrophy, Thick nasal alae, Prominent nasal bridge, Underdeveloped nasal alae, Bulbous... ORPHA:363958
Dihydropyrimidine Dehydrogenase Deficiency
Depressed nasal bridge, Anteverted nares, Irritability, Prominent nasal tip, Abnormal social beha... ORPHA:1675
Aregenerative Anemia
Emotional lability, Abnormality of interleukin secretion, Depression ORPHA:101096
Non-Progressive Cerebellar Ataxia With Intellectual Disability
Wide nose, Anteverted nares, Aggressive behavior, Bulbous nose, Abnormal social behavior ORPHA:314647
Tuberous Sclerosis Complex
Hyperactivity, Impulsivity, Aggressive behavior, Repetitive compulsive behavior, Depression, Self... ORPHA:805
Niemann-Pick Disease Type C
Aggressive behavior, Aplasia/Hypoplasia of the abdominal wall musculature, Depression, Disinhibit... ORPHA:646
Rubinstein-Taybi Syndrome Due To 16P13.3 Microdeletion
Hyperactivity, Impulsivity, Aggressive behavior, Abnormal fear-induced behavior, Self-injurious b... ORPHA:353281
Trichothiodystrophy
Reduced social reciprocity, Multiple joint contractures, Panhypogammaglobulinemia ORPHA:33364
Parenteral Nutrition-Associated Cholestasis
Abnormality of cytokine secretion ORPHA:567983
Infection-Related Hemolytic Uremic Syndrome
Increased circulating interleukin 6 concentration, Abnormality of chemokine secretion, Abnormalit... ORPHA:544482
Rubinstein-Taybi Syndrome Due To Ep300 Haploinsufficiency
Hyperactivity, Impulsivity, Aggressive behavior, Abnormal fear-induced behavior, Prominent nasal ... ORPHA:353284
Rubinstein-Taybi Syndrome Due To Crebbp Mutations
Hyperactivity, Impulsivity, Aggressive behavior, Abnormal fear-induced behavior, Prominent nasal ... ORPHA:353277
Williams Syndrome
Wide nasal bridge, Depression, Macroglossia, Myopathy, Attention deficit hyperactivity disorder, ... ORPHA:904

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Lgals1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Lgals1.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Galectin-1 accelerates high-fat diet-induced obesity by activation of peroxisome proliferator-activated receptor gamma (PPARĪ³) in mice. Cell death & disease (January 2021) Lgals1tm1(KOMP)Vlcg PMC7801586

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MGI Allele Allele Type Produced
Lgals1tm1e(KOMP)Mbp Targeted, non-conditional allele ES Cells
Lgals1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, ES Cells
Lgals1tm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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