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Gene: Krt15 MGI:96689

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
keratin 15
Synonyms:
K15,  Krt1-15

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Krt15 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Krt15 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Tracheoesophageal Fistula With Or Without Esophageal Atresia
Esophageal atresia, Tracheoesophageal fistula OMIM:189960
Gastroesophageal Reflux
Esophageal neoplasm, Barrett esophagus, Gastroesophageal reflux, Esophagitis OMIM:109350
Barrett Esophagus
Esophageal ulceration, Esophageal carcinoma, Barrett esophagus, Gastroesophageal reflux OMIM:614266
Visceral Myopathy 2
Intestinal obstruction, Necrotizing enterocolitis, Intestinal pseudo-obstruction, Intestinal malr... OMIM:619350
Proton-Pump Inhibitor-Responsive Esophageal Eosinophilia
Abnormal peristalsis, Esophageal food impaction, Lactose intolerance, Esophageal stenosis, Eosino... ORPHA:411696
Portal Hypertension, Noncirrhotic, 1
Esophageal varix OMIM:617068
Leiomyoma Of Vulva And Esophagus
Esophageal obstruction OMIM:150700
Oculogastrointestinal Muscular Dystrophy
Abnormality of the gastrointestinal tract, Spontaneous esophageal perforation, Intestinal pseudo-... ORPHA:1876
Epidermolysis Bullosa, Junctional 6, With Pyloric Atresia
Esophageal stenosis, Congenital pyloric atresia OMIM:619817
Retinitis Pigmentosa 89
Esophageal varix OMIM:618955
Cholesteryl Ester Storage Disease
Esophageal varix ORPHA:75234
Epidermolysis Bullosa Dystrophica, Autosomal Recessive
Spontaneous esophageal perforation, Esophageal stricture, Abnormal esophagus morphology, Dysphagia OMIM:226600
Dyskeratosis Congenita, Autosomal Recessive 5
Esophageal stenosis, Colitis OMIM:615190
Budd-Chiari Syndrome
Gastrointestinal hemorrhage, Intestinal obstruction, Malabsorption, Esophageal varix, Gastrointes... ORPHA:131
Bronchogenic Cyst
Abnormal esophagus morphology, Dysphagia, Abnormal stomach morphology ORPHA:2357
Cerebroretinal Microangiopathy With Calcifications And Cysts 2
Gastrointestinal hemorrhage, Esophageal varix OMIM:617341
Portal Hypertension, Noncirrhotic, 2
Esophageal varix, Hepatocellular carcinoma OMIM:619463
X-Linked Alport Syndrome-Diffuse Leiomyomatosis
Esophageal stenosis, Hypoperistalsis, Esophageal neoplasm, Abnormal esophagus morphology, Gastroe... ORPHA:1018
Noonan Syndrome 7
Impaired oropharyngeal swallow response, Abnormal esophagus morphology, Dysphagia OMIM:613706
Wolman Disease
Esophageal varix, Steatorrhea ORPHA:75233
Plummer-Vinson Syndrome
Glossitis, Tongue atrophy, Esophageal web, Dysphagia ORPHA:54028
Visceral Myopathy, Familial, With External Ophthalmoplegia
Spontaneous esophageal perforation OMIM:277320
Dyskeratosis Congenita, Autosomal Dominant 6
Esophageal stenosis, Oral leukoplakia OMIM:616553
Methimazole Embryofetopathy
Esophageal atresia, Tracheoesophageal fistula ORPHA:1923
Autosomal Recessive Generalized Dystrophic Epidermolysis Bullosa, Intermediate Form
Esophageal stenosis, Anal fissure, Esophageal stricture, Gastroesophageal reflux, Dysphagia, Anky... ORPHA:89842
Adams-Oliver Syndrome 6
Esophageal varix OMIM:616589
Systemic Sclerosis
Abnormality of the gastrointestinal tract, Abnormal small intestine morphology, Barrett esophagus... ORPHA:90291
Ectodermal Dysplasia/Short Stature Syndrome
Esophageal stricture, Dysphagia OMIM:616029
Glycogen Storage Disease Iv
Esophageal varix OMIM:232500
Coffin-Siris Syndrome 11
Esophageal atresia, High palate, Bifid uvula, Cleft soft palate OMIM:618779
Non-Syndromic Posterior Hypospadias
Esophageal atresia, Anal atresia, Cleft palate ORPHA:95706
Hepatoportal Sclerosis
Gastrointestinal hemorrhage, Esophageal varix, Gastric varix, Hepatocellular carcinoma ORPHA:64743
Aspergillosis
Abnormal esophagus morphology ORPHA:1163
Gastrointestinal Ulceration, Recurrent, With Dysfunctional Platelets
Esophageal ulceration, Gastric ulcer, Duodenal ulcer OMIM:618372
Congenital Disorder Of Glycosylation, Type Iil
Inflammation of the large intestine, Esophageal varix OMIM:614576
Fanconi Anemia, Complementation Group Q
Anteriorly placed anus, Esophageal atresia OMIM:615272
Dyskeratosis Congenita, Autosomal Recessive 8
Oral leukoplakia, Pancolitis, Inflammation of the large intestine, Esophageal stricture OMIM:620133
Rhombencephalosynapsis
Esophageal atresia, Aganglionic megacolon, Tracheoesophageal fistula, Anal atresia ORPHA:59315
Chromosome 17Q12 Duplication Syndrome
Esophageal atresia, Cleft soft palate OMIM:614526
Vacterl Association, X-Linked, With Or Without Hydrocephalus
Esophageal atresia, Tracheoesophageal fistula, Anal atresia OMIM:314390
Epidermolysis Bullosa, Junctional 5B, With Pyloric Atresia
Esophageal atresia, Congenital pyloric atresia OMIM:226730
Vertebral, Cardiac, Tracheoesophageal, Renal, And Limb Defects
Esophageal atresia, Submucous cleft hard palate, Tracheoesophageal fistula, Duodenal atresia OMIM:619227
Microgastria-Limb Reduction Defect Syndrome
Intestinal malrotation, Hiatus hernia, Esophageal atresia, Rectal atresia, Tracheoesophageal fist... ORPHA:2538
Localized Dystrophic Epidermolysis Bullosa, Acral Form
Esophageal stricture ORPHA:158673
Phosphoribosylaminoimidazole Carboxylase Deficiency
Esophageal atresia, Tracheoesophageal fistula OMIM:619859
Anophthalmia/Microphthalmia-Esophageal Atresia Syndrome
Esophageal atresia, Tracheoesophageal fistula ORPHA:77298
Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency
Esophageal varix ORPHA:367
Coach Syndrome 1
Esophageal varix OMIM:216360
Cholesteryl Ester Storage Disease
Esophageal varix, Steatorrhea OMIM:278000
Fanconi Anemia, Complementation Group B
Esophageal atresia, Tracheoesophageal fistula, Duodenal atresia OMIM:300514
Septo-Optic Dysplasia Spectrum
Esophageal atresia, Tracheoesophageal fistula, Cleft palate ORPHA:3157
Recessive Dystrophic Epidermolysis Bullosa Inversa
Esophageal stricture, Gastrointestinal inflammation ORPHA:79409
Cirrhosis, Familial
Esophageal varix OMIM:215600
Adams-Oliver Syndrome
Gastrointestinal hemorrhage, Esophageal varix ORPHA:974
Cholestasis, Progressive Familial Intrahepatic, 8
Esophageal varix OMIM:619662
Adams-Oliver Syndrome 5
Esophageal varix OMIM:616028
Benign Schwannoma
Intestinal polyposis, Abnormal parotid gland morphology, Abnormal esophagus morphology ORPHA:252164
Feingold Syndrome
Esophageal atresia, Duodenal atresia ORPHA:1305
Cartilage-Hair Hypoplasia
Esophageal atresia, Anal stenosis, Aganglionic megacolon, Malabsorption OMIM:250250
Alacrima, Achalasia, And Impaired Intellectual Development Syndrome
Achalasia, Esophageal stenosis, Dysphagia OMIM:615510
Glycogen Storage Disease Due To Liver Phosphorylase Kinase Deficiency
Esophageal varix, Hepatocellular adenoma ORPHA:264580
Apert Syndrome
Esophageal atresia, Cleft palate, Narrow palate, Ectopic anus, Bifid uvula ORPHA:87
Dyskeratosis Congenita
Esophageal stenosis, Malabsorption, Anorectal anomaly, Tracheoesophageal fistula, Oral leukoplakia ORPHA:1775
Immunodeficiency 12
Esophageal stricture OMIM:615468
Mandibulofacial Dysostosis, Guion-Almeida Type
Esophageal atresia, Cleft palate OMIM:610536
Mirage Syndrome
Achalasia, Gastroesophageal reflux, Esophageal stricture OMIM:617053
Kindler Syndrome
Anal stenosis, Esophageal stenosis, Oral leukoplakia, Dysphagia OMIM:173650
Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease
Hematemesis, Esophageal varix OMIM:263200
Hereditary Hemorrhagic Telangiectasia
Intestinal polyposis, Esophageal varix, Gastrointestinal hemorrhage ORPHA:774
Dyskeratosis Congenita, Autosomal Recessive 1
Esophageal stricture, Oral leukoplakia OMIM:224230
Feingold Syndrome Type 1
Jejunal atresia, Esophageal atresia, Gastrointestinal atresia, Anal atresia, Duodenal atresia ORPHA:391641
Dyskeratosis Congenita, Autosomal Dominant 2
Esophageal stricture, Oral leukoplakia OMIM:613989
Immunodeficiency 23
Esophageal stricture, High palate OMIM:615816
Apert Syndrome
Pyloric stenosis, Esophageal atresia, Narrow palate, Cleft palate, Ectopic anus, Bifid uvula OMIM:101200
Chronic Graft Versus Host Disease
Esophageal stricture, Xerostomia, Abnormal esophagus morphology, Gastroesophageal reflux, Dysphag... ORPHA:99921
Vacterl With Hydrocephalus
Esophageal atresia, Tracheoesophageal fistula, Anal atresia ORPHA:3412
Classic Homocystinuria
Gastrointestinal hemorrhage, Esophageal varix, High palate ORPHA:394
Caroli Disease
Cholangiocarcinoma, Esophageal varix ORPHA:53035
Fanconi Anemia, Complementation Group L
Esophageal atresia, Anal atresia, Tracheoesophageal fistula, Cleft palate OMIM:614083
Short-Rib Thoracic Dysplasia 20 With Polydactyly
Esophageal diverticulum, Cleft palate, Hamartoma of tongue, Anal atresia OMIM:617925
Feingold Syndrome 1
Jejunal atresia, Esophageal atresia, Gastrointestinal atresia, Tracheoesophageal fistula, High pa... OMIM:164280
Wilson Disease
Esophageal varix, Dysphagia, Hepatocellular carcinoma OMIM:277900
Hardikar Syndrome
Cleft soft palate, Intestinal malrotation, Celiac disease, Hematemesis, Esophageal varix, Bilater... OMIM:301068
Trisomy 18
Esophageal atresia, Narrow palate, Anal atresia, Cleft palate ORPHA:3380
Kindler Epidermolysis Bullosa
Esophageal stricture, Inflammation of the large intestine, Colitis, Esophagitis, Dysphagia, Abnor... ORPHA:2908
Caroli Syndrome
Melena, Cholangiocarcinoma, Esophageal varix, Hematemesis ORPHA:480520
Fryns Syndrome
Aganglionic megacolon, Intestinal malrotation, Esophageal atresia, Cleft palate, Meckel diverticu... OMIM:229850
Cirrhosis-Dystonia-Polycythemia-Hypermanganesemia Syndrome
Esophageal varix ORPHA:309854
Autosomal Recessive Polycystic Kidney Disease
Gastrointestinal hemorrhage, Cholangiocarcinoma, Esophageal varix, Protein-losing enteropathy, He... ORPHA:731
Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Intestinal malrotation, Esophageal atresia, Tracheoesophageal fistula, Cleft palate, Congenital s... OMIM:265380
Rajab Interstitial Lung Disease With Brain Calcifications 1
Gastroesophageal reflux, Esophageal varix, High palate, Intestinal malrotation OMIM:613658
Senior-Boichis Syndrome
Esophageal varix ORPHA:84081
Lysosomal Acid Lipase Deficiency
Esophageal varix, Steatorrhea ORPHA:275761
Stevens-Johnson Syndrome
Gastrointestinal hemorrhage, Esophageal stricture, Dysphagia ORPHA:36426
Van Esch-O'Driscoll Syndrome
Esophageal atresia, Tracheoesophageal fistula, Bifid uvula OMIM:301030
Distal Deletion 12Q
High, narrow palate, Esophageal atresia, Pyloric stenosis, Microglossia, Duodenal atresia ORPHA:96149
Vasculitis, Autoinflammation, Immunodeficiency, And Hematologic Defects Syndrome
Esophageal varix OMIM:615688
Fanconi Anemia, Complementation Group D2
Esophageal atresia, Tracheoesophageal fistula OMIM:227646
Maternal Phenylketonuria
Esophageal atresia, High palate ORPHA:2209
Arima Syndrome
Esophageal varix OMIM:243910
Congenital Tracheomalacia
Esophageal atresia, Gastroesophageal reflux, Tracheoesophageal fistula ORPHA:95430
Gaucher Disease-Ophthalmoplegia-Cardiovascular Calcification Syndrome
Gastric ulcer, Esophageal varix ORPHA:2072
Microphthalmia, Syndromic 3
Esophageal atresia OMIM:206900
Neurodevelopmental Disorder With Hypotonia And Dysmorphic Facies
High palate, Esophageal varix, Cleft soft palate, Dysphagia OMIM:619503
Autosomal Recessive Generalized Dystrophic Epidermolysis Bullosa, Severe Form
Anal fissure, Gastrointestinal inflammation, Gastroesophageal reflux, Dysphagia, Esophageal ulcer... ORPHA:79408
Dyskeratosis Congenita, X-Linked
Esophageal stricture, Oral leukoplakia, Anal mucosal leukoplakia OMIM:305000
Gabriele-De Vries Syndrome
Esophageal atresia, High palate, Oral-pharyngeal dysphagia ORPHA:506358
Progeroid Short Stature With Pigmented Nevi
Esophageal ulceration OMIM:176690
Severe Generalized Junctional Epidermolysis Bullosa
Esophageal stricture, Gastrointestinal inflammation ORPHA:79404
Vater/Vacterl Association
Esophageal atresia, Tracheoesophageal fistula, Anal atresia OMIM:192350
Charge Syndrome
Anal stenosis, Esophageal atresia, Tracheoesophageal fistula, Cleft palate, Dysphagia, Anal atres... OMIM:214800
Biliary, Renal, Neurologic, And Skeletal Syndrome
Gastroesophageal reflux, Esophageal varix OMIM:619534
Short Rib-Polydactyly Syndrome, Verma-Naumoff Type
Esophageal atresia, Ectopic anus, Bifid tongue, Anal atresia ORPHA:93271
Alström Syndrome
Gastroesophageal reflux, Esophageal varix ORPHA:64

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Krt15

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Krt15.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Long-lived keratin 15+ esophageal progenitor cells contribute to homeostasis and regeneration. The Journal of clinical investigation (May 2017) Krt15tm1(KOMP)Vlcg PMC5451220

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MGI Allele Allele Type Produced
Krt15tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Krt15tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Krt15tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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