Not currently registered for phenotyping at IMPC
Phenotyping is currently not planned for a knockout strain of this gene.
Gene Summary
IMPC Data Collections
- No Body Weight Data
- No Embryo Imaging Data
- No Viability Data
Phenotyping is currently not planned for a knockout strain of this gene.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Igfbp4 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Type 1 Diabetes Mellitus 15 | Type I diabetes mellitus, Diabetes mellitus | OMIM:601666 | |
Type 2 Diabetes Mellitus | Type II diabetes mellitus, Insulin resistance, Increased waist to hip ratio | OMIM:125853 | |
Maturity-Onset Diabetes Of The Young, Type 11 | Overweight, Obesity, Maturity-onset diabetes of the young | OMIM:613375 | |
Mody | Large for gestational age, Overweight, Transient neonatal diabetes mellitus, Insulin-resistant di... | ORPHA:552 |
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Igfbp4.
There are 2 publications which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
IGFBP4 Is Required for Adipogenesis and Influences the Distribution of Adipose Depots. | Endocrinology (October 2017) | Igfbp4tm1(KOMP)Vlcg | 28938423 |
IGFBP-4 regulates adult skeletal growth in a sex-specific manner. | The Journal of endocrinology (February 2017) | Igfbp4tm1(KOMP)Vlcg | PMC5425953 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Igfbp4tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | Mice, ES Cells |
Igfbp4tm38472(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
Igfbp4tm1(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) | Targeting vectors, ES Cells |
Igfbp4tm38472(L1L2_st1) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
Igfbp4tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
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