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Gene: H2-Eb1 MGI:95901

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Gene Summary

Name:
histocompatibility 2, class II antigen E beta
Synonyms:
H-2Eb,  Ia-4,  Ia4

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal spine curvature H2-Eb1b-tm1a(KOMP)Wtsi HOM Early adult 5.04×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Skull Dorso Ventral Orientation

14 Images

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X-ray

XRay Images Whole Body Dorso Ventral

15 Images

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DSS Histology

Images

8 Images

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X-ray

XRay Images Whole Body Lateral Orientation

13 Images

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X-ray

XRay Images Forepaw

14 Images

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X-ray

XRay Images Skull Lateral Orientation

14 Images

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Legacy Phenotype Associated Images
H2-Eb1tm1a(KOMP)Wtsi
HOM, Female, WTSI
H2-Eb1tm1a(KOMP)Wtsi
HOM, Female, WTSI
H2-Eb1tm1a(KOMP)Wtsi
HOM, Male, WTSI
H2-Eb1tm1a(KOMP)Wtsi
HOM, Male, WTSI
H2-Eb1tm1a(KOMP)Wtsi
HOM, Male, WTSI

View all 70 images

H2-Eb1tm1a(KOMP)Wtsi
Fused cornea and lens, HOM, Female, WTSI
H2-Eb1tm1a(KOMP)Wtsi
Fused cornea and lens, HOM, Female, WTSI

Human diseases caused by H2-Eb1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to H2-Eb1 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Giant Cell Arteritis
ORPHA:397
Sarcoidosis, Susceptibility To, 1
OMIM:181000
Narcolepsy Type 1
ORPHA:2073
Systemic-Onset Juvenile Idiopathic Arthritis
ORPHA:85414
Narcolepsy Type 2
ORPHA:83465
Diffuse Cutaneous Systemic Sclerosis
ORPHA:220393
Systemic Lupus Erythematosus
ORPHA:536
Autoimmune Pulmonary Alveolar Proteinosis
ORPHA:747
Bullous Pemphigoid
ORPHA:703
Multiple Sclerosis, Susceptibility To
OMIM:126200
Sarcoidosis
ORPHA:797
Limited Cutaneous Systemic Sclerosis
ORPHA:220402
Follicular Lymphoma
ORPHA:545

The table below shows human diseases predicted to be associated to H2-Eb1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Scoliosis, Isolated, Susceptibility To, 1
Scoliosis OMIM:181800
Giant Cell Arteritis
ORPHA:397
Sarcoidosis, Susceptibility To, 1
OMIM:181000
Narcolepsy Type 1
ORPHA:2073
Systemic-Onset Juvenile Idiopathic Arthritis
ORPHA:85414
Narcolepsy Type 2
ORPHA:83465
Diffuse Cutaneous Systemic Sclerosis
ORPHA:220393
Systemic Lupus Erythematosus
ORPHA:536
Autoimmune Pulmonary Alveolar Proteinosis
ORPHA:747
Bullous Pemphigoid
ORPHA:703
Multiple Sclerosis, Susceptibility To
OMIM:126200
Sarcoidosis
ORPHA:797
Limited Cutaneous Systemic Sclerosis
ORPHA:220402
Follicular Lymphoma
ORPHA:545

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for H2-Eb1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to H2-Eb1.

There are 5 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) H2-Eb1tm1a(KOMP)Wtsi PMC7263671
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) H2-Eb1tm1a(KOMP)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) H2-Eb1tm1a(KOMP)Wtsi PMC6459510
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) H2-Eb1tm1a(KOMP)Wtsi PMC5827107
A Genome-Wide Association Study for Regulators of Micronucleus Formation in Mice. G3 (Bethesda, Md.) (August 2016) H2-Eb1tm1a(KOMP)Wtsi PMC4978889

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
H2-Eb1b-tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
H2-Eb1b-tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells

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