Gene: Got2 MGI:95792
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The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
embryonic growth retardation | Got2em1(IMPC)Mbp | HET | E15.5 | 0.00 | ||
abnormal neural tube closure | Got2em1(IMPC)Mbp | HOM | E9.5 | 0.00 | ||
abnormal embryo turning | Got2em1(IMPC)Mbp | HOM | E9.5 | 0.00 | ||
small spleen | Got2em1(IMPC)Mbp | HET | Early adult | 0.00 | ||
prenatal lethality prior to heart atrial septation | Got2em1(IMPC)Mbp | HOM | E15.5 | 0.00 | ||
abnormal neural tube morphology | Got2em1(IMPC)Mbp | HOM | E9.5 | 0.00 | ||
preweaning lethality, complete penetrance | Got2em1(IMPC)Mbp | HOM | Early adult | 0.00 | ||
abnormal vitelline vasculature morphology | Got2em1(IMPC)Mbp | HOM | E9.5 | 0.00 | ||
abnormal pharyngeal arch morphology | Got2em1(IMPC)Mbp | HOM | E9.5 | 0.00 | ||
hemorrhage | Got2em1(IMPC)Mbp | HOM | E9.5 | 0.00 | ||
abnormal heart morphology | Got2em1(IMPC)Mbp | HOM | E9.5 | 0.00 | ||
embryonic growth retardation | Got2em1(IMPC)Mbp | HOM | E9.5 | 0.00 | ||
abnormal forebrain development | Got2em1(IMPC)Mbp | HOM | E9.5 | 0.00 | ||
abnormal blood vessel morphology | Got2em1(IMPC)Mbp | HOM | E9.5 | 0.00 | ||
abnormal visceral yolk sac morphology | Got2em1(IMPC)Mbp | HOM | E9.5 | 0.00 | ||
abnormal midbrain development | Got2em1(IMPC)Mbp | HOM | E9.5 | 0.00 | ||
abnormal hindbrain development | Got2em1(IMPC)Mbp | HOM | E9.5 | 0.00 |
Human diseases caused by Got2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Got2 by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Developmental And Epileptic Encephalopathy 82 | Short stature | OMIM:618721 |
The table below shows human diseases predicted to be associated to Got2 by phenotypic similarity.
Histopathology
Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.
There is no histopathology data for Got2
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MGI Allele | Allele Type | Produced |
---|---|---|
Got2tm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Got2tm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | ES Cells |
Got2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | ES Cells |
Got2tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | ES Cells |
Got2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Got2em1(IMPC)Mbp | Exon Deletion | Mice, Tissue |
Got2tm3a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
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