Gene: Gnao1

Order

Name guanine nucleotide binding protein, alpha O

Synonyms
  • alphaO
  • Galphao
  • Go alpha

Status ES CellsMice
tm1b
Mice
tm1a
phenotype data available

Links MGI:95775    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Gnao1

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Gnao1 data for that phenotype.

Embryo Data: 3D Embryo Imaging
Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, complete penetrance Gnao1tm1b(EUCOMM)Hmgu HOM Female Male n/a 0.0
decreased fasted circulating glucose level Gnao1tm1b(EUCOMM)Hmgu HET Male postnatal 2.71E-13
hyperactivity Gnao1tm1b(EUCOMM)Hmgu HET Female Male postnatal 3.78E-7
decreased bone mineral content Gnao1tm1b(EUCOMM)Hmgu HET Female postnatal 1.21E-6
abnormal behavior Gnao1tm1b(EUCOMM)Hmgu HET Female Male postnatal 2.07E-6
impaired righting response Gnao1tm1b(EUCOMM)Hmgu HET Female postnatal 8.88E-6
increased circulating triglyceride level Gnao1tm1b(EUCOMM)Hmgu HET Male postnatal 1.64E-5
decreased startle reflex Gnao1tm1b(EUCOMM)Hmgu HET Male postnatal 3.93E-5
decreased circulating iron level Gnao1tm1b(EUCOMM)Hmgu HET Female Male postnatal 8.98E-5
increased circulating creatinine level Gnao1tm1b(EUCOMM)Hmgu HET Female Male postnatal 9.16E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (5/393) (2/2)
Aorta 2 No (1/562)
Bone 2 No (1/539) (2/2)
Brain 2 No (6/562) (2/2)
Brainstem 2 No (4/562) (2/2)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/562)
Cerebellum 2 No (4/562) (2/2)
Cerebral cortex 2 No (5/562) (2/2)
Esophagus 2 No (2/393) (2/2)
Eye 2 No (1/562) (1/2)
Gall bladder 2 No (2/2)
Heart 2 No (3/562) (2/2)
Hippocampus 2 No (5/562) (2/2)
Hypothalamus 2 No (4/562) (2/2)
Kidney 2 No (20/562) (2/2)
Large intestine 2 No (12/562) (2/2)
Liver 2 No
Lower urinary tract 2 No (3/562) (2/2)
Lung 2 No (3/562) (2/2)
Lymph node 2 No (1/562)
Mammary gland 2 No
Olfactory lobe 2 No (4/393) (2/2)
Oral epithelium 2 No
Ovary 2 No (1/562)
Oviduct 2 No (2/562) (1/2)
Pancreas 2 No (6/562) (2/2)
Parathyroid gland 2 No (2/540)
Peripheral nervous system 2 No (3/562) (2/2)
Peyer's patch 2 No (1/393)
Pituitary gland 2 No (1/562) (2/2)
Prostate gland 2 No (5/562) (1/2)
Skeletal muscle 2 No
Skin 2 No (1/562)
Small intestine 2 No (11/562) (2/2)
Spinal cord 2 No (3/562) (2/2)
Spleen 2 No (4/562)
Stomach 2 No (9/562) (2/2)
Striatum 2 No (4/562) (2/2)
Testis 2 No (4/562) (1/2)
Thymus 2 No
Thyroid gland 2 No (16/562) (2/2)
Trachea 2 No (3/562) (2/2)
Uterus 2 No (2/562) (1/2)
Vascular system 2 No (1/393) (2/2)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system
    postnatal mouse
    respiratory system
    digestive system
    cardiovascular system
    nervous system
    sensory organ
    reproductive system
    musculoskeletal system
    exocrine system
    trunk
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/482) (4/4)
Ear 2 (1/482) (2/4)
Embryo 2 (1/482) (4/4)
Eye 2 (1/482) (4/4)
Foot 2 (1/482)
Forebrain 2 (1/482) (4/4)
Forelimb 2 (1/482)
Hand 2 (1/482)
Head 2 (5/482) (4/4)
Heart 2 (1/482) (4/4)
Hindbrain 2 (6/482) (4/4)
Hindlimb 2 (1/482)
Liver 2 (1/482)
Lung 2 (1/482) (1/4)
Mandibular process 2 (1/482)
Maxillary process 2 (1/482)
Midbrain 2 (1/482) (4/4)
Oral cavity 2 (1/482)
Skin 2 (1/482)
Tail 2 (1/482)
Tail somite 2 (1/482)


Associated Images

Associated Images
  • Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
    4 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    11 Images
  • Echo: M-Mode Images
    24 Images
  • Adult LacZ: LacZ Images Wholemount
    21 Images
  • X-ray: XRay Images Dorso Ventral
    11 Images
  • X-ray: XRay Images Lateral Orientation
    11 Images
  • Embryo LacZ: LacZ images wholemount
    8 Images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Gnao1tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Gnao1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene