banner
Genes Phenotypes Help, News, Blog

Gene: Fn1 MGI:95566

Log in to follow
Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
fibronectin 1
Synonyms:
Fn,  Fn-1

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Fn1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Fn1 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Fibronectin Glomerulopathy
Hypoalbuminemia ORPHA:84090
Spondylometaphyseal Dysplasia, 'Corner Fracture' Type
Iron deficiency anemia ORPHA:93315
Glomerulopathy With Fibronectin Deposits 2
Hypertension OMIM:601894
Spondylometaphyseal Dysplasia, Corner Fracture Type
Short stature OMIM:184255

The table below shows human diseases predicted to be associated to Fn1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Proliferating Trichilemmal Cyst
Epidermoid cyst, Skin ulcer ORPHA:492
Non-Epidermolytic Palmoplantar Keratoderma
Papule, Erythema, Skin ulcer ORPHA:2337
Immunodeficiency 107, Susceptibility To Invasive Staphylococcus Aureus Infection
Pyoderma gangrenosum OMIM:619986
Dermatofibrosarcoma Protuberans
Subcutaneous nodule, Erythema, Skin ulcer ORPHA:31112
Congenital Factor Xii Deficiency
Penetrating foot ulcers ORPHA:330
Hyperkeratosis Lenticularis Perstans
Papule, Aplasia/Hypoplasia of the skin, Skin ulcer ORPHA:409
Necrobiosis Lipoidica
Indurated nodule, Skin nodule, Erythema, Skin ulcer, Atrophic scars, Annular cutaneous lesion, Sk... ORPHA:542592
Chilblain Lupus 1
Skin ulcer OMIM:610448
Aplasia Cutis Congenita
Aplasia cutis congenita over the scalp vertex, Skin ulcer, Congenital localized absence of skin ORPHA:1114
Juvenile Hyaline Fibromatosis
Subcutaneous nodule, Papule, Aplasia/Hypoplasia of the skin, Skin ulcer ORPHA:2028
Aplasia Cutis-Myopia Syndrome
Aplasia cutis congenita, Skin ulcer ORPHA:1117
Buerger Disease
Skin ulcer ORPHA:36258
Neuropathy, Hereditary Sensory, Type Iic
Acral ulceration OMIM:614213
Severe Hereditary Thrombophilia Due To Congenital Protein S Deficiency
Aplasia/Hypoplasia of the skin, Thin skin, Skin ulcer, Purpura ORPHA:743
Dracunculiasis
Subcutaneous nodule, Skin ulcer ORPHA:231
Acrogeria
Excessive wrinkled skin, Aplasia/Hypoplasia of the skin, Thin skin, Skin ulcer ORPHA:2500
Familial Keratoacanthoma
Papule, Subcutaneous nodule, Skin ulcer ORPHA:493
Classic Mycosis Fungoides
Erythema, Hypopigmented skin patches, Skin ulcer, Skin plaque, Dry skin ORPHA:2584
Mutilating Hereditary Sensory Neuropathy With Spastic Paraplegia
Acral ulceration, Skin ulcer ORPHA:139578
Lichen Planopilaris
Dermal atrophy, Papule, Hypopigmented skin patches, Skin ulcer ORPHA:525
Cervical Hypertrichosis-Peripheral Neuropathy Syndrome
Skin ulcer ORPHA:2218
Chilblain Lupus
Erythematous papule, Skin ulcer ORPHA:90280
Brooke-Spiegler Syndrome
Skin-colored papule, Skin nodule, Skin ulcer, Nodular changes affecting the eyelids ORPHA:79493
Limited Cutaneous Systemic Sclerosis
Hypopigmented skin patches, Skin ulcer ORPHA:220402
Pyoderma Gangrenosum
Skin vesicle, Atrophic scars, Papule, Skin ulcer ORPHA:48104
Subcutaneous Panniculitis-Like T-Cell Lymphoma
Erythematous plaque, Erythematous papule, Skin ulcer ORPHA:86884
Ollier Disease
Subcutaneous nodule, Skin ulcer ORPHA:296
Bare Lymphocyte Syndrome, Type I
Skin ulcer OMIM:604571
Autosomal Dominant Epidermolytic Ichthyosis
Skin ulcer ORPHA:312
Familial Multiple Nevi Flammei
Nevus flammeus, Skin ulcer, Hypermelanotic macule, Papule ORPHA:624
Leishmaniasis
Skin plaque, Skin ulcer, Pallor, Papule ORPHA:507
Hemoglobin D Disease
Increased HbA2 hemoglobin, Decreased mean corpuscular hemoglobin concentration, HbS hemoglobin, A... ORPHA:90039
Reticular Dysgenesis
Skin ulcer ORPHA:33355
Polyarteritis Nodosa
Erythema, Subcutaneous nodule, Skin ulcer ORPHA:767
Neuropathy, Hereditary Sensory And Autonomic, Type Iib
Acral ulceration OMIM:613115
Flynn-Aird Syndrome
Dermal atrophy, Skin ulcer ORPHA:2047
Combined Immunodeficiency Due To Dock8 Deficiency
Skin ulcer ORPHA:217390
Adult Polyglucosan Body Disease
Skin ulcer ORPHA:206583
Hereditary Sensory And Autonomic Neuropathy Type 1
Penetrating foot ulcers, Skin ulcer ORPHA:36386
Attenuated Chédiak-Higashi Syndrome
Skin ulcer ORPHA:352723
Beta-Thalassemia
Pallor, Skin ulcer ORPHA:848
Acquired Purpura Fulminans
Macule, Erythematous macule, Pyoderma gangrenosum, Macular purpura ORPHA:49566
Neuropathy, Hereditary Sensory And Autonomic, Type Ic
Skin ulcer OMIM:613640
Isolated Agammaglobulinemia
Skin ulcer ORPHA:229717
Squamous Cell Carcinoma Of The Anal Canal
Skin ulcer ORPHA:424019
Dermatoosteolysis, Kirghizian Type
Aplasia/Hypoplasia of the skin, Skin ulcer ORPHA:1657
Calciphylaxis
Skin ulcer ORPHA:280062
Free Sialic Acid Storage Disease
Skin ulcer ORPHA:834
Papa Syndrome
Skin ulcer ORPHA:69126
Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, And Acne
Pyoderma gangrenosum OMIM:604416
Takayasu Arteritis
Subcutaneous nodule, Skin ulcer ORPHA:3287
Immunodeficiency, Common Variable, 12, With Autoimmunity
Pyoderma gangrenosum OMIM:616576
Prolidase Deficiency
Aplasia/Hypoplasia of the skin, Erythema, Skin ulcer, Thin skin, Dry skin, Papule ORPHA:742
Meige Disease
Atypical scarring of skin, Skin erosion, Skin dimple, Skin ulcer ORPHA:90186
Infantile Myofibromatosis
Subcutaneous nodule, Skin ulcer ORPHA:2591
Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques
Erythema, Skin ulcer, Skin fissure ORPHA:659
Periodic Fever, Immunodeficiency, And Thrombocytopenia Syndrome
Pyoderma gangrenosum OMIM:150550
Cryoglobulinemic Vasculitis
Petechiae, Skin ulcer, Purpura ORPHA:91138
Acute Radiation Syndrome
Dermal atrophy, Scaling skin, Skin ulcer ORPHA:454831
Neutrophilic Dermatosis, Acute Febrile
Erythema, Pyoderma gangrenosum OMIM:608068
X-Linked Agammaglobulinemia
Hypopigmented skin patches, Skin ulcer ORPHA:47
Epidermolysis Bullosa, Junctional 2C, Laryngoonychocutaneous
Skin ulcer OMIM:245660
Prolidase Deficiency
Petechiae, Skin ulcer OMIM:170100
Autosomal Dominant Hyper-Ige Syndrome
Skin vesicle, Skin ulcer, Papule ORPHA:2314
Adult Syndrome
Dry skin, Thin skin, Skin ulcer, Melanocytic nevus ORPHA:978
Chronic Granulomatous Disease
Macule, Hypermelanotic macule, Skin ulcer ORPHA:379
Chronic Mucocutaneous Candidiasis
Erythema, Skin ulcer, Papule ORPHA:1334
Neuropathy, Hereditary Sensory And Autonomic, Type Ia
Acral ulceration OMIM:162400
Attrv122I Amyloidosis
Abnormal EKG, Angina pectoris, Abnormal atrioventricular conduction, Cardiomegaly, Cardiac amyloi... ORPHA:85451
Reynolds Syndrome
Skin ulcer ORPHA:779
Livedoid Vasculopathy
Skin ulcer, Atrophic scars, Macular purpura, Ecchymosis, Erythematous papule ORPHA:542643
Ectodermal Dysplasia-Blindness Syndrome
Skin ulcer ORPHA:1806
Hydrops, Lactic Acidosis, And Sideroblastic Anemia
Sideroblastic anemia, Overriding aorta, Ventricular septal defect, Extramedullary hematopoiesis, ... OMIM:617021
Acrodermatitis Enteropathica
Erythema, Dry skin, Skin ulcer ORPHA:37
Microscopic Polyangiitis
Erythema, Subcutaneous nodule, Skin ulcer ORPHA:727
Peripartum Cardiomyopathy
Ventricular tachycardia, Left bundle branch block, Right ventricular dilatation, Abnormal T-wave,... ORPHA:563
Werner Syndrome
Aplasia/Hypoplasia of the skin, Lack of skin elasticity, Skin ulcer ORPHA:902
Diffuse Cutaneous Systemic Sclerosis
Skin ulcer ORPHA:220393
Infantile Systemic Hyalinosis
Subcutaneous nodule, Skin ulcer ORPHA:2176
Hereditary Spherocytosis
Pallor, Skin ulcer ORPHA:822
Beta-Thalassemia Intermedia
Pallor, Skin ulcer ORPHA:231222
Autosomal Dominant Severe Congenital Neutropenia
Pyoderma gangrenosum ORPHA:486
Neuropathy, Hereditary Sensory And Autonomic, Type Iia
Acral ulceration OMIM:201300
Hemolytic Anemia Due To Red Cell Pyruvate Kinase Deficiency
Reticulocytosis, Anisocytosis, Abnormal erythrocyte morphology, Reduced red cell pyruvate kinase ... ORPHA:766
Malakoplakia
Subcutaneous nodule, Skin ulcer, Papule ORPHA:556
Neuropathy, Hereditary Sensory, With Spastic Paraplegia, Autosomal Recessive
Acral ulceration OMIM:256840
Sweet Syndrome
Skin nodule, Pyoderma gangrenosum, Erythematous plaque, Skin vesicle, Erythematous papule ORPHA:3243
Hereditary Acrokeratotic Poikiloderma
Erythema, Hypopigmented skin patches, Skin ulcer, Thin skin, Papule ORPHA:2907
Fusariosis
Subcutaneous nodule, Skin ulcer, Skin detachment, Papule ORPHA:228119
Catastrophic Antiphospholipid Syndrome
Skin ulcer ORPHA:464343
Anemia, Congenital Dyserythropoietic, Type Iv
Decreased hemoglobin concentration, Hemolytic anemia, Circulating nucleated red blood cells, Reti... OMIM:613673
Dyskeratosis Congenita
Macule, Aplasia/Hypoplasia of the skin, Hypermelanotic macule, Hypopigmented skin patches, Skin u... ORPHA:1775
Juvenile Dermatomyositis
Erythema, Dry skin, Skin ulcer ORPHA:93672
Immunoglobulin A Vasculitis
Macule, Erythema, Skin ulcer, Purpura ORPHA:761
Giant Cell Arteritis
Skin ulcer ORPHA:397
Dominant Beta-Thalassemia
Pallor, Skin ulcer ORPHA:231226
Leukocyte Adhesion Deficiency, Type I
Skin ulcer OMIM:116920
Neuropathy, Hereditary Sensory And Autonomic, Type V
Acral ulceration OMIM:608654
Hb Bart'S Hydrops Fetalis
Pericarditis, Abnormal hemoglobin, Splenomegaly, Congestive heart failure, Hydrocephalus, Anemia ORPHA:163596
Toxic Epidermal Necrolysis
Macule, Erythema, Skin ulcer ORPHA:537
Parkes Weber Syndrome
Erythematous plaque, Capillary malformation, Scaling skin, Skin ulcer ORPHA:90307
Incontinentia Pigmenti
Erythema, Hypopigmented skin patches, Skin ulcer ORPHA:464
Beta-Thalassemia Major
Pallor, Skin ulcer ORPHA:231214
Adenocarcinoma Of The Anal Canal
Skin ulcer ORPHA:424016
Blau Syndrome
Intermittent generalized erythematous papular rash, Skin ulcer OMIM:186580
Systemic Sclerosis
Cutaneous sclerotic plaque, Digital pitting scar, Spotty hypopigmentation, Digital ulcer, Acral u... ORPHA:90291
Granulomatosis With Polyangiitis
Skin ulcer OMIM:608710
Pgm3-Cdg
Skin ulcer ORPHA:443811
Dermatomyositis
Aplasia/Hypoplasia of the skin, Erythema, Skin ulcer, Dry skin, Papule ORPHA:221
Amoebiasis Due To Free-Living Amoebae
Subcutaneous nodule, Skin ulcer, Papule ORPHA:68
Microcephaly-Lymphedema-Chorioretinopathy Syndrome
Dry skin, Subcutaneous nodule, Scaling skin, Skin ulcer ORPHA:2526
Vasculitis, Autoinflammation, Immunodeficiency, And Hematologic Defects Syndrome
Urticarial plaque, Skin ulcer, Purpura OMIM:615688
Leprosy
Urticarial plaque, Hypopigmented macule, Skin nodule, Penetrating foot ulcers, Verrucous papule, ... ORPHA:548
Charcot-Marie-Tooth Disease Type 4B2
Penetrating foot ulcers ORPHA:99956
Insensitivity To Pain, Congenital, With Anhidrosis
Acral ulceration OMIM:256800
Chime Syndrome
Erythema, Skin ulcer ORPHA:3474
Hajdu-Cheney Syndrome
Dry skin, Skin ulcer ORPHA:955
Wiskott-Aldrich Syndrome
Petechiae, Skin ulcer, Purpura ORPHA:906
Cushing Disease
Skin ulcer, Thin skin, Ecchymosis, Striae distensae, Purpura ORPHA:96253
Granulomatosis With Polyangiitis
Skin ulcer, Papule, Purpura ORPHA:900
Simple Cryoglobulinemia
Localized skin lesion, Acral ulceration, Purpura ORPHA:91139
Primary Sjögren Syndrome
Dry skin, Lichenoid skin lesion, Skin ulcer, Purpura ORPHA:289390
Oculocerebrorenal Syndrome Of Lowe
Atypical scarring of skin, Skin ulcer ORPHA:534
Blau Syndrome
Erythema, Dry skin, Skin ulcer, Papule ORPHA:90340
Atypical Werner Syndrome
Aplasia/Hypoplasia of the skin, Thin skin, Skin ulcer, Lack of skin elasticity ORPHA:79474
Gaucher Disease-Ophthalmoplegia-Cardiovascular Calcification Syndrome
Ecchymosis, Skin ulcer ORPHA:2072
Chronic Graft Versus Host Disease
Skin vesicle, Erythema, Intermittent generalized erythematous papular rash, Skin ulcer ORPHA:99921
Plague
Localized skin lesion, Dry skin, Skin ulcer ORPHA:707
Mitochondrial Dna Depletion Syndrome 6 (Hepatocerebral Type)
Acral ulceration OMIM:256810
Cushing Syndrome Due To Ectopic Acth Secretion
Skin ulcer, Thin skin, Ecchymosis, Striae distensae, Purpura ORPHA:99889
Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Spectrum
Atypical scarring of skin, Skin ulcer ORPHA:95455
Split Cord Malformation
Skin dimple, Penetrating foot ulcers ORPHA:573278
Leukocyte Adhesion Deficiency
Pyoderma gangrenosum ORPHA:2968
Homozygous Familial Hypercholesterolemia
Precocious atherosclerosis, Tendon xanthomatosis, Peripheral arterial stenosis, Calcification of ... ORPHA:391665
Fibronectin Glomerulopathy
Hypoalbuminemia ORPHA:84090
Spondylometaphyseal Dysplasia, 'Corner Fracture' Type
Iron deficiency anemia ORPHA:93315
Glomerulopathy With Fibronectin Deposits 2
Hypertension OMIM:601894
Spondylometaphyseal Dysplasia, Corner Fracture Type
Short stature OMIM:184255

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Fn1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Fn1.

No publications found that use IMPC mice or data for Fn1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Fn1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter