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Gene: Ppp1r1b MGI:94860

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
protein phosphatase 1, regulatory inhibitor subunit 1B
Synonyms:
DARPP-32,  Darpp32

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Ppp1r1b mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ppp1r1b by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Attention Deficit-Hyperactivity Disorder
Hyperactivity, Attention deficit hyperactivity disorder OMIM:143465
Kleine-Levin Syndrome
Confusion, Abnormal eating behavior, Repetitive compulsive behavior, Sweet craving, Hypersexualit... ORPHA:33543
Renal Glucosuria
Polydipsia, Polyphagia OMIM:233100
Type 1 Diabetes Mellitus
Polydipsia, Polyphagia OMIM:222100
Huntington Disease
Bradyphrenia, Aggressive behavior, Oral-pharyngeal dysphagia, Mental deterioration, Addictive alc... ORPHA:399
Acquired Central Diabetes Insipidus
Polydipsia ORPHA:95626
Hereditary Central Diabetes Insipidus
Polydipsia ORPHA:30925
Marchiafava-Bignami Disease
Confusion, Aggressive behavior, Dementia, Addictive alcohol use, Cognitive impairment, Memory imp... ORPHA:221074
Senior-Loken Syndrome 4
Polydipsia OMIM:606996
Central Diabetes Insipidus
Polydipsia, Anorexia ORPHA:178029
Nephronophthisis-Like Nephropathy 2
Polydipsia OMIM:619468
Teratoma, Pineal
Polydipsia OMIM:273120
Methanol Poisoning
Addictive alcohol use, Confusion ORPHA:31825
Familial Cold Urticaria
Polydipsia ORPHA:47045
Brain-Lung-Thyroid Syndrome
Short attention span, Hyperactivity, Abnormal eating behavior, Abnormal drinking behavior, Compul... ORPHA:209905
Bardet-Biedl Syndrome 9
Polydipsia, Polyphagia OMIM:615986
Secondary Non-Traumatic Avascular Necrosis
Addictive alcohol use ORPHA:399180
Acquired Aneurysmal Subarachnoid Hemorrhage
Cognitive impairment, Memory impairment, Addictive alcohol use, Progressive neurologic deterioration ORPHA:90065
Ochoa Syndrome
Polydipsia ORPHA:2704
Bardet-Biedl Syndrome 17
Polydipsia, Cognitive impairment OMIM:615994
Familial Hyperaldosteronism Type I
Polydipsia ORPHA:403
Nephronophthisis 4
Polydipsia OMIM:606966
Hyperaldosteronism, Familial, Type Iii
Polydipsia OMIM:613677
Staphylococcal Necrotizing Pneumonia
Addictive alcohol use, Confusion ORPHA:36238
Senior-Loken Syndrome 3
Polydipsia OMIM:606995
Cystinosis
Polydipsia, Abnormal repetitive mannerisms ORPHA:213
Pediatric-Onset Graves Disease
Hyperactivity, Polydipsia, Polyphagia ORPHA:525731
East Syndrome
Polydipsia, Salt craving ORPHA:199343
Diabetes Insipidus, Nephrogenic, 2, Autosomal
Polydipsia OMIM:125800
Diabetes Insipidus, Nephrogenic, 1, X-Linked
Polydipsia OMIM:304800
Acute Lung Injury
Addictive alcohol use ORPHA:178320
Isolated Osteopoikilosis
Addictive alcohol use ORPHA:166119
Familial Hyperaldosteronism Type Iii
Polydipsia ORPHA:251274
Nephronophthisis 3
Polydipsia OMIM:604387
Nephrogenic Diabetes Insipidus
Polydipsia, Anorexia ORPHA:223
Herpes Simplex Virus Encephalitis
Addictive alcohol use ORPHA:1930
Nephronophthisis 1
Polydipsia OMIM:256100
Primary Unilateral Adrenal Hyperplasia
Polydipsia ORPHA:231580
Senior-Boichis Syndrome
Polydipsia, Agitation, Attention deficit hyperactivity disorder, Aggressive behavior ORPHA:84081
Acute Promyelocytic Leukemia
Addictive alcohol use, Anorexia ORPHA:520
Primary Hyperaldosteronism-Seizures-Neurological Abnormalities Syndrome
Polydipsia ORPHA:369929
Nephronophthisis 11
Polydipsia OMIM:613550
Apparent Mineralocorticoid Excess
Polydipsia ORPHA:320
Whipple Disease
Polydipsia, Anorexia ORPHA:3452
Septo-Optic Dysplasia Spectrum
Polydipsia ORPHA:3157
Senior-Loken Syndrome 1
Polydipsia OMIM:266900
Renal Hypoplasia
Polydipsia ORPHA:93101
Seizures, Sensorineural Deafness, Ataxia, Impaired Intellectual Development, And Electrolyte Imbalance
Polydipsia, Salt craving OMIM:612780
Helix Syndrome
Polydipsia OMIM:617671
Infantile Nephropathic Cystinosis
Polydipsia, Cognitive impairment ORPHA:411629
Hyperparathyroidism, Neonatal Severe
Polydipsia OMIM:239200
Pituitary Dermoid And Epidermoid Cysts
Polydipsia ORPHA:91351
Ethylene Glycol Poisoning
Addictive alcohol use, Confusion ORPHA:31826
Cirrhotic Cardiomyopathy
Addictive alcohol use ORPHA:57777
Wolfram Syndrome
Polydipsia, Dementia ORPHA:3463
Panhypophysitis
Polydipsia ORPHA:95513
Gitelman Syndrome
Polydipsia, Salt craving OMIM:263800
Porphyria Cutanea Tarda
Addictive alcohol use ORPHA:101330
Oligomeganephronia
Polydipsia ORPHA:2260
Toxic Epidermal Necrolysis
Polydipsia, Dysphagia ORPHA:537
Rabson-Mendenhall Syndrome
Polydipsia ORPHA:769
Hypomagnesemia 3, Renal
Polydipsia OMIM:248250
Cystinosis, Nephropathic
Polydipsia, Progressive neurologic deterioration, Dysphagia, Oral-pharyngeal dysphagia OMIM:219800
Erdheim-Chester Disease
Polydipsia ORPHA:35687
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Aggressive behavior, Self-injurious behavior, Compulsive behaviors, Polydipsia, Polyphagia ORPHA:293987
Hyperparathyroidism-Jaw Tumor Syndrome
Polydipsia, Dysphagia ORPHA:99880
Parathyroid Carcinoma
Polydipsia, Dysphagia ORPHA:143
Hnf1B-Related Autosomal Dominant Tubulointerstitial Kidney Disease
Polydipsia ORPHA:93111
Distal Renal Tubular Acidosis
Polydipsia ORPHA:18
Arima Syndrome
Polydipsia OMIM:243910
Juvenile Nephropathic Cystinosis
Polydipsia ORPHA:411634
Autosomal Recessive Polycystic Kidney Disease
Polydipsia, Cognitive impairment ORPHA:731
Bartter Syndrome, Type 4A, Neonatal, With Sensorineural Deafness
Polydipsia OMIM:602522
Gitelman Syndrome
Polydipsia, Salt craving ORPHA:358
Proximal Renal Tubular Acidosis
Polydipsia ORPHA:47159
Bartter Syndrome, Type 2, Antenatal
Polydipsia OMIM:241200

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ppp1r1b

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ppp1r1b.

No publications found that use IMPC mice or data for Ppp1r1b.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Ppp1r1btm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ppp1r1btm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells

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