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Gene: Ckm MGI:88413

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
creatine kinase, muscle
Synonyms:
Ckmm,  MCK,  M-CK

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Ckm mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ckm by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Multifocal Atrial Tachycardia
Atrial septal defect, Atrial flutter, Tachycardia, Atrial fibrillation, Ventricular septal defect... ORPHA:3282
Obesity Due To Sim1 Deficiency
Glucose intolerance, Postural hypotension with compensatory tachycardia, Hyperinsulinemia, Hypote... ORPHA:369873
Cardiomyopathy, Familial Restrictive, 3
Myocardial sarcomeric disarray, Abnormal ST segment, Reduced left ventricular ejection fraction, ... OMIM:612422
Carnitine-Acylcarnitine Translocase Deficiency
Ventricular hypertrophy, Hepatomegaly, Hypoglycemia, Cardiac arrest, Rhabdomyolysis, Ventricular ... OMIM:212138
Glycogen Storage Disease Of Heart, Lethal Congenital
Prolonged QRS complex, Left axis deviation, Cardiomegaly, Congestive heart failure, ST segment el... OMIM:261740
Snakebite Envenomation
Tachycardia, Epistaxis, Myocardial infarction, Rhabdomyolysis, Intracranial hemorrhage, Cerebral ... ORPHA:449285
Tako-Tsubo Cardiomyopathy
Prolonged QTc interval, Mildly reduced left ventricular ejection fraction, Bradycardia, Hypotensi... ORPHA:66529
Cardiogenic Shock
Abnormal EKG, Increased pulmonary capillary wedge pressure, Cardiac arrest, Myocardial infarction... ORPHA:97292
Mitochondrial Trifunctional Protein Deficiency 2
Tricuspid regurgitation, Hypoglycemia, Cerebral hemorrhage, Dilated cardiomyopathy, Mitral regurg... OMIM:620300
Congenital Tricuspid Stenosis
Tricuspid regurgitation, Tricuspid stenosis, Congestive heart failure, Heart murmur, Hypotension,... ORPHA:95459
Adult Acute Respiratory Distress Syndrome
Shock, Diabetic ketoacidosis, Vasculitis, Hypotension ORPHA:70578
Carnitine-Acylcarnitine Translocase Deficiency
Hepatomegaly, Rhabdomyolysis, Ventricular tachycardia, Cardiomyopathy, Hypotension, Fasting hypog... ORPHA:159
Congenital Isolated Acth Deficiency
Hypotension, Neonatal hypoglycemia, Hypoglycemic seizures ORPHA:199296
Necrotizing Enterocolitis
Shock, Abnormal heart morphology, Bradycardia, Hypotension, Abnormal glucose homeostasis, Hypergl... ORPHA:391673
Chromosome 5Q12 Deletion Syndrome
Ventricular septal defect, Macroglossia, Hypotension, Atrial septal defect, Patent foramen ovale OMIM:615668
Malignant Hyperthermia, Susceptibility To, 1
Tachycardia, Rhabdomyolysis, Hypotension OMIM:145600
Neuroendocrine Tumor Of The Colon
Hepatomegaly, Tricuspid regurgitation, Abnormal pulmonary valve cusp morphology, Right ventricula... ORPHA:100080
Post-Traumatic Pituitary Deficiency
Hypoglycemia, Hypotension ORPHA:95619
Analbuminemia
Hypotension OMIM:616000
Perry Syndrome
Hypotension ORPHA:178509
Neuroendocrine Tumor Of The Rectum
Hepatomegaly, Tricuspid regurgitation, Abnormal pulmonary valve cusp morphology, Right ventricula... ORPHA:100081
Neuroendocrine Tumor Of Anal Canal
Hepatomegaly, Tricuspid regurgitation, Abnormal pulmonary valve cusp morphology, Right ventricula... ORPHA:100082
Whipple Disease
Gastrointestinal hemorrhage, Hepatomegaly, Pericarditis, Myositis, Myocardial infarction, Myocard... ORPHA:3452
Infant Acute Respiratory Distress Syndrome
Tachycardia, Bradycardia, Cardiac arrest, Hypotension ORPHA:70587
Nipah Virus Disease
Hypotension ORPHA:99825
Cutaneous Mastocytoma
Telangiectasia of the skin, Hypotension, Telangiectasia macularis eruptiva perstans ORPHA:79455
Acquired Von Willebrand Syndrome
Aortic regurgitation, Gastrointestinal hemorrhage, Epistaxis, Intracranial hemorrhage, Melena, Mi... ORPHA:99147
Aa Amyloidosis
Hepatomegaly, Enlarged kidney, Hypotension, Abnormal heart morphology ORPHA:85445
Dengue Fever
Gastrointestinal hemorrhage, Hepatomegaly, Epistaxis, Cerebral hemorrhage, Hypotension ORPHA:99828
Bronchial Neuroendocrine Tumor
Hepatomegaly, Tricuspid regurgitation, Abnormal pulmonary valve cusp morphology, Right ventricula... ORPHA:97287
Corticosteroid-Binding Globulin Deficiency
Hypertension, Hypotension OMIM:611489
Car T Cell Therapy-Associated Cytokine Release Syndrome
Tachycardia, Heart block, Capillary leak, Reduced left ventricular ejection fraction, Hypotension... ORPHA:542323
Pituitary Deficiency Due To Empty Sella Turcica Syndrome
Hypotension ORPHA:91354
Staphylococcal Necrotizing Pneumonia
Shock, Diabetes mellitus, Hypotension ORPHA:36238
Beta-Ketothiolase Deficiency
Hepatomegaly, Hypoglycemia, Hypertension, Hypotension, Hyperglycemia ORPHA:134
Late-Onset Familial Hypoaldosteronism
Orthostatic hypotension, Hypotension ORPHA:556037
Systemic Capillary Leak Syndrome
Myocarditis, Pericarditis, Arrhythmia, Hypotension ORPHA:188
Neuroendocrine Tumor Of Stomach
Hepatomegaly, Tricuspid regurgitation, Abnormal pulmonary valve cusp morphology, Right ventricula... ORPHA:100075
Pseudohypoaldosteronism, Type Ib2, Autosomal Recessive
Hypotension OMIM:620125
Scrub Typhus
Splenomegaly, Myocarditis, Hypotension ORPHA:83317
Early-Onset Familial Hypoaldosteronism
Orthostatic hypotension, Hypotension ORPHA:556030
Erythrocytosis, Familial, 2
Hypotension, Pulmonary arterial hypertension, Cerebral hemorrhage OMIM:263400
Pseudohypoaldosteronism, Type Ib1, Autosomal Recessive
Hypotension OMIM:264350
Hydroxykynureninuria
Tachycardia, Hypotension ORPHA:79155
Poliomyelitis
Skeletal muscle atrophy, Hypoplasia of the musculature, Abnormal skeletal muscle morphology, Uppe... ORPHA:2912
Legionnaires Disease
Pericarditis, Splenomegaly, Myocarditis, Endocarditis, Hypotension, Arrhythmia ORPHA:549
Corticosterone Methyloxidase Type I Deficiency
Hypotension OMIM:203400
Diffuse Cutaneous Mastocytosis
Gastrointestinal hemorrhage, Hepatomegaly, Hypotension ORPHA:79456
Inhalational Anthrax
Internal hemorrhage, Hypotension ORPHA:247257
Aggressive Systemic Mastocytosis
Hypotension, Gastrointestinal hemorrhage, Portal hypertension, Hepatosplenomegaly ORPHA:98850
Mercury Poisoning
Hypertension, Tachycardia, Hypotension ORPHA:330021
Familial Glucocorticoid Deficiency
Hypotension, Hypertrophic cardiomyopathy, Ketotic hypoglycemia, Hypoglycemic seizures ORPHA:361
Infant Botulism
Hypertension, Cardiac arrest, Hypotension ORPHA:178478
Serotonin Syndrome
Hypertension, Tachycardia, Rhabdomyolysis, Hypotension ORPHA:43116
Congenital Enterovirus Infection
Myocarditis, Cardiomyopathy, Pericardial effusion, Hypotension ORPHA:292
Pseudohypoaldosteronism, Type I, Autosomal Dominant
Hypotension OMIM:177735
3-Hydroxy-3-Methylglutaric Aciduria
Nonketotic hypoglycemia, Hepatomegaly, Cardiac arrest, Dilated cardiomyopathy, Recurrent hypoglyc... ORPHA:20
Meningococcal Meningitis
Shock, Hypotension ORPHA:33475
Relapsing Fever
Tachycardia, Epistaxis, Hypotension ORPHA:91547
Cocaine Intoxication
Prolonged QT interval, Tachycardia, Prolonged QRS complex, Myocardial infarction, Diffuse alveola... ORPHA:90068
Cholera
Hypovolemic shock, Tachycardia, Hypoglycemia, Hypotension ORPHA:173
Colchicine Poisoning
Myocarditis, Congestive heart failure, Hypovolemia, Hypotension, Cardiogenic shock, Arrhythmia ORPHA:31824
Ileal Neuroendocrine Tumor
Tricuspid stenosis, Right ventricular failure, Arterial occlusion, Palpitations, Hypotension, Pul... ORPHA:100078
Ethylene Glycol Poisoning
Prolonged QT interval, Shock, Tachycardia, Atrial fibrillation, Facial palsy, Congestive heart fa... ORPHA:31826
Pde4D Haploinsufficiency Syndrome
Hypotension ORPHA:439822
Late-Onset Isolated Acth Deficiency
Type I diabetes mellitus, Orthostatic hypotension, Hypoglycemia, Hypotension ORPHA:199299
Renal Tubular Dysgenesis
Hypotension OMIM:267430
Familial Hypoaldosteronism
Orthostatic hypotension, Hypovolemia, Hypotension ORPHA:427
Bacterial Toxic-Shock Syndrome
Shock, Tachycardia, Myositis, Myocarditis, Capillary leak, Hypotension ORPHA:36234
Pituitary Apoplexy
Hypertension, Hypoglycemia, Hypotension ORPHA:95613
Gitelman Syndrome
Prolonged QT interval, Maternal diabetes, Raynaud phenomenon, Pericardial effusion, Insulin resis... ORPHA:358
Alexander Disease
Diabetes mellitus, Facial palsy, Sudden cardiac death, Hypertension, Hypotension ORPHA:58
Sepsis In Premature Infants
Hepatomegaly, Tachycardia, Splenomegaly, Bradycardia, Hypotension ORPHA:90051
Hennekam-Beemer Syndrome
Arrhythmia, Telangiectasia of the skin, Camptodactyly of finger, Hypotension ORPHA:2135
Acute Radiation Syndrome
Hypotension, Telangiectasia ORPHA:454831
Neuroleptic Malignant Syndrome
Tachycardia, Pulmonary embolism, Rhabdomyolysis, Hypertension, Bradycardia, Hypotension, Arrhythm... ORPHA:94093
Aromatic L-Amino Acid Decarboxylase Deficiency
Torticollis, Hypotension, Limb hypertonia OMIM:608643
Acute Adrenal Insufficiency
Orthostatic hypotension, Hypoglycemia, Myocardial infarction, Hypovolemia, Hypotension ORPHA:95409
Crimean-Congo Hemorrhagic Fever
Bundle branch block, Abnormal left ventricular function, Internal hemorrhage, Hepatomegaly, Peric... ORPHA:99827
Systemic Mastocytosis With Associated Hematologic Neoplasm
Hepatomegaly, Tachycardia, Splenomegaly, Syncope, Hypotension ORPHA:98849
Congenital Adrenal Hyperplasia Due To 3-Beta-Hydroxysteroid Dehydrogenase Deficiency
Hypotension, Neonatal hypoglycemia ORPHA:90791
Gitelman Syndrome
Prolonged QT interval, Rhabdomyolysis, Ventricular tachycardia, Palpitations, Hypotension OMIM:263800
Lujo Hemorrhagic Fever
Shock, Myocarditis, Subconjunctival hemorrhage, Bradycardia, Hypotension ORPHA:319213
Hemorrhagic Fever-Renal Syndrome
Shock, Tachycardia, Epistaxis, Hematemesis, Capillary leak, Intracranial hemorrhage, Hypertension... ORPHA:340
Autosomal Dominant Hypocalcemia
Congestive heart failure, Arrhythmia, Hypotension ORPHA:428
Tubulointerstitial Kidney Disease, Autosomal Dominant, 2
Hypertension, Hypotension OMIM:174000
Neuroendocrine Neoplasm Of Appendix
Hepatomegaly, Tricuspid stenosis, Heart murmur, Palpitations, Hypotension ORPHA:100079
Marburg Hemorrhagic Fever
Shock, Tachycardia, Pericarditis, Hypoglycemia, Hypovolemia, Capillary leak, Subconjunctival hemo... ORPHA:99826
Deficiency In Anterior Pituitary Function-Variable Immunodeficiency Syndrome
Recurrent hypoglycemia, Hypotension ORPHA:293978
Non-Functioning Pituitary Adenoma
Hypotension ORPHA:91349
Addison Disease
Type I diabetes mellitus, Orthostatic hypotension, Hypoglycemia, Hypotension ORPHA:85138
Hellp Syndrome
Cerebral hemorrhage, Internal hemorrhage, Hypotension ORPHA:244242
Exercise-Induced Malignant Hyperthermia
Prolonged QT interval, Rhabdomyolysis, ST segment depression, Hypotension, Abnormal T-wave, Abnor... ORPHA:466650
Fragile X-Associated Tremor/Ataxia Syndrome
Hypertension, Hypotension ORPHA:93256
Tsh-Secreting Pituitary Adenoma
Supraventricular arrhythmia, Pericardial effusion, Congestive heart failure, Hypertension, Palpit... ORPHA:91347
46,Xy Difference Of Sex Development-Adrenal Insufficiency Due To Cyp11A1 Deficiency
Hypotension, Hypovolemia, Neonatal hypoglycemia ORPHA:168558
Inherited Isolated Adrenal Insufficiency Due To Partial Cyp11A1 Deficiency
Hypotension, Hypovolemia, Neonatal hypoglycemia ORPHA:289548
Leptospirosis
Hepatomegaly, Pericarditis, First degree atrioventricular block, Rhabdomyolysis, Retinal hemorrha... ORPHA:509
Prolactinoma
Hypotension ORPHA:2965
Hereditary Angioedema Type 1
Hypotension ORPHA:100050
Lysosomal Acid Lipase Deficiency
Pulmonary arterial hypertension, Hypovolemia, Hypotension, Hepatosplenomegaly ORPHA:275761
Bartter Syndrome, Type 3
Hypotension OMIM:607364
Acute Liver Failure
Shock, Gastrointestinal hemorrhage, Hypoglycemia, Intracranial hemorrhage, Hypotension ORPHA:90062
Non-Acquired Panhypopituitarism
Hypoglycemia, Hypotension ORPHA:90695
Classic Congenital Adrenal Hyperplasia Due To 21-Hydroxylase Deficiency
Hypotension, Shock, Hypovolemia, Neonatal hypoglycemia ORPHA:90794
Plague
Hepatomegaly, Tachycardia, Hematemesis, Splenomegaly, Endocarditis, Hypotension, Arrhythmia ORPHA:707
Combined Pituitary Hormone Deficiencies, Genetic Forms
Hypoglycemia, Hypotension ORPHA:95494
Bartter Syndrome, Type 1, Antenatal
Low-to-normal blood pressure OMIM:601678
Bartter Syndrome, Type 2, Antenatal
Low-to-normal blood pressure OMIM:241200

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ckm

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ckm.

No publications found that use IMPC mice or data for Ckm.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Ckmtm2e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Ckmtm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ckmtm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Ckmtm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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