Gene: Cacna1b

Name calcium channel, voltage-dependent, N type, alpha 1B subunit

Synonyms
  • Cchn1a
  • alpha(1B)
  • Cav2.2

Status ES CellsMice
tm1a
Mice
tm1b
Mice
tm1c
phenotype data available

Links MGI:88296   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Viable

Phenotype associations for Cacna1b

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Cacna1b data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
hyperactivity Cacna1btm1b(KOMP)Wtsi HOM Female Male postnatal 1.16E-12
increased circulating triglyceride level Cacna1btm1b(KOMP)Wtsi HOM Female Male postnatal 3.35E-10
abnormal gait Cacna1btm1b(KOMP)Wtsi HOM Female postnatal 1.02E-9
decreased grip strength Cacna1btm1b(KOMP)Wtsi HOM Female Male postnatal 2.36E-9
abnormal behavior Cacna1btm1b(KOMP)Wtsi HOM Male postnatal 4.2E-9
increased circulating alanine transaminase level Cacna1btm1b(KOMP)Wtsi HOM Female Male postnatal 2.33E-5
decreased fasted circulating glucose level Cacna1btm1b(KOMP)Wtsi HOM Female Male postnatal 5.34E-5
decreased neutrophil cell number Cacna1btm1b(KOMP)Wtsi HOM Female Male postnatal 8.73E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (5/393) (2/2)
Aorta 2 No (1/562)
Bone 2 No (1/539)
Brain 2 No (6/562) (2/2)
Brainstem 2 No (4/562) (2/2)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/562)
Cerebellum 2 No (4/562)
Cerebral cortex 2 No (5/562) (2/2)
Esophagus 2 No (2/393) (2/2)
Eye 2 No (1/562)
Gall bladder 2 No
Heart 2 No (3/562)
Hippocampus 2 No (5/562) (2/2)
Hypothalamus 2 No (4/562) (2/2)
Kidney 2 No (20/562)
Large intestine 2 No (12/562) (2/2)
Liver 2 No
Lower urinary tract 2 No (3/562) (2/2)
Lung 2 No (3/562)
Lymph node 2 No (1/562)
Mammary gland 2 No
Olfactory lobe 2 No (4/393) (2/2)
Oral epithelium 2 No
Ovary 2 No (1/562)
Oviduct 2 No (2/562)
Pancreas 2 No (6/562)
Parathyroid gland 2 No (2/540)
Peripheral nervous system 2 No (3/562) (2/2)
Peyer's patch 2 No (1/393)
Pituitary gland 2 No (1/562) (2/2)
Prostate gland 2 No (5/562)
Skeletal muscle 2 No
Skin 2 No (1/562)
Small intestine 2 No (11/562) (2/2)
Spinal cord 2 No (3/562) (2/2)
Spleen 2 No (4/562)
Stomach 2 No (9/562) (2/2)
Striatum 2 No (4/562) (2/2)
Testis 2 No (4/562) (1/2)
Thymus 2 No
Thyroid gland 2 No (16/562)
Trachea 2 No (3/562)
Uterus 2 No (2/562)
Vascular system 2 No (1/393)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system
    postnatal mouse
    digestive system
    nervous system
    reproductive system
    trunk
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/440) (4/4)
Ear 2 (1/440) (1/4)
Embryo 2 (1/440) (4/4)
Eye 2 (1/440) (2/4)
Foot 2
Forebrain 2 (1/440) (2/4)
Forelimb 2 (1/440)
Hand 2
Head 2 (5/440) (4/4)
Heart 2 (1/440) Image Only
Hindbrain 2 (5/440) (4/4)
Hindlimb 2 (1/440)
Liver 2 (1/440)
Lung 2 (1/440)
Mandibular process 2 (1/440)
Maxillary process 2 (1/440)
Midbrain 2 (1/440) (3/4)
Oral cavity 2 (1/440)
Skin 2 (1/440)
Tail 2 (1/440)
Tail somite 2 (1/440)


Associated Images

Associated Images
  • X-ray: XRay Images Dorso Ventral
    11 Images
  • X-ray: XRay Images Lateral Orientation
    11 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    11 Images
  • Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
    4 Images
  • Embryo LacZ: LacZ images wholemount
    8 Images
  • Echo: M-Mode Images
    32 Images
  • Adult LacZ: LacZ Images Wholemount
    11 Images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Cacna1btm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Cacna1btm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Cacna1btm1c(KOMP)Wtsi Wild type floxed exon (post-Flp)
Vector
Gene