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Gene: C2 MGI:88226

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
complement C2
Synonyms:
classical-complement pathway C3/C5 convertase

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by C2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.
No human diseases associated to this gene by phenotypic similarity.

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for C2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to C2.

There are 10 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Inceptor facilitates acrosomal vesicle formation in spermatids and is required for male fertility. Frontiers in cell and developmental biology (August 2023) 5330417C22Riktm1a(EUCOMM)Hmgu PMC10483240
Centriolar Protein C2cd3 Is Required for Craniofacial Development. Frontiers in cell and developmental biology (June 2021) C2cd3tm1a(EUCOMM)Wtsi PMC8239364
Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis. Diabetologia (January 2021) C2cd4bem1(IMPC)Wtsi C2cd4aem1(IMPC)H PMC7829492
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) C2cd4bem1(IMPC)Wtsi PMC7263671
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation. Nature immunology (December 2019) A730017C20Riktm1b(KOMP)Wtsi PMC7338221
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) A730017C20Riktm1b(KOMP)Wtsi C2cd4bem1(IMPC)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) A730017C20Riktm1b(KOMP)Wtsi PMC6459510
A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction. Nature communications (October 2017) A730017C20Riktm1b(KOMP)Wtsi PMC5638796
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) A730017C20Riktm1b(KOMP)Wtsi PMC5827107
Changes in expression of C2cd4c in pancreatic endocrine cells during pancreatic development. FEBS letters (July 2016) C2cd4ctm1(KOMP)Mbp PMC5129588

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MGI Allele Allele Type Produced
C2tm84505(L1L2_Pgk_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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