Gene: Acvr2b

Order

Name activin receptor IIB

Synonyms ActRIIB

Status ES CellsMice
tm1.1
Mice
tm1
phenotype data available

Links MGI:87912    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Subviable

Phenotype associations for Acvr2b

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Acvr2b data for that phenotype.

Embryo Data: 3D Embryo Imaging
Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal embryo size Acvr2btm1.1(KOMP)Vlcg HET Female Male embryonic day 12.5 0.0
abnormal eye morphology Acvr2btm1.1(KOMP)Vlcg HET Female Male embryonic day 12.5 0.0
pale yolk sac Acvr2btm1.1(KOMP)Vlcg HET Female Male embryonic day 12.5 0.0
pallor Acvr2btm1.1(KOMP)Vlcg HET Female Male embryonic day 12.5 0.0
preweaning lethality, incomplete penetrance Acvr2btm1.1(KOMP)Vlcg HOM Female Male n/a 0.0
decreased startle reflex Acvr2btm1.1(KOMP)Vlcg HET Male postnatal 5.48E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 1 No (2/415)
Aorta 1 No
Blood 1 No
Bone marrow 1 No
Brain 1 No
Brainstem 1 No
Brown adipose tissue 1 No
Cartilage tissue 1 No
Cecum 1 No (12/383)
Cerebellum 1 No
Cerebral cortex 1 No
Chest bone 1 No
Colon 1 No (12/127)
Diaphragm 1 No
Duodenum 1 No (2/127)
Epididymis 1 No (18/134) (1/1)
Esophagus 1 No (7/415)
Eye 1 No
Gall bladder 1 No
Gonadal fat pad 1 No
Harderian gland 1 No
Heart 1 No
Hindlimb 1 No
Hippocampus 1 No
Hypothalamus 1 No
Ileum 1 No (14/127) (1/1)
Jejunum 1 No (6/127)
Kidney 1 No (18/584)
Large intestine 1 No (10/584)
Liver 1 No
Lower urinary tract 1 No
Lung 1 No
Lymph node 1 No
Mammary gland 1 No
Mesenteric lymph node 1 No
Mesenteric adipose tissue 1 No
Midbrain 1 No
Olfactory lobe 1 No
Ovary 1 No (1/584)
Oviduct 1 No
Pancreas 1 No (5/584)
Parathyroid gland 1 No
Parotid gland 1 No
Penis 1 No
Peripheral nervous system 1 No
Peyer's patch 1 No
Pituitary gland 1 No
Prostate gland 1 No (12/584) (1/1)
Quadriceps 1 No
Sciatic nerve 1 No
Skeletal muscle 1 No
Skin 1 No
Small intestine 1 No (9/584)
Spinal cord 1 No
Spleen 1 No (2/584)
Stomach 1 No (12/584)
Stomach pyloric region 1 No
Striatum 1 No
Sublingual gland 1 No
Submandibular gland 1 No (2/132)
Testis 1 No (2/584)
Thymus 1 No
Thyroid gland 1 No (15/584)
Tongue 1 No (5/127)
Trachea 1 No
Trigeminal V nerve 1 No
Urinary bladder 1 No
Uterus 1 No
Vagina 1 No
Vas deferens 1 No (15/388) (1/1)
Vascular system 1 No
Vesicular gland 1 No
White adipose tissue 1 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse digestive system reproductive system exocrine system trunk
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 2 (1/51)
Brain 2 (6/485) (2/2)
Central nervous system ganglion 2 (1/51)
Ear 2 (1/485)
Embryo 2 (1/485) (2/2)
Eye 2 (1/485) (2/2)
Foot 2 (1/485)
Forebrain 2 (1/485) (2/2)
Forelimb 2 (1/485)
Gut 2 (1/50) (2/2)
Hand 2 (1/485)
Head 2 (5/485)
Heart 2 (1/485) (2/2)
Hindbrain 2 (6/485) (2/2)
Hindlimb 2 (1/485)
Liver 2 (1/485)
Lung 2 (1/485)
Mandibular process 2 (1/485)
Maxillary process 2 (1/485)
Midbrain 2 (1/485) (2/2)
Nose 2 (1/51)
Oral cavity 2 (1/485)
Skeleton 2 (1/51)
Skin 2 (1/485)
Spinal cord 2 (1/50)
Tail 2 (1/485)
Tail somite 2 (1/485)
Trachea 2 (1/50)
Urinary system 2 (1/50) (2/2)


Associated Images

Associated Images
  • X-ray: XRay Images Dorso Ventral
    40 Images
  • X-ray: XRay Images Lateral Orientation
    20 Images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Acvr2btm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette)
Vector
Gene
Fixed Tissue
Acvr2btm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene