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Gene: Chrna2 MGI:87886

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Gene Summary

Name:
cholinergic receptor nicotinic alpha 2 subunit
Synonyms:
Acra-2,  Acra2

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
thick skin Chrna2em1(IMPC)Mbp HOM Early adult 0.00
abnormal kidney morphology Chrna2em1(IMPC)Mbp HOM Early adult 0.00
small kidney Chrna2em1(IMPC)Mbp HOM Early adult 0.00
abnormal skin morphology Chrna2em1(IMPC)Mbp HOM Early adult 0.00
abnormal caudal vertebrae morphology Chrna2em1(IMPC)Mbp HOM   Early adult 1.54×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

33 Images

View images
X-ray

XRay Images Whole Body Lateral Orientation

11 Images

View images

Human diseases caused by Chrna2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Chrna2 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Autosomal Dominant Nocturnal Frontal Lobe Epilepsy
Urinary incontinence ORPHA:98784
Epilepsy, Nocturnal Frontal Lobe, 4
OMIM:610353

The table below shows human diseases predicted to be associated to Chrna2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Autosomal Dominant Nocturnal Frontal Lobe Epilepsy
Urinary incontinence ORPHA:98784
Epilepsy, Nocturnal Frontal Lobe, 4
OMIM:610353

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Chrna2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Chrna2.

No publications found that use IMPC mice or data for Chrna2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Chrna2tm208612(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Chrna2em1(IMPC)Mbp Inter-exon deletion Mice

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